Objective: To determine the effect of flurbiprofen combined with prednisolone on interleukin-6 in elderly surgery patients. Methods: In this double-blind randomized controlled study, patients aged 65 to 80 who we...Objective: To determine the effect of flurbiprofen combined with prednisolone on interleukin-6 in elderly surgery patients. Methods: In this double-blind randomized controlled study, patients aged 65 to 80 who were undergoing spinal fusion surgery for disc herniation were administered flurbiprofen 100 mg (P group, flurbiprofen group), prednisolone 0.6 mg/kg (D group, prednisolone group), prednisolone 0.6 mg/kg plus flurbiprofen 100 mg (P + D group, flurbiprofen + prednisolone group) or normal saline (S group, saline group) 15 minutes before the induction of anesthesia. Plasma samples were collected before surgery (T0) and on day 1 (T1), day 2 (T2) and day 3 (T3) following surgery. At the same time, systemic inflammatory response syndrome (SIRS) was assessed by SIRS criteria. The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) for collected samples were measured. Results: Other groups had significantly lower levels of IL-6, CRP and occurrence of SIRS than S group (p < 0.05). Compared to groups P and D, the levels of IL-6 and CRP in P + D group were significantly lower on T1 (p < 0.05). Peak levels of IL-6 in all groups were presented on T1 (p 0.05). The levels of CRP within three days were significantly different but did not show peak levels (p > 0.05). Conclusion: Compared to prednisolone or flurbiprofen, combining flurbiprofen with prednisolone in elderly surgery patients led to an increased suppression of IL-6.展开更多
Soil alkali-hydrolyzable nitrogen, which is sensitive to N fertilization rate, is one of the indicators of soil nitrogen supplying capacity. Two field experiments were conducted in Dongtai(120°19″ E, 32°52...Soil alkali-hydrolyzable nitrogen, which is sensitive to N fertilization rate, is one of the indicators of soil nitrogen supplying capacity. Two field experiments were conducted in Dongtai(120°19″ E, 32°52″ N), Jiangsu, China in 2009 and Dafeng(120°28″ E, 33°12″ N), Jiangsu province, China in 2010. Six nitrogen rates(0, 150, 300, 375, 450, and 600 kg ha^(-1)) were used to study the effect of N fertilization rate on soil alkali-hydrolyzable nitrogen content(SAHNC), subtending leaf nitrogen concentration(SLNC), yield, and fiber quality. In both Dongtai and Dafeng experiment station, the highest yield(1709 kg ha^(-1)), best quality(fiber length 30.6 mm, fiber strength 31.6 c N tex^(-1), micronaire 4.82), and highest N agronomic efficiency(2.03 kg kg^(-1)) were achieved at the nitrogen fertilization rate of 375 kg ha^(-1). The dynamics of SAHNC and SLNC could be simulated with a cubic and an exponential function,respectively. The changes in SAHNC were consistent with the changes in SLNC. Optimal average rate(0.276 mg day^(-1)) and duration(51.8 days) of SAHNC rapid decline were similar to the values obtained at the nitrogen rate of 375 kg ha^(-1)at which cotton showed highest fiber yield, quality, and N agronomic efficiency. Thus, the levels and strategies of nitrogen fertilization can affect SAHNC dynamics. The N fertilization rate that optimizes soil alkali-hydrolyzable nitrogen content would optimize the subtending leaf nitrogen concentration and thereby increase the yield and quality of the cotton fiber.展开更多
Faced with hundreds of thousands of news articles in the news websites,it is difficult for users to find the news articles they are interested in.Therefore,various news recommender systems were built.In the news recom...Faced with hundreds of thousands of news articles in the news websites,it is difficult for users to find the news articles they are interested in.Therefore,various news recommender systems were built.In the news recommendation,these news articles read by a user is typically in the form of a time sequence.However,traditional news recommendation algorithms rarely consider the time sequence characteristic of user browsing behaviors.Therefore,the performance of traditional news recommendation algorithms is not good enough in predicting the next news article which a user will read.To solve this problem,this paper proposes a time-ordered collaborative filtering recommendation algorithm(TOCF),which takes the time sequence characteristic of user behaviors into account.Besides,a new method to compute the similarity among different users,named time-dependent similarity,is proposed.To demonstrate the efficiency of our solution,extensive experiments are conducted along with detailed performance analysis.展开更多
