Continuous androgen deprivation therapy(ADT)is the m ainstay of treatment for metastatic prostate cancer.Both injectable luteinizing horm onereleasing hormone(LHRH)agonists and antagonists(here LHRH interchangeable to...Continuous androgen deprivation therapy(ADT)is the m ainstay of treatment for metastatic prostate cancer.Both injectable luteinizing horm onereleasing hormone(LHRH)agonists and antagonists(here LHRH interchangeable to gon adotrop in-releasin g horm one,GnRH)are the current standard of care for ADT in prostate cancer.The novel oral form o f effective GnRH antagonist is a very promising alternative to the current landscape of ADT.展开更多
Despite androgen dependence in a majority of castration-resistant prostate cancers,some cancer cells are independent of androgen receptor(AR)function,a feature of heterogeneity in prostate cancer.One of the aggressive...Despite androgen dependence in a majority of castration-resistant prostate cancers,some cancer cells are independent of androgen receptor(AR)function,a feature of heterogeneity in prostate cancer.One of the aggressive variants of prostate cancer that are AR independent is neuroendocrine prostate cancer(NEPC).This manuscript will focus on the new finding of human one cut domain family member 2(ONECUT2)transcription factor and its role in castration resistance,especially in NEPC.展开更多
文摘Continuous androgen deprivation therapy(ADT)is the m ainstay of treatment for metastatic prostate cancer.Both injectable luteinizing horm onereleasing hormone(LHRH)agonists and antagonists(here LHRH interchangeable to gon adotrop in-releasin g horm one,GnRH)are the current standard of care for ADT in prostate cancer.The novel oral form o f effective GnRH antagonist is a very promising alternative to the current landscape of ADT.
文摘Despite androgen dependence in a majority of castration-resistant prostate cancers,some cancer cells are independent of androgen receptor(AR)function,a feature of heterogeneity in prostate cancer.One of the aggressive variants of prostate cancer that are AR independent is neuroendocrine prostate cancer(NEPC).This manuscript will focus on the new finding of human one cut domain family member 2(ONECUT2)transcription factor and its role in castration resistance,especially in NEPC.
