Background Unstable angina occurs when atherosclerotic plaquerupture.Recent evidence suggests a role for inflammation in this process.Leukocyte-endothelial cell interactions are important in inflammationand are regula...Background Unstable angina occurs when atherosclerotic plaquerupture.Recent evidence suggests a role for inflammation in this process.Leukocyte-endothelial cell interactions are important in inflammationand are regulated by cell adhesion melecules.As a kind of cell adhesionmelecules,P-selectin in platelets and endothelial cells mediates adhesiveinteraction with leukocytes to form thrombi.The purpuru of this studywar to invvstigate plasma levels of soluble P-selectin in patients withunstable angina and in health volunteers.Methods and Results Plasma P-selectin levels were determinedby a monoclonal antibody-bared enzyme immunoassay on plasma samplestaken from 27 patients with unstable angina,46 healthy volunteers.Patientswith unstable angina had angina at rest associated with ECG changes.Blood sample(2ml)was collected within 3 hours after the attack .Inpatiants with unstable angina,plasma P-seleatin levels(23.2±7.5ng/ml)were significently(P【0.005)higher than those in volunteers(10.12±7.61ng/ml)Conclusions our data indicate that soluble P-selectin released intothe blood after the attack of unstable angina and the levels of P-selectin inpatients with unstable angina were increased significantly.Our data indicatethat measur-ements of plasma P-selectin may help us to understandthe pathophysiology of unstable angina and may be clinically usefulas a new molecular marker of platelet aggregation and thrombus fomationin acute coronary syndrom.展开更多
文摘Background Unstable angina occurs when atherosclerotic plaquerupture.Recent evidence suggests a role for inflammation in this process.Leukocyte-endothelial cell interactions are important in inflammationand are regulated by cell adhesion melecules.As a kind of cell adhesionmelecules,P-selectin in platelets and endothelial cells mediates adhesiveinteraction with leukocytes to form thrombi.The purpuru of this studywar to invvstigate plasma levels of soluble P-selectin in patients withunstable angina and in health volunteers.Methods and Results Plasma P-selectin levels were determinedby a monoclonal antibody-bared enzyme immunoassay on plasma samplestaken from 27 patients with unstable angina,46 healthy volunteers.Patientswith unstable angina had angina at rest associated with ECG changes.Blood sample(2ml)was collected within 3 hours after the attack .Inpatiants with unstable angina,plasma P-seleatin levels(23.2±7.5ng/ml)were significently(P【0.005)higher than those in volunteers(10.12±7.61ng/ml)Conclusions our data indicate that soluble P-selectin released intothe blood after the attack of unstable angina and the levels of P-selectin inpatients with unstable angina were increased significantly.Our data indicatethat measur-ements of plasma P-selectin may help us to understandthe pathophysiology of unstable angina and may be clinically usefulas a new molecular marker of platelet aggregation and thrombus fomationin acute coronary syndrom.
