Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanor...Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanoreceptors on the surface of monocytes/macrophages, especially adhesion G protein-coupled receptors (aGPCRs), play important roles in force sensing.However, its role in the regulation of osteoclast differentiation remains unclear. Herein, through single-cell analysis, we revealed that CD97, a novel mechanosensitive aGPCR, was expressed in macrophages. Compression upregulated CD97 expression and inhibited osteoclast differentiation;while knockdown of CD97 partially rescued osteoclast differentiation. It suggests that CD97 may be an important mechanosensitive receptor during osteoclast differentiation. RNA sequencing analysis showed that the Rap1a/ERK signalling pathway mediates the effects of CD97 on osteoclast differentiation under compression. Consistently, we clarified that administration of the Rap1a inhibitor GGTI298 increased osteoclast activity, thereby accelerating tooth movement. In conclusion,our results indicate that CD97 suppresses osteoclast differentiation through the Rap1a/ERK signalling pathway under orthodontic compressive force.展开更多
Model parameters estimation is a pivotal issue for runoff modeling in ungauged catchments.The nonlinear relationship between model parameters and catchment descriptors is a major obstacle for parameter regionalization...Model parameters estimation is a pivotal issue for runoff modeling in ungauged catchments.The nonlinear relationship between model parameters and catchment descriptors is a major obstacle for parameter regionalization,which is the most widely used approach.Runoff modeling was studied in 38 catchments located in the Yellow–Huai–Hai River Basin(YHHRB).The values of the Nash–Sutcliffe efficiency coefficient(NSE),coefficient of determination(R2),and percent bias(PBIAS)indicated the acceptable performance of the soil and water assessment tool(SWAT)model in the YHHRB.Nine descriptors belonging to the categories of climate,soil,vegetation,and topography were used to express the catchment characteristics related to the hydrological processes.The quantitative relationships between the parameters of the SWAT model and the catchment descriptors were analyzed by six regression-based models,including linear regression(LR)equations,support vector regression(SVR),random forest(RF),k-nearest neighbor(kNN),decision tree(DT),and radial basis function(RBF).Each of the 38 catchments was assumed to be an ungauged catchment in turn.Then,the parameters in each target catchment were estimated by the constructed regression models based on the remaining 37 donor catchments.Furthermore,the similaritybased regionalization scheme was used for comparison with the regression-based approach.The results indicated that the runoff with the highest accuracy was modeled by the SVR-based scheme in ungauged catchments.Compared with the traditional LR-based approach,the accuracy of the runoff modeling in ungauged catchments was improved by the machine learning algorithms because of the outstanding capability to deal with nonlinear relationships.The performances of different approaches were similar in humid regions,while the advantages of the machine learning techniques were more evident in arid regions.When the study area contained nested catchments,the best result was calculated with the similarity-based parameter regionalization scheme because of the high catchment density and short spatial distance.The new findings could improve flood forecasting and water resources planning in regions that lack observed data.展开更多
Interbasin water-transfer schemes provide an engineering solution for reconciling the conflict between water demand and availability.In the context of climate change,which brings great uncertainties to water resource ...Interbasin water-transfer schemes provide an engineering solution for reconciling the conflict between water demand and availability.In the context of climate change,which brings great uncertainties to water resource distribution,interbasin water transfer plays an increasingly important role in the global water–food–energy nexus.However,the transfer of water resources simultaneously changes the hydrological regime and the characteristics of local water bodies,affecting biotic communities accordingly.Compared with high economic and technical inputs water-transfer projects require,the environmental and ecological implications of water-transfer schemes have been inadequately addressed.This work selects the largest water-transfer project in China,the South-to-North Water Diversion(SNWD)Project,to critically review its eco-environmental impacts on donor and recipient basins,as well as on regions along the diversion route.The two operated routes of the SNWD Project represent two typical water diversion approaches:The Middle Route uses an excavated canal,while the East Route connects existent river channels.An overview of the eco-environmental implications of these two routes is valuable for the design and optimization of future water-transfer megaprojects.展开更多
Conservation of endangered or economic fish and control of invasive fish is a great challenge of hydraulic engineering worldwide.Flow velocity has been recognized to affect the spawning of fishes delivering drifting e...Conservation of endangered or economic fish and control of invasive fish is a great challenge of hydraulic engineering worldwide.Flow velocity has been recognized to affect the spawning of fishes delivering drifting eggs in rivers.However,solid scientific supports and associated mechanisms to establish quantitative relations between flow velocity and fish reproduction,taking into account spawning,fertilizing,hatching,as well as surviving,are lacking.In this paper,we quantified the relationship between flow velocity and reproduction of Chinese carps through both lab and field experiments.The results showed that a minimum velocity was required to trigger Hypophthalmichthys molitrix(H.molitrix)releasing eggs,and a velocity range was preferred to sustain spawning activity.However,the embryo incubation and larvae development of H.molitrix were found to be inhibited with the increase in flow velocity.Considering the requirements of spawning and hatching,as well as larvae surviving,an optimized flow velocity processes was identified for the reproduction of H.molitrix in rivers.These findings were of great significance to the adaptive operation of reservoirs to create reasonable and precise ecological flows for managing fish reproduction,as shown by the promising results in the engineering application to the Three Gorges Reservoir.展开更多
