Jiawei Xiaoyao San(JWXYS)has shown excellent clinical efficacy in anxiety disorder,but has not yet attracted widespread attention.The animal experiments,clinical trials and mechanism studies of JWXYS were reviewed in ...Jiawei Xiaoyao San(JWXYS)has shown excellent clinical efficacy in anxiety disorder,but has not yet attracted widespread attention.The animal experiments,clinical trials and mechanism studies of JWXYS were reviewed in this article,which may provide a reference for developing new anxiolytic drugs based on this prescription.The literature was searched in PubMed and CNKI and the documents written in English or with English abstracts were selected.JWXYS could reduce the anxiety symptoms of patients alone and reduce the adverse reactions when it is used in combination with other drugs in the clinic.In preclinical studies,JWXYS also showed therapeutic effects in reducing anxiety-like behavior.The mechanisms may include improving the hypothalamic–pituitaryadrenal(HPA)axis and hormone disorders,increasing neurotransmitter content,neurogenesis,and regulating the synthesis of related enzymes.This article shows that JWXYS could effectively treat anxiety disorders by regulating the central nervous system.In the future,with the participation of more researchers,it is expected to develop innovative drugs for the treatment of anxiety disorders based on JWXYS.展开更多
With the increasing development of intelligent robots and wearable electronics,the demand for high-performance flexible energy storage devices is drastically increasing.In this study,flexible symmetric microsupercapac...With the increasing development of intelligent robots and wearable electronics,the demand for high-performance flexible energy storage devices is drastically increasing.In this study,flexible symmetric microsupercapacitors(MSCs)that could operate in a wide working voltage window were developed by combining laser-direct-writing graphene(LG)electrodes with a phosphoric acid-nonionic surfactant liquid crystal(PA-NI LC)gel electrolyte.To increase the flexibility and enhance the conformal ability of the MSC devices to anisotropic surfaces,after the interdigitated LG formed on the polyimide(PI)film surface,the devices were further transferred onto a flexible,stretchable and transparent polydimethylsiloxane(PDMS)substrate;this substrate displayed favorable flexibility and mechanical characteristics in the bending test.Furthermore,the electrochemical performances of the symmetric MSCs with various electrode widths(300,400,500 and 600μm)were evaluated.The findings revealed that symmetric MSC devices could operate in a large voltage range(0–1.5 V);additionally,the device with a 300μm electrode width(MSC-300)exhibited the largest areal capacitance of 2.3 mF cm^(−2)at 0.07 mA cm^(−2)and an areal(volumetric)energy density of 0.72μWh cm−2(0.36 mWh cm^(−3))at 55.07μWcm−2(27.54mWcm−3),along with favorable mechanical and cycling stability.After charging for~20 s,two MSC-300 devices connected in series could supply energy to a calculator to operate for~130 s,showing its practical application potential as an energy storage device.Moreover,the device displayed favorable reversibility,stability and durability.After 12 months of aging in air at room temperature,its electrochemical performance was not altered,and after charging-discharging measurements for 5000 cycles at 0.07 mA cm^(−2),~93.6%of the areal capacitance was still retained;these results demonstrated its practical long-term application potential as an energy storage device.展开更多
This paper reports an experimental study on the supersonic jet surface flow structure visualization and shear stress field measurement issuing from a rectangular nozzle with extended shelf. The evolution of the near-f...This paper reports an experimental study on the supersonic jet surface flow structure visualization and shear stress field measurement issuing from a rectangular nozzle with extended shelf. The evolution of the near-field surface flow structures with an increased Nozzle Pressure Ratio(NPR) is successfully captured by the surface oil flow, infrared detection technology, and the Shear-Sensitive Liquid Crystal Coating(SSLCC) technique. Results reveal that under smaller NPR, the wall flow structure is similar to that of a jet without the extended shelf i.e., clean jets,and this is caused by insufficient effect on the boundary layer. However, at higher amplitudes of NPR, there exists a significant effect of the boundary layer, as a near triangular separation forms on the trailing edge of the Mach stem due to the adverse pressure gradient, which is visualized for the very first time in this paper. Furthermore, the vector field of shear stress is measured quantitatively by SSLCC technique. Results shows that the magnitude of shear stress heightened with NPR increasing, and the directions of shear stress changes across the shock wave and expansion fans. In addition, surface streamlines measured by SSLCC is significantly consistent with the streamlines visualized using the oil flow technique.展开更多
基金supported by the National Natural Science Foundation of China(No.81173541).
