The electromagnetic separation method is a new approach to treat ship-based marine oily wastewater,in which oil droplets are dispersed in seawater(oil-seawater mixed flow).In order to clarify the separation process an...The electromagnetic separation method is a new approach to treat ship-based marine oily wastewater,in which oil droplets are dispersed in seawater(oil-seawater mixed flow).In order to clarify the separation process and determine the separation characteristics,the flow field and volume fraction of the oil droplets of the oil-seawater mixed flow under an applied electromagnetic field with different operating conditions were investigated by 2D numerical simulations with the Eulerian model.The results show that:(1)the downward Lorentz force causes seawater to flow downwards and the oil droplets to move upwards due to the electromagnetic separation force in the effective section of the separation channel;(2)the volume fraction of the oil droplets at the top of the outlet section increases with the current density,magnetic field,and the diameter of the oil droplet and decreases with the inlet velocity of the oily seawater.The results provide useful guidance for the design of electromagnetic separation devices of the oil-seawater mixed flow.展开更多
Most previous research on areas with abundant rainfall shows that simulations using rainfall-runoff modes have a very high prediction accuracy and applicability when using a back-propagation(BP), feed-forward, multila...Most previous research on areas with abundant rainfall shows that simulations using rainfall-runoff modes have a very high prediction accuracy and applicability when using a back-propagation(BP), feed-forward, multilayer perceptron artificial neural network(ANN). However, in runoff areas with relatively low rainfall or a dry climate, more studies are needed. In these areas—of which oasis-plain areas are a particularly good example—the existence and development of runoff depends largely on that which is generated from alpine regions. Quantitative analysis of the uncertainty of runoff simulation under climate change is the key to improving the utilization and management of water resources in arid areas. Therefore, in this context, three kinds of BP feed-forward, three-layer ANNs with similar structure were chosen as models in this paper.Taking the oasis–plain region traverse by the Qira River Basin in Xinjiang, China, as the research area, the monthly accumulated runoff of the Qira River in the next month was simulated and predicted. The results showed that the training precision of a compact wavelet neural network is low; but from the forecasting results, it could be concluded that the training algorithm can better reflect the whole law of samples. The traditional artificial neural network(TANN) model and radial basis-function neural network(RBFNN) model showed higher accuracy in the training and prediction stage. However, the TANN model, more sensitive to the selection of input variables, requires a large number of numerical simulations to determine the appropriate input variables and the number of hidden-layer neurons. Hence, The RBFNN model is more suitable for the study of such problems. And it can be extended to other similar research arid-oasis areas on the southern edge of the Kunlun Mountains and provides a reference for sustainable water-resource management of arid-oasis areas.展开更多
A digital image watermarking algorithm based on fast curvelet transform is proposed. Firstly, the carrier image is decomposed by fast curvelet transform, and, the watermarking image is scrambled by Arnold transform. S...A digital image watermarking algorithm based on fast curvelet transform is proposed. Firstly, the carrier image is decomposed by fast curvelet transform, and, the watermarking image is scrambled by Arnold transform. Secondly, the binary watermarking image is embedded into the medium frequency coefficients according to the human visual characteristics and curvelet coefficients. Experiment results show that the proposed algorithm has good performance in both invisibility and security and also has good robustness against the noise, cropping, filtering, JPEG compression and other attacks.展开更多
CFSFDP(Clustering by fast search and find of density peak)is a simple and crisp density clustering algorithm.It does not only have the advantages of density clustering algorithm,but also can find the peak of cluster a...CFSFDP(Clustering by fast search and find of density peak)is a simple and crisp density clustering algorithm.It does not only have the advantages of density clustering algorithm,but also can find the peak of cluster automatically.However,the lack of adaptability makes it difficult to apply in intrusion detection.The new input cannot be updated in time to the existing profiles,and rebuilding profiles would waste a lot of time and computation.Therefore,an adaptive anomaly detection algorithm based on CFSFDP is proposed in this paper.By analyzing the influence of new input on center,edge and discrete points,the adaptive problem mainly focuses on processing with the generation of new cluster by new input.The improved algorithm can integrate new input into the existing clustering without changing the original profiles.Meanwhile,the improved algorithm takes the advantage of multi-core parallel computing to deal with redundant computing.A large number of experiments on intrusion detection on Android platform and KDDCUP 1999 show that the improved algorithm can update the profiles adaptively without affecting the original detection performance.Compared with the other classical algorithms,the improved algorithm based on CFSFDP has the good basic performance and more room of improvement.展开更多