Background: Subclinical necrotic enteritis(SNE), a common intestinal disease of broiler caused by Clostridium perfringens, could reduce production performance of broilers by chronic intestinal damage and poor absorpti...Background: Subclinical necrotic enteritis(SNE), a common intestinal disease of broiler caused by Clostridium perfringens, could reduce production performance of broilers by chronic intestinal damage and poor absorption of nutrients. Ellagic acid(EA) has been reported to present antioxidant and anti-inflammatory properties on human and animals in many aspects. This study was conducted to evaluate the effect and mechanism of EA in relieving SNE in broilers induced by C. perfringens.Results: C. perfringens challenge decreased body weight(BW), average daily gain(ADG), jejunal villi height/crypt depth(V/C) ratio, the activity of catalase(CAT) and the mRNA expression of zonula occludens 1(ZO-1) in jejunal mucosa of broilers. While feed conversion ratios(FCR), jejunal crypt depth(CD), the activities of myeloperoxidase(MPO) and diamine oxidase(DAO), as well as the concentrations of interleukin 6(IL-6), C-reactive protein(CRP) and procalcitonin(PCT) in serum, the activities of inducible nitric oxide synthase(iNOS) and lysozyme(LZM), the concentration of malondialdehyde(MDA), and the mRNA expressions of claudin-2, TNF-α, IL-1β, TLR-4, TLR-2, NF-κB,JAK3, STAT6 and iNOS in jejunal mucosa of broilers were increased by C. perfringens challenge. Dietary EA supplement relieved these adverse effects, and heightened jejunal villi height(VH), the concentration of D-xylose in plasma, activity of superoxide dismutase(SOD), and the mRNA expression of occludin in jejunal mucosa of broilers.The alpha diversity of cecal microbiota indicated that dietary EA supplement increased observed species and Shannon index. C. perfringens challenge increased the relative abundance of Firmicutes and decreased the relative abundance of Desulfobacterota in cecal microbiota. EA increased the relative abundance of Firmicutes in cecal microbiota. LEfSe analysis showed that C. perfringens challenge triggered the imbalance of cecal microbiota in broilers, dietary EA supplementation led to a small beneficial effect on microbiota, while the simultaneous effect of them seemed to stimulate the immune function of broilers by improving the microbiota balance.Conclusions: Dietary EA ameliorated C. perfringens-induced SNE in broilers via regulating jejunal inflammation signaling pathways TLR/NF-κB and JAK3/STAT6, relieving jejunal oxidative stress and balancing cecal microbiota to inhibit intestinal barrier damage, prevent systemic inflammatory response and improve nutrient absorption capacity,finally protect and enhance growth performance of broilers.展开更多
A decoupling-estimation signal parameters via rotarional invariance technique(ESPRIT) method is presented for multi-target localization with unknown mutual coupling in bistatic multiple-input multiple-output(MIMO)...A decoupling-estimation signal parameters via rotarional invariance technique(ESPRIT) method is presented for multi-target localization with unknown mutual coupling in bistatic multiple-input multiple-output(MIMO) radar.Two steps are carried out in this method.The decoupling operation between angle and mutual coupling estimates is realized by choosing the auxiliary elements on both sides of the transmit and receive uniform linear arrays(ULAs).Then the ESPRIT method is resilient against the unknown mutual coupling matrix(MCM) and can be directly utilized to estimate the direction of departure(DOD) and the direction of arrival(DOA).Moreover,the mutual coupling coefficient is estimated by finding the solution of the linear constrained optimization problem.The proposed method allows an efficient DOD and DOA estimates with automatic pairing.Simulation results are presented to verify the effectiveness of the proposed method.展开更多
Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis challenging.In this study,we applied a whole-genome shallow sequencing approac...Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis challenging.In this study,we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations(CNAs)using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples.Freshly frozen tissue specimens from OF(n=29)and FD(n=28)patients were obtained for analysis.Lesion fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection(LCM),with~30–50 cells(5000–10000µm2)per sample.We found that the rate of recurrent CNAs in OF cases was much higher(44.8%,13 of 29)than that in FD cases(3.6%,1 of 28).Sixty-nine percent(9 of 13)of the CNA-containing OF cases involved segmental amplifications and deletions on Chrs 7 and 12.We also identified eight CNA-associated genes(HILPDA,CALD1,C1GALT1,MICALL2,PHF14,AIMP2,MDM2,and CDK4)with amplified expression,which was consistent with the copy number changes.We further confirmed a jaw lesion with a previous uncertain diagnosis due to its ambiguous morphological features and the absence of GNAS mutation as OF based on the typical Chr 12 amplification pattern in its CNA profile.Moreover,analysis of a set of longitudinal samples collected from an individual with a cellular lesion in suspicion of OF at the first surgery,recurrence and the latest malignant transformation revealed identical CNA patterns at the three time points,suggesting that copy number profiling can be used as an important tool to identify borderline lesions or lesions with malignant potential.Overall,CNA profiling of fibro-osseous lesions can greatly improve differential diagnosis between OF and FD and help predict disease progression.展开更多
Background:The current study was carried out to provide a reference for the control of mycotoxin contamination in feed ingredients and complete feeds for swine.Methods:A total of 55 feed ingredients,including 14 cor...Background:The current study was carried out to provide a reference for the control of mycotoxin contamination in feed ingredients and complete feeds for swine.Methods:A total of 55 feed ingredients,including 14 corn,13 wheat bran,11 soybean meal and 17 dried distillers grains with solubles(DDGS) as well as 76 complete swine feeds including 7 creep feeds,14 starter feeds,14 grower feeds,18 grower-finisher feeds,10 gestating sow feeds,and 13 lactating sow feeds were randomly collected from15 swine farms located in the Beijing region of China from July to August 2011.Immunoaffinity clean-up,using High-Performance Liquid Chromatography(HPLC) in combination with UV or Fluorescence Detection,was used for quantitative analysis of aflatoxin B,(AFB,),deoxynivalenol(DON),zearalenone(ZEA) and ochratoxin A(OTA) in the ingredients and complete feeds.Results:DON and ZEA were the most prevalent mycotoxins found.DON was detected at percentages of 93,92,54,100 and 97%with a mean level of 1.01,0.44,0.05,1.36 and 0.65 ppm in the samples of corn,wheat bran,soybean meal,DDGS and complete feeds,respectively.The detected percentages of ZEA were 100,100,54,100 and 100 with mean levels of 109.1,14.9,9.2,882.7 and 58.9 ppb in the same samples.In the wheat bran and soybean meal samples,the content of all four mycotoxins were below the maximum limits set by Chinese regulations while the percentage of samples that exceeded regulatory limits were 7,57 and 7%for corn,and 7,14 and 3%for the complete feeds for AFB,,DON and OTA respectively.DDGS showed the most serious mycotoxin contamination and the percentage of samples that exceeded regulatory limits were 6,88 and 41%,for AFB,,DON and ZEA,respectively.Conclusions:This paper is the first to present data on the natural occurrence of AFB,,DON,ZEA and OTA in ingredients and complete feeds obtained from swine farms in China's Beijing region.The data shows that feed ingredients and complete swine feeds obtained from these farms are most often contaminated with DON followed by contamination with AFB,and ZEA.展开更多
Odontogenic keratocysts(OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome(NBCCS). OKCs are locally aggressive, ca...Odontogenic keratocysts(OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome(NBCCS). OKCs are locally aggressive, cause marked destruction of the jaw bones and have a propensity to recur. PTCH1 mutations(at ~80%) are frequently detected in the epithelia of both NBCCS-related and sporadic OKCs, suggesting that PTCH1 inactivation might constitutively activate sonic hedgehog(SHH) signalling and play a major role in disease pathogenesis. Thus, small molecule inhibitors of SHH signalling might represent a new treatment strategy for OKCs. However, studies on the molecular mechanisms associated with OKCs have been hampered by limited epithelial cell yields during OKC explant culture. Here, we constructed an isogenic PTCH1^(R135 X/+) cellular model of PTCH1 inactivation by introducing a heterozygous mutation, namely, c.403 C>T(p.R135 X), which has been identified in OKC patients, into a human embryonic stem cell line using the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated 9(Cas9) system. This was followed by the induction of epithelial differentiation. Using this in vitro isogenic cellular model, we verified that the PTCH1 R135 X/+heterozygous mutation causes ligand-independent activation of SHH signalling due to PTCH1 haploinsufficiency. This activation was found to be downregulated in a dose-dependent manner by the SHH pathway inhibitor GDC-0449. In addition, through inhibition of activated SHH signalling, the enhanced proliferation observed in these induced cells was suppressed, suggesting that GDC-0449 might represent an effective inhibitor of the SHH pathway for use during OKC treatment.展开更多
