Preparation of waterborne polyurethane/β-cyclodextrin composite nanosponge by ion condensation method and its application in removing of dyes from wastewater

Currently,polymer nanosponges have received extensive attention.However,developing new synthetic techniques for novel nanosponges remains a challenge.Furthermore,to date,composite nanosponge adsorbents based on waterborne polyurethane(WPU)andβ-cyclodextrin(β-CD)have not been reported.Herein,a novel green method,ion condensation method,was developed in this study for the preparation of polymer nanosponge adsorbents for efficient removal of dyes from wastewater.Based on the principle of charge repulsion between nanoparticles to maintain emulsion stability,waterborne polyurethane/β-cyclodextrin composite nanosponges(WPU-x,y)were prepared by coagulating the emulsions synthesized from 2,2-dimethylolpropionic acid,polypropylene glycol and hexamethylene diisocyanate as raw materials in a mixture of hydrochloric acid and anhydrous ethanol.The structure and appearance of WPU-x,y were characterized by attenuated total reflectance Fourier transform infrared spectroscopy,thermal gravimetric analyzer,scanning electron microscope and mercury intrusion porosimetry.The adsorption capacity of WPU-x,y was tested by parameters such as cross-linking degree,β-CD dosage,contact time,initial dye concentration and p H value.The study found that WPU-4,4.62 had the best adsorption effect on methylene blue(MB),the maximum removal rate was 93.42%,and the maximum adsorption capacity was 136.03 mg·g^(-1).Moreover,the Sips isotherm and pseudo-second-order-model were suitable for MB adsorption.Therefore,this study provides some perspectives for the fabrication of nanosponge adsorbents.

Ten1p promotes the telomeric DNA-binding activity of Cdc13p： implication for its function in telomere length regulation

在 Saccharomyces cerevisiae，必要基因 CDC13 编码 telomeric 遗传上并且身体上与 Stn1p 和 Ten1p 交往的搁浅单人赛的 DNA 有约束力的蛋白质，并且为 telomere 结束保护和 telomere 长度控制被要求。Ten1 由参予 telomere 长度规定和染色体结束保护的分子的机制留下逃犯。在这个工作，我们用净化的 recombinant Cdc13p 和 Ten1p 在胶化过滤分析观察了 Cdc13p 和 Ten1p 的一个弱相互作用。Ten1p 本身展出一项弱 DNA 有约束力的活动，但是提高 telomeric TG1 鈥吗？Cdc13p 的 DNA 有约束力的能力。Cdc13p 是有 Ten1p 的 co-immunoprecipitated。在变异的 ten1-55 或 ten1-66 房间，在 Ten1p 和 Cdc13p 之间的损害相互作用与 telomeric DNA 导致长得多的 telomeres，以及 Cdc13p 的一个减少的协会。一致地， Ten1-55 和 Ten1-66 异种蛋白质没能刺激 telomeric 在 vitro 的 Cdc13p 的 DNA 有约束力的活动。这些结果建议 Ten1p 提高 telomeric Cdc13p 到的 DNA 有约束力的活动否定地调整 telomere 长度。

Hybrid co-based MOF nanoboxes/CNFs interlayer as microreactors for polysulfides-trapping in lithium-sulfur batteries

Lithium-sulfur battery is desirable for the future potential electrochemical energy storage device with advantages of high theoretical energy density,low cost and environmental friendliness.However,some natural hindrances,particularly fast capacity degradation resulting from the migration of dissolved polysulfide intermediates,remain to be significant challenges prior to the practical applications.In this work,a composite interlayer of carbon nanofibers(CNFs)which are enriched by Co-based metal organic frameworks(ZIF-67)growth in-situ is exploited.Notably,physical blocking and chemical trapping abilities are obtained synergistically from the ZIF/CNFs interlayer,which enables to restrain the dissolution of polysulfides and alleviate shuttle effect.Moreover,the three-dimensional fiber networks provide an interconnected conductive framework between each ZIF microreactor to promote fast electron transfer during cycling,thus contributing to excellent rate and cycling performance.As a result,Li-S cells with ZIF/CNFs interlayer show a high specific capacity of 1334 mAh g^(-1) at 1 C with an excellent cycling stability over 300 cycles.Besides,this scalable and affordable electrospinning fabrication method provides a promising approach for the design of MOFs-derived carbon materials for high performance Li-S batteries.

