Prostate homeostasis and regeneration rely on the proper function of adult stem/progenitor cells(Ousset et al., 2012), which have also been considered as potential cells of origin for prostate cancer(Visvader, 2011) g...Prostate homeostasis and regeneration rely on the proper function of adult stem/progenitor cells(Ousset et al., 2012), which have also been considered as potential cells of origin for prostate cancer(Visvader, 2011) given their key positions in the lineage hierarchy and self-renewal capability. Accumulating evidence reveals the existence of multipotent progenitor cells in both basal and luminal cells.展开更多
基金supported by the grant JCYJ20200109141229255 from Science, Technology and Innovation Commission of Shenzhen Municipalitysupported by grants R01CA171189 and R01CA193455 from the National Cancer Institute, National Institutes of Healthsupported in part by the Emory Integrated Genomics Core, Integrated Cellular Imaging Core Facility, Winship Research Pathology Core, and Transgenic Mouse and Gene Targeting Core of Emory University Winship Cancer Institute and NIH/NCI under award number P30CA138292。
文摘Prostate homeostasis and regeneration rely on the proper function of adult stem/progenitor cells(Ousset et al., 2012), which have also been considered as potential cells of origin for prostate cancer(Visvader, 2011) given their key positions in the lineage hierarchy and self-renewal capability. Accumulating evidence reveals the existence of multipotent progenitor cells in both basal and luminal cells.