Background:The present study aimed at evaluating the effect of vitamin K(VK)supplementation on bone health of laying hens challenged by Salmonella Enteritidis.Methods:A total of 8032-week-old double negative salmonell...Background:The present study aimed at evaluating the effect of vitamin K(VK)supplementation on bone health of laying hens challenged by Salmonella Enteritidis.Methods:A total of 8032-week-old double negative salmonella-free brown-egg laying hens were randomly assigned to 4 treatments with 20 replicates each(1 bird per replicate)according to a 2×2 factorial design with 2 dietary VK supplementation levels[0 mg/kg(VK0)vs 2 mg/kg VK(VK2)and 2 challenge treatments[Salmonella Enteritidis(SE)vs physiological saline solution(PS)].During the last 3 days of week 43 of age,birds of both VK treatments were either orally challenged with 1.0 mL suspension of 109 cfu/mL S.Enteritidis daily or received the same volume of PS.Results:The laying rate,daily egg mass,tibia strength,CT,cOC and cOC/(cOC+ucOC)of VK2 treatment increased(P<0.05)in contrast to VK0,however,the medullary area and ucOC of VK2 treatment decreased(P<0.05)in contrast to VK0.Mortality,medullary area,serum Ca content of SE treatments increased(P<0.05)in contrast to PS treatments.In both SE treatments,the decrease(P<0.05)in birds’tibia strength was associated with higher(P<0.05)Ca levels in serum.There is an interaction(P<0.05)between SE challenge and VK levels with regard to tibia strength and serum Ca levels.At week 42,serum CT was positively correlated with cOC(R=0.99,P=0.009);at week 44,tibia strength was positively correlated with BMD(R=0.95,P=0.045),but negatively correlated with medullary area(R=−0.98,P=0.018).Conclusions:VK(2 mg/kg)supplementation to diets of laying hens can enhance bone strength under challenge situations with Salmonella Enteritidis.Medullary area has proven to be a sensitive biomarker for bone calcium loss caused by SE infection.展开更多
This paper focuses on the general case (GC) airborne bistatic synthetic aperture radar (SAR) data processing, and a new analytical imaging algorithm based on the extended Loffeld's bistatic formula (ELBF) is pr...This paper focuses on the general case (GC) airborne bistatic synthetic aperture radar (SAR) data processing, and a new analytical imaging algorithm based on the extended Loffeld's bistatic formula (ELBF) is proposed. According to the bistatic SAR geometry, the track decoupling formulas that convert the bistatic geometry to the receiver-referenced geometry in a concise way are derived firstly. Then phase terms of ELBF are decomposed into two independent phase terms as the range phase term and the azimuth phase term in a new way. To get the focusing result, the bistatic deformation (BD) term is compensated in the two-dimensional (2- D) frequency domain, and the space-variances of the range phase term and the azimuth phase term are eliminated by chirp scaling (CS) and chirp z-transform (CZT), respectively. The effectiveness of the proposed algorithm is verified by the simulation results.展开更多
The Asia Pacific Economic Cooperation(APEC)comprises of the world’s largest producers and consumers of energy,accounting for 60.3%of primary energy supply,50.0%of final energy consumption,and 63.0%of electricity gene...The Asia Pacific Economic Cooperation(APEC)comprises of the world’s largest producers and consumers of energy,accounting for 60.3%of primary energy supply,50.0%of final energy consumption,and 63.0%of electricity generation worldwide in 2016.This study discusses the primary energy supply and final energy consumption situation of the APEC and analyzes the characteristics of electricity in terms of its generation structure based on fuel,consumption by the end-use sector,access to electricity,and so on.The renewable energy and electricity generation projections up to 2030 based on trends in the APEC are also assessed.It is seen that electricity in final energy consumption has been on an upward trend,with an average annual growth rate of about 4.8%during 2006–2016,in 2016,its share reached 24.3%.The industry sector consumes the largest share of electricity,accounting for about 45.5%in 2016.Coal supply and consumption peaked in 2011 and then began to decline,while renewable energy has been on an upward trend,with its primary energy supply share increasing from 4.80%in 2010 to 6.29%in 2016.Solar photovoltaic and onshore wind power are on the verge of costing less than the operating cost of existing coal-fired plants in 2018.In the APEC’s target scenario in which renewable energy is doubled,the predicted net growth from 2017 to 2030 of solar,wind,and hydro power is about 963,497,and 157 GW,respectively,and to reach this target,the APEC economies need to accelerate renewable energy development.展开更多
River damming is believed to largely intercept nutrients,particularly retain more phosphorus(P)than nitrogen(N),and thus harm primary productivity,fishery catches,and food security downstream,which seriously constrain...River damming is believed to largely intercept nutrients,particularly retain more phosphorus(P)than nitrogen(N),and thus harm primary productivity,fishery catches,and food security downstream,which seriously constrain global hydropower development and poverty relief in undeveloped regions and can drive geo-political disputes between nations along trans-boundary rivers.In this study,we investigated whether reservoirs can instead improve nutrient regimes downstream.We measured different species of N and P as well as microbial functions in water and sediment of cascade reservoirs in the upper Mekong River over 5 years and modelled the influx and outflux of N and P species in each reservoir.Despite partially retaining total N and total P,reservoirs increased the downstream flux of ammonium and soluble reactive phosphorus(SRP).The increase in ammonium and SRP between outflux and influx showed positive linear relationships with the hydraulic residence time of the cascade reservoirs;and the ratio of SRP to dissolved inorganic nitrogen increased along the reservoir cascade.The lentic environment of reservoirs stimulated algae-mediated conversion of nitrate into ammonium in surface water;the hypoxic condition and the priming effect of algae-induced organic matter enhanced release of ammonium from sediment;the synergy of microbial phosphorylation,reductive condition and sediment geochemical properties increased release of SRP.This study is the first to provide solid evidence that hydropower reservoirs improve downstream nutrient bioavailability and N-P balance through a process of retention-transformation-transport,which may benefit primary productivity.These findings could advance our understanding of the eco-environmental impacts of river damming.展开更多
Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma,which indicates a high potential of malignancy.The malignant transformation of oral leukoplakia seriously affects patient survival and qual...Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma,which indicates a high potential of malignancy.The malignant transformation of oral leukoplakia seriously affects patient survival and quality of life;however,it is difficult to identify oral leukoplakia patients who will develop carcinoma because no biomarker exists to predict malignant transformation for effective clinical management.As a major problem in the field of head and neck pathologies,it is imperative to identify biomarkers of malignant transformation in oral leukoplakia.In this review,we discuss the potential biomarkers of malignant transformation reported in the literature and explore the translational probabilities from bench to bedside.Although no single biomarker has yet been applied in the clinical setting,profiling for genomic instability might be a promising adjunct.展开更多
The Tibetan Plateau(TP)is the headwater of the Yangtze,Yellow,and the transboundary Yarlung Zangbo,Lancang,and Nujiang Rivers,providing essential and pristine freshwater to around 1.6 billion people in Southeast and S...The Tibetan Plateau(TP)is the headwater of the Yangtze,Yellow,and the transboundary Yarlung Zangbo,Lancang,and Nujiang Rivers,providing essential and pristine freshwater to around 1.6 billion people in Southeast and South Asia.However,the temperature rise TP has experienced is almost three times that of the global warming rate.The rising temperature has resulted in glacier retreat,snow cover reduction,permafrost layer thawing,and so forth.Here we show,based on the longest observed streamflow data available for the region so far,that changing climatic conditions in the TP already had significant impacts on the streamflow in the headwater basins in the area.Our analysis indicated that the annual average temperature in the headwater basins of these five major rivers has been rising on a trend averaging 0.38℃-decade^(-1) since 1998,almost triple the rate before 1998,and the change of streamflow has been predominantly impacted by precipitation in these headwater basins.As a result,streamflow in the Yangtze,Yarlung Zangbo,Lancang,and Nujiang River headwater areas is on a decreasing trend with a reduction of flow ranging from 3.0-10^(9)-5.9-10^(9) m^(3)·decade^(-1)(-9.12%to-16.89%per decade)since 1998.The increased precipitation in the Tangnahai(TNH)and Lanzhou(LZ)Basins contributed to the increase of their streamflows at 8.04%and 14.29%per decade,respectively.Although the increased streamflow in the headwater basins of the Yellow River may ease some of the water resources concerns,the decreasing trend of streamflow in the headwater areas of the southeastern TP region since 1998 could lead to a water crisis in transboundary river basins for billions of people in Southeast and South Asia.展开更多
Despite frequent cyanobacterial blooms increasing in magnitude and duration,Taihu Lake remains one of the most important water sources in the Yangtze River Delta of China.To meet the rising water demand from social–e...Despite frequent cyanobacterial blooms increasing in magnitude and duration,Taihu Lake remains one of the most important water sources in the Yangtze River Delta of China.To meet the rising water demand from social–economic development and secure water source during cyanobacterial blooms,the Water Diversion Project from the Yangtze River to Taihu Lake(WDYT)through the Wangyuhe(WYH)River channel was initiated in 2002 and has been in operation since 2007.展开更多
Polygonatum odoratum is distributed in several countries around the world as a medicinal and dual-use plant,and its rhizomes are used in China as a traditional Chinese medicine,also as vegetables,foods,functional food...Polygonatum odoratum is distributed in several countries around the world as a medicinal and dual-use plant,and its rhizomes are used in China as a traditional Chinese medicine,also as vegetables,foods,functional foods or tea,with a history of application for more than 2000 years,with precise efficacy and no toxic side effects.However,few reviews are published on its chemical composition and its pharmacological effects.There are many components of P.odoratum,including steroidal saponins,homoisoflavanones,isoflavones,flavonoids,alkaloids,lignin,volatile oil,polysaccharides and lectins.In this review,recent advances of the history and consumption of P.odoratum,the types of chemical components,and the pharmacological effects manifested in antitumour and anticancer,antioxidant,slowing senescence,relieving fatigue and immune regulation are summarized and discussed.Presumably,the main active ingredients of the plant are homoisoflavanones,polysaccharides,saponins,and lectins.The review provides a reference for its development and utilization in the field of functional food and medicine in the future.展开更多
This study was conducted to evaluate the effects of sporoderm-broken spores of Ganoderma lucidum(SSGL),a traditional Chinese medicinal herb,on growth performance,antioxidant ability,and immunity of broilers.Three hund...This study was conducted to evaluate the effects of sporoderm-broken spores of Ganoderma lucidum(SSGL),a traditional Chinese medicinal herb,on growth performance,antioxidant ability,and immunity of broilers.Three hundred male broilers with similar body weights(40.0±1.0 g)at 1 d of age were assigned randomly to 4 treatments.Each treatment contained 5 replicates of 15 birds per replicate.The dietary treatments were corn-soybean meal basal diet supple mented with SSGL at the concentrations of0(control),100,200 and 500 mg/kg diet.The results showed that diets supplemented with SSGL significantly increased(P<0.05)the average daily gain and decreased(P<0.05)the feed:gain(F:G)ratio of birds during the finisher period(22 to 44 d of age).Moreover,the total antioxidant capability,glutathione reductase and catalase activities in the liver and spleen were significantly higher(P<0.05)in broilers fed diets with SSGL than in broilers fed the control diet.Additionally,dietary SSGL also increased(P<0.05)the serum interleukin(IL)-2,immunoglobulin(Ig)A and IgG levels of broilers compared with the control diet.These results suggest that SSGL have ameliorative effects on growth performance,free radical-scavenging activity,antioxidant capability,and immune function of broilers.展开更多
基金supported by the Natural Science Foundation of Hebei Province (H2020206226)Hebei Province Science and Technology Support Program (18277756D)+1 种基金the Science and Technology Research Project of Hebei Higher Education Institutions (ZD2022010)High-level Talent Funding Project of Hebei (C20231141) to W.W。
文摘Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanoreceptors on the surface of monocytes/macrophages, especially adhesion G protein-coupled receptors (aGPCRs), play important roles in force sensing.However, its role in the regulation of osteoclast differentiation remains unclear. Herein, through single-cell analysis, we revealed that CD97, a novel mechanosensitive aGPCR, was expressed in macrophages. Compression upregulated CD97 expression and inhibited osteoclast differentiation;while knockdown of CD97 partially rescued osteoclast differentiation. It suggests that CD97 may be an important mechanosensitive receptor during osteoclast differentiation. RNA sequencing analysis showed that the Rap1a/ERK signalling pathway mediates the effects of CD97 on osteoclast differentiation under compression. Consistently, we clarified that administration of the Rap1a inhibitor GGTI298 increased osteoclast activity, thereby accelerating tooth movement. In conclusion,our results indicate that CD97 suppresses osteoclast differentiation through the Rap1a/ERK signalling pathway under orthodontic compressive force.
