BACKGROUND Systemic lupus erythematosus(SLE),characterized by the production of autoantibodies and widespread deposition of immune complexes,predominantly affects women of childbearing age.More than one-third of SLE p...BACKGROUND Systemic lupus erythematosus(SLE),characterized by the production of autoantibodies and widespread deposition of immune complexes,predominantly affects women of childbearing age.More than one-third of SLE patients present ocular manifestations.Choroidal disease is currently not completely understood,and its precise differentiation from central serous chorioretinopathy is rarely achieved.To date,no more than 60 patients with choroidal involvement have been reported.CASE SUMMARY A 37-year-old Chinese woman experienced decreased visual acuity bilaterally,accompanied by increasing periorbital swelling and severe conjunctival chemosis.Decreased breath sounds in both bases were detected via auscultation,as well as pitting edema in both ankles.SLE and lupus nephritis were diagnosed based on serositis,renal disorder,leukopenia and positive anti-Smith and anti-nuclear antibodies.Lupus choroidopathy was diagnosed based on ocular presentation and imaging. The patient was treated with systemic corticosteroids, spironolactone, hydroxychloroquine(HCQ), mycophenolate mofetil (MMF), and intravenous immunoglobulin. After 4 wkof hospitalization, the patient was discharged. Indocyanine green angiography showed no leakagefrom choroidal vessels, and ocular coherence tomography detected low amounts of subretinalfluid right before discharge. The patient was prescribed oral methylprednisolone, HCQ, and MMF.Two months after the first visit, ophthalmological examination revealed a visual acuity of 20/20bilaterally, and SLE disease activity was well controlled;her symptoms disappeared completely.CONCLUSIONHere we presented a case of lupus choroidopathy, successfully treated with systemic corticosteroids,and discussed previously reported cases, focusing on differential diagnosis with a centralserous chorioretinopathy.展开更多
文摘BACKGROUND Systemic lupus erythematosus(SLE),characterized by the production of autoantibodies and widespread deposition of immune complexes,predominantly affects women of childbearing age.More than one-third of SLE patients present ocular manifestations.Choroidal disease is currently not completely understood,and its precise differentiation from central serous chorioretinopathy is rarely achieved.To date,no more than 60 patients with choroidal involvement have been reported.CASE SUMMARY A 37-year-old Chinese woman experienced decreased visual acuity bilaterally,accompanied by increasing periorbital swelling and severe conjunctival chemosis.Decreased breath sounds in both bases were detected via auscultation,as well as pitting edema in both ankles.SLE and lupus nephritis were diagnosed based on serositis,renal disorder,leukopenia and positive anti-Smith and anti-nuclear antibodies.Lupus choroidopathy was diagnosed based on ocular presentation and imaging. The patient was treated with systemic corticosteroids, spironolactone, hydroxychloroquine(HCQ), mycophenolate mofetil (MMF), and intravenous immunoglobulin. After 4 wkof hospitalization, the patient was discharged. Indocyanine green angiography showed no leakagefrom choroidal vessels, and ocular coherence tomography detected low amounts of subretinalfluid right before discharge. The patient was prescribed oral methylprednisolone, HCQ, and MMF.Two months after the first visit, ophthalmological examination revealed a visual acuity of 20/20bilaterally, and SLE disease activity was well controlled;her symptoms disappeared completely.CONCLUSIONHere we presented a case of lupus choroidopathy, successfully treated with systemic corticosteroids,and discussed previously reported cases, focusing on differential diagnosis with a centralserous chorioretinopathy.
