To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction, 23 patients were assessed using magnetic resonance diffus...To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction, 23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction. The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days. The diffusion coefficient remained unchanged. Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction.展开更多
Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment.G.lucidum spores(GLS)are tiny germ cells released from the mushroom cap during the mature stage of growth....Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment.G.lucidum spores(GLS)are tiny germ cells released from the mushroom cap during the mature stage of growth.They contain all the genetic active substances of G.lucidum.G.lucidum spore oil(GLSO)is a lipid component extracted from broken-walled Ganoderma spores using supercritical CO_(2)extraction technology.GLSO contains fatty acids,Ganoderma triterpenes,sterols and other bioactive compounds.Previous studies have demonstrated that GLSO has a wide range of pharmacological properties,including anti-tumor,anti-aging,neuroprotection,immunomodulation,hepatoprotection and modulation of metabolic diseases.This review summarizes the research progress of GLSO over the past two decades in terms of its bioactive components,extraction and processing techniques,pharmacological effects and safety evaluation.This provides a solid foundation for further research and application of GLSO.展开更多
Arboviruses,a diverse group of vector-borne pathogens transmitted by various vectors such as mosquitoes,ticks,and flies,encompass members of the Flaviviridae,Togaviridae,Phenuviridae,Peribunyaviridae,Reoviridae,Asfarv...Arboviruses,a diverse group of vector-borne pathogens transmitted by various vectors such as mosquitoes,ticks,and flies,encompass members of the Flaviviridae,Togaviridae,Phenuviridae,Peribunyaviridae,Reoviridae,Asfarviridae,Rhabdoviridae,Poxviridae,and Orthomyxoviridae families[1].展开更多
目的:探讨角膜中央与周边的厚度差异对角膜生物力学特性的影响。方法:回顾性系列病例研究。收集2006年10月至2007年10月在邯郸眼科医院测量的健康人群336例(336眼),来自邯郸眼科研究。运用Orbscan-II测量角膜中央厚度(CCT)、角膜最薄点(...目的:探讨角膜中央与周边的厚度差异对角膜生物力学特性的影响。方法:回顾性系列病例研究。收集2006年10月至2007年10月在邯郸眼科医院测量的健康人群336例(336眼),来自邯郸眼科研究。运用Orbscan-II测量角膜中央厚度(CCT)、角膜最薄点(TCP)以及3、4、5、6、7 mm处颞侧、上方、鼻侧及下方的角膜厚度;通过计算3、4、5、6、7 mm区域角膜厚度与中央厚度的比值,得到反映角膜中央与周边厚度差异的角膜厚度指数(CTI)。通过眼反应分析仪(ORA)测量角膜迟滞系数(CH)、角膜阻力因子(CRF);采用Pearson相关和Spearman相关分析CH、CRF与角膜厚度及年龄之间的相关性;采用独立样本t检验分析7 mm CTI总体分布中两端的最大5%与最小5%两组之间CH和CRF的差异。结果:研究对象4、5、6、7 mm角膜厚度与年龄均呈负相关(r=-0.15,P=0.003;r=-0.23,P<0.001;r=-0.33,P<0.001;r=-0.41,P<0.001),且随直径增大相关性逐渐增加;角膜最薄点、CCT及3 mm区域角膜厚度与年龄无相关性。5、6、7 mm CTI与年龄呈负相关(r=-0.18,P=0.001;r=-0.27,P<0.001;r=-0.27,P<0.001),3、4 mm CTI与年龄无相关性。CH与年龄无明显相关性,CRF与年龄呈负相关(r=-0.15,P=0.006)。CH与3、4、5、6 mm CTI呈负相关(r=-0.13,P=0.023;r=-0.14,P=0.010;r=-0.15,P=0.008;r=-0.13,P=0.019),CRF与3、4、5、6 mm CTI也呈负相关(r=-0.21,P<0.001;r=-0.24,P<0.001;r=-0.26,P<0.001;r=-0.16,P=0.005)。7 mm CTI位于总体分布中两端的最大5%与最小5%两组之间比较,CH和CRF差异有统计学意义(t=2.93,P=0.006;t=2.78,P=0.009)。结论:随年龄增加,健康人群CCT变化不大而周边厚度明显下降。CCT与周边厚度差异较大的角膜可能存在抵抗眼内压及外力作用能力下降的风险。展开更多
The study of pixelated metamaterials that integrate both the functions of linear and circular polarization filters is rapidly growing due to the need for full-Stokes polarization imaging. However, there is a lack of l...The study of pixelated metamaterials that integrate both the functions of linear and circular polarization filters is rapidly growing due to the need for full-Stokes polarization imaging. However, there is a lack of large-area, ultracompact pixelated full-Stokes metamaterials with excellent performance, especially circular polarization filters with a high extinction ratio, a broad operating bandwidth, and a low-cost, high-quality, efficient manufacturing process, which limits the practical applications of pixelated full-Stokes metamaterials. In this study, we propose a universal design and fabrication scheme for large-area, ultracompact pixelated aluminum wire-grid-based metamaterials used in Vis-NIR full-Stokes polarization imaging. The aluminum wire-grid was designed as a linear polarization