Four new diterpenoids, phyllostachysins I-L （1-4）, along with a known one, hebeiabinin B （5）, were isolated from the aerial parts oflsodonphyllostachys （I.phyllostachys）. Compounds 1 and 2 feature an ent-kaurane...Four new diterpenoids, phyllostachysins I-L （1-4）, along with a known one, hebeiabinin B （5）, were isolated from the aerial parts oflsodonphyllostachys （I.phyllostachys）. Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines （HL-60, SMMC-7721, A-549, MCF-7 and SW-480）, and strongly inhibited NO production in LPS-stimulated RAW264.7 cells.展开更多
基金supported by the NSFC-Joint Foundation of Yunnan Province (U1302223)the National Natural Science Foundation of China (21322204)the West Light Foundation of the Chinese Academy of Sciences (J-X Pu)
文摘Four new diterpenoids, phyllostachysins I-L （1-4）, along with a known one, hebeiabinin B （5）, were isolated from the aerial parts oflsodonphyllostachys （I.phyllostachys）. Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines （HL-60, SMMC-7721, A-549, MCF-7 and SW-480）, and strongly inhibited NO production in LPS-stimulated RAW264.7 cells.