基金the funding provided by the National Key Research and Development Program of China(2021YFC3200201)the National Natural Science Foundation of China(52121006,U2240203,and 51779144)+2 种基金the Second Tibetan Plateau Scientific Expedition and Research(2019QZKK0203)the Fundamental Research Funds for the Central Universities of China(B210204015 and B210204014)the Consulting Research Project of Chinese Academy of Engineering(2020-ZD-20 and 2021-ZD-CQ-2)。
基金funded by the National Key Research and Development Program of China(2017YFA0605002,2017YFA0605004,and 2016YFA0601501)the National Natural Science Foundation of China(41961124007,51779145,and 41830863)“Six top talents”in Jiangsu Province(RJFW-031)。
文摘Model parameters estimation is a pivotal issue for runoff modeling in ungauged catchments.The nonlinear relationship between model parameters and catchment descriptors is a major obstacle for parameter regionalization,which is the most widely used approach.Runoff modeling was studied in 38 catchments located in the Yellow–Huai–Hai River Basin(YHHRB).The values of the Nash–Sutcliffe efficiency coefficient(NSE),coefficient of determination(R2),and percent bias(PBIAS)indicated the acceptable performance of the soil and water assessment tool(SWAT)model in the YHHRB.Nine descriptors belonging to the categories of climate,soil,vegetation,and topography were used to express the catchment characteristics related to the hydrological processes.The quantitative relationships between the parameters of the SWAT model and the catchment descriptors were analyzed by six regression-based models,including linear regression(LR)equations,support vector regression(SVR),random forest(RF),k-nearest neighbor(kNN),decision tree(DT),and radial basis function(RBF).Each of the 38 catchments was assumed to be an ungauged catchment in turn.Then,the parameters in each target catchment were estimated by the constructed regression models based on the remaining 37 donor catchments.Furthermore,the similaritybased regionalization scheme was used for comparison with the regression-based approach.The results indicated that the runoff with the highest accuracy was modeled by the SVR-based scheme in ungauged catchments.Compared with the traditional LR-based approach,the accuracy of the runoff modeling in ungauged catchments was improved by the machine learning algorithms because of the outstanding capability to deal with nonlinear relationships.The performances of different approaches were similar in humid regions,while the advantages of the machine learning techniques were more evident in arid regions.When the study area contained nested catchments,the best result was calculated with the similarity-based parameter regionalization scheme because of the high catchment density and short spatial distance.The new findings could improve flood forecasting and water resources planning in regions that lack observed data.
基金supported by National Key Science and Technology Program of China(2022YFC3203802)National Natural Science Foundation of China(52121006,92047303,and 51879165)+1 种基金supported by the Xplorer Prizesupported by the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(2021QNRC001)。
文摘Interbasin water-transfer schemes provide an engineering solution for reconciling the conflict between water demand and availability.In the context of climate change,which brings great uncertainties to water resource distribution,interbasin water transfer plays an increasingly important role in the global water–food–energy nexus.However,the transfer of water resources simultaneously changes the hydrological regime and the characteristics of local water bodies,affecting biotic communities accordingly.Compared with high economic and technical inputs water-transfer projects require,the environmental and ecological implications of water-transfer schemes have been inadequately addressed.This work selects the largest water-transfer project in China,the South-to-North Water Diversion(SNWD)Project,to critically review its eco-environmental impacts on donor and recipient basins,as well as on regions along the diversion route.The two operated routes of the SNWD Project represent two typical water diversion approaches:The Middle Route uses an excavated canal,while the East Route connects existent river channels.An overview of the eco-environmental implications of these two routes is valuable for the design and optimization of future water-transfer megaprojects.
基金This work is supported by the National Key Research and Development Program of China(2016YFC0502205)the National Natural Science Foundation of China(51425902).
文摘Conservation of endangered or economic fish and control of invasive fish is a great challenge of hydraulic engineering worldwide.Flow velocity has been recognized to affect the spawning of fishes delivering drifting eggs in rivers.However,solid scientific supports and associated mechanisms to establish quantitative relations between flow velocity and fish reproduction,taking into account spawning,fertilizing,hatching,as well as surviving,are lacking.In this paper,we quantified the relationship between flow velocity and reproduction of Chinese carps through both lab and field experiments.The results showed that a minimum velocity was required to trigger Hypophthalmichthys molitrix(H.molitrix)releasing eggs,and a velocity range was preferred to sustain spawning activity.However,the embryo incubation and larvae development of H.molitrix were found to be inhibited with the increase in flow velocity.Considering the requirements of spawning and hatching,as well as larvae surviving,an optimized flow velocity processes was identified for the reproduction of H.molitrix in rivers.These findings were of great significance to the adaptive operation of reservoirs to create reasonable and precise ecological flows for managing fish reproduction,as shown by the promising results in the engineering application to the Three Gorges Reservoir.
基金supported by the National Key Research and Development Program of China(2017YFE0129900)Poultry Nutrition and Feed Technology Innovation Team Program of China Agricultural Universitythe Youth Elite Development Program(Grade A)of College of Animal Science and Technology,China Agricultural University.