Pathological tissue segmentation by using deep neural networks

Objective:The process of manually recognize the lesion tissue in pathological images is a key,laborious and subjective step in tumor diagnosis.An automatic segmentation method is proposed to segment lesion tissue in pathological images.Methods:We present a region of interest(ROI)method to generate a new pre-training dataset for training initial weights on DNNs to solve the overfitting problem.To improve the segmentation performance,a multiscale and multi-resolution ensemble strategy is proposed.Our methods are validated on a public segmentation dataset of colonoscopy images.Results:By using the ROI pre-training method,the Dice score of DeepLabV3 and ResUNet increases from 0.607 to 0.739 and from 0.572 to 0.741,respectively.The ensemble method is used in the testing phase,the Dice score of DeepLabV3 and ResUNet increased to 0.760 and 0.786.Conclusion:The ROI pre-training method and ensemble strategy can be applied to DeepLabV3 and ResUNet to improve the segmentation performance of colonoscopy images.

Nonlocal symmetries,soliton-cnoidal wave solution and soliton molecules to a(2+1)-dimensional modified KdV system

A(2+1)-dimensional modified KdV(2DmKdV)system is considered from several perspectives.Firstly,residue symmetry,a type of nonlocal symmetry,and the Bäcklund transformation are obtained via the truncated Painlevéexpansion method.Subsequently,the residue symmetry is localized to a Lie point symmetry of a prolonged system,from which the finite transformation group is derived.Secondly,the integrability of the 2DmKdV system is examined under the sense of consistent tanh expansion solvability.Simultaneously,explicit soliton-cnoidal wave solutions are provided.Finally,abundant patterns of soliton molecules are presented by imposing the velocity resonance condition on the multiple-soliton solution.

One-step assembly of Pd-Keggin-polyoxometalates for catalytic benzothiadiazole generation and derived cell-imaging probe application

One-step assembly of organic-ligand modified Pd-Keggin-POMs has been rarely reported,so as for their applications in catalytic benzothiadiazole generation and derived cell-imaging probing.Herein,three PdKeggin-POMs(compounds 1-3)have been successfully synthesized via a one-step assembly strategy.Thus-obtained Pd-Keggin-POMs with well-defined structures and heterogeneous properties enable highly efficient catalytic benzothiadiazole generation.Specifically,compound 3 showed outstanding catalytic activities in Suzuki-Miyaura coupling reactions for the generation of benzothiadiazole derivatives(yields,90%-97%)and was represented as one of the best catalysts reported to date.Consequently,the obtained benzothiadiazoles were used as the bio-probe for tracking lipid droplets in living-cells and exhibited large Stokes shifts(130 nm),low cytotoxicity and good targeting,which could be also applied to mark the distribution of LDs in living He La cells.Systematic investigations clearly decipher the functions of PdKeggin-POMs toward finding novel bio-probe materials,highlighting a new insight into the generation of sustainable materials in life-science.

