Low Complexity Detection Algorithms Based on ADMIN for Massive MIMO

This paper proposes the alternating direction method of multipliers-based infinity-norm(ADMIN) with threshold(ADMIN-T) and with percentage(ADMIN-P) detection algorithms,which make full use of the distribution of the signal to interference plus noise ratio(SINR) for an uplink massive MIMO system.The ADMIN-T and ADMIN-P detection algorithms are improved visions of the ADMIN detection algorithm,in which an appropriate SINR threshold in the ADMIN-T detection algorithm and a certain percentage in the ADMIN-P detection algorithm are designed to reduce the overall computational complexity.The detected symbols are divided into two parts by the SINR threshold which is based on the cumulative probability density function(CDF) of SINR and a percentage,respectively.The symbols in higher SINR part are detected by MMSE.The interference of these symbols is then cancelled by successive interference cancellation(SIC).Afterwards the remaining symbols with low SINR are iteratively detected by ADMIN.The simulation results show that the ADMIIN-T and the ADMIN-P detection algorithms provide a significant performance gain compared with some recently proposed detection algorithms.In addition,the computational complexity of ADMIN-T and ADMIN-P are significantly reduced.Furthermore,in the case of same number of transceiver antennas,the proposed algorithms have a higher performance compared with the case of asymmetric transceiver antennas.

间变性淋巴瘤激酶抑制剂不良反应管理西南专家建议(2021年版)

间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)融合基因作为肿瘤驱动基因,对非小细胞肺癌(non-small cell lung cancer,NSCLC)的发生和发展至关重要,而靶向ALK融合基因已成为ALK阳性NSCLC患者的主要治疗手段。第一、二代ALK抑制剂(ALK inhibitor,ALKi)克唑替尼、塞瑞替尼、阿来替尼、恩沙替尼已在中国上市并广泛应用。然而,针对ALKi不良反应尚无统一的管理指导规范,在一定程度上降低甚至限制了ALKi的临床使用及患者获益。本文由四川省肿瘤学会肺癌专业委员会及四川省肿瘤性疾病医疗质量控制中心牵头,针对国内已经获批上市的ALKi,参考国内外临床研究和相关文献,并结合专家实践经验,总结出《ALKi不良反应管理专家建议(2021年版)》,以期为临床提供切实可行的ALKi不良反应的管理策略。

Upregulation of GLE1 and LCP2 Genes in H5N1 Influenza Virus Infected Patients

Previous study showed that the Gle1 RNA export mediator-like (Gle1l) gene and the lymphocyte cytosolic protein 2 (Lcp2) gene were upregulated in response to influenza virus A/Puerto Rico/8/1934 (H1N1) in a mouse mode. To determine whether these two genes were upregulated in humans after influenza A virus infection, nasopharyngeal swabs were collected from eleven patients with flu-like symptoms for viral RNA extraction and PCR amplification. Sequencing analysis revealed that nucleoprotein (NP) gene fragments amplified from nasopharyngeal swabs of four patients shared the highest similarity with the NP gene from avian influenza A (H5N1) virus (A/ goose/Shantou/753/2002). Peripheral blood samples were then collected from four patients for quantitative analysis of GLE1 and LCP2 gene expression. Our results demonstrated that both GLE1 and LCP2 genes were upregulated in H5N1 influenza A virus infected patients, suggesting that upregulation of GLE1 and LCP2 genes may be important for the host defense against influenza A viruses.

Study of Annealing the Damaged HPGe Detector

High purity germanium detectors have important applications in many fields. Detector’s performance deteriorated significantly due to radiation of neutron. The annealing of damaged HPGe detector is expounded in this monograph. The experiment results indicate that raising the temperature to 70°C for five days, the restoration efficiency can reach 90%.