Agricultural environmental pollution emergencies have become a hot research topic because of the high incidence and influence depth.This paper introduces classification and features of agricultural environmental pollu...Agricultural environmental pollution emergencies have become a hot research topic because of the high incidence and influence depth.This paper introduces classification and features of agricultural environmental pollution emergencies:by pollutant type,it falls into organic pollution emergencies and inorganic pollution emergencies;by the approach of entering agricultural environment,it falls into water resource agricultural environmental pollution emergencies and non-water resource agricultural environmental pollution emergencies.Hazards of agricultural environmental pollution emergencies are analyzed from 4 perspectives:personal security,indirect loss,ecological environment and social stability.In view of the hazards,countermeasures are given to deal with the pollution emergencies as(i)establishing a risk evaluation mechanism for agricultural environment;(ii)enhancing the capacity of handling agricultural environmental pollution emergencies;(iii)introducing new management concepts for environmental emergencies,and cultivating keen emergency management consciousness.展开更多
China's intangible cultural heritage as an important part and the soul of the traditional Chinese culture is the cultural treasure of China and even the world.As the concept of cultural protection is deeply rooted...China's intangible cultural heritage as an important part and the soul of the traditional Chinese culture is the cultural treasure of China and even the world.As the concept of cultural protection is deeply rooted in the minds of people,the state attaches increasing importance to intangible cultural heritage.The unique forms of cultural expressions and the special places of these expressions are deeply rooted in the Chinese culture and they should also be an important content in China's efficient ideological and political education.This article mainly explores the significance of intangible cultural heritage in ideological and political teaching as well as the strategies to effectively integrate intangible cultural heritage into ideological and political teaching in order to achieve the educational purposes of condensing the consensus of traditional Chinese culture,enhancing the cultural consciousness among teachers and students in colleges and universities,and enhancing the patriotic enthusiasm and cultural confidence.展开更多
Radix Astragali,one of the most popular herbs in traditional Chinese medicine(TCM),is used to strengthen the immune system,protect liver function,fight bacteria and viruses,and treat diabetes,heart failure and seasona...Radix Astragali,one of the most popular herbs in traditional Chinese medicine(TCM),is used to strengthen the immune system,protect liver function,fight bacteria and viruses,and treat diabetes,heart failure and seasonal allergies.In recent years,a new form of Radix Astragali material processed by cell wall disrupting technology,namely ultrafine granular powder(UGP)has been introduced into the market.In order to determine chemical consistency and homogeneity of the UGP material prepared from sliced traditional materials(TM)of Radix Astragali,multiple batches of the UGP and TM samples derived from Astragalus membranaceus var.mongholicus were analyzed by UHPLC/DAD-MS using isoflavones and triterpenoid glycosides as marker compounds.The results demonstrated that the chemical profiles of UGP was identical or similar to that of TM,but UGP was highly homogeneous in terms of marker compound contents as assessed,e.g.,by the relative standard deviation values of the nine marker compounds in the range of 8.55%−43.80%for TM2 compared against 1.70%−8.38%for UGP2.Macromolecular component preparation and 1H NMR analyses indicated that TM4 and its corresponding UGP4 produced similar polysaccharides,but the later had approximately two-fold dissolution rate of the polysaccharides when compared to the former(yield 7.22±0.35%vs 3.39±0.20%).This study confirms that UGP of Radix Astragali is chemically consistent and homogenous,supporting its use as a promising material in TCM prescriptions.展开更多
