Medicinal leeches have been utilized in therapy for thousands of years. However, the adaptation physiology between leeches and hosts is not fully understand. To disclose the molecular mechanisms of adaptation between ...Medicinal leeches have been utilized in therapy for thousands of years. However, the adaptation physiology between leeches and hosts is not fully understand. To disclose the molecular mechanisms of adaptation between leech and host, the body transcriptomes of hunger and fed blood-sucking Poecilobdella javanica, Haemadipsa cavatuses, and Hirudo nipponia leeches were obtained by RNA sequencing, after comparison, a stratified unigenes group was obtained, which closely correlated to body distension. In the group, Rfamide receptor decreased significantly (P < 0.05) while serotonin receptor increased significantly (P < 0.05). Moreover, four KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways, including cardiac muscle contraction, complement and coagulation cascades, renin-angiotensin system, and hypertrophic cardiomyopathy were significantly enriched. The unigenes annotation, neuroregulators correlation analysis and induced function of the KEGG pathways, were consistently supported the same result as: vasoconstriction and systole reaction enhance in hunger leeches and vice versa vasodilation and diastole increase in fed leeches, meanwhile, Interspecific comparison and correlative analyses of physiological function showed that the strongest reaction of induced heart failure from four KEGG occur in strongest reaction of systole in hungry P. javanica and in strongest reaction of diastole in fed H. nipponia. Overall, heart failure is likely a physiological function involved in feeding behaviour.展开更多
The joint optimization problem of energy procurement and retail pricing for an electricity retailer is converted into separately determining the optimal procurement strategy and optimal pricing strategy,under the“pri...The joint optimization problem of energy procurement and retail pricing for an electricity retailer is converted into separately determining the optimal procurement strategy and optimal pricing strategy,under the“price-taker”assumption.The aggregate energy consumption of end use customers(EUCs)is predicted to solve for the optimal procurement strategy vis a long short-term memory(LSTM)-based supervised learning method.The optimal retail pricing problem is formulated as a Markov decision process(MDP),which can be solved by using deep reinforcement learning(DRL)algorithms.However,the performance of existing DRL approaches may deteriorate due to their insufficient ability to extract discriminative features from the time-series vectors in the environmental states.We propose a novel deep deterministic policy gradient(DDPG)network structure with a shared LSTM-based representation network that fully exploits the Actor’s and Critic’s losses.The designed shared representation network and the joint loss function can enhance the environment perception capability of the proposed approach and further improve the optimization performance,resulting in a more profitable pricing strategy.Numerical simulations demonstrate the effectiveness of the proposed approach.展开更多
文摘Medicinal leeches have been utilized in therapy for thousands of years. However, the adaptation physiology between leeches and hosts is not fully understand. To disclose the molecular mechanisms of adaptation between leech and host, the body transcriptomes of hunger and fed blood-sucking Poecilobdella javanica, Haemadipsa cavatuses, and Hirudo nipponia leeches were obtained by RNA sequencing, after comparison, a stratified unigenes group was obtained, which closely correlated to body distension. In the group, Rfamide receptor decreased significantly (P < 0.05) while serotonin receptor increased significantly (P < 0.05). Moreover, four KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways, including cardiac muscle contraction, complement and coagulation cascades, renin-angiotensin system, and hypertrophic cardiomyopathy were significantly enriched. The unigenes annotation, neuroregulators correlation analysis and induced function of the KEGG pathways, were consistently supported the same result as: vasoconstriction and systole reaction enhance in hunger leeches and vice versa vasodilation and diastole increase in fed leeches, meanwhile, Interspecific comparison and correlative analyses of physiological function showed that the strongest reaction of induced heart failure from four KEGG occur in strongest reaction of systole in hungry P. javanica and in strongest reaction of diastole in fed H. nipponia. Overall, heart failure is likely a physiological function involved in feeding behaviour.
基金This work was supported in part by Natural Science Foundation of Jiangsu Province(BK20210002)National Key R&D Program of China(2018AAA0101504)。
文摘The joint optimization problem of energy procurement and retail pricing for an electricity retailer is converted into separately determining the optimal procurement strategy and optimal pricing strategy,under the“price-taker”assumption.The aggregate energy consumption of end use customers(EUCs)is predicted to solve for the optimal procurement strategy vis a long short-term memory(LSTM)-based supervised learning method.The optimal retail pricing problem is formulated as a Markov decision process(MDP),which can be solved by using deep reinforcement learning(DRL)algorithms.However,the performance of existing DRL approaches may deteriorate due to their insufficient ability to extract discriminative features from the time-series vectors in the environmental states.We propose a novel deep deterministic policy gradient(DDPG)network structure with a shared LSTM-based representation network that fully exploits the Actor’s and Critic’s losses.The designed shared representation network and the joint loss function can enhance the environment perception capability of the proposed approach and further improve the optimization performance,resulting in a more profitable pricing strategy.Numerical simulations demonstrate the effectiveness of the proposed approach.