Improvement of Beam Energy Measurement System for BES-III

The beam energy measurement system is significant and profit for both BES-III detector and BEPC-II accelerator. The detection of the high energy scattering photons is realized by virtue of the Compton backscattering principle. Many advanced techniques and precise instruments are employed to acquire the highly accurate measurement of positron/electron beam energy. During five years’ running period, in order to satisfy the requirement of data taking and enhance the capacity of measurement itself, the upgradation of system is continued, which involves the components reformation of laser and optics subsystem, replacement of view-port of the laser to vacuum insertion subsystem, the usage of electric cooling system for high purity germanium detector, and the refinement of data acquisition and processing subsystem. The upgrading of system guarantees the smooth and effective measuring of beam energy at BEPC-II and accommodates the accurate offline energy values for further physics analysis at BES-III.

From Zeolitic Imidazolate Framework-8 to Metal-Organic Frameworks (MOFs): Representative Substance for the General Study of Pioneering MOF Applications

Metal-organic frameworks(MOFs)have been intensely studied for the past few decades as an enormous family of highly tunable porous materials with promisingly applicable functionalities in adsorption,separation,catalysis,sensing,electrochemistry,and a great number of emerging purposes.As a classic MOF,zeolitic imidazolate framework-8(ZIF-8)is conventionally one of the very few MOF members that has been commercialized with considerable production.

On Two Cryogenic Systems of High Purity Germanium Detector

Two cryogenic systems of high purity germanium detector, liquid nitrogen and mechanical cooler, are expounded, to- gether with explanations of merits and demerits for each kind of cooling methods. The resolutions of detector to the characteristic lines of 152Eu under different cooling conditions are studied. The laboratory results indicate that the me- chanical cooler (X-Cooler II) is an ideal replacement candidate for the liquid nitrogen cooling system that is being util- ized by BEMS at BEPC-II.

通过表面终止化学设计实现高度可逆的锌金属阳极

锌表面自然形成的非均匀氧化层(ZnO)会与电解液发生反应形成Zn_(4)(OH)_(6)SO_(4)·xH_(2)O(ZSH)副产物,导致锌负极表面非均匀沉积,从而阻碍水性锌离子电池实际应用.为了排除氧化层分布形式的影响,本文利用表面终止化学设计策略在锌负极表面制备了一层完全氧化的ZnO层,研究发现锌负极均匀分布的ZnO层会原位演化形成致密的ZSH功能层.均匀且致密的ZSH能够有效隔绝电解液的腐蚀,从而有效提高锌负极界面的稳定性.此外,ZSH(002)晶面边缘的不饱和悬空键(如-O)更容易和Zn(H_(2)O)_(6)^(2+)结构中的锌离子形成强Zn-O键,可以促进Zn(H_(2)O)_(6)^(2+)的脱溶剂化和锌离子沿边扩散,实现了高度可逆的锌沉积行为并限制了副反应.基于此,本文提出与“表面脱水-晶体通道转移”机制明显不同的“边缘脱水-沿边缘转移”锌离子输运新机制.更重要的是,基于此组装的全电池显示出高循环稳定性(超过1000次循环)和高库仑效率(99.07%),验证了其潜在的实际应用价值.

Extended pancreatoduodenectomy with portal vein and inferior vena cava resection and reconstruction combined with sorafenib for hepatoid carcinoma of the pancreas:a strategy of superextended surgery combined with targeted therapy

Hepatoid carcinoma of the pancreas(HCP)is an extremely rare pancreatic cancer resembling hepatocellular carcinoma,a type of liver cancer(1).Most reports have shown that it has an aggressive behavior and is associated with early metastasis.There is no standardized treatment for HCP due to its rarity,and the limited number of cases reported in the literature(2,3).However,treatment options for this type of rare cancer include surgery,chemotherapy,and radiation therapy,depending on the stage of the cancer.Nevertheless,the prognosis of HCP is poor.