Schistosoma infection is one of the major causes of liver fibrosis.Emerging roles of hepatic progenitor cells(HPCs)in the pathogenesis of liver fibrosis have been identified.Nevertheless,the precise mechanism underlyi...Schistosoma infection is one of the major causes of liver fibrosis.Emerging roles of hepatic progenitor cells(HPCs)in the pathogenesis of liver fibrosis have been identified.Nevertheless,the precise mechanism underlying the role of HPCs in liver fibrosis in schistosomiasis remains unclear.This study examined how autophagy in HPCs affects schistosomiasis-induced liver fibrosis by modulating exosomal miRNAs.The activation of HPCs was verified by immunohistochemistry(IHC)and immunofluorescence(IF)staining in fibrotic liver from patients and mice with Schistosoma japonicum infection.By coculturing HPCs with hepatic stellate cells(HSCs)and assessing the autophagy level in HPCs by proteomic analysis and in vitro phenotypic assays,we found that impaired autophagy degradation in these activated HPCs was mediated by lysosomal dysfunction.Blocking autophagy by the autophagy inhibitor chloroquine(CQ)significantly diminished liver fibrosis and granuloma formation in S.japonicum-infected mice.HPC-secreted extracellular vehicles(EVs)were further isolated and studied by miRNA sequencing.miR-1306-3p,miR-493-3p,and miR-34a-5p were identified,and their distribution into EVs was inhibited due to impaired autophagy in HPCs,which contributed to suppressing HSC activation.In conclusion,we showed that the altered autophagy process upon HPC activation may prevent liver fibrosis by modulating exosomal miRNA release and inhibiting HSC activation in schistosomiasis.Targeting the autophagy degradation process may be a therapeutic strategy for liver fibrosis during Schistosoma infection.展开更多
To the Editor:Patients with severe persistent asthma experience greater morbidity with more impairment in quality of life despite higher use of health care resources and being treated with existing asthma treatments s...To the Editor:Patients with severe persistent asthma experience greater morbidity with more impairment in quality of life despite higher use of health care resources and being treated with existing asthma treatments such as inhaled corticosteroids and b-agonists,and sometimes oral corticosteroid(OCS)therapy.Type-2(T2)high asthma has been identified as a phenotype that responds to targeted T2 biologic therapies such as anti-IgE,anti-interleukin(IL)5,or anti-IL5Ra and anti-IL4Ra monoclonal antibodies,which are currently available in Europe and North America,and are currently introduced in the rest of the world.[1]展开更多
In December 2019,an outbreak of novel coronavirus(2019-nCoV)occurred in Wuhan,Hubei Province,China.By February 14,2020,it has led to 66492 confirmed patients in China and high mortality up to^2.96%(1123/37914)in Wuhan...In December 2019,an outbreak of novel coronavirus(2019-nCoV)occurred in Wuhan,Hubei Province,China.By February 14,2020,it has led to 66492 confirmed patients in China and high mortality up to^2.96%(1123/37914)in Wuhan.Here we report the first family case of coronavirus disease 2019(COVID-19)confirmed in Wuhan and treated using the combination of western medicine and Chinese traditional patent medicine Shuanghuanglian oral liquid(SHL).This report describes the identification,diagnosis,clinical course,and management of three cases from a family,suggests the expected therapeutic effects of SHL on COVID-19,and warrants further clinical trials.展开更多
We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by...We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by three doses(56 in low dose,61 in middle dose,and 59 in high dose)in addition to standard care.The control group was composed of 59 patients who received standard therapy alone.Treatment with SHL was not associated with a difference from standard care in the time to disease recovery.Patients with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group(93.4%vs.73.9%,P=0.006).Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia,which was evaluated by density reduction of inflammatory focus from baseline,at day 7(mean difference(95%CI),−46.39(−86.83 to−5.94)HU;P=0.025)and day 14(mean difference(95%CI),−74.21(−133.35 to−15.08)HU;P=0.014).No serious adverse events occurred in the SHL groups.This study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19.展开更多
Dear Editor,Since December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been rapidly spreading worldwide.Hydroxychloroquine and chloroquine are candidates for the treatment of coronavirus diseas...Dear Editor,Since December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been rapidly spreading worldwide.Hydroxychloroquine and chloroquine are candidates for the treatment of coronavirus disease 2019(COVID-19)owing to its antiviral effect and immunomodulation properties.展开更多
Coronavirus disease 2019(COVID-19)is a highly contagious disease and a serious threat to human health.COVID-19 can cause multiple organ dysfunction,such as respiratory and circulatory failure,liver and kidney injury,d...Coronavirus disease 2019(COVID-19)is a highly contagious disease and a serious threat to human health.COVID-19 can cause multiple organ dysfunction,such as respiratory and circulatory failure,liver and kidney injury,disseminated intravascular coagulation,and thromboembolism,and even death.The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%.Currently,the number of severe cases worldwide has increased rapidly,but the experience in the treatment of infected patients is still limited.Given the lack of specific antiviral drugs,multi-organ function support treatment is important for patients with COVID-19.To improve the cure rate and reduce the mortality of patients with severe-and critical-type COVID-19,this paper summarizes the experience of organ function support in patients with severe-and criticaltype COVID-19 in Optical Valley Branch of Tongji Hospital,Wuhan,China.This paper systematically summarizes the procedures of functional support therapies for multiple organs and systems,including respiratory,circulatory,renal,hepatic,and hematological systems,among patients with severe-and critical-type COVID-19.This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide.展开更多
