Frustrated quantum magnets are expected to host many exotic quantum spin states like quantum spin liquid(QSL), and have attracted numerous interest in modern condensed matter physics. The discovery of the triangular...Frustrated quantum magnets are expected to host many exotic quantum spin states like quantum spin liquid(QSL), and have attracted numerous interest in modern condensed matter physics. The discovery of the triangular lattice spin liquid candidate YbMgGaO_4 stimulated an increasing attention on the rare-earth-based frustrated magnets with strong spin-orbit coupling. Here we report the synthesis and characterization of a large family of rare-earth chalcogenides AReCh_2(A = alkali or monovalent ions, Re = rare earth, Ch = O,S,Se). The family compounds share the same structure(R3 m) as YbMgGaO_4,and antiferromagnetically coupled rare-earth ions form perfect triangular layers that are well separated along the c-axis. Specific heat and magnetic susceptibility measurements on NaYbO_2,NaYbS_2 and NaYbSe_2 single crystals and polycrystals, reveal no structural or magnetic transition down to 50 mK. The family, having the simplest structure and chemical formula among the known QSL candidates, removes the issue on possible exchange disorders in YbMgGaO_4. More excitingly, the rich diversity of the family members allows tunable charge gaps, variable exchange coupling, and many other advantages.This makes the family an ideal platform for fundamental research of QSLs and its promising applications.展开更多
Tooth enamel is prone to be attacked by injurious factors,leading to a de/remineralization imbalance.To repair demineralized enamel and prevent pulp inflammation caused by biofilm accumulation,measures are needed to p...Tooth enamel is prone to be attacked by injurious factors,leading to a de/remineralization imbalance.To repair demineralized enamel and prevent pulp inflammation caused by biofilm accumulation,measures are needed to promote remineralization and inhibit bacterial adhesion on the tooth surface.An innovative material,poly(aspartic acid)-polyethylene glycol(PASP-PEG),was designed and synthesized to construct a mineralizing and anti-adhesive surface that could be applied to repair demineralized enamel.A cytotoxicity assay revealed the low cytotoxicity of synthesized PASP-PEG.Adsorption results demonstrated that PASPPEG possesses a high binding affinity to the hydroxyapatite(HA)/tooth surface.In vitro experiments and scanning electron microscopy(SEM)demonstrated a strong capacity of PASP-PEG to induce in situ remineralization and direct the oriented growth of apatite nanocrystals.Energy dispersive X-ray spectroscopy(EDS),X-ray diffraction analysis(XRD)and Vickers hardness tests demonstrated that minerals induced by PASP-PEG were consistent with healthy enamel in Ca/P ratio,crystal form and surface micro-hardness.Contact angle tests and bacterial adhesion experiments demonstrated that PASP-PEG yielded a strong antiadhesive effect.In summary,PASP-PEG could achieve dual effects for enamel repair and anti-adhesion of bacteria,thereby widening its application in enamel repair.展开更多
Biomineralization is the process by which organisms form mineralized tissues with hierarchical structures and excellent properties,including the bones and teeth in vertebrates.The underlying mechanisms and pathways of...Biomineralization is the process by which organisms form mineralized tissues with hierarchical structures and excellent properties,including the bones and teeth in vertebrates.The underlying mechanisms and pathways of biomineralization provide inspiration for designing and constructing materials to repair hard tissues.In particular,the formation processes of minerals can be partly replicated by utilizing bioinspired artificial materials to mimic the functions of biomolecules or stabilize intermediate mineral phases involved in biomineralization.Here,we review recent advances in biomineralization-inspired materials developed for hard tissue repair.Biomineralization-inspired materials are categorized into different types based on their specific applications,which include bone repair,dentin remineralization,and enamel remineralization.Finally,the advantages and limitations of these materials are summarized,and several perspectives on future directions are discussed.展开更多
