Folates—tetrahydrofolate(THF)and its derivatives(also known collectively as vitamin B9)—are essential micronutrients for almost all living organisms.Acting as carriers of one-carbon(C1)units,folates participate in t...Folates—tetrahydrofolate(THF)and its derivatives(also known collectively as vitamin B9)—are essential micronutrients for almost all living organisms.Acting as carriers of one-carbon(C1)units,folates participate in the biosynthesis of numerous biomolecules and play central roles in cellular methylation reactions(Strobbe and Van Der Straeten,2017).展开更多
Dear Editor,Micronutrient malnutrition,also referred to as hidden hunger,is a major threat to global health.Folates,a group of water-soluble B vitamins(B9),are essential organic molecules for almost all organisms by m...Dear Editor,Micronutrient malnutrition,also referred to as hidden hunger,is a major threat to global health.Folates,a group of water-soluble B vitamins(B9),are essential organic molecules for almost all organisms by mediating one-carbon metabolism.Plants and microbes can synthesize folates de novo,whereas humans lack this ability and depend on dietary intakes.Most staple cereals,particularly rice,are poor sources of folates.Insufficient folate intake can result in several human disorders,such as anemia and cardiovascular disease(Nazki et al.,2014).Indeed,folate deficiency is widespread.展开更多
基金supported by the National Natural Science Foundation of China(grants 32241042 and 32301849)the National Key R&D Program of China(2021YFF1000103)+2 种基金the China Agricultural Research System(CARS06-13.5-A04)a fellowship from the China Postdoctoral Science Foundation(2022M723443)the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences。
文摘Folates—tetrahydrofolate(THF)and its derivatives(also known collectively as vitamin B9)—are essential micronutrients for almost all living organisms.Acting as carriers of one-carbon(C1)units,folates participate in the biosynthesis of numerous biomolecules and play central roles in cellular methylation reactions(Strobbe and Van Der Straeten,2017).
基金supported by the National Key Research and Development Program of China(2021YFF1000304)Nanfan special project,CAAS,grant no.YYLH2403.
文摘Dear Editor,Micronutrient malnutrition,also referred to as hidden hunger,is a major threat to global health.Folates,a group of water-soluble B vitamins(B9),are essential organic molecules for almost all organisms by mediating one-carbon metabolism.Plants and microbes can synthesize folates de novo,whereas humans lack this ability and depend on dietary intakes.Most staple cereals,particularly rice,are poor sources of folates.Insufficient folate intake can result in several human disorders,such as anemia and cardiovascular disease(Nazki et al.,2014).Indeed,folate deficiency is widespread.