filter with an average linear polarization extinction ratio of 36,000 and a circular polarization filter with an average circular polarization extinction ratio of 110 in Vis-NIR. A large-area, ultracompact 320 × 320pixelated aluminum wire-grid-based full-Stokes metamaterial was fabricated using nanoimprint lithography and nano transfer printing with the advantages of low cost and high efficiency. This metamaterial was used to achieve full-Stokes polarization imaging with errors within 8.77%, 12.58%, 14.04%, and 25.96% for Stokes parameters S_(0), S_(1), S_(2), and S_(3), respectively. The inversion errors of the compensated Stokes parameters can be reduced to0.21%, 0.21%, 0.42%, and 1.96%, respectively.展开更多
Dear Editor The rapid evolution of SARS-CoV-2 mandates a better under-standing of cross-neutralization and cross-protection among variants.Such information is essential to guide vaccine strategy and public policy.To e...Dear Editor The rapid evolution of SARS-CoV-2 mandates a better under-standing of cross-neutralization and cross-protection among variants.Such information is essential to guide vaccine strategy and public policy.To examine the cross-protection among different variant spikes,we initially prepared four chimeric SARS-CoV-2 viruses(Fig.1a),each bearing the spike gene from Alpha,Beta,Gamma,or Epsilon in the backbone of USA-WA1/2020[isolated in January 2020 and defned as wild-type(WT)].展开更多
基金supported by the National Stroke Rehabilitation Research Foundation of the Ministry of Health, China,No.01BA703B18bthe Young and Middle-Aged Clinical Scientists Research Foundation of Shanghai Government,No.01YZK
文摘To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction, 23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction. The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days. The diffusion coefficient remained unchanged. Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction.
基金supported by Pearl River S&T Nova Program of Guangzhou(No.201610010113)the Open Research Fund of NMPA Key Laboratory for Rapid Testing Technology of Drugs,Guangdong Institute for Drug Control(No.KF2022002,KF2022006)Research Project of Chinese Medicine in TCM Bureau of Guangdong Province(No.20231202).
文摘Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment.G.lucidum spores(GLS)are tiny germ cells released from the mushroom cap during the mature stage of growth.They contain all the genetic active substances of G.lucidum.G.lucidum spore oil(GLSO)is a lipid component extracted from broken-walled Ganoderma spores using supercritical CO_(2)extraction technology.GLSO contains fatty acids,Ganoderma triterpenes,sterols and other bioactive compounds.Previous studies have demonstrated that GLSO has a wide range of pharmacological properties,including anti-tumor,anti-aging,neuroprotection,immunomodulation,hepatoprotection and modulation of metabolic diseases.This review summarizes the research progress of GLSO over the past two decades in terms of its bioactive components,extraction and processing techniques,pharmacological effects and safety evaluation.This provides a solid foundation for further research and application of GLSO.
基金supported by the National Key R&D Program of China(2021YFC2300200,2021YFC2302405,and 2022YFC2303200)the National Natural Science Foundation of China(32188101,31825001,81961160737,and 82102389)+7 种基金the Young Elite Scientists Sponsorship Program(2021QNRC001)the Yunnan Cheng Gong Expert Workstation(202005AF150034)the Innovation Team Project of Yunnan Science and Technology Department(202105AE160020)the Tsinghua-Foshan Innovation Special Fund(2022THFS6124)the Shenzhen San-Ming Project for Prevention and Research on Vector-borne Diseasesthe Research Fund-Vanke School of Public HealthTsinghua University(2023JC002)the XPLORER PRIZE from Tencent Foundation。
文摘Arboviruses,a diverse group of vector-borne pathogens transmitted by various vectors such as mosquitoes,ticks,and flies,encompass members of the Flaviviridae,Togaviridae,Phenuviridae,Peribunyaviridae,Reoviridae,Asfarviridae,Rhabdoviridae,Poxviridae,and Orthomyxoviridae families[1].