Effective mineralization of biological structures poses a significant challenge in hard tissue engineering as it necessitates overcoming geometric complexities and multistep biomineralization processes.In this regard,...Effective mineralization of biological structures poses a significant challenge in hard tissue engineering as it necessitates overcoming geometric complexities and multistep biomineralization processes.In this regard,we propose“mineral-in-shell nanoarchitectonics”,inspired by the nanostructure of matrix vesicles,which can influence multiple mineralization pathways.Our nanostructural design empowers mineral precursors with tailorable properties through encapsulating amorphous calcium phosphate within a multifunctional tannic acid(TA)and silk fibroin(SF)nanoshell.The bioinspired nanosystem facilitates efficient recruitment of mineral precursors throughout the dentin structures,followed by large-scale intradentinal mineralization both in vitro and in vivo,which provides persistent protection against external stimuli.Theoretical simulations combined with experimental studies attribute the success of intradentinal mineralization to the TA-SF nanoshell,which exhibits a strong affinity for the dentin structure,stabilizing amorphous precursors and thereby facilitating concomitant mineral formation.Overall,this bioinspired mineral-in-shell nanoarchitectonics shows a promising prospect for hard tissue repair and serves as a blueprint for next-generation biomineralization-associated materials.展开更多
The invasion of etched dentinal tubules(DTs)by external substances induces dentin hypersensitivity(DH).The deep and compact occlusion of DTs is highly desirable for treating DH but still challenging due to the limited...The invasion of etched dentinal tubules(DTs)by external substances induces dentin hypersensitivity(DH).The deep and compact occlusion of DTs is highly desirable for treating DH but still challenging due to the limited penetrability and mineralization capacities of most current desensitizers.Matrix vesicles(MVs)participate in the regulation of ectopic mineralization.Herein,ectopic MV analogs are prepared by employing natural cell membranes to endow mineral precursors with natural biointerfaces and integrated biofunctions for stimulating dentin remineralization.The analogs quickly access DTs(>20μm)in only 5 min and further penetrate deep into the interior of DTs(an extraordinary~200μm)in 7 days.Both in vitro and in vivo studies confirm that the DTs are efficiently sealed by the newly formed minerals(>50μm)with excellent resistance to wear and acid erosion,which is significantly deeper than most reported values.After repair,the microhardness of the damaged dentin can be recovered to those of healthy dentin.For the first time,cell membrane coating nanotechnology is used as a facile and efficient therapy for in-depth remineralization of DTs in treating DH with thorough and long-term effects,which provides insights into their potential for hard tissue repair.展开更多
Zwitterionic materials are now widely used to fabricate various functionalized surfaces for biomedical applications due to their excellent non-fouling properties.However,a newly-discovered zwitterionic material,cholin...Zwitterionic materials are now widely used to fabricate various functionalized surfaces for biomedical applications due to their excellent non-fouling properties.However,a newly-discovered zwitterionic material,choline phosphate(CP),was reported to be cell-adhesive,which makes it different from traditional non-fouling zwitterionic materials such as sulfobetaine,carboxybetaine and phosphorylcholine(PC).To further investigate the properties of CP,a comparative study was conducted and the widely-reported zwitterionic PC was employed as a control which has the same chemical component but opposite orientation of charged groups with CP.For this purpose,CP and PC-functionalized surfaces were prepared by surface-initiated atom transfer radical polymerization(Si-ATRP),and their non-fouling properties were probed by protein adsorption and eukaryotic cell adhesion measurement.Results showed that CP-functionalized surfaces exhibited almost equivalent amounts of adsorbed proteins to that of PC,but they were more beneficial to cells initial adhesion and further spreading in serum-free medium,indicating that CP had a promising prospect of application in tissue engineering.展开更多
