A Study on the Effect of Exercise Intervention on Function and Pain in Patients with Low Back Pain

Lower back pain(LBP)has a relatively high incidence across various age groups,characterized by discomfort in the lumbosacral and iliosacral regions above the gluteal striatum and within the region below the costal margins.Some patients also experience varying degrees of leg pain,with many experiencing prolonged and recurrent symptoms.International consensus confirms that exercise intervention is an effective treatment method for lower back pain,offering safe and efficient physical therapy.Extensive practical experience suggests that Pilates exercises can effectively regulate the strength of muscle tissue in the peripheral region of the spine,improve muscle endurance,and alleviate low back pain caused by muscular factors.This study analyzes the effects of exercise intervention on the function and pain of patients with lower back pain.It explores various exercise modalities,utilizes SPSS26 statistics to gather data,and draws conclusions with the aim of providing theoretical references for exercise interventions in patients with lower back pain.

Technical factors affecting the performance of anion exchange membrane water electrolyzer

Anion exchange membrane(AEM)electrolysis is a promising membrane-based green hydrogen production technology.However,AEM electrolysis still remains in its infancy,and the performance of AEM electrolyzers is far behind that of well-developed alkaline and proton exchange membrane electrolyzers.Therefore,breaking through the technical barriers of AEM electrolyzers is critical.On the basis of the analysis of the electrochemical performance tested in a single cell,electrochemical impedance spectroscopy,and the number of active sites,we evaluated the main technical factors that affect AEM electrolyzers.These factors included catalyst layer manufacturing(e.g.,catalyst,carbon black,and anionic ionomer)loadings,membrane electrode assembly,and testing conditions(e.g.,the KOH concentration in the electrolyte,electrolyte feeding mode,and operating temperature).The underlying mechanisms of the effects of these factors on AEM electrolyzer performance were also revealed.The irreversible voltage loss in the AEM electrolyzer was concluded to be mainly associated with the kinetics of the electrode reaction and the transport of electrons,ions,and gas-phase products involved in electrolysis.Based on the study results,the performance and stability of AEM electrolyzers were significantly improved.

Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy

Osteoarthritis is the most prevalent chronic and debilitating joint disease,resulting in huge medical and socioeconomic burdens.Intra-articular administration of agents is clinically used for pain management.However,the effectiveness is inapparent caused by the rapid clearance of agents.To overcome this issue,nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeutic agents.Given the therapeutic programs are inseparable from pathological progress of osteoarthritis,an ideal delivery system should allow the release of therapeutic agents upon specific features of disorders.In this review,we firstly introduce the pathological features of osteoarthritis and the design concept for accurate localization within cartilage for sustained drug release.Then,we review the interactions of nanoparticles with cartilage microenvironment and the rational design.Furthermore,we highlight advances in the therapeutic schemes according to the pathology signals.Finally,armed with an updated understanding of the pathological mechanisms,we place an emphasis on the development of“smart”bioresponsive and multiple modality nanoparticles on the near horizon to interact with the pathological signals.We anticipate that the exploration of nanoparticles by balancing the efficacy,safety,and complexity will lay down a solid foundation tangible for clinical translation.

Surface Passivation of Perovskite Solar Cells Toward Improved Efficiency and Stability

The advancement of perovskite solar cells(PVSCs)technology toward commercialized promotion needs high efficiency and optimum stability.By introducing a small molecular material such as tetratetracontane(TTC,CH3(CH2)42CH3)at the fullerene(C60)/perovskite interface of planar p-i-n PVSCs,we significantly reduced the interfacial traps,thereby suppressing electron recombination and facilitating electron extraction.Consequently,an improved efficiency of 20.05% was achieved with a high fill factor of 79.4%,which is one of the best performances for small molecular-modified PVSCs.Moreover,the hydrophobic TTC successfully protects the perovskite film from water damage.As a result,we realized a better long-term stability that maintains 87% of the initial efficiency after continuous exposure for 200 h in air.

The Application of Dead Trees or Dying Trees in Landscape Design

In the development of landscape design,plants have always been one of the important elements in the landscape design,and play a very important role in the landscape.In the selection and application of landscape plants,living plants have always occupied a dominant position,but the research and application of dead trees are few.People tend to think that dead plants are no longer valuable,and all dead trees should be removed or replaced.In a sense,this is a waste of resources,and also increases the cost of landscape.In fact,the proper use of dead trees in landscapes design is more likely to display the artistic conception and theme of the landscape.In many natural landscapes,large trees,ancient trees and precious tree die because of natural laws or natural disasters,forming withered trees.This kind of withered tree endows the site with certain historical connotation,which could narrate the history and ecological change of site to people and evoke the imagination of people to the past.In addition,these dead wood still have high economic,ornamental,ecological and cultural values.This study focused on dead trees and dying trees as its subject,analyzing the outstanding dead trees application cases in natural landscape,and discusses the different functions of dead tree,such as ecological function,ornamental function,cultural function and others.In addition,the Beijing Wild Duck Lake National Wetland Park will serve as a special experimental site,dead tree will be designed and applied in the lake of park.And based on these data analyses,the final chapter will return to address the research questions and offer advice on how to apply dead tree to urban landscape and further enhance the value of dead trees in landscape design.

Advanced Hydrogel systems for mandibular reconstruction

Mandibular defect becomes a prevalent maxillofacial disease resulting in mandibular dysfunctions and huge psychological burdens to the