Atherosclerotic cardiovascular disease resulting from dysregulated lipid metabolism is the leading cause of morbidity and mortality worldwide.Apolipoprotein E(ApoE)plays a critical role in cholesterol metabolism.Knock...Atherosclerotic cardiovascular disease resulting from dysregulated lipid metabolism is the leading cause of morbidity and mortality worldwide.Apolipoprotein E(ApoE)plays a critical role in cholesterol metabolism.Knockouts in lipid-metabolizing proteins including ApoE in multiple model organisms such as mice and rats exhibiting elevated levels of cholesterol have been widely used for dissecting the pathology of atherosclerosis,but few of these animal models exhibit advanced atherosclerotic plaques leading to ischemia-induced clinical symptoms,limiting their use for translational studies.Here we report hypercholesterolemia and severe atherosclerosis characterized by stenosis and occlusion of arteries,together with clinical manifestations of stroke and gangrene,in ApoE knockout dogs generated by CRISPR/Cas9 and cloned by somatic cell nuclear transfer technologies.Importantly,the hypercholesterolemia and atherosclerotic complications in F0 mutants are recapitulated in their offspring.As the ApoE-associated atherosclerosis and clinical manifestations in mutant dogs are more similar to that in human patients compared with those in other animal models,these mutant dogs will be invaluable in developing and evaluating new therapies,including endovascular procedures,against atherosclerosis and related disorders.展开更多
基金The Tianjin Science and Technology Plan Project under contract No.15YFYSGX00010the Tianjin Bureau of Marine Science and Technology Plan Project under contract No.KJXH2015-05
文摘The electromagnetic separation method is a new approach to treat ship-based marine oily wastewater,in which oil droplets are dispersed in seawater(oil-seawater mixed flow).In order to clarify the separation process and determine the separation characteristics,the flow field and volume fraction of the oil droplets of the oil-seawater mixed flow under an applied electromagnetic field with different operating conditions were investigated by 2D numerical simulations with the Eulerian model.The results show that:(1)the downward Lorentz force causes seawater to flow downwards and the oil droplets to move upwards due to the electromagnetic separation force in the effective section of the separation channel;(2)the volume fraction of the oil droplets at the top of the outlet section increases with the current density,magnetic field,and the diameter of the oil droplet and decreases with the inlet velocity of the oily seawater.The results provide useful guidance for the design of electromagnetic separation devices of the oil-seawater mixed flow.
基金financially supported by the regional collaborative innovation project for Xinjiang Uygur Autonomous Region (Shanghai cooperation organization science and technology partnership project) (2017E01029)the "Western Light" program of the Chinese Academy of Sciences (2017XBQNXZ-B-016)+1 种基金the National Natural Science Foundation of China (41601595, U1603343, 41471031)the State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences (G201802-08)
文摘Most previous research on areas with abundant rainfall shows that simulations using rainfall-runoff modes have a very high prediction accuracy and applicability when using a back-propagation(BP), feed-forward, multilayer perceptron artificial neural network(ANN). However, in runoff areas with relatively low rainfall or a dry climate, more studies are needed. In these areas—of which oasis-plain areas are a particularly good example—the existence and development of runoff depends largely on that which is generated from alpine regions. Quantitative analysis of the uncertainty of runoff simulation under climate change is the key to improving the utilization and management of water resources in arid areas. Therefore, in this context, three kinds of BP feed-forward, three-layer ANNs with similar structure were chosen as models in this paper.Taking the oasis–plain region traverse by the Qira River Basin in Xinjiang, China, as the research area, the monthly accumulated runoff of the Qira River in the next month was simulated and predicted. The results showed that the training precision of a compact wavelet neural network is low; but from the forecasting results, it could be concluded that the training algorithm can better reflect the whole law of samples. The traditional artificial neural network(TANN) model and radial basis-function neural network(RBFNN) model showed higher accuracy in the training and prediction stage. However, the TANN model, more sensitive to the selection of input variables, requires a large number of numerical simulations to determine the appropriate input variables and the number of hidden-layer neurons. Hence, The RBFNN model is more suitable for the study of such problems. And it can be extended to other similar research arid-oasis areas on the southern edge of the Kunlun Mountains and provides a reference for sustainable water-resource management of arid-oasis areas.