Currently,biological drugs such as gene,protein,and monoclonal antibody are widely applied in the clinic due to their excellent effectiveness.However,they still have some problems,including poor solubility,instability...Currently,biological drugs such as gene,protein,and monoclonal antibody are widely applied in the clinic due to their excellent effectiveness.However,they still have some problems,including poor solubility,instability,toxicity,and weak capability to cross cell membranes.Owing to the specific structure of cyclodextrins(CDs)and the advantage of polymeric backbones,various cyclodextrin polymers(CDPs)have been designed as delivery systems for biotech drugs.In this review,after a brief introduction on CDPs and discussion of their physicochemical and biological properties,we will focus on recent advances in the use of CDPs for the delivery of biotech drugs.This review highlights the structure-function relationship of CDPs to their performance in biotech drug delivery.Finally,an outlook will be proposed on the developing trends and challenge in this field.展开更多
In order to improve the life quality of diabetic patients,it is very important to develop rapid-acting insulin formulations that can mimic the physiological meal-time secretion profile of insulin in healthy people.Alt...In order to improve the life quality of diabetic patients,it is very important to develop rapid-acting insulin formulations that can mimic the physiological meal-time secretion profile of insulin in healthy people.Although several insulin analogues have been designed to provide postprandial glycemic control,still there are some serious disadvantages.A supramolecular strategy is presented here to inhibit insulin aggregation and improve its bioactivity by using Cp1-11 peptide.As a fragment of C-peptide in proinsulin,Cp1-11 peptide was found to influence insulin oligomerization by supramolecular interactions.This work demonstrates that the Cp1-11 peptide can interact with oligomeric insulin and facilitate its disaggregation into the physiologically active monomeric form.Computer simulation indicates that Cp1-11 can insert into the space between the C-terminal tail and the N-terminal helix of the B-chain of insulin,causing dissociation of the insulin dimer.The supramolecular assembly of Cp1-11 and insulin can improve the bioavailability and therapeutic effect of insulin on the control of in vivo blood glucose levels.These results suggest that Cp1-11 peptide can modulate the intermolecular interaction of aggregated insulin and prevent the transition from monomeric to multimeric states,and shows great potential for the development of an effective rapid-acting strategy to treat diabetes.展开更多
Nanocelluloses,also referred as nano-structured cellulose,including cellulose nanocrystals(CNC),cellulose nanofibrils(CNF)and bacterial cellulose(BC),are a family of abundant biomass and renewable materials in nature....Nanocelluloses,also referred as nano-structured cellulose,including cellulose nanocrystals(CNC),cellulose nanofibrils(CNF)and bacterial cellulose(BC),are a family of abundant biomass and renewable materials in nature.Because of their excellent physical,mechanical,and biological properties,in particular biocompatibility,biodegradability,and low cytotoxicity,nanocelluloses have become indispensable for the design of new biomaterials.展开更多
Chemodynamic therapy(CDT),a noninvasive strategy,has emerged as a promising alternative to conventional chemotherapy for treating tumors.However,its therapeutic effect is limited by the amount of H_(2)O_(2),pH value,t...Chemodynamic therapy(CDT),a noninvasive strategy,has emerged as a promising alternative to conventional chemotherapy for treating tumors.However,its therapeutic effect is limited by the amount of H_(2)O_(2),pH value,the hypoxic environment of tumors,and it has suboptimal tumor-targeting ability.In this study,tumor cell membrane-camouflaged mesoporous Fe_(3)O_(4) nanoparticles loaded with perfluoropentane(PFP)and glucose oxidase(GOx)are used as a tumor microenvironment-adaptive nanoplatform(M-mFeP@O_(2)-G),which synergistically enhances the antitumor effect of CDT.Mesoporous Fe_(3)O_(4) nanoparticles are selected as inducers for photothermal and Fenton reactions and as nanocarriers.GOx depletes glucose within tumor cells for starving the cells,while producing H2O2 for subsequent⋅OH generation.Moreover,PFP,which can carry O_(2),relieves hypoxia in tumor cells and provides O_(2) for the cascade reaction.Finally,the nanoparticles are camouflaged with osteosarcoma cell membranes,endowing the nanoparticles with homologous targeting and immune escape abilities.Both in vivo and in vitro evaluations reveal high synergistic therapeutic efficacy of M-mFeP@O_(2)-G,with a desirable tumor-inhibition rate(90.50%),which indicates the great potential of this platform for clinical treating cancer.展开更多
