Alternative splicing(AS)has been shown to be frequently present in human tumors.Specifically,it has been observed in some experimental studies thatmulti-exon skipping(MES)events often appear in tumorous tissues.Prompt...Alternative splicing(AS)has been shown to be frequently present in human tumors.Specifically,it has been observed in some experimental studies thatmulti-exon skipping(MES)events often appear in tumorous tissues.Prompted by this observation,we conducted a genome-wide analysis of MES events to investigate their association with tumors.The results show that MES events are more likely associated with tumors than single-exon skipping(SES)and the degree of association increases with the num-ber of skipped exons.Furthermore,MES events are found to be less conserved than their SES counterparts,which provides additional evidence for our results because dis-ease-associated AS events should be eliminated during evolution.Interestingly,these differences still existed even after comparison of MES and SES events with similar-length skipped regions.These results demonstrate that MES events may be associated with tumors and suggest that MES isoforms might be useful in cancer diagnosis.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos.60775002,60572086).
文摘Alternative splicing(AS)has been shown to be frequently present in human tumors.Specifically,it has been observed in some experimental studies thatmulti-exon skipping(MES)events often appear in tumorous tissues.Prompted by this observation,we conducted a genome-wide analysis of MES events to investigate their association with tumors.The results show that MES events are more likely associated with tumors than single-exon skipping(SES)and the degree of association increases with the num-ber of skipped exons.Furthermore,MES events are found to be less conserved than their SES counterparts,which provides additional evidence for our results because dis-ease-associated AS events should be eliminated during evolution.Interestingly,these differences still existed even after comparison of MES and SES events with similar-length skipped regions.These results demonstrate that MES events may be associated with tumors and suggest that MES isoforms might be useful in cancer diagnosis.
