As human‐machine interaction(HMI)in healthcare continues to evolve,the issue of trust in HMI in healthcare has been raised and explored.It is critical for the development and safety of healthcare that humans have pro...As human‐machine interaction(HMI)in healthcare continues to evolve,the issue of trust in HMI in healthcare has been raised and explored.It is critical for the development and safety of healthcare that humans have proper trust in medical machines.Intelligent machines that have applied machine learning(ML)technologies continue to penetrate deeper into the medical environment,which also places higher demands on intelligent healthcare.In order to make machines play a role in HMI in healthcare more effectively and make human‐machine cooperation more harmonious,the authors need to build good humanmachine trust(HMT)in healthcare.This article provides a systematic overview of the prominent research on ML and HMT in healthcare.In addition,this study explores and analyses ML and three important factors that influence HMT in healthcare,and then proposes a HMT model in healthcare.Finally,general trends are summarised and issues to consider addressing in future research on HMT in healthcare are identified.展开更多
L-theanine has been shown to have a therapeutic effect on depression.However,whether L-theanine has an excellent preventive effect on depression in children and adolescents and what its mechanism is have not been well...L-theanine has been shown to have a therapeutic effect on depression.However,whether L-theanine has an excellent preventive effect on depression in children and adolescents and what its mechanism is have not been well explained.Given the complexity of the pathogenesis of depression,this study investigated the preventive effect and mechanism of L-theanine on depression in juvenile rats by combining serum and hippocampal metabolomic strategies.Behavioral tests,hippocampal tissue sections,and serum and hippocampal biochemical indexes were studied,and the results confirmed the preventive effect of Ltheanine.Untargeted reversed-phase liquid chromatography-quadrupole-time-of-flight mass spectrometry and targeted hydrophilic interaction liquid chromatography-triple quadrupole mass spectrometry were developed to analyze the metabolism changes in the serum and hippocampus to screen for potential biomarkers related to L-theanine treatment.The results suggested that 28 abnormal metabolites in the serum and hippocampus that were considered as potential biomarkers returned to nearnormal levels after L-theanine administration.These biomarkers were involved in various metabolic pathways,mainly including amino acid metabolism and lipid metabolism.The levels of amino acids and neurotransmitters in the phenylalanine,tryptophan,and glutamic acid pathways were significantly reduced after L-theanine administration compared with chronic unpredictable mild stress-induced rats.In summary,L-theanine had a significant preventive effect on depression and achieved its preventive results on depression by regulating various aspects of the body,such as amino acids,lipids,and inflammation.This research systematically analyzed the mechanism of L-theanine in preventing depression and laid the foundation for applying L-theanine to prevent depression in children and adolescents.展开更多
The coronavirus disease 2019(COVID-19)pandemic is an unprecedented worldwide health crisis.Many previous research studies have found and investigated its links with one or some natural or human environmental factors.H...The coronavirus disease 2019(COVID-19)pandemic is an unprecedented worldwide health crisis.Many previous research studies have found and investigated its links with one or some natural or human environmental factors.However,a review on the relationship between COVID-19 incidence and both the natural and human environment is still lacking.This review summarizes the inter-correlation between COVID-19 incidence and environmental factors.Based on keyword searching,we reviewed 100 relevant peer-reviewed articles and other research literature published since January 2020.This review is focused on three main findings.One,we found that individual environmental factors have impacts on COVID-19 incidence,but with spatial heterogeneity and uncertainty.Two,environmental factors exert interactive effects on COVID-19 incidence.In particular,the interactions of natural factors can affect COVID-19 transmission in micro-and macro-ways by impacting SARS-CoV-2 survival,as well as human mobility and behaviors.Three,the impact of COVID-19 incidence on the environment lies in the fact that COVID-19-induced lockdowns caused air quality improvement,wildlife shifts and socio-economic depression.The additional value of this review is that we recommend future research perspectives and adaptation strategies regarding the interactions of the environment and COVID-19.Future research should be extended to cover both the effects of the environment on the COVID-19 pandemic and COVID-19-induced impacts on the environment.Future adaptation strategies should focus on sustainable environmental and public policy responses.展开更多