For the purpose of decomposing the processing gases CF4 from semiconductor manufacturers, ceramic honeycomb regenerative burner system is suggested by using the principle of HTAC. A simulated high temperature air comb...For the purpose of decomposing the processing gases CF4 from semiconductor manufacturers, ceramic honeycomb regenerative burner system is suggested by using the principle of HTAC. A simulated high temperature air combustion furnace has been used to determine the features of HTAC flames and the results of the decomposition of CF4. The preheat air temperature of it is above 900℃. The exhaust gas released into the atmosphere is lower than 150℃. Moreover, the efficiency of recovery of waste heat is higher than 80%, the NOx level in exhaust gas is less than 198 mg/m3 and the distribution of temperature in the furnace is nearly uniform. The factors influencing on heat transfer, temperature profile in chamber and NOX emission were discussed. Also some CF4 can be decomposed in this system.展开更多
In this work,dopamine methacrylamide(DMA)and eugenyl methacrylate(EMA)were used to synthesize polymeric particles of Poly(DMA-co-EMA)by free radical precipitation copolymerization.These two monomers were modified from...In this work,dopamine methacrylamide(DMA)and eugenyl methacrylate(EMA)were used to synthesize polymeric particles of Poly(DMA-co-EMA)by free radical precipitation copolymerization.These two monomers were modified from dopamine(consisting of the catechol moieties adhering to various materials)and eugenol(with antibacterial property),respectively.The proton nuclear magnetic resonance(^(1)H NMR)and Fourier transform infrared(FT-IR)spectroscopy were applied to confirm the successful synthesis of the two monomers and copolymer.The scanning electron microscope(SEM)images showed the size and morphology of the polymer particles.The results indicated that regular particles with uniform size could be obtained with a monomer feeding ratio of 5꞉5.The results of antibacterial activity test indicated that the obtained polymer particles have an antibacterial rate over 90%to Eugenia coli.展开更多
The Journal of Bioresources and Bioproducts(JBB)is devoted to publish high-quality peer-reviewed technical research articles on the science and technology related to bio-resources and bio-products.As the petroleum-bas...The Journal of Bioresources and Bioproducts(JBB)is devoted to publish high-quality peer-reviewed technical research articles on the science and technology related to bio-resources and bio-products.As the petroleum-based economy will be phasing out in a foreseeable period of time,the industrial and scientific societies are paying much attention to the renewable and sustainable resources:bioresources.展开更多
基金Supported by the Ministry of Science and Technology of China under Grant Nos 2016YFA0300504,2017YFA0302904 and 2016YFA0301001the Natural Science Foundation of China under Grant Nos 11774419,11474357,11822412,11774423 and 11574394
文摘Frustrated quantum magnets are expected to host many exotic quantum spin states like quantum spin liquid(QSL), and have attracted numerous interest in modern condensed matter physics. The discovery of the triangular lattice spin liquid candidate YbMgGaO_4 stimulated an increasing attention on the rare-earth-based frustrated magnets with strong spin-orbit coupling. Here we report the synthesis and characterization of a large family of rare-earth chalcogenides AReCh_2(A = alkali or monovalent ions, Re = rare earth, Ch = O,S,Se). The family compounds share the same structure(R3 m) as YbMgGaO_4,and antiferromagnetically coupled rare-earth ions form perfect triangular layers that are well separated along the c-axis. Specific heat and magnetic susceptibility measurements on NaYbO_2,NaYbS_2 and NaYbSe_2 single crystals and polycrystals, reveal no structural or magnetic transition down to 50 mK. The family, having the simplest structure and chemical formula among the known QSL candidates, removes the issue on possible exchange disorders in YbMgGaO_4. More excitingly, the rich diversity of the family members allows tunable charge gaps, variable exchange coupling, and many other advantages.This makes the family an ideal platform for fundamental research of QSLs and its promising applications.
基金This work was supported by the National Natural Science Foundation of China(81670977 and 51903169)Sichuan Province Science and Technology Support Program(2017SZ0030)+3 种基金China Postdoctoral Science Foundation(2019M663529)Special Funding of State Key Laboratory of Oral Diseases(SKLOD202019)Postdoctoral Cross Funding of Sichuan University(0040304153059)Research Funding for talents developing,West China Hospital of Stomatology,Sichuan University(RCDWJS2020-17).