文摘Jiawei Xiaoyao San(JWXYS)has shown excellent clinical efficacy in anxiety disorder,but has not yet attracted widespread attention.The animal experiments,clinical trials and mechanism studies of JWXYS were reviewed in this article,which may provide a reference for developing new anxiolytic drugs based on this prescription.The literature was searched in PubMed and CNKI and the documents written in English or with English abstracts were selected.JWXYS could reduce the anxiety symptoms of patients alone and reduce the adverse reactions when it is used in combination with other drugs in the clinic.In preclinical studies,JWXYS also showed therapeutic effects in reducing anxiety-like behavior.The mechanisms may include improving the hypothalamic–pituitaryadrenal(HPA)axis and hormone disorders,increasing neurotransmitter content,neurogenesis,and regulating the synthesis of related enzymes.This article shows that JWXYS could effectively treat anxiety disorders by regulating the central nervous system.In the future,with the participation of more researchers,it is expected to develop innovative drugs for the treatment of anxiety disorders based on JWXYS.
基金supported by the National Key Research&Development(R&D)Program of China(grant number 2021YFB3203200)the Shaanxi 2023 Natural Science Basic Research Plan(grant number 2023-JC-QN-0489)+1 种基金the National Natural Science Foundation of China(grant number 52175548)the financial support from Shaanxi Province Postdoctoral Research Project Funding,State Key Laboratory for Manufacturing Systems Engineering and Free Exploration and Innovation-Teacher Program of Basic Scientific Research Business Expenses of Xi’an Jiaotong University(xzy012023054).
文摘With the increasing development of intelligent robots and wearable electronics,the demand for high-performance flexible energy storage devices is drastically increasing.In this study,flexible symmetric microsupercapacitors(MSCs)that could operate in a wide working voltage window were developed by combining laser-direct-writing graphene(LG)electrodes with a phosphoric acid-nonionic surfactant liquid crystal(PA-NI LC)gel electrolyte.To increase the flexibility and enhance the conformal ability of the MSC devices to anisotropic surfaces,after the interdigitated LG formed on the polyimide(PI)film surface,the devices were further transferred onto a flexible,stretchable and transparent polydimethylsiloxane(PDMS)substrate;this substrate displayed favorable flexibility and mechanical characteristics in the bending test.Furthermore,the electrochemical performances of the symmetric MSCs with various electrode widths(300,400,500 and 600μm)were evaluated.The findings revealed that symmetric MSC devices could operate in a large voltage range(0–1.5 V);additionally,the device with a 300μm electrode width(MSC-300)exhibited the largest areal capacitance of 2.3 mF cm^(−2)at 0.07 mA cm^(−2)and an areal(volumetric)energy density of 0.72μWh cm−2(0.36 mWh cm^(−3))at 55.07μWcm−2(27.54mWcm−3),along with favorable mechanical and cycling stability.After charging for~20 s,two MSC-300 devices connected in series could supply energy to a calculator to operate for~130 s,showing its practical application potential as an energy storage device.Moreover,the device displayed favorable reversibility,stability and durability.After 12 months of aging in air at room temperature,its electrochemical performance was not altered,and after charging-discharging measurements for 5000 cycles at 0.07 mA cm^(−2),~93.6%of the areal capacitance was still retained;these results demonstrated its practical long-term application potential as an energy storage device.
基金supported by the National Natural Science Foundation of China (Nos. 12072157 and 51776096)。
文摘This paper reports an experimental study on the supersonic jet surface flow structure visualization and shear stress field measurement issuing from a rectangular nozzle with extended shelf. The evolution of the near-field surface flow structures with an increased Nozzle Pressure Ratio(NPR) is successfully captured by the surface oil flow, infrared detection technology, and the Shear-Sensitive Liquid Crystal Coating(SSLCC) technique. Results reveal that under smaller NPR, the wall flow structure is similar to that of a jet without the extended shelf i.e., clean jets,and this is caused by insufficient effect on the boundary layer. However, at higher amplitudes of NPR, there exists a significant effect of the boundary layer, as a near triangular separation forms on the trailing edge of the Mach stem due to the adverse pressure gradient, which is visualized for the very first time in this paper. Furthermore, the vector field of shear stress is measured quantitatively by SSLCC technique. Results shows that the magnitude of shear stress heightened with NPR increasing, and the directions of shear stress changes across the shock wave and expansion fans. In addition, surface streamlines measured by SSLCC is significantly consistent with the streamlines visualized using the oil flow technique.
