A convenient and environmentally friendly synthetic route from 2-vinylbenzimide to 3-hydroxy-isoindolinones through visible light-promoted transformations via iron/disulfide catalysis and molecular oxygen oxidation ha...A convenient and environmentally friendly synthetic route from 2-vinylbenzimide to 3-hydroxy-isoindolinones through visible light-promoted transformations via iron/disulfide catalysis and molecular oxygen oxidation has been developed.A range of 3-hydroxy-isoindolinones was obtained in moderate to good yields,which exhibit excellent functional group compatibility and broad substrate scope.Further mechanistic investigations proved that dioxetane might be a key intermediate being involved in the reaction.展开更多
基金supported by the National Natural Science Foundation of China(grant no.21776130,21878145 and 22078150).
文摘A convenient and environmentally friendly synthetic route from 2-vinylbenzimide to 3-hydroxy-isoindolinones through visible light-promoted transformations via iron/disulfide catalysis and molecular oxygen oxidation has been developed.A range of 3-hydroxy-isoindolinones was obtained in moderate to good yields,which exhibit excellent functional group compatibility and broad substrate scope.Further mechanistic investigations proved that dioxetane might be a key intermediate being involved in the reaction.