A new method to constrain shallow crustal S-wave velocities based on direct P-wave amplitudes in receiver functions and its application in northeastern Tibet

A new method is developed to constrain S-wave velocity structures of the shallow crust based on frequencydependent amplitudes of direct P-waves in P-wave receiver functions(P-RFs). This method involves the following two steps:first, the high-frequency approximate amplitude formula of direct P-waves in P-RFs of individual stations is used to fit the observed amplitude distribution against the ray parameters at different frequencies, and second, the S-wave velocity depth profile beneath each station is constrained according to an empirical correlation between frequency and depth. Unlike traditional inversion techniques, the newly developed method is not dependent on initial velocity models, and the lateral and vertical resolutions of the results are controlled by the interstation distance and the data frequency, respectively. The effectiveness of the method is verified by synthetic tests on various models. The method is then applied to teleseismic P-RF data from a NW-SEtrending linear seismic array extending from the northeastern Tibetan Plateau to the central Sichuan Basin to construct an S-wave velocity image of the shallow crust along the array. The imaged velocity structure is further analysed and compared with the regional geology. In particular, the structural differences of sedimentary basins in the cratonic area of the stable Sichuan Basin and tectonically active belts in northeastern Tibet are investigated. By combining our results with previous observations, the relationship between the surficial geology and deep processes in the study region is also discussed.

Crustal structure study based on principal component analysis of receiver functions

The receiver function(RF) technique is an effective method for studying crustal structure. For a single station, the average 1-D crustal structure is usually derived by stacking the radial RFs from all back-azimuths, whereas structural variations(such as dipping discontinuities or anisotropy) can be constrained through analysis of waveform dependence on the backazimuth of both the radial and tangential RFs. However, it is often difficult to directly extract information about structural variations from the waveform of RF, due to the common presence of noise in real data. In this study, we proposed a new method to derive structural variation information for individual stations by applying principal component analysis(PCA) to RFs sorted by back-azimuth. In this method(termed as RF-PCA), a set of principal components(PCs), which are uncorrelated with each other and reflect different characteristics of the RF data, were extracted and utilized separately to reconstruct new RFs. Synthetic tests show that the first PC of the radial RFs contains the average structural information of the crust beneath the corresponding station, and the second PC of the radial RFs and the first PC of the tangential RFs both reflect the variations of the crustal structure. Our synthetic modeling results indicate that the new RF-PCA method is valid for a variety of synthetic models with intra-crustal dipping discontinuities and/or anisotropy. We applied this method to the real data from a broadband temporary seismic station(s233) in the central part of the Sichuan Basin. The results suggest that the RF data can be best explained by the presence of two nearly parallel dipping discontinuities within the crust. Combining with previous logging data, seismic exploration and deep sounding observations, we interpret the shallow dipping discontinuity as the top boundary of the Precambrian crystalline basement of the Sichuan Basin and the deep one corresponding to the Conrad interface between the upper and lower crust, consistent with the geological feature of the study area. In this work, both synthetic tests and real data application results demonstrate the effectiveness of the RF-PCA method for studying crustal structures.

Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial

Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting.

Active fuel design A way to manage the right fuel for HCCI engines

Homogenous charge compression ignition （HCCI） engines feature high thermal efficiency and ultralow emissions compared to gasoline engines. However, unlike SI engines, HCCI combustion does not have a direct way to trigger the in-cylinder combustion. Therefore, gasoline HCCI combustion is facing challenges in the control of ignition and, combustion, and operational range extension. In this paper, an active fuel design concept was proposed to explore a potential pathway to optimize the HCCI engine combustion and broaden its operational range. The active fuel design concept was realized by real time control of dual-fuel （gasoline and n-heptane） port injection, with exhaust gas recirculation （EGR） rate and intake temperature adjusted. It was found that the cylinder- to-cylinder variation in HCCI combustion could be effectively reduced by the optimization in fuel injection proportion, and that the rapid transition process from SI to HCCI could be realized. The active fuel design technology could significantly increase the adaptability of HCCI combustion to increased EGR rate and reduced intake temperature. Active fuel design was shown to broaden the operational HCCI load to 9.3 bar indicated mean effective pressure （IMEP）. HCCI operation was used by up to 70% of the SI mode load while reducing fuel consumption and nitrogen oxides emissions. Therefore, the active fuel design technology could manage the right fuel for clean engine combustion, and provide a potential pathway for engine fuel diversification and future engine concept.