文摘Background: Subclinical necrotic enteritis(SNE), a common intestinal disease of broiler caused by Clostridium perfringens, could reduce production performance of broilers by chronic intestinal damage and poor absorption of nutrients. Ellagic acid(EA) has been reported to present antioxidant and anti-inflammatory properties on human and animals in many aspects. This study was conducted to evaluate the effect and mechanism of EA in relieving SNE in broilers induced by C. perfringens.Results: C. perfringens challenge decreased body weight(BW), average daily gain(ADG), jejunal villi height/crypt depth(V/C) ratio, the activity of catalase(CAT) and the mRNA expression of zonula occludens 1(ZO-1) in jejunal mucosa of broilers. While feed conversion ratios(FCR), jejunal crypt depth(CD), the activities of myeloperoxidase(MPO) and diamine oxidase(DAO), as well as the concentrations of interleukin 6(IL-6), C-reactive protein(CRP) and procalcitonin(PCT) in serum, the activities of inducible nitric oxide synthase(iNOS) and lysozyme(LZM), the concentration of malondialdehyde(MDA), and the mRNA expressions of claudin-2, TNF-α, IL-1β, TLR-4, TLR-2, NF-κB,JAK3, STAT6 and iNOS in jejunal mucosa of broilers were increased by C. perfringens challenge. Dietary EA supplement relieved these adverse effects, and heightened jejunal villi height(VH), the concentration of D-xylose in plasma, activity of superoxide dismutase(SOD), and the mRNA expression of occludin in jejunal mucosa of broilers.The alpha diversity of cecal microbiota indicated that dietary EA supplement increased observed species and Shannon index. C. perfringens challenge increased the relative abundance of Firmicutes and decreased the relative abundance of Desulfobacterota in cecal microbiota. EA increased the relative abundance of Firmicutes in cecal microbiota. LEfSe analysis showed that C. perfringens challenge triggered the imbalance of cecal microbiota in broilers, dietary EA supplementation led to a small beneficial effect on microbiota, while the simultaneous effect of them seemed to stimulate the immune function of broilers by improving the microbiota balance.Conclusions: Dietary EA ameliorated C. perfringens-induced SNE in broilers via regulating jejunal inflammation signaling pathways TLR/NF-κB and JAK3/STAT6, relieving jejunal oxidative stress and balancing cecal microbiota to inhibit intestinal barrier damage, prevent systemic inflammatory response and improve nutrient absorption capacity,finally protect and enhance growth performance of broilers.
基金supported by the National Natural Science Foundation of China (60702015)
文摘A decoupling-estimation signal parameters via rotarional invariance technique(ESPRIT) method is presented for multi-target localization with unknown mutual coupling in bistatic multiple-input multiple-output(MIMO) radar.Two steps are carried out in this method.The decoupling operation between angle and mutual coupling estimates is realized by choosing the auxiliary elements on both sides of the transmit and receive uniform linear arrays(ULAs).Then the ESPRIT method is resilient against the unknown mutual coupling matrix(MCM) and can be directly utilized to estimate the direction of departure(DOD) and the direction of arrival(DOA).Moreover,the mutual coupling coefficient is estimated by finding the solution of the linear constrained optimization problem.The proposed method allows an efficient DOD and DOA estimates with automatic pairing.Simulation results are presented to verify the effectiveness of the proposed method.
基金This research was supported by research grants from the National Natural Science Foundation of China(81671006,81700994,22050002,22050004)and CAMS Innovation Fund for Medical Sciences(2019-I2M-5-038).
文摘Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis challenging.In this study,we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations(CNAs)using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples.Freshly frozen tissue specimens from OF(n=29)and FD(n=28)patients were obtained for analysis.Lesion fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection(LCM),with~30–50 cells(5000–10000µm2)per sample.We found that the rate of recurrent CNAs in OF cases was much higher(44.8%,13 of 29)than that in FD cases(3.6%,1 of 28).Sixty-nine percent(9 of 13)of the CNA-containing OF cases involved segmental amplifications and deletions on Chrs 7 and 12.We also identified eight CNA-associated genes(HILPDA,CALD1,C1GALT1,MICALL2,PHF14,AIMP2,MDM2,and CDK4)with amplified expression,which was consistent with the copy number changes.We further confirmed a jaw lesion with a previous uncertain diagnosis due to its ambiguous morphological features and the absence of GNAS mutation as OF based on the typical Chr 12 amplification pattern in its CNA profile.Moreover,analysis of a set of longitudinal samples collected from an individual with a cellular lesion in suspicion of OF at the first surgery,recurrence and the latest malignant transformation revealed identical CNA patterns at the three time points,suggesting that copy number profiling can be used as an important tool to identify borderline lesions or lesions with malignant potential.Overall,CNA profiling of fibro-osseous lesions can greatly improve differential diagnosis between OF and FD and help predict disease progression.
基金supported by the Introduction of International Advanced Agriculture Science and Technology Project(948 Project)(GrantNo.2013-Z20)the Program of Beijing Municipal Bureau of Agriculture(GrantNo.20120633)National Key Technology Research and Development Program of the Ministry of Science and Technology of China(GrantNo.2011BAD26B04)
文摘Background:The current study was carried out to provide a reference for the control of mycotoxin contamination in feed ingredients and complete feeds for swine.Methods:A total of 55 feed ingredients,including 14 corn,13 wheat bran,11 soybean meal and 17 dried distillers grains with solubles(DDGS) as well as 76 complete swine feeds including 7 creep feeds,14 starter feeds,14 grower feeds,18 grower-finisher feeds,10 gestating sow feeds,and 13 lactating sow feeds were randomly collected from15 swine farms located in the Beijing region of China from July to August 2011.Immunoaffinity clean-up,using High-Performance Liquid Chromatography(HPLC) in combination with UV or Fluorescence Detection,was used for quantitative analysis of aflatoxin B,(AFB,),deoxynivalenol(DON),zearalenone(ZEA) and ochratoxin A(OTA) in the ingredients and complete feeds.Results:DON and ZEA were the most prevalent mycotoxins found.DON was detected at percentages of 93,92,54,100 and 97%with a mean level of 1.01,0.44,0.05,1.36 and 0.65 ppm in the samples of corn,wheat bran,soybean meal,DDGS and complete feeds,respectively.The detected percentages of ZEA were 100,100,54,100 and 100 with mean levels of 109.1,14.9,9.2,882.7 and 58.9 ppb in the same samples.In the wheat bran and soybean meal samples,the content of all four mycotoxins were below the maximum limits set by Chinese regulations while the percentage of samples that exceeded regulatory limits were 7,57 and 7%for corn,and 7,14 and 3%for the complete feeds for AFB,,DON and OTA respectively.DDGS showed the most serious mycotoxin contamination and the percentage of samples that exceeded regulatory limits were 6,88 and 41%,for AFB,,DON and ZEA,respectively.Conclusions:This paper is the first to present data on the natural occurrence of AFB,,DON,ZEA and OTA in ingredients and complete feeds obtained from swine farms in China's Beijing region.The data shows that feed ingredients and complete swine feeds obtained from these farms are most often contaminated with DON followed by contamination with AFB,and ZEA.