文摘Tooth enamel is prone to be attacked by injurious factors,leading to a de/remineralization imbalance.To repair demineralized enamel and prevent pulp inflammation caused by biofilm accumulation,measures are needed to promote remineralization and inhibit bacterial adhesion on the tooth surface.An innovative material,poly(aspartic acid)-polyethylene glycol(PASP-PEG),was designed and synthesized to construct a mineralizing and anti-adhesive surface that could be applied to repair demineralized enamel.A cytotoxicity assay revealed the low cytotoxicity of synthesized PASP-PEG.Adsorption results demonstrated that PASPPEG possesses a high binding affinity to the hydroxyapatite(HA)/tooth surface.In vitro experiments and scanning electron microscopy(SEM)demonstrated a strong capacity of PASP-PEG to induce in situ remineralization and direct the oriented growth of apatite nanocrystals.Energy dispersive X-ray spectroscopy(EDS),X-ray diffraction analysis(XRD)and Vickers hardness tests demonstrated that minerals induced by PASP-PEG were consistent with healthy enamel in Ca/P ratio,crystal form and surface micro-hardness.Contact angle tests and bacterial adhesion experiments demonstrated that PASP-PEG yielded a strong antiadhesive effect.In summary,PASP-PEG could achieve dual effects for enamel repair and anti-adhesion of bacteria,thereby widening its application in enamel repair.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.51925304 and 51903175)the Postdoctoral Science Foundation of China(Grant No.2019M663503).
文摘Biomineralization is the process by which organisms form mineralized tissues with hierarchical structures and excellent properties,including the bones and teeth in vertebrates.The underlying mechanisms and pathways of biomineralization provide inspiration for designing and constructing materials to repair hard tissues.In particular,the formation processes of minerals can be partly replicated by utilizing bioinspired artificial materials to mimic the functions of biomolecules or stabilize intermediate mineral phases involved in biomineralization.Here,we review recent advances in biomineralization-inspired materials developed for hard tissue repair.Biomineralization-inspired materials are categorized into different types based on their specific applications,which include bone repair,dentin remineralization,and enamel remineralization.Finally,the advantages and limitations of these materials are summarized,and several perspectives on future directions are discussed.
基金support provided by the National Natural Science Foundation of China(Nos.52273135,51925304,52203180).
文摘Effective mineralization of biological structures poses a significant challenge in hard tissue engineering as it necessitates overcoming geometric complexities and multistep biomineralization processes.In this regard,we propose“mineral-in-shell nanoarchitectonics”,inspired by the nanostructure of matrix vesicles,which can influence multiple mineralization pathways.Our nanostructural design empowers mineral precursors with tailorable properties through encapsulating amorphous calcium phosphate within a multifunctional tannic acid(TA)and silk fibroin(SF)nanoshell.The bioinspired nanosystem facilitates efficient recruitment of mineral precursors throughout the dentin structures,followed by large-scale intradentinal mineralization both in vitro and in vivo,which provides persistent protection against external stimuli.Theoretical simulations combined with experimental studies attribute the success of intradentinal mineralization to the TA-SF nanoshell,which exhibits a strong affinity for the dentin structure,stabilizing amorphous precursors and thereby facilitating concomitant mineral formation.Overall,this bioinspired mineral-in-shell nanoarchitectonics shows a promising prospect for hard tissue repair and serves as a blueprint for next-generation biomineralization-associated materials.
基金the National Natural Science Foundation of China(Nos.51925304,51903175,and 51973133).
文摘The invasion of etched dentinal tubules(DTs)by external substances induces dentin hypersensitivity(DH).The deep and compact occlusion of DTs is highly desirable for treating DH but still challenging due to the limited penetrability and mineralization capacities of most current desensitizers.Matrix vesicles(MVs)participate in the regulation of ectopic mineralization.Herein,ectopic MV analogs are prepared by employing natural cell membranes to endow mineral precursors with natural biointerfaces and integrated biofunctions for stimulating dentin remineralization.The analogs quickly access DTs(>20μm)in only 5 min and further penetrate deep into the interior of DTs(an extraordinary~200μm)in 7 days.Both in vitro and in vivo studies confirm that the DTs are efficiently sealed by the newly formed minerals(>50μm)with excellent resistance to wear and acid erosion,which is significantly deeper than most reported values.After repair,the microhardness of the damaged dentin can be recovered to those of healthy dentin.For the first time,cell membrane coating nanotechnology is used as a facile and efficient therapy for in-depth remineralization of DTs in treating DH with thorough and long-term effects,which provides insights into their potential for hard tissue repair.