基金Qinglan Project of Jiangsu Province of China,Grant/Award Number:BK20180820National Natural Science Foundation of China,Grant/Award Numbers:12271255,61701243,71771125,72271126,12227808+2 种基金Major Projects of Natural Sciences of University in Jiangsu Province of China,Grant/Award Numbers:21KJA630001,22KJA630001Postgraduate Research and Practice Innovation Program of Jiangsu Province,Grant/Award Number:KYCX23_2343supported by the National Natural Science Foundation of China(no.72271126,12271255,61701243,71771125,12227808)。
文摘As human‐machine interaction(HMI)in healthcare continues to evolve,the issue of trust in HMI in healthcare has been raised and explored.It is critical for the development and safety of healthcare that humans have proper trust in medical machines.Intelligent machines that have applied machine learning(ML)technologies continue to penetrate deeper into the medical environment,which also places higher demands on intelligent healthcare.In order to make machines play a role in HMI in healthcare more effectively and make human‐machine cooperation more harmonious,the authors need to build good humanmachine trust(HMT)in healthcare.This article provides a systematic overview of the prominent research on ML and HMT in healthcare.In addition,this study explores and analyses ML and three important factors that influence HMT in healthcare,and then proposes a HMT model in healthcare.Finally,general trends are summarised and issues to consider addressing in future research on HMT in healthcare are identified.
文摘L-theanine has been shown to have a therapeutic effect on depression.However,whether L-theanine has an excellent preventive effect on depression in children and adolescents and what its mechanism is have not been well explained.Given the complexity of the pathogenesis of depression,this study investigated the preventive effect and mechanism of L-theanine on depression in juvenile rats by combining serum and hippocampal metabolomic strategies.Behavioral tests,hippocampal tissue sections,and serum and hippocampal biochemical indexes were studied,and the results confirmed the preventive effect of Ltheanine.Untargeted reversed-phase liquid chromatography-quadrupole-time-of-flight mass spectrometry and targeted hydrophilic interaction liquid chromatography-triple quadrupole mass spectrometry were developed to analyze the metabolism changes in the serum and hippocampus to screen for potential biomarkers related to L-theanine treatment.The results suggested that 28 abnormal metabolites in the serum and hippocampus that were considered as potential biomarkers returned to nearnormal levels after L-theanine administration.These biomarkers were involved in various metabolic pathways,mainly including amino acid metabolism and lipid metabolism.The levels of amino acids and neurotransmitters in the phenylalanine,tryptophan,and glutamic acid pathways were significantly reduced after L-theanine administration compared with chronic unpredictable mild stress-induced rats.In summary,L-theanine had a significant preventive effect on depression and achieved its preventive results on depression by regulating various aspects of the body,such as amino acids,lipids,and inflammation.This research systematically analyzed the mechanism of L-theanine in preventing depression and laid the foundation for applying L-theanine to prevent depression in children and adolescents.
基金supported by the National Key Research and Development Program of China (No. 2012CB955501)the Fundamental Research Funds for the Central Universities
文摘The coronavirus disease 2019(COVID-19)pandemic is an unprecedented worldwide health crisis.Many previous research studies have found and investigated its links with one or some natural or human environmental factors.However,a review on the relationship between COVID-19 incidence and both the natural and human environment is still lacking.This review summarizes the inter-correlation between COVID-19 incidence and environmental factors.Based on keyword searching,we reviewed 100 relevant peer-reviewed articles and other research literature published since January 2020.This review is focused on three main findings.One,we found that individual environmental factors have impacts on COVID-19 incidence,but with spatial heterogeneity and uncertainty.Two,environmental factors exert interactive effects on COVID-19 incidence.In particular,the interactions of natural factors can affect COVID-19 transmission in micro-and macro-ways by impacting SARS-CoV-2 survival,as well as human mobility and behaviors.Three,the impact of COVID-19 incidence on the environment lies in the fact that COVID-19-induced lockdowns caused air quality improvement,wildlife shifts and socio-economic depression.The additional value of this review is that we recommend future research perspectives and adaptation strategies regarding the interactions of the environment and COVID-19.Future research should be extended to cover both the effects of the environment on the COVID-19 pandemic and COVID-19-induced impacts on the environment.Future adaptation strategies should focus on sustainable environmental and public policy responses.