文摘目的:探讨角膜中央与周边的厚度差异对角膜生物力学特性的影响。方法:回顾性系列病例研究。收集2006年10月至2007年10月在邯郸眼科医院测量的健康人群336例(336眼),来自邯郸眼科研究。运用Orbscan-II测量角膜中央厚度(CCT)、角膜最薄点(TCP)以及3、4、5、6、7 mm处颞侧、上方、鼻侧及下方的角膜厚度;通过计算3、4、5、6、7 mm区域角膜厚度与中央厚度的比值,得到反映角膜中央与周边厚度差异的角膜厚度指数(CTI)。通过眼反应分析仪(ORA)测量角膜迟滞系数(CH)、角膜阻力因子(CRF);采用Pearson相关和Spearman相关分析CH、CRF与角膜厚度及年龄之间的相关性;采用独立样本t检验分析7 mm CTI总体分布中两端的最大5%与最小5%两组之间CH和CRF的差异。结果:研究对象4、5、6、7 mm角膜厚度与年龄均呈负相关(r=-0.15,P=0.003;r=-0.23,P<0.001;r=-0.33,P<0.001;r=-0.41,P<0.001),且随直径增大相关性逐渐增加;角膜最薄点、CCT及3 mm区域角膜厚度与年龄无相关性。5、6、7 mm CTI与年龄呈负相关(r=-0.18,P=0.001;r=-0.27,P<0.001;r=-0.27,P<0.001),3、4 mm CTI与年龄无相关性。CH与年龄无明显相关性,CRF与年龄呈负相关(r=-0.15,P=0.006)。CH与3、4、5、6 mm CTI呈负相关(r=-0.13,P=0.023;r=-0.14,P=0.010;r=-0.15,P=0.008;r=-0.13,P=0.019),CRF与3、4、5、6 mm CTI也呈负相关(r=-0.21,P<0.001;r=-0.24,P<0.001;r=-0.26,P<0.001;r=-0.16,P=0.005)。7 mm CTI位于总体分布中两端的最大5%与最小5%两组之间比较,CH和CRF差异有统计学意义(t=2.93,P=0.006;t=2.78,P=0.009)。结论:随年龄增加,健康人群CCT变化不大而周边厚度明显下降。CCT与周边厚度差异较大的角膜可能存在抵抗眼内压及外力作用能力下降的风险。
基金National Natural Science Foundation of China(52175265, 52275281)Fundamental Research Funds for the Central Universities (DUT21GF308, DUT21ZD101)。
文摘The study of pixelated metamaterials that integrate both the functions of linear and circular polarization filters is rapidly growing due to the need for full-Stokes polarization imaging. However, there is a lack of large-area, ultracompact pixelated full-Stokes metamaterials with excellent performance, especially circular polarization filters with a high extinction ratio, a broad operating bandwidth, and a low-cost, high-quality, efficient manufacturing process, which limits the practical applications of pixelated full-Stokes metamaterials. In this study, we propose a universal design and fabrication scheme for large-area, ultracompact pixelated aluminum wire-grid-based metamaterials used in Vis-NIR full-Stokes polarization imaging. The aluminum wire-grid was designed as a linear polarization filter with an average linear polarization extinction ratio of 36,000 and a circular polarization filter with an average circular polarization extinction ratio of 110 in Vis-NIR. A large-area, ultracompact 320 × 320pixelated aluminum wire-grid-based full-Stokes metamaterial was fabricated using nanoimprint lithography and nano transfer printing with the advantages of low cost and high efficiency. This metamaterial was used to achieve full-Stokes polarization imaging with errors within 8.77%, 12.58%, 14.04%, and 25.96% for Stokes parameters S_(0), S_(1), S_(2), and S_(3), respectively. The inversion errors of the compensated Stokes parameters can be reduced to0.21%, 0.21%, 0.42%, and 1.96%, respectively.
文摘Dear Editor The rapid evolution of SARS-CoV-2 mandates a better under-standing of cross-neutralization and cross-protection among variants.Such information is essential to guide vaccine strategy and public policy.To examine the cross-protection among different variant spikes,we initially prepared four chimeric SARS-CoV-2 viruses(Fig.1a),each bearing the spike gene from Alpha,Beta,Gamma,or Epsilon in the backbone of USA-WA1/2020[isolated in January 2020 and defned as wild-type(WT)].