基金supported by the National Natural Science Foundation of China (81671006, 81300894)Beijing Natural Science Foundation (7172238)
文摘Odontogenic keratocysts(OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome(NBCCS). OKCs are locally aggressive, cause marked destruction of the jaw bones and have a propensity to recur. PTCH1 mutations(at ~80%) are frequently detected in the epithelia of both NBCCS-related and sporadic OKCs, suggesting that PTCH1 inactivation might constitutively activate sonic hedgehog(SHH) signalling and play a major role in disease pathogenesis. Thus, small molecule inhibitors of SHH signalling might represent a new treatment strategy for OKCs. However, studies on the molecular mechanisms associated with OKCs have been hampered by limited epithelial cell yields during OKC explant culture. Here, we constructed an isogenic PTCH1^(R135 X/+) cellular model of PTCH1 inactivation by introducing a heterozygous mutation, namely, c.403 C>T(p.R135 X), which has been identified in OKC patients, into a human embryonic stem cell line using the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated 9(Cas9) system. This was followed by the induction of epithelial differentiation. Using this in vitro isogenic cellular model, we verified that the PTCH1 R135 X/+heterozygous mutation causes ligand-independent activation of SHH signalling due to PTCH1 haploinsufficiency. This activation was found to be downregulated in a dose-dependent manner by the SHH pathway inhibitor GDC-0449. In addition, through inhibition of activated SHH signalling, the enhanced proliferation observed in these induced cells was suppressed, suggesting that GDC-0449 might represent an effective inhibitor of the SHH pathway for use during OKC treatment.
基金supported by the National Science Foundation of China(Grant No.31772627)a Special Fund for China Agricultural Research System program(CARS-40-K08)+5 种基金the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation,328017493/GRK 2366)National Key Research and Development Program of China(2017YFD0500500)National Science Foundation of China(Grant No.31772627)was funding for the design of the study and collect sample.A Special Fund for China Agricultural Research System program(CARS-40-K08)was funding for writing the manuscriptDeutsche Forschungsgemeinschaft(DFG,German Research Foundation,328017493/GRK 2366)National Key Research and Development Program of China(2017YFD0500500)were funding for analysis the sample.
文摘Background:The present study aimed at evaluating the effect of vitamin K(VK)supplementation on bone health of laying hens challenged by Salmonella Enteritidis.Methods:A total of 8032-week-old double negative salmonella-free brown-egg laying hens were randomly assigned to 4 treatments with 20 replicates each(1 bird per replicate)according to a 2×2 factorial design with 2 dietary VK supplementation levels[0 mg/kg(VK0)vs 2 mg/kg VK(VK2)and 2 challenge treatments[Salmonella Enteritidis(SE)vs physiological saline solution(PS)].During the last 3 days of week 43 of age,birds of both VK treatments were either orally challenged with 1.0 mL suspension of 109 cfu/mL S.Enteritidis daily or received the same volume of PS.Results:The laying rate,daily egg mass,tibia strength,CT,cOC and cOC/(cOC+ucOC)of VK2 treatment increased(P<0.05)in contrast to VK0,however,the medullary area and ucOC of VK2 treatment decreased(P<0.05)in contrast to VK0.Mortality,medullary area,serum Ca content of SE treatments increased(P<0.05)in contrast to PS treatments.In both SE treatments,the decrease(P<0.05)in birds’tibia strength was associated with higher(P<0.05)Ca levels in serum.There is an interaction(P<0.05)between SE challenge and VK levels with regard to tibia strength and serum Ca levels.At week 42,serum CT was positively correlated with cOC(R=0.99,P=0.009);at week 44,tibia strength was positively correlated with BMD(R=0.95,P=0.045),but negatively correlated with medullary area(R=−0.98,P=0.018).Conclusions:VK(2 mg/kg)supplementation to diets of laying hens can enhance bone strength under challenge situations with Salmonella Enteritidis.Medullary area has proven to be a sensitive biomarker for bone calcium loss caused by SE infection.
文摘This paper focuses on the general case (GC) airborne bistatic synthetic aperture radar (SAR) data processing, and a new analytical imaging algorithm based on the extended Loffeld's bistatic formula (ELBF) is proposed. According to the bistatic SAR geometry, the track decoupling formulas that convert the bistatic geometry to the receiver-referenced geometry in a concise way are derived firstly. Then phase terms of ELBF are decomposed into two independent phase terms as the range phase term and the azimuth phase term in a new way. To get the focusing result, the bistatic deformation (BD) term is compensated in the two-dimensional (2- D) frequency domain, and the space-variances of the range phase term and the azimuth phase term are eliminated by chirp scaling (CS) and chirp z-transform (CZT), respectively. The effectiveness of the proposed algorithm is verified by the simulation results.
基金sponsored by the National Key Research and Development Program of China (Grant No. 2018YFC0704400)the Programmer of Introducing Talents (Grant No. B13011)
文摘The Asia Pacific Economic Cooperation(APEC)comprises of the world’s largest producers and consumers of energy,accounting for 60.3%of primary energy supply,50.0%of final energy consumption,and 63.0%of electricity generation worldwide in 2016.This study discusses the primary energy supply and final energy consumption situation of the APEC and analyzes the characteristics of electricity in terms of its generation structure based on fuel,consumption by the end-use sector,access to electricity,and so on.The renewable energy and electricity generation projections up to 2030 based on trends in the APEC are also assessed.It is seen that electricity in final energy consumption has been on an upward trend,with an average annual growth rate of about 4.8%during 2006–2016,in 2016,its share reached 24.3%.The industry sector consumes the largest share of electricity,accounting for about 45.5%in 2016.Coal supply and consumption peaked in 2011 and then began to decline,while renewable energy has been on an upward trend,with its primary energy supply share increasing from 4.80%in 2010 to 6.29%in 2016.Solar photovoltaic and onshore wind power are on the verge of costing less than the operating cost of existing coal-fired plants in 2018.In the APEC’s target scenario in which renewable energy is doubled,the predicted net growth from 2017 to 2030 of solar,wind,and hydro power is about 963,497,and 157 GW,respectively,and to reach this target,the APEC economies need to accelerate renewable energy development.
基金supported by the National Key Program of Science and Technology(2022YFC3203900)the National Natural Science Foundation of China(52121006 and 92047303)supported by the Xplorer prize。
文摘River damming is believed to largely intercept nutrients,particularly retain more phosphorus(P)than nitrogen(N),and thus harm primary productivity,fishery catches,and food security downstream,which seriously constrain global hydropower development and poverty relief in undeveloped regions and can drive geo-political disputes between nations along trans-boundary rivers.In this study,we investigated whether reservoirs can instead improve nutrient regimes downstream.We measured different species of N and P as well as microbial functions in water and sediment of cascade reservoirs in the upper Mekong River over 5 years and modelled the influx and outflux of N and P species in each reservoir.Despite partially retaining total N and total P,reservoirs increased the downstream flux of ammonium and soluble reactive phosphorus(SRP).The increase in ammonium and SRP between outflux and influx showed positive linear relationships with the hydraulic residence time of the cascade reservoirs;and the ratio of SRP to dissolved inorganic nitrogen increased along the reservoir cascade.The lentic environment of reservoirs stimulated algae-mediated conversion of nitrate into ammonium in surface water;the hypoxic condition and the priming effect of algae-induced organic matter enhanced release of ammonium from sediment;the synergy of microbial phosphorylation,reductive condition and sediment geochemical properties increased release of SRP.This study is the first to provide solid evidence that hydropower reservoirs improve downstream nutrient bioavailability and N-P balance through a process of retention-transformation-transport,which may benefit primary productivity.These findings could advance our understanding of the eco-environmental impacts of river damming.