文摘A digital image watermarking algorithm based on fast curvelet transform is proposed. Firstly, the carrier image is decomposed by fast curvelet transform, and, the watermarking image is scrambled by Arnold transform. Secondly, the binary watermarking image is embedded into the medium frequency coefficients according to the human visual characteristics and curvelet coefficients. Experiment results show that the proposed algorithm has good performance in both invisibility and security and also has good robustness against the noise, cropping, filtering, JPEG compression and other attacks.
基金supported in part by the National Key Research and Development Program of China under Grant No.2018YFB1800303the Science and Technology Planning Project of Jilin Province under Grant No.20190302070GXthe Science and Technology Projects of Jilin Provincial Education Department(the 13th five year plan)under Grant Nos.JJKH20190593KJ,JJKH20190546KJ,and JJKH20200795KJ.
文摘CFSFDP(Clustering by fast search and find of density peak)is a simple and crisp density clustering algorithm.It does not only have the advantages of density clustering algorithm,but also can find the peak of cluster automatically.However,the lack of adaptability makes it difficult to apply in intrusion detection.The new input cannot be updated in time to the existing profiles,and rebuilding profiles would waste a lot of time and computation.Therefore,an adaptive anomaly detection algorithm based on CFSFDP is proposed in this paper.By analyzing the influence of new input on center,edge and discrete points,the adaptive problem mainly focuses on processing with the generation of new cluster by new input.The improved algorithm can integrate new input into the existing clustering without changing the original profiles.Meanwhile,the improved algorithm takes the advantage of multi-core parallel computing to deal with redundant computing.A large number of experiments on intrusion detection on Android platform and KDDCUP 1999 show that the improved algorithm can update the profiles adaptively without affecting the original detection performance.Compared with the other classical algorithms,the improved algorithm based on CFSFDP has the good basic performance and more room of improvement.
基金Supported by Humanities and Social Science Fund of Henan Provincial Department of Education(2013-QN-027)Doctoral Fund of Henan Polytechnic University(B2012-008)
文摘Agricultural environmental pollution emergencies have become a hot research topic because of the high incidence and influence depth.This paper introduces classification and features of agricultural environmental pollution emergencies:by pollutant type,it falls into organic pollution emergencies and inorganic pollution emergencies;by the approach of entering agricultural environment,it falls into water resource agricultural environmental pollution emergencies and non-water resource agricultural environmental pollution emergencies.Hazards of agricultural environmental pollution emergencies are analyzed from 4 perspectives:personal security,indirect loss,ecological environment and social stability.In view of the hazards,countermeasures are given to deal with the pollution emergencies as(i)establishing a risk evaluation mechanism for agricultural environment;(ii)enhancing the capacity of handling agricultural environmental pollution emergencies;(iii)introducing new management concepts for environmental emergencies,and cultivating keen emergency management consciousness.
基金2020 Shanxi Province Art Science Planning Project-Shanxi Intangible Cultural Heritage is Integrated into the Teaching Research of College Ideological and Political Courses(Project number:2020A018).
文摘China's intangible cultural heritage as an important part and the soul of the traditional Chinese culture is the cultural treasure of China and even the world.As the concept of cultural protection is deeply rooted in the minds of people,the state attaches increasing importance to intangible cultural heritage.The unique forms of cultural expressions and the special places of these expressions are deeply rooted in the Chinese culture and they should also be an important content in China's efficient ideological and political education.This article mainly explores the significance of intangible cultural heritage in ideological and political teaching as well as the strategies to effectively integrate intangible cultural heritage into ideological and political teaching in order to achieve the educational purposes of condensing the consensus of traditional Chinese culture,enhancing the cultural consciousness among teachers and students in colleges and universities,and enhancing the patriotic enthusiasm and cultural confidence.