Continuous flow synthesis of porous materials

Porous materials play an important role in chemical catalysis,separation and other industrial applications.High-efficiency preparation of porous materials has become an active research area.Conventional synthesis of porous materials has been dominated by one-pot solution processing conditions carried out by bulk mixing under conventional electric heating via hydrothermal,solvothermal or ionothermal reactions where high temperatures and pressures are the standard.Continuous flow synthesis has many key advantages in terms of efficient mass and heat transfer,precise control of residence times,improved opportunities for automation and feedback control of synthesis,scaling-up reactions and improved safety parameters compared to above mentioned conventional batch scale synthetic methods.In this review,continuous flow synthesis of various crystalline porous materials such as metal-organic frameworks(MOFs),covalent-organic frameworks(COFs),porous organic cages and zeolites is discussed.Combination of microfluidic methods with other techniques are also shown including various heating ways and various methods of substrate adding.

Three-dimensional-printed collagen/chitosan/secretome derived from HUCMSCs scaffolds for efficient neural network reconstruction in canines with traumatic brain injury

The secretome secreted by stem cells and bioactive material has emerged as a promising therapeutic choice for traumatic brain injury(TBI).We aimed to determine the effect of 3D-printed collagen/chitosan/secretome derived from human umbilical cord blood mesenchymal stem cells scaffolds(3D-CC-ST)on the injured tissue regeneration process.3D-CC-ST was performed using 3D printing technology at a low temperature(20C),and the physical properties and degeneration rate were measured.The utilization of low temperature contributed to a higher cytocompatibility of fabricating porous 3D architectures that provide a homogeneous distribution of cells.Immediately after the establishment of the canine TBI model,3D-CC-ST and 3D-CC(3D-printed collagen/chitosan scaffolds)were implanted into the cavity of TBI.Following implantation of scaffolds,neurological examination and motor evoked potential detection were performed to analyze locomotor function recovery.Histological and immunofluorescence staining were performed to evaluate neuro-regeneration.The group treated with 3D-CC-ST had good performance of behavior functions.Implanting 3D-CC-ST significantly reduced the cavity area,facilitated the regeneration of nerve fibers and vessel reconstruction,and promoted endogenous neuronal differentiation and synapse formation after TBI.The implantation of 3D-CC-ST also markedly reduced cell apoptosis and regulated the level of systemic inflammatory factors after TBI.

Effects of fuel combination and IVO timing on combustion and emissions of a dual-fuel HCCI combustion engine

This paper experimentally and numerically studied the effects of fuel combination and intake valve opening(IVO)timing on combustion and emissions of an n-heptane and gasoline dual-flicl homogeneous charge compression ignition(HCCI)engine.By changing the gasoline fraction(GF)from 0」to 0.5 and the IVO timing from-15°CA ATDC to 35°CA ATDC,the in-cylinder pressure traces,heat release behaviors,and HC and CO emissions were investigated.The results showed that both the increased GF and the retarded IVO timing delay the combustion phasing,lengthen the combustion duration,and decrease the peak heat release rate and the maximum average combustion temperature,whereas the IVO timing has a more obvious influence on combustion than GF.HC and CO emissions are decreased with reduced GF,advanced IVO timing and increased operational load.

Annealing restoration of HPGe detector

Introduction HPGe detector is used widely,its property is affected by neutron.Annealing to the germanium crystal is a good approach to recover the detector.Purpose To raise the temperature of germanium crystal to recover the resolution for the HPGe detector.Method A special copper ingot is designed and manufactured to increase the heating efficiency.Two temperature controlled power supplies are used to heat the germanium crystal and keep the temperature for cooling rod.Conclusion The experiment results indicate that raising temperature to 70℃for five days,the restoration efficiency is better than 90%.