基金support by the National Natural Science Foundation of China(51503126,21534008,51573110)Scientific Research Foundation for Young Teachers of Sichuan University(2015SCU11005)Miaozi Project in Science and Technology Innovation Program of Sichuan Province(2016087).
文摘Zwitterionic materials are now widely used to fabricate various functionalized surfaces for biomedical applications due to their excellent non-fouling properties.However,a newly-discovered zwitterionic material,choline phosphate(CP),was reported to be cell-adhesive,which makes it different from traditional non-fouling zwitterionic materials such as sulfobetaine,carboxybetaine and phosphorylcholine(PC).To further investigate the properties of CP,a comparative study was conducted and the widely-reported zwitterionic PC was employed as a control which has the same chemical component but opposite orientation of charged groups with CP.For this purpose,CP and PC-functionalized surfaces were prepared by surface-initiated atom transfer radical polymerization(Si-ATRP),and their non-fouling properties were probed by protein adsorption and eukaryotic cell adhesion measurement.Results showed that CP-functionalized surfaces exhibited almost equivalent amounts of adsorbed proteins to that of PC,but they were more beneficial to cells initial adhesion and further spreading in serum-free medium,indicating that CP had a promising prospect of application in tissue engineering.
基金Financial support from the National Natural Science Foundation of China(Grant No.21534008,51322303,and 51573110)State Key Laboratory of Polymer Materials Engineering(sklpme2014-3-01)are gratefully acknowledged.
文摘Currently,biological drugs such as gene,protein,and monoclonal antibody are widely applied in the clinic due to their excellent effectiveness.However,they still have some problems,including poor solubility,instability,toxicity,and weak capability to cross cell membranes.Owing to the specific structure of cyclodextrins(CDs)and the advantage of polymeric backbones,various cyclodextrin polymers(CDPs)have been designed as delivery systems for biotech drugs.In this review,after a brief introduction on CDPs and discussion of their physicochemical and biological properties,we will focus on recent advances in the use of CDPs for the delivery of biotech drugs.This review highlights the structure-function relationship of CDPs to their performance in biotech drug delivery.Finally,an outlook will be proposed on the developing trends and challenge in this field.
基金supported by National Natural Science Foundation of China (21534008,51322303 and 21174088)Program for Changjiang Scholars and Innovative Research Team in University (IRT_15R48)State Key Laboratory of Polymer Materials Engineering (Grant No.sklpme2017-2-02).
文摘In order to improve the life quality of diabetic patients,it is very important to develop rapid-acting insulin formulations that can mimic the physiological meal-time secretion profile of insulin in healthy people.Although several insulin analogues have been designed to provide postprandial glycemic control,still there are some serious disadvantages.A supramolecular strategy is presented here to inhibit insulin aggregation and improve its bioactivity by using Cp1-11 peptide.As a fragment of C-peptide in proinsulin,Cp1-11 peptide was found to influence insulin oligomerization by supramolecular interactions.This work demonstrates that the Cp1-11 peptide can interact with oligomeric insulin and facilitate its disaggregation into the physiologically active monomeric form.Computer simulation indicates that Cp1-11 can insert into the space between the C-terminal tail and the N-terminal helix of the B-chain of insulin,causing dissociation of the insulin dimer.The supramolecular assembly of Cp1-11 and insulin can improve the bioavailability and therapeutic effect of insulin on the control of in vivo blood glucose levels.These results suggest that Cp1-11 peptide can modulate the intermolecular interaction of aggregated insulin and prevent the transition from monomeric to multimeric states,and shows great potential for the development of an effective rapid-acting strategy to treat diabetes.
基金support from the National Natural Science Foundation of China (Grant No.21534008 and 51322303).
文摘Nanocelluloses,also referred as nano-structured cellulose,including cellulose nanocrystals(CNC),cellulose nanofibrils(CNF)and bacterial cellulose(BC),are a family of abundant biomass and renewable materials in nature.Because of their excellent physical,mechanical,and biological properties,in particular biocompatibility,biodegradability,and low cytotoxicity,nanocelluloses have become indispensable for the design of new biomaterials.