BACKGROUND Acute urinary retention(AUR)is rare during pregnancy.CASE SUMMARY We report on three pregnant women with AUR between the 10^(th) and 18^(th) wk of gestation.Case 1 was first diagnosed as urinary tract infec...BACKGROUND Acute urinary retention(AUR)is rare during pregnancy.CASE SUMMARY We report on three pregnant women with AUR between the 10^(th) and 18^(th) wk of gestation.Case 1 was first diagnosed as urinary tract infection and developed a urinary tract infection due to urinary retention caused by urethral obstruction.Case 2 had a history of previous abdominal surgery for pelvic tuberculosis,leading to severe adhesions and a persistent retroverted uterus.In case 3,healthcare providers focused on the patient’s gastrointestinal symptoms and did not investigate her inability to void.Case 1 required manual disimpaction of the uterus and the knee-chest position.The other cases required immediate catheterization.The condition resolved in cases 1 and 2;these patients had normal pregnancies.Case 3 had severe complications at the time of consultation,leading to an abortion.CONCLUSION Retroverted uterus is the most common cause of AUR.Prompt recognition and diagnosis are required.Clinicians should be aware of the risk factors,etiology,and clinical presentation of AUR in the first and second trimester of pregnancy.展开更多
Vertical records are critically important when determining the rupture model of an earthquake, especially a thrust earthquake. Due to the relatively low fitness level of near-field vertical displacements, the precisio...Vertical records are critically important when determining the rupture model of an earthquake, especially a thrust earthquake. Due to the relatively low fitness level of near-field vertical displacements, the precision of previous rupture models is relatively low, and the seismic hazard evaluated thereafter should be further updated. In this study, we applied three-component displacement records from GPS stations in and around the source region of the 2013 MW6.6 Lushan earthquake to re-investigate the rupture model.To improve the resolution of the rupture model, records from both continuous and campaign GPS stations were gathered, and secular deformations of the GPS movements were removed from the records of the campaign stations to ensure their reliability. The rupture model was derived by the steepest descent method(SDM), which is based on a layered velocity structure. The peak slip value was about 0.75 m, with a seismic moment release of 9.89 × 10^(18) N·m, which was equivalent to an M_W6.6 event. The inferred fault geometry coincided well with the aftershock distribution of the Lushan earthquake. Unlike previous rupture models, a secondary slip asperity existed at a shallow depth and even touched the ground surface. Based on the distribution of the co-seismic ruptures of the Lushan and Wenchuan earthquakes, post-seismic relaxation of the Wenchuan earthquake, and tectonic loading process, we proposed that the seismic hazard is quite high and still needs special attention in the seismic gap between the two earthquakes.展开更多
BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is frequently diagnosed and treated in advanced tumor stages with poor prognosis.More effective screening programs and novel therapeutic means are urgently needed.Recen...BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is frequently diagnosed and treated in advanced tumor stages with poor prognosis.More effective screening programs and novel therapeutic means are urgently needed.Recent studies have regarded tight junction protein claudin 18.2(CLDN18.2)as a candidate target for cancer treatment,and zolbetuximab(formerly known as IMAB362)has been developed against CLDN18.2.However,there are few data reported thus far related to the clinicopathological characteristics of CLDN18.2 expression for PDAC.AIM To investigate the expression of CLDN18.2 in PDAC patients and subsequently propose a new target for the treatment of PDAC.METHODS The Cancer Genome Atlas,Genotype-Tissue Expression,Gene Expression Omnibus,and European Genome-phenome Archive databases were first employed to analyze the CLDN18 gene expression in normal pancreatic tissue compared to that in pancreatic cancer tissue.Second,we analyzed the expression of CLDN18.2 in 93 primary PDACs,86 para-cancer tissues,and 13 normal pancreatic tissues by immunohistochemistry.Immunostained tissues were assessed applying the histoscore.subsequently,they fell into two groups according to the expression state of CLDN18.2.Furthermore,the correlations between CLDN18.2 expression and diverse clinicopathological characteristics,including survival,were investigated.RESULTS The gene expression of CLDN18 was