Effect of particle degradation on electrostatic sensor measurements and flow characteristics in dilute pneumatic conveying

Vigorous particle collisions and mechanical processes occurring during high-velocity pneumatic con- veying often lead to particle degradation. The resulting particle size reduction and particle number increase will impact on the flow characteristics, and subsequently affect the electrostatic type of flow measurements. This study investigates this phenomenon using both experimental and numerical meth- ods. Particle degradation was induced experimentally by recursively conveying the fillite material within a pneumatic pipeline. The associated particle size reduction was monitored. Three electrostatic sensors were embedded along the pipeline to monitor the flow. The results indicated a decreasing trend in the electrostatic sensor outputs with decreasing particle size, which suggested the attenuation of the flow velocity fluctuation. This trend was more apparent at higher conveying velocities, which suggested that more severe particle degradation occurred under these conditions. Coupled computational fluid dynamics and discrete element methods （CFD-DEM） analysis was used to qualitatively validate these experimental results. The numerical results suggested that smaller particles exhibited lower flow velocity fluctua- tions, which was consistent with the observed experimental results. These findings provide important information for the accurate aoolication of electrostatic measurement devices in oneumatic conveyors.

Coordination-Driven Terpyridyl Phosphine Pd(Ⅱ) Gels

Incorporation of phosphine-Pd catalytic centers in gel network is an important strategy to develop highly active catalysts.In this contribution we show that catalytically active phosphine-Pd(II)gels can be readily obtained via re-action of rigid bridging terpyridyl phosphines and Pd(II).The terpyridyl phosphines,Py2P2 and Py2P,contain one 4,2':6',4"-terpyridyl group and two/one diphenylphosphino groups.Reactions of Py2P2/Py2P and Pd(II)in CHCl_(3)-MeOH afforded the corresponding phosphine-Pd(II)gels at room temperature or at elevated temperature(40℃).The gelation is driven by formation of metal-organic coordination.Mild heating is important in triggering the formation of Py2P-Pd(II)gel.The gels have a coherent,rigid spongy porous network of continuous nanome-ter-sized particles.The phosphine-Pd(II)gels showed high activity in the Suzuki-Miyaura reactions of aryl bro-mides under ambient conditions and could be recycled and reused.

A low-error calibration function for an electrostatic gas-solid flow meter obtained via machine learning techniques with experimental data

In this paper,modeling and machine learning with experimental data and a novel calibration function for a gas-solid flow sensor fusion are presented.Sensor fusion is the use of software that intelligently combines data from multiple sensors in order to improve overall system performance.This technique can be applied to measurement of mass flow rate of solids in a pipeline with non-intrusive electrostatic techniques.Data fusion from multiple heterogeneous/homogenous sensors can overcome the limitations of an individual sensor and measured variable.It is shown that the output voltage of a ring-shaped electrode is predominantly a function of solids mass flow rate and velocity for a flow of bulk solids in a pipeline,when particle size,properties and ambient conditions remain constant.By incorporating solids flow velocity in a proposed mathematical model(obtained via machine learning),meter output voltage could be predicted with superior accuracy,for wide range of different flow pa-rameters from numerous experiments with a pneumatic conveying system.Transposing the model yields a new calibration function which,when deployed in signal processing software,enables accurate mass flow measure-ment with velocity compensation.The described method also de-necessitates determination of air solids ratio or solids volumetric concentration,thereby enabling simplification of the overall measurement system whilst yielding higher accuracy than calibration methods from previous studies.Accurate flow measurement facilitates enhanced monitoring and controllability of blast furnaces,power stations,chemical reactors,process plants etc.where there are bulk solids flows in pipelines.Optimization of such highly materially consumptive and energy intensive processes can yield significant reductions in waste and emissions(CO 2,NOx)and increased efficiencies in global production of energy and materials.