基金The authors thank the financial support from National Natural Science Foundation of China(51925304,52173140 and 51803173)Sichuan Science and Technology Program(2021YJ0192)the Opening Project of State Key Laboratory of Polymer Materials Engineering(Sichuan University)(Grant No.sklpme2020-4-13).
文摘Chemodynamic therapy(CDT),a noninvasive strategy,has emerged as a promising alternative to conventional chemotherapy for treating tumors.However,its therapeutic effect is limited by the amount of H_(2)O_(2),pH value,the hypoxic environment of tumors,and it has suboptimal tumor-targeting ability.In this study,tumor cell membrane-camouflaged mesoporous Fe_(3)O_(4) nanoparticles loaded with perfluoropentane(PFP)and glucose oxidase(GOx)are used as a tumor microenvironment-adaptive nanoplatform(M-mFeP@O_(2)-G),which synergistically enhances the antitumor effect of CDT.Mesoporous Fe_(3)O_(4) nanoparticles are selected as inducers for photothermal and Fenton reactions and as nanocarriers.GOx depletes glucose within tumor cells for starving the cells,while producing H2O2 for subsequent⋅OH generation.Moreover,PFP,which can carry O_(2),relieves hypoxia in tumor cells and provides O_(2) for the cascade reaction.Finally,the nanoparticles are camouflaged with osteosarcoma cell membranes,endowing the nanoparticles with homologous targeting and immune escape abilities.Both in vivo and in vitro evaluations reveal high synergistic therapeutic efficacy of M-mFeP@O_(2)-G,with a desirable tumor-inhibition rate(90.50%),which indicates the great potential of this platform for clinical treating cancer.
文摘For the purpose of decomposing the processing gases CF4 from semiconductor manufacturers, ceramic honeycomb regenerative burner system is suggested by using the principle of HTAC. A simulated high temperature air combustion furnace has been used to determine the features of HTAC flames and the results of the decomposition of CF4. The preheat air temperature of it is above 900℃. The exhaust gas released into the atmosphere is lower than 150℃. Moreover, the efficiency of recovery of waste heat is higher than 80%, the NOx level in exhaust gas is less than 198 mg/m3 and the distribution of temperature in the furnace is nearly uniform. The factors influencing on heat transfer, temperature profile in chamber and NOX emission were discussed. Also some CF4 can be decomposed in this system.
基金This work was supported by the National Natural Science Foundation of China (51173118, 51273124, 51273126 and 51121001) and the National Science Fund for Distinguished Young Scholars of China (51425305). We thank Prof. Zhang HR (Southwest University for Nationalities, Sichuan) for help with an- tibacterial test.
基金National Key Research and Development Program of China(No.2016YFC1100404)State Key Laboratory of Polymer Materials Engineering(No.sklpme2018-3-10)Fundamental Research Funds for Central Universities(No.YJ201854).
文摘In this work,dopamine methacrylamide(DMA)and eugenyl methacrylate(EMA)were used to synthesize polymeric particles of Poly(DMA-co-EMA)by free radical precipitation copolymerization.These two monomers were modified from dopamine(consisting of the catechol moieties adhering to various materials)and eugenol(with antibacterial property),respectively.The proton nuclear magnetic resonance(^(1)H NMR)and Fourier transform infrared(FT-IR)spectroscopy were applied to confirm the successful synthesis of the two monomers and copolymer.The scanning electron microscope(SEM)images showed the size and morphology of the polymer particles.The results indicated that regular particles with uniform size could be obtained with a monomer feeding ratio of 5꞉5.The results of antibacterial activity test indicated that the obtained polymer particles have an antibacterial rate over 90%to Eugenia coli.
文摘The Journal of Bioresources and Bioproducts(JBB)is devoted to publish high-quality peer-reviewed technical research articles on the science and technology related to bio-resources and bio-products.As the petroleum-based economy will be phasing out in a foreseeable period of time,the industrial and scientific societies are paying much attention to the renewable and sustainable resources:bioresources.