Recently, the CRISPR/Cas9 system is emerging as a powerful tool for genome editing (Chang et al., 2013; Li et al., 2013; Niu et al., 2014; Shen et al., 2013; Wan et al., 2015; Wang et al., 2013) and genetic screeni...Recently, the CRISPR/Cas9 system is emerging as a powerful tool for genome editing (Chang et al., 2013; Li et al., 2013; Niu et al., 2014; Shen et al., 2013; Wan et al., 2015; Wang et al., 2013) and genetic screening (Konermann et al., 2015), and holds great promise for biomedical applications in disease modeling and gene therapy by in vivo genome editing (Mad- dalo et al., 2014; Xue et al., 2014).展开更多
文摘Recently, the CRISPR/Cas9 system is emerging as a powerful tool for genome editing (Chang et al., 2013; Li et al., 2013; Niu et al., 2014; Shen et al., 2013; Wan et al., 2015; Wang et al., 2013) and genetic screening (Konermann et al., 2015), and holds great promise for biomedical applications in disease modeling and gene therapy by in vivo genome editing (Mad- dalo et al., 2014; Xue et al., 2014).