文摘Radix Astragali,one of the most popular herbs in traditional Chinese medicine(TCM),is used to strengthen the immune system,protect liver function,fight bacteria and viruses,and treat diabetes,heart failure and seasonal allergies.In recent years,a new form of Radix Astragali material processed by cell wall disrupting technology,namely ultrafine granular powder(UGP)has been introduced into the market.In order to determine chemical consistency and homogeneity of the UGP material prepared from sliced traditional materials(TM)of Radix Astragali,multiple batches of the UGP and TM samples derived from Astragalus membranaceus var.mongholicus were analyzed by UHPLC/DAD-MS using isoflavones and triterpenoid glycosides as marker compounds.The results demonstrated that the chemical profiles of UGP was identical or similar to that of TM,but UGP was highly homogeneous in terms of marker compound contents as assessed,e.g.,by the relative standard deviation values of the nine marker compounds in the range of 8.55%−43.80%for TM2 compared against 1.70%−8.38%for UGP2.Macromolecular component preparation and 1H NMR analyses indicated that TM4 and its corresponding UGP4 produced similar polysaccharides,but the later had approximately two-fold dissolution rate of the polysaccharides when compared to the former(yield 7.22±0.35%vs 3.39±0.20%).This study confirms that UGP of Radix Astragali is chemically consistent and homogenous,supporting its use as a promising material in TCM prescriptions.
基金supported by the National Natural Science Foundation of China(No.82003403(Jianping Zhao),No.81974077,and No.82170633(Qian Chen)).
文摘Schistosoma infection is one of the major causes of liver fibrosis.Emerging roles of hepatic progenitor cells(HPCs)in the pathogenesis of liver fibrosis have been identified.Nevertheless,the precise mechanism underlying the role of HPCs in liver fibrosis in schistosomiasis remains unclear.This study examined how autophagy in HPCs affects schistosomiasis-induced liver fibrosis by modulating exosomal miRNAs.The activation of HPCs was verified by immunohistochemistry(IHC)and immunofluorescence(IF)staining in fibrotic liver from patients and mice with Schistosoma japonicum infection.By coculturing HPCs with hepatic stellate cells(HSCs)and assessing the autophagy level in HPCs by proteomic analysis and in vitro phenotypic assays,we found that impaired autophagy degradation in these activated HPCs was mediated by lysosomal dysfunction.Blocking autophagy by the autophagy inhibitor chloroquine(CQ)significantly diminished liver fibrosis and granuloma formation in S.japonicum-infected mice.HPC-secreted extracellular vehicles(EVs)were further isolated and studied by miRNA sequencing.miR-1306-3p,miR-493-3p,and miR-34a-5p were identified,and their distribution into EVs was inhibited due to impaired autophagy in HPCs,which contributed to suppressing HSC activation.In conclusion,we showed that the altered autophagy process upon HPC activation may prevent liver fibrosis by modulating exosomal miRNA release and inhibiting HSC activation in schistosomiasis.Targeting the autophagy degradation process may be a therapeutic strategy for liver fibrosis during Schistosoma infection.
基金supported by grants from AstraZeneca,China,and the National Natural Science Foundation of China(No.82070026).
文摘To the Editor:Patients with severe persistent asthma experience greater morbidity with more impairment in quality of life despite higher use of health care resources and being treated with existing asthma treatments such as inhaled corticosteroids and b-agonists,and sometimes oral corticosteroid(OCS)therapy.Type-2(T2)high asthma has been identified as a phenotype that responds to targeted T2 biologic therapies such as anti-IgE,anti-interleukin(IL)5,or anti-IL5Ra and anti-IL4Ra monoclonal antibodies,which are currently available in Europe and North America,and are currently introduced in the rest of the world.[1]
基金This work was supported by Tongji Hospital Clinical Research Flagship Program(No.2019CR207).
