A Theory of Bio-Quantum Genetics

The physical mechanism of heredity or inheritance of genes is a quantum mechanical and/or quantum computational process. A theory of bio-quantum genetics is established in this paper. Principle of Bio-quantum Genetics is suggested. I propose and define the soft-genes of genetics controlling the processes of heredity or inheritance of genes. This research deals with the quantum mechanisms of Mendel plant heredity and family inheritance as examples of bio-quantum genetics, deepening our understanding of heredity or inheritance. I believe that more contributions will be made to promote researches of bio-quantum genetics or quantum biology at large.

A nonlocal strain gradient shell model incorporating surface effects for vibration analysis of functionally graded cylindrical nanoshells

In this pap er, a novel size-dep endent functionally graded (FG) cylindrical shell model is develop ed based on the nonlocal strain gradient theory in conjunction with the Gurtin-Murdoch surface elasticity theory . The new model containing a nonlocal parameter, a material length scale parameter, and several surface elastic constants can capture three typical typ es of size e ects simultaneously , which are the nonlocal stress ef- fect, the strain gradient e ect, and the surface energy e ects. With the help of Hamilton’s principle and rst-order shear deformation theory , the non-classical governing equations and related b oundary conditions are derived. By using the prop osed model, the free vibra- tion problem of FG cylindrical nanoshells with material prop erties varying continuously through the thickness according to a p ower-law distribution is analytically solved, and the closed-form solutions for natural frequencies under various b oundary conditions are obtained. After verifying the reliability of the prop osed model and analytical method by comparing the degenerated results with those available in the literature, the in uences of nonlocal parameter, material length scale parameter, p ower-law index, radius-to-thickness ratio, length-to-radius ratio, and surface e ects on the vibration characteristic of func- tionally graded cylindrical nanoshells are examined in detail.

Combined forecast method of HMM and LS-SVM about electronic equipment state based on MAGA

For the deficiency that the traditional single forecast methods could not forecast electronic equipment states, a combined forecast method based on the hidden Markov model（HMM） and least square support vector machine（LS-SVM） is presented. The multi-agent genetic algorithm（MAGA） is used to estimate parameters of HMM to overcome the problem that the Baum-Welch algorithm is easy to fall into local optimal solution. The state condition probability is introduced into the HMM modeling process to reduce the effect of uncertain factors. MAGA is used to estimate parameters of LS-SVM. Moreover, pruning algorithms are used to estimate parameters to get the sparse approximation of LS-SVM so as to increase the ranging performance. On the basis of these, the combined forecast model of electronic equipment states is established. The example results show the superiority of the combined forecast model in terms of forecast precision,calculation speed and stability.

A Quantum Mechanical Proof of Insecurity of the Theoretical QKD Protocols

Cryptography is crucial to communication security. In 1984, a well-known QKD (quantum key distribution) protocol, BB84, was published by Bennett and Brassard. The BB84 Protocol was followed by the QKD protocols published by Ekert (1991) (E91) and Bennett (1992) (B92). Some authors proved security of the theoretical QKD protocols in different theoretical frameworks by defining security of QKD protocols differently. My argument is that the previous proofs of security are neither unique nor exhaustive for each theoretical QKD protocol, which means that proof of security of the theoretical QKD protocols has not been completed or achieved. The non-uniqueness and the non-exhaustiveness of the proofs will lead to more proofs. However, a coming “proof” of security of the theoretical QKD protocols is possible to be a disproof. The research by quantum mechanics in this paper disproves security of the theoretical QKD protocols, by establishing the theoretical framework of quantum mechanical proof, defining security of QKD protocols, establishing the quantum state of the final key of the theoretical protocols from their information leakages, and applying Grover’s fast quantum mechanical algorithm for database search to the quantum state of the final key to result in the Insecurity Theorem. This result is opposite to those of the previous proofs where the theoretical QKD protocols were secure. It is impossible for Alice and Bob to protect their communications from information leakage by stopping or canceling the protocols. The theoretical QKD keys are conventional and basically insecure. Disproof of security of the theoretical QKD protocols is logical.

Controlled wrinkling analysis of thin films on gradient substrates

The paper investigates continuously changing wrinkle patterns of thin films bonded to a gradient substrate. Three types of gradient substrates including exponential, power-law, and symmetry models are considered. The Galerkin method is used to dis- cretize the governing equation of film bonded to gradient substrates. The wavelength and the normalized amplitude of the wrinkles for substrates of various material gradients are obtained. The numerical simulation based on the finite element method （FEM） is used to evolve the wrinkle patterns. The result agrees well with that of the analytical model. It is concluded that localization of wrinkle patterns strongly depends on the material gradient. The critical membrane force depends on both the minimum value of wrinkle stiffness and the gradient of wrinkle stiffness when the wrinkle stiffness is at its minimum. This work provides a better understanding for local wrinkle formation caused by gradient substrates.

