It has long been recognized that the valence electrons of an atom dominate the chemical properties, while the innershell electrons or outer empty orbital do not participate in chemical reactions. Pressure, as a fundam...It has long been recognized that the valence electrons of an atom dominate the chemical properties, while the innershell electrons or outer empty orbital do not participate in chemical reactions. Pressure, as a fundamental thermodynamic variable, plays an important role in the preparation of new materials. More recently, pressure stabilized a series of unconventional stoichiometric compounds with new oxidation states, in which the inner-shell electrons or outer empty orbital become chemically active. Here, we mainly focus on the recent advances in high-pressure new chemistry including novel chemical bonding and new oxidation state, identified by first-principles swarm intelligence structural search calculations.The aim of this review is to provide an up-to-date research progress on the chemical bonding with inner-shell electrons or outer empty orbital, abnormal interatomic charge transfer, hypervalent compounds, and chemical reactivity of noble gases.Personal outlook on the challenge and opportunity in this field are proposed in the conclusion.展开更多
N6-methyladenosine(m6A)is the most prevalent post-transcriptional RNA modification in mRNA and long non-coding RNAs of eukaryotes,and its biological functions are mediated by m6A writers,erasers and readers.1 A nuclea...N6-methyladenosine(m6A)is the most prevalent post-transcriptional RNA modification in mRNA and long non-coding RNAs of eukaryotes,and its biological functions are mediated by m6A writers,erasers and readers.1 A nuclear methyltransferase complex consisting of METTL3,METTL14,WTAP,VIRMA,ZC3H13,RBM15(or RBM15B),YWHAG,TRA2A and CAPRIN1 catalyzes the m6A modifications,acting as m6A writers.1 m6A demethylase ALKBH5 as well as m6A demethylase FTO mediate the demethylation of m6As,acting as the m6A erasers.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.21573037,21873017,11704062,and 51732003)the Postdoctoral Science Foundation of China(Grant No.2013M541283)+2 种基金the Natural Science Foundation of Jilin Province,China(Grant No.20190201231JC)the “111” Project,China(Grant No.B13013)the Fundamental Research Funds for the Central Universities of China(Grant No.2412017QD006)
文摘It has long been recognized that the valence electrons of an atom dominate the chemical properties, while the innershell electrons or outer empty orbital do not participate in chemical reactions. Pressure, as a fundamental thermodynamic variable, plays an important role in the preparation of new materials. More recently, pressure stabilized a series of unconventional stoichiometric compounds with new oxidation states, in which the inner-shell electrons or outer empty orbital become chemically active. Here, we mainly focus on the recent advances in high-pressure new chemistry including novel chemical bonding and new oxidation state, identified by first-principles swarm intelligence structural search calculations.The aim of this review is to provide an up-to-date research progress on the chemical bonding with inner-shell electrons or outer empty orbital, abnormal interatomic charge transfer, hypervalent compounds, and chemical reactivity of noble gases.Personal outlook on the challenge and opportunity in this field are proposed in the conclusion.
基金supported by China Postdoctoral Science Foundation(No.2020M683623XB)National Natural Science Foundation of China(No.82160389)+1 种基金Guangxi Medical University Training Program for Distinguished Young Scholars(to Junjun Jiang)Guangxi Science Fund for Distinguished Young Scholars(No.2018GXNSFFA281001).
文摘N6-methyladenosine(m6A)is the most prevalent post-transcriptional RNA modification in mRNA and long non-coding RNAs of eukaryotes,and its biological functions are mediated by m6A writers,erasers and readers.1 A nuclear methyltransferase complex consisting of METTL3,METTL14,WTAP,VIRMA,ZC3H13,RBM15(or RBM15B),YWHAG,TRA2A and CAPRIN1 catalyzes the m6A modifications,acting as m6A writers.1 m6A demethylase ALKBH5 as well as m6A demethylase FTO mediate the demethylation of m6As,acting as the m6A erasers.