文摘In December 2019,an outbreak of novel coronavirus(2019-nCoV)occurred in Wuhan,Hubei Province,China.By February 14,2020,it has led to 66492 confirmed patients in China and high mortality up to^2.96%(1123/37914)in Wuhan.Here we report the first family case of coronavirus disease 2019(COVID-19)confirmed in Wuhan and treated using the combination of western medicine and Chinese traditional patent medicine Shuanghuanglian oral liquid(SHL).This report describes the identification,diagnosis,clinical course,and management of three cases from a family,suggests the expected therapeutic effects of SHL on COVID-19,and warrants further clinical trials.
基金This work was supported by the National Key R&D Program of China(No.2020YFC0841400)Tongji Hospital Clinical Research Project(Nos.XXGZBDYJ009 and 2019YBKY019).
文摘We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by three doses(56 in low dose,61 in middle dose,and 59 in high dose)in addition to standard care.The control group was composed of 59 patients who received standard therapy alone.Treatment with SHL was not associated with a difference from standard care in the time to disease recovery.Patients with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group(93.4%vs.73.9%,P=0.006).Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia,which was evaluated by density reduction of inflammatory focus from baseline,at day 7(mean difference(95%CI),−46.39(−86.83 to−5.94)HU;P=0.025)and day 14(mean difference(95%CI),−74.21(−133.35 to−15.08)HU;P=0.014).No serious adverse events occurred in the SHL groups.This study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19.
基金supported by MOST(Ministry of Science and Technology of the People's Republic of China)foundation for SARS-Co V-2 Research(2020YFC0844500)the“13th Five-Year”National Science and Technology Major Project of China(2017ZX09101001-002-001,2017ZX09304012)Peking University Health Center Foundation for Combating the Pandemic Programs(BMU2020HKYZX011)。
文摘Dear Editor,Since December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been rapidly spreading worldwide.Hydroxychloroquine and chloroquine are candidates for the treatment of coronavirus disease 2019(COVID-19)owing to its antiviral effect and immunomodulation properties.
文摘Coronavirus disease 2019(COVID-19)is a highly contagious disease and a serious threat to human health.COVID-19 can cause multiple organ dysfunction,such as respiratory and circulatory failure,liver and kidney injury,disseminated intravascular coagulation,and thromboembolism,and even death.The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%.Currently,the number of severe cases worldwide has increased rapidly,but the experience in the treatment of infected patients is still limited.Given the lack of specific antiviral drugs,multi-organ function support treatment is important for patients with COVID-19.To improve the cure rate and reduce the mortality of patients with severe-and critical-type COVID-19,this paper summarizes the experience of organ function support in patients with severe-and criticaltype COVID-19 in Optical Valley Branch of Tongji Hospital,Wuhan,China.This paper systematically summarizes the procedures of functional support therapies for multiple organs and systems,including respiratory,circulatory,renal,hepatic,and hematological systems,among patients with severe-and critical-type COVID-19.This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide.
基金supported by the National Natural Science Foundation of China(NSFC,81620108011)the Ministry of Science and Technology of China(MOST,2017YFC1308401)+3 种基金supported by NSFC(31830036 and 31921002)the Beijing Municipal Science&Technology Commission(Z181100001518001)MOST(2019YFA0707100)the Chinese Academy of Sciences(XDBS1020100)。
文摘Atherosclerotic cardiovascular disease resulting from dysregulated lipid metabolism is the leading cause of morbidity and mortality worldwide.Apolipoprotein E(ApoE)plays a critical role in cholesterol metabolism.Knockouts in lipid-metabolizing proteins including ApoE in multiple model organisms such as mice and rats exhibiting elevated levels of cholesterol have been widely used for dissecting the pathology of atherosclerosis,but few of these animal models exhibit advanced atherosclerotic plaques leading to ischemia-induced clinical symptoms,limiting their use for translational studies.Here we report hypercholesterolemia and severe atherosclerosis characterized by stenosis and occlusion of arteries,together with clinical manifestations of stroke and gangrene,in ApoE knockout dogs generated by CRISPR/Cas9 and cloned by somatic cell nuclear transfer technologies.Importantly,the hypercholesterolemia and atherosclerotic complications in F0 mutants are recapitulated in their offspring.As the ApoE-associated atherosclerosis and clinical manifestations in mutant dogs are more similar to that in human patients compared with those in other animal models,these mutant dogs will be invaluable in developing and evaluating new therapies,including endovascular procedures,against atherosclerosis and related disorders.