角膜塑形术后光学治疗区大小及偏心对光学及视觉质量的影响

目的:分析角膜塑形镜配戴后角膜高阶像差、对比敏感度的变化,以及光学治疗区大小及偏心对二者的影响。方法:前瞻性临床研究。选取2017年3-8月于温州医科大学附属第三医院验配角膜塑形镜的近视儿童31例(31眼),测量戴镜前及戴镜1个月后的角膜地形图、对比敏感度、角膜高阶像差,分析光学治疗区大小及偏心情况对角膜高阶像差、对比敏感度变化的影响。对比敏感度以对比敏感度函数对数曲线下面积(AULCSF)衡量大小。采用配对t检验、Pearson相关分析、逐步多项线性回归分析等方法进行统计。结果:角膜塑形镜配戴1个月后,光学治疗区直径(3.48±0.49)mm,偏心距离(0.64±0.27)mm,偏心方向以颞下方为主(45%)。角膜总高阶像差、球差、垂直彗差、水平彗差均较配戴前明显增加(t=10.99、10.19、-2.21、-3.50,P<0.05);光学治疗区垂直偏心距离(标准化B=0.620,P=0.001)和水平偏心距离(标准化B=0.422,P=0.049)分别是影响角膜垂直彗差增加量和水平彗差增加量的唯一因素。配戴1个月后亮环境及暗环境AULCSF有下降趋势,但与戴镜前相比差异无统计学意义;亮环境AULCSF下降幅度与屈光度改变量有关(标准化B=0.452,P=0.021),而暗环境AULCSF下降幅度则与屈光度改变量(标准化B=0.528,P=0.004)、偏心距离(标准化B=0.458,P=0.027)均相关。结论:角膜塑形镜偏心会导致角膜高阶像差增加,但对对比敏感度影响不大。

The Presentation Problem of the Conjugate Cone of the Hardy Space Hp(0 < p≤1)

The Hardy space Hpis not locally convex if 0 < p < 1, even though its conjugate space(Hp) separates the points of Hp. But then it is locally p-convex, and its conjugate cone(Hp) p is large enough to separate the points of Hp. In this case, the conjugate cone can be used to replace its conjugate space to set up the duality theory in the p-convex analysis. This paper deals with the representation problem of the conjugate cone(Hp) p of Hpfor 0 < p ≤ 1, and obtains the subrepresentation theorem(Hp) p L∞(T, C p).

利用活细胞超分辨病理学揭示佩梅病致病的不同分子机制

由于分辨率低及光漂白毒性高等缺点,传统的荧光或超分辨率显微镜都难以看清与疾病相关的分子/细胞器动态和相互作用的变化.本研究应用超灵敏海森结构光超分辨率显微成像研究了7例临床从重到轻的先天性、中间型和经典型佩梅病(PMD)患者的PLP1蛋白突变,细胞水平上划分为三类PLP1蛋白转运和定位的异常,结果与临床分型高度一致;筛选出胆固醇和姜黄素可以选择性改善先天型PMD的细胞病理,揭示了PMD的不同致病机制,并提供了精准治疗依据.据此提出活细胞超分辨率病理学的概念作为体外研究疾病发生发展机制和药物筛选的通用工具.

Mitochondria determine the sequential propagation of the calcium macrodomains revealed by the super-resolution calcium lantern imaging

Despite the wide application of super-resolution(SR)microscopy in biological studies of cells,the technology is rarely used to monitor functional changes in live cells.By combining fast spinning disc-confocal structured illumination microscopy(SD-SIM)with loading of cytosolic fluorescent Ca2+indicators,we have developed an SR method for visualization of regional Ca2+dynamics and related cellular organelle morphology and dynamics,termed SR calcium lantern imaging.In COS-7 cells stimulated with ATP,we have identified various calcium macrodomains characterized by different types of Ca2+release from endoplasmic reticulum(ER)stores.Finally,we demonstrated various roles of mitochondria in mediating calcium signals from different sources;while mitochondria can globally potentiate the Ca2+entry associated with store release,mitochondria also locally control Ca2+release from the neighboring ER stores and assist in their refilling processes.

New patterns of localized excitations in (2+1)-dimensions:The fifth-order asymmetric Nizhnik-Novikov-Veselov equation

By applying the mastersymmetry of degree one to the time-independent symmetry K_(1), the fifth-order asymmetric Nizhnik-Novikov-Veselov system is derived. The variable separation solution is obtained by using the truncated Painlevé expansion with a special seed solution. New patterns of localized excitations, such as dromioff, instanton moving on a curved line, and tempo-spatial breather, are constructed. Additionally, fission or fusion solitary wave solutions are presented,graphically illustrated by several interesting examples.