Metal ions are involved in Aβ aggregate deposition and neurotoxicity via various processes, including acceleration of Aβ aggregation, disruption of normal metal homeostasis, and formation of reactive oxygen species ...Metal ions are involved in Aβ aggregate deposition and neurotoxicity via various processes, including acceleration of Aβ aggregation, disruption of normal metal homeostasis, and formation of reactive oxygen species （ROS）. Although metal chelation is a promising therapeutic strategy for Alzheimer＇s disease （AD）, the widespread use of chelation therapy faces a significant problem; namely, it is difficult to differentiate toxic metals associated with Aβ plaques from those required by normal metal homeostasis. Furthermore, the multifactorial nature of AD and the current lack of an accepted unitary theory to account for AD neurodegeneration also restrict AD treatment through a single therapeutic strategy. This paper presents a novel bifunctional platform by integrating nonpharmacological and pharmacological cues into one system for AD treatment. This electrically responsive drug release platform, based on conducting polymer polypyrrole （PPy） incorporated with graphene-mesoporous silica nanohybrids （GSN） nanoreserviors, could realize on-demand controlled drug delivery with spatial and temporal control. Electrochemical stimulation can treat peripheral nerve injury （PNI） to stimulate neurite outgrowth. This novel system can also effectively inhibit Aβ aggregate formation, decrease cellular ROS, and protect cells from Aβ-related toxicity. The purpose of this research is to promote the design of noninvasive remote-controlled multifunctional systems for AD treatment.展开更多
The biological functions of amyloid β(Aβ)peptides have received much attention,playing a central role in the pathogenesis of Alzheimer’s disease(AD).Recent studies have demonstrated that AD is asso-ciated with canc...The biological functions of amyloid β(Aβ)peptides have received much attention,playing a central role in the pathogenesis of Alzheimer’s disease(AD).Recent studies have demonstrated that AD is asso-ciated with cancer.However,it is still unknown if there is a correlation between Aβand cancer.展开更多
文摘Metal ions are involved in Aβ aggregate deposition and neurotoxicity via various processes, including acceleration of Aβ aggregation, disruption of normal metal homeostasis, and formation of reactive oxygen species （ROS）. Although metal chelation is a promising therapeutic strategy for Alzheimer＇s disease （AD）, the widespread use of chelation therapy faces a significant problem; namely, it is difficult to differentiate toxic metals associated with Aβ plaques from those required by normal metal homeostasis. Furthermore, the multifactorial nature of AD and the current lack of an accepted unitary theory to account for AD neurodegeneration also restrict AD treatment through a single therapeutic strategy. This paper presents a novel bifunctional platform by integrating nonpharmacological and pharmacological cues into one system for AD treatment. This electrically responsive drug release platform, based on conducting polymer polypyrrole （PPy） incorporated with graphene-mesoporous silica nanohybrids （GSN） nanoreserviors, could realize on-demand controlled drug delivery with spatial and temporal control. Electrochemical stimulation can treat peripheral nerve injury （PNI） to stimulate neurite outgrowth. This novel system can also effectively inhibit Aβ aggregate formation, decrease cellular ROS, and protect cells from Aβ-related toxicity. The purpose of this research is to promote the design of noninvasive remote-controlled multifunctional systems for AD treatment.
基金This work was supported by the National Natural Science Foundation(NSFC,21431007,21533008,21820102009,91856205,21871249,and 21807096)Key Program of Frontier of Sciences(CAS QYZDJ-SSW-SLH052),China.
文摘The biological functions of amyloid β(Aβ)peptides have received much attention,playing a central role in the pathogenesis of Alzheimer’s disease(AD).Recent studies have demonstrated that AD is asso-ciated with cancer.However,it is still unknown if there is a correlation between Aβand cancer.