statistically higher(P<0.01)in pancreatic tumors than in normal tissues.However,there was no significant correlation between CLDN18 expression and survival in pancreatic cancer patients.CLDN18.2 was expressed in 88(94.6%)of the reported PDACs.Among these tumors,50(56.8%)cases showed strong immunostaining.The para-cancer tissues were positive in 81(94.2%)cases,among which 32(39.5%)of cases were characterized for strong staining intensities.Normal pancreatic tissue was identified solely via weak immunostaining.Finally,CLDN18.2 expression significantly correlated with lymph node metastasis,distant metastasis,nerve invasion,stage,and survival of PDAC patients,while there was no correlation between CLDN18.2 expression and localization,tumor size,patient age and sex,nor any other clinicopathological characteristic.CONCLUSION CLDN18.2 expression is frequently increased in PDAC patients.Thus,it may act as a potential therapeutic target for zolbetuximab in PDAC.展开更多
Seven fractions were isolated from the ethyl acetate extract of Prinsepia utilis Royle by silica gel column chromatography. The antibacterial activities determined by disc diffusion method in vitro, indicated that the...Seven fractions were isolated from the ethyl acetate extract of Prinsepia utilis Royle by silica gel column chromatography. The antibacterial activities determined by disc diffusion method in vitro, indicated that the first and fourth fractions showed better antibacterial activity than the other fractions, while the sixth and seventh fractions did not showed any antibacterial activity. The diameters of the inhibition zone of first and fourth fractions were greater than 10 mm against three standard strains (Staphylococcus aureus ATCC25923, Escherichia coli ATCC44102 and Salmonella sp. CMCC(B)50041) at the concentration of 20 mg/ml. The first fraction was then repeatedly recrystallized in acetone to yield a white snowflake-like compound A, the inhibition zones of which were 14.03 mm, 11.54 mm and 12 mm, respectively. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were measured by broth dilution method at the concentrations ranging from 20 to 0.313 mg/mL. The MIC and MBC values of the first, fourth fractions and compound A were lower than that of oregano oil (positive control) against S. aureus ATCC25923.展开更多
The complex heat of BF_3 with methanol was measured by utilizing the principle of the Bunsen ice calorimeter. The complex heat of BF_3 –methanol was found to be 49.2 and 58.1 kJ/mol when the molar ratio of BF_3 to me...The complex heat of BF_3 with methanol was measured by utilizing the principle of the Bunsen ice calorimeter. The complex heat of BF_3 –methanol was found to be 49.2 and 58.1 kJ/mol when the molar ratio of BF_3 to methanol was 1:2 and 1:1,respectively. In addition,the complex heat of BF_3 –anisole was also measured to test the apparatus error. The BF_3 –anisole result showed a calorimeter value of 53.1 kJ/mol with a system error of 2.3% as compared with the value reported in the literature. The mechanism of the reaction of BF_3 and methanol was interpreted based on our obtained results. This apparatus is useful and suitable for measuring the heat of other liquid–gas and liquid–liquid reactions.展开更多
文摘Objective: To determine the effect of flurbiprofen combined with prednisolone on interleukin-6 in elderly surgery patients. Methods: In this double-blind randomized controlled study, patients aged 65 to 80 who were undergoing spinal fusion surgery for disc herniation were administered flurbiprofen 100 mg (P group, flurbiprofen group), prednisolone 0.6 mg/kg (D group, prednisolone group), prednisolone 0.6 mg/kg plus flurbiprofen 100 mg (P + D group, flurbiprofen + prednisolone group) or normal saline (S group, saline group) 15 minutes before the induction of anesthesia. Plasma samples were collected before surgery (T0) and on day 1 (T1), day 2 (T2) and day 3 (T3) following surgery. At the same time, systemic inflammatory response syndrome (SIRS) was assessed by SIRS criteria. The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) for collected samples were measured. Results: Other groups had significantly lower levels of IL-6, CRP and occurrence of SIRS than S group (p < 0.05). Compared to groups P and D, the levels of IL-6 and CRP in P + D group were significantly lower on T1 (p < 0.05). Peak levels of IL-6 in all groups were presented on T1 (p 0.05). The levels of CRP within three days were significantly different but did not show peak levels (p > 0.05). Conclusion: Compared to prednisolone or flurbiprofen, combining flurbiprofen with prednisolone in elderly surgery patients led to an increased suppression of IL-6.