On Security of Quantum Cryptography by Probabilistic Analysis

The existing quantum cryptography is a classical cryptography in nature and basically insecure because of its classical (conventional) bits, classical encryption algorithm and classical (public) channel. A novel topic about successful communication between the legitimate users, Alice and Bob, is discussed with probability of solution uniqueness of Bob’s decryption equation. We find, by probabilistic analysis, that success of communication between Alice and Bob is probabilistic with a probability bigger than 1/2. It is also novel to define insecurity of the quantum cryptography by probability of solution uniqueness of the search equation of Eve, the eavesdropper. The probability of Eve’s success to find the plain-text of Alice (and Bob) is greater than 1/2, and so the quantum cryptography is seriously insecure.

Lorentz Transformation Derived from Relativity of Time

The principles of special relativity and Einstein’s simple derivation of the Lorentz transformation are reviewed. A new simple derivation of the Lorentz transformation is developed in this paper, by a new approach of light-pulse observation or time-dilation observation. Therefore, under the two principles of special relativity, there exist two equivalent simple derivations of or two equivalent approaches to the Lorentz transformation. Einstein’s approach emphasizes or highlights relativity of space while our approach emphasizes or highlights relativity of time. This research reveals, in a particular way, the equivalence of relativity of space and relativity of time in special relativity. Combination of Einstein’s approach and the approach developed in this paper makes the methodology of simple derivation of the Lorentz transformation complete and perfect.

Lycorine derivative effectively inhibits the replication of coronaviruses both in vitro and in vivo

The established and ongoing prevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and seasonal human coronaviruses(HCoV)like HCoV-OC43,HCoV-NL63,and HCoV-229E,pose a continuous threat to public health.Therefore,it is urgently needed to explore antiviral drugs with broad-spectrum anti-coronavirus activity.Our previous studies have revealed that lycorine is a potent broad-spectrum anti-coronavirus drug,a natural alkaloid extracted from Amaryllidaceae with various pharmacological and microbiological effects.However,it is unsafe to directly use lycorine as a clinical antiviral drug due to the cytotoxicity and induction of cell apoptosis.In this study,a series of lycorine derivatives were designed and synthesized.One of them,named Ly-8,was found to effectively inhibit the replication of different coronavirus strains in vitro,including SARS-CoV-2.Moreover,Ly-8 was also shown to effectively inhibit HCoVOC43 replication in the central nervous system,and provide effective protection against HCoV-OC43 infection in mice with low drug toxicity.Furthermore,Ly-8-resistant mutants were not observed during the 30 times sequential passages in cell culture.Collectively,these findings suggest that Ly-8 may be a potential candidate drug for the future development of broad-spectrum anti-coronavirus drugs.

近冰点多孔介质中甲烷水合物生成的温度敏感性

水合物技术是实现天然气储存、气体分离、海水淡化和二氧化碳捕集等的潜在可行途径之一,水合物技术为了降低生产成本同时又保持系统流动性,通常选择冰粉或冰浆等形式使生成反应在冰点附近进行;自然界的天然气水合物多数赋存于天然的多孔介质内,随着全球气温升高,甲烷水合物在临界条件附近的敏感性会导致储层的稳定性下降及潜在的甲烷大量释放,尤其是受气候变化影响较大的冻土带天然气水合物,其储层温度一般也处于冰点附近。本工作研究了硅砂(0.1~0.5 mm)中甲烷水合物在近冰点的形成过程与动力学特征,分别在273.75,273.85和273.95 K小温差下研究了压力、温度、反应速率和甲烷吸收量变化,分析并计算了硅砂孔隙中水合物、水相和气相的最终体积饱和度。温度与反应速率的变化表明,水合物生成过程呈现出明显的三个阶段,在不同的阶段,温度和反应速率表现出独特的变化特征如峰值、持续时间等,同时对环境温度的敏感性非常强,温度升高后甲烷水合物生长速率及其在孔隙中的饱和度均有所降低,低温下水合物生长点晚及对应诱导期持续更长。

Morphable three-dimensional electronic mesofliers capable of on-demand unfolding

Development of miniaturized three-dimensional(3 D)fliers with integrated functional components has important implications to a diverse range of engineering areas.Among the various active and passive miniaturized 3 D fliers reported previously,a class of 3 D electronic fliers inspired by wind-dispersed seeds show promising potentials,owing to the lightweight and noiseless features,aside from the stable rotational fall associated with a low falling velocity.While on-demand shape-morphing capabilities are essential for those 3 D electronic fliers,the realization of such miniaturized systems remains very challenging,due to the lack of fast-response 3 D actuators that can be seamlessly integrated with 3 D electronic fliers.Here we develop a type of morphable3 D mesofliers with shape memory polymer(SMP)-based electrothermal actuators,capable of large degree of actuation deformations,with a fast response(e.g.,~1 s).Integration of functional components,including sensors,controllers,and chip batteries,enables development of intelligent 3 D mesoflier systems that can achieve the on-demand unfolding,triggered by the processing of real-time sensed information(e.g.,acceleration and humidity data).Such intelligent electronic mesofliers are capable of both the low-air-drag rising and the low-velocity falling,and thereby,can be used to measure the humidity fields in a wide 3 D space by simple hand throwing,according to our demonstrations.The developed electronic mesofliers can also be integrated with other types of physical/chemical sensors for uses in different application scenarios.