基金supported by the National Natural Science Foundation of China(Nos.81671006 and 81300894)the CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-038)+2 种基金the National Clinical Key Discipline Construction Project(No.PKUSSNKP-202102)the Program for New Clinical Techniques and Therapies of Peking University Hospital of Stomatology(No.PKUSSNCT-22A14)the Innovation Fund for Outstanding Doctoral Candidates of Peking University Health Science Center(No.BMU2022BSS001),China.
文摘Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma,which indicates a high potential of malignancy.The malignant transformation of oral leukoplakia seriously affects patient survival and quality of life;however,it is difficult to identify oral leukoplakia patients who will develop carcinoma because no biomarker exists to predict malignant transformation for effective clinical management.As a major problem in the field of head and neck pathologies,it is imperative to identify biomarkers of malignant transformation in oral leukoplakia.In this review,we discuss the potential biomarkers of malignant transformation reported in the literature and explore the translational probabilities from bench to bedside.Although no single biomarker has yet been applied in the clinical setting,profiling for genomic instability might be a promising adjunct.
基金funded by the Second Tibetan Plateau Scientific Expedition and Research Program (2019QZKK0203)the National Key Research and Development Programs of China (2021YFC3201100).
文摘The Tibetan Plateau(TP)is the headwater of the Yangtze,Yellow,and the transboundary Yarlung Zangbo,Lancang,and Nujiang Rivers,providing essential and pristine freshwater to around 1.6 billion people in Southeast and South Asia.However,the temperature rise TP has experienced is almost three times that of the global warming rate.The rising temperature has resulted in glacier retreat,snow cover reduction,permafrost layer thawing,and so forth.Here we show,based on the longest observed streamflow data available for the region so far,that changing climatic conditions in the TP already had significant impacts on the streamflow in the headwater basins in the area.Our analysis indicated that the annual average temperature in the headwater basins of these five major rivers has been rising on a trend averaging 0.38℃-decade^(-1) since 1998,almost triple the rate before 1998,and the change of streamflow has been predominantly impacted by precipitation in these headwater basins.As a result,streamflow in the Yangtze,Yarlung Zangbo,Lancang,and Nujiang River headwater areas is on a decreasing trend with a reduction of flow ranging from 3.0-10^(9)-5.9-10^(9) m^(3)·decade^(-1)(-9.12%to-16.89%per decade)since 1998.The increased precipitation in the Tangnahai(TNH)and Lanzhou(LZ)Basins contributed to the increase of their streamflows at 8.04%and 14.29%per decade,respectively.Although the increased streamflow in the headwater basins of the Yellow River may ease some of the water resources concerns,the decreasing trend of streamflow in the headwater areas of the southeastern TP region since 1998 could lead to a water crisis in transboundary river basins for billions of people in Southeast and South Asia.
基金funded by the National Natural Science Foundation of China(52121006,52070132,and U2040209)the Outstanding Youth Fund of Jiangsu Province(BK20200053).
文摘Despite frequent cyanobacterial blooms increasing in magnitude and duration,Taihu Lake remains one of the most important water sources in the Yangtze River Delta of China.To meet the rising water demand from social–economic development and secure water source during cyanobacterial blooms,the Water Diversion Project from the Yangtze River to Taihu Lake(WDYT)through the Wangyuhe(WYH)River channel was initiated in 2002 and has been in operation since 2007.
基金This research was supported financially by the scientific research project of the Hebei Administration of Traditional Chinese Medicine,China(2022098,2022365)the Doctoral Research Foundation of Hebei University of Chinese Medicine,China(BSZ2020007,BSZ2021019)+1 种基金the Modern Agricultural Technology Innovation Team Project in Hebei Province,China(HBCT2018060205)the Traditional Chinese Medicine Resources Survey Project of China(Z135080000022).
文摘Polygonatum odoratum is distributed in several countries around the world as a medicinal and dual-use plant,and its rhizomes are used in China as a traditional Chinese medicine,also as vegetables,foods,functional foods or tea,with a history of application for more than 2000 years,with precise efficacy and no toxic side effects.However,few reviews are published on its chemical composition and its pharmacological effects.There are many components of P.odoratum,including steroidal saponins,homoisoflavanones,isoflavones,flavonoids,alkaloids,lignin,volatile oil,polysaccharides and lectins.In this review,recent advances of the history and consumption of P.odoratum,the types of chemical components,and the pharmacological effects manifested in antitumour and anticancer,antioxidant,slowing senescence,relieving fatigue and immune regulation are summarized and discussed.Presumably,the main active ingredients of the plant are homoisoflavanones,polysaccharides,saponins,and lectins.The review provides a reference for its development and utilization in the field of functional food and medicine in the future.
基金funded by Beijing Municipal Natural Science Foundation(Grant No.6172017),ChinaOpening Foundation of Key Laboratory of Biomass Energy and Materials of Jiangsu Province(JSBEM2016013),ChinaNational Key Research and Development Program of China(2017YFD0500500),China.
文摘This study was conducted to evaluate the effects of sporoderm-broken spores of Ganoderma lucidum(SSGL),a traditional Chinese medicinal herb,on growth performance,antioxidant ability,and immunity of broilers.Three hundred male broilers with similar body weights(40.0±1.0 g)at 1 d of age were assigned randomly to 4 treatments.Each treatment contained 5 replicates of 15 birds per replicate.The dietary treatments were corn-soybean meal basal diet supple mented with SSGL at the concentrations of0(control),100,200 and 500 mg/kg diet.The results showed that diets supplemented with SSGL significantly increased(P<0.05)the average daily gain and decreased(P<0.05)the feed:gain(F:G)ratio of birds during the finisher period(22 to 44 d of age).Moreover,the total antioxidant capability,glutathione reductase and catalase activities in the liver and spleen were significantly higher(P<0.05)in broilers fed diets with SSGL than in broilers fed the control diet.Additionally,dietary SSGL also increased(P<0.05)the serum interleukin(IL)-2,immunoglobulin(Ig)A and IgG levels of broilers compared with the control diet.These results suggest that SSGL have ameliorative effects on growth performance,free radical-scavenging activity,antioxidant capability,and immune function of broilers.