基金funded by the National Key Technology R&D Program of China (No. 2014BAD11B02)the Special Fund for Agro-scientific Research in the Public Interest (No. 201203096)+1 种基金the National Natural Science Foundation of China (Nos. 31401327, 30971735)the China Agriculture Research System (No. CARS-18-20)
文摘Soil alkali-hydrolyzable nitrogen, which is sensitive to N fertilization rate, is one of the indicators of soil nitrogen supplying capacity. Two field experiments were conducted in Dongtai(120°19″ E, 32°52″ N), Jiangsu, China in 2009 and Dafeng(120°28″ E, 33°12″ N), Jiangsu province, China in 2010. Six nitrogen rates(0, 150, 300, 375, 450, and 600 kg ha^(-1)) were used to study the effect of N fertilization rate on soil alkali-hydrolyzable nitrogen content(SAHNC), subtending leaf nitrogen concentration(SLNC), yield, and fiber quality. In both Dongtai and Dafeng experiment station, the highest yield(1709 kg ha^(-1)), best quality(fiber length 30.6 mm, fiber strength 31.6 c N tex^(-1), micronaire 4.82), and highest N agronomic efficiency(2.03 kg kg^(-1)) were achieved at the nitrogen fertilization rate of 375 kg ha^(-1). The dynamics of SAHNC and SLNC could be simulated with a cubic and an exponential function,respectively. The changes in SAHNC were consistent with the changes in SLNC. Optimal average rate(0.276 mg day^(-1)) and duration(51.8 days) of SAHNC rapid decline were similar to the values obtained at the nitrogen rate of 375 kg ha^(-1)at which cotton showed highest fiber yield, quality, and N agronomic efficiency. Thus, the levels and strategies of nitrogen fertilization can affect SAHNC dynamics. The N fertilization rate that optimizes soil alkali-hydrolyzable nitrogen content would optimize the subtending leaf nitrogen concentration and thereby increase the yield and quality of the cotton fiber.
基金supported by the Natural Science Foundation of China(No.61170174, 61370205)Tianjin Training plan of University Innovation Team(No.TD12-5016)
文摘Faced with hundreds of thousands of news articles in the news websites,it is difficult for users to find the news articles they are interested in.Therefore,various news recommender systems were built.In the news recommendation,these news articles read by a user is typically in the form of a time sequence.However,traditional news recommendation algorithms rarely consider the time sequence characteristic of user browsing behaviors.Therefore,the performance of traditional news recommendation algorithms is not good enough in predicting the next news article which a user will read.To solve this problem,this paper proposes a time-ordered collaborative filtering recommendation algorithm(TOCF),which takes the time sequence characteristic of user behaviors into account.Besides,a new method to compute the similarity among different users,named time-dependent similarity,is proposed.To demonstrate the efficiency of our solution,extensive experiments are conducted along with detailed performance analysis.
文摘BACKGROUND Acute urinary retention(AUR)is rare during pregnancy.CASE SUMMARY We report on three pregnant women with AUR between the 10^(th) and 18^(th) wk of gestation.Case 1 was first diagnosed as urinary tract infection and developed a urinary tract infection due to urinary retention caused by urethral obstruction.Case 2 had a history of previous abdominal surgery for pelvic tuberculosis,leading to severe adhesions and a persistent retroverted uterus.In case 3,healthcare providers focused on the patient’s gastrointestinal symptoms and did not investigate her inability to void.Case 1 required manual disimpaction of the uterus and the knee-chest position.The other cases required immediate catheterization.The condition resolved in cases 1 and 2;these patients had normal pregnancies.Case 3 had severe complications at the time of consultation,leading to an abortion.CONCLUSION Retroverted uterus is the most common cause of AUR.Prompt recognition and diagnosis are required.Clinicians should be aware of the risk factors,etiology,and clinical presentation of AUR in the first and second trimester of pregnancy.
基金supported by the grant from the National Sichuan-Yunnan earthquake prediction experimental field of CEA (grant No. 2016CESE0204)
文摘Vertical records are critically important when determining the rupture model of an earthquake, especially a thrust earthquake. Due to the relatively low fitness level of near-field vertical displacements, the precision of previous rupture models is relatively low, and the seismic hazard evaluated thereafter should be further updated. In this study, we applied three-component displacement records from GPS stations in and around the source region of the 2013 MW6.6 Lushan earthquake to re-investigate the rupture model.To improve the resolution of the rupture model, records from both continuous and campaign GPS stations were gathered, and secular deformations of the GPS movements were removed from the records of the campaign stations to ensure their reliability. The rupture model was derived by the steepest descent method(SDM), which is based on a layered velocity structure. The peak slip value was about 0.75 m, with a seismic moment release of 9.89 × 10^(18) N·m, which was equivalent to an M_W6.6 event. The inferred fault geometry coincided well with the aftershock distribution of the Lushan earthquake. Unlike previous rupture models, a secondary slip asperity existed at a shallow depth and even touched the ground surface. Based on the distribution of the co-seismic ruptures of the Lushan and Wenchuan earthquakes, post-seismic relaxation of the Wenchuan earthquake, and tectonic loading process, we proposed that the seismic hazard is quite high and still needs special attention in the seismic gap between the two earthquakes.
