The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,sp...The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense significance.Herein,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their ligands.This hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural bone.The resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and miR-26a.In vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,respectively.In vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral bone.This biomaterial delivery approach represents a significant toward improved osteochondral repair.展开更多
Hydrogen evolution production via electrolysis of water in alkaline solution is a promising mean of industrial hydrogen production.However,inefficiency and high cost restrict its industrialization development.Based on...Hydrogen evolution production via electrolysis of water in alkaline solution is a promising mean of industrial hydrogen production.However,inefficiency and high cost restrict its industrialization development.Based on extensive studies of experimental and theoretical investigations,two-dimensional(2D)materials are promising substitute of noble metals for hydrogen evolution reaction(HER)with low cost and high-efficiency.Herein,recent progress in 2D metal-organic frameworks(MOFs)for HER in alkaline electrolyte is systematically discussed and summarized.This review describes the strategies about how to design and optimize the structure of 2D MOF-based materials as HER electrocatalysts with well performance and aims to provide potential avenues for industrial hydrogen production.Additionally,the challenges and future directions ahead in this field are also proposed.展开更多
基金the Natural Science Foundation of China(Grant Nos.82072413,82101649)National Key Research and Development Program of China(Grant Nos.2021YFE0105400).
文摘The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense significance.Herein,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their ligands.This hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural bone.The resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and miR-26a.In vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,respectively.In vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral bone.This biomaterial delivery approach represents a significant toward improved osteochondral repair.
基金supported by the Overseas High-level Talents Plan of China and Guangdong Provincethe Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07C069)the National Natural Science Foundation of China(22075321,21821003,21890380)
文摘Hydrogen evolution production via electrolysis of water in alkaline solution is a promising mean of industrial hydrogen production.However,inefficiency and high cost restrict its industrialization development.Based on extensive studies of experimental and theoretical investigations,two-dimensional(2D)materials are promising substitute of noble metals for hydrogen evolution reaction(HER)with low cost and high-efficiency.Herein,recent progress in 2D metal-organic frameworks(MOFs)for HER in alkaline electrolyte is systematically discussed and summarized.This review describes the strategies about how to design and optimize the structure of 2D MOF-based materials as HER electrocatalysts with well performance and aims to provide potential avenues for industrial hydrogen production.Additionally,the challenges and future directions ahead in this field are also proposed.