基金Supported by the Basic Research Project of Natural Science of Shaanxi Province,No.2020JQ-943,2021JQ-916 and 2021JQ-914Research Project of Chinese Society of Clinical Oncology-Sai Sheng Fund,No.Y-2020Sciclone/qn-0181+2 种基金Science and Technology Support Program of Shaanxi Provincial People’s Hospital,No.2021JY-26,2021JY-38,2021JY-50 and 2021BJ-13Research Fund Project of Shaanxi Provincial People’s Hospital,No.2021YJY-18China Postdoctoral Science Foundation,No.2021M702607.
文摘BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is frequently diagnosed and treated in advanced tumor stages with poor prognosis.More effective screening programs and novel therapeutic means are urgently needed.Recent studies have regarded tight junction protein claudin 18.2(CLDN18.2)as a candidate target for cancer treatment,and zolbetuximab(formerly known as IMAB362)has been developed against CLDN18.2.However,there are few data reported thus far related to the clinicopathological characteristics of CLDN18.2 expression for PDAC.AIM To investigate the expression of CLDN18.2 in PDAC patients and subsequently propose a new target for the treatment of PDAC.METHODS The Cancer Genome Atlas,Genotype-Tissue Expression,Gene Expression Omnibus,and European Genome-phenome Archive databases were first employed to analyze the CLDN18 gene expression in normal pancreatic tissue compared to that in pancreatic cancer tissue.Second,we analyzed the expression of CLDN18.2 in 93 primary PDACs,86 para-cancer tissues,and 13 normal pancreatic tissues by immunohistochemistry.Immunostained tissues were assessed applying the histoscore.subsequently,they fell into two groups according to the expression state of CLDN18.2.Furthermore,the correlations between CLDN18.2 expression and diverse clinicopathological characteristics,including survival,were investigated.RESULTS The gene expression of CLDN18 was statistically higher(P<0.01)in pancreatic tumors than in normal tissues.However,there was no significant correlation between CLDN18 expression and survival in pancreatic cancer patients.CLDN18.2 was expressed in 88(94.6%)of the reported PDACs.Among these tumors,50(56.8%)cases showed strong immunostaining.The para-cancer tissues were positive in 81(94.2%)cases,among which 32(39.5%)of cases were characterized for strong staining intensities.Normal pancreatic tissue was identified solely via weak immunostaining.Finally,CLDN18.2 expression significantly correlated with lymph node metastasis,distant metastasis,nerve invasion,stage,and survival of PDAC patients,while there was no correlation between CLDN18.2 expression and localization,tumor size,patient age and sex,nor any other clinicopathological characteristic.CONCLUSION CLDN18.2 expression is frequently increased in PDAC patients.Thus,it may act as a potential therapeutic target for zolbetuximab in PDAC.
文摘Seven fractions were isolated from the ethyl acetate extract of Prinsepia utilis Royle by silica gel column chromatography. The antibacterial activities determined by disc diffusion method in vitro, indicated that the first and fourth fractions showed better antibacterial activity than the other fractions, while the sixth and seventh fractions did not showed any antibacterial activity. The diameters of the inhibition zone of first and fourth fractions were greater than 10 mm against three standard strains (Staphylococcus aureus ATCC25923, Escherichia coli ATCC44102 and Salmonella sp. CMCC(B)50041) at the concentration of 20 mg/ml. The first fraction was then repeatedly recrystallized in acetone to yield a white snowflake-like compound A, the inhibition zones of which were 14.03 mm, 11.54 mm and 12 mm, respectively. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were measured by broth dilution method at the concentrations ranging from 20 to 0.313 mg/mL. The MIC and MBC values of the first, fourth fractions and compound A were lower than that of oregano oil (positive control) against S. aureus ATCC25923.
文摘The complex heat of BF_3 with methanol was measured by utilizing the principle of the Bunsen ice calorimeter. The complex heat of BF_3 –methanol was found to be 49.2 and 58.1 kJ/mol when the molar ratio of BF_3 to methanol was 1:2 and 1:1,respectively. In addition,the complex heat of BF_3 –anisole was also measured to test the apparatus error. The BF_3 –anisole result showed a calorimeter value of 53.1 kJ/mol with a system error of 2.3% as compared with the value reported in the literature. The mechanism of the reaction of BF_3 and methanol was interpreted based on our obtained results. This apparatus is useful and suitable for measuring the heat of other liquid–gas and liquid–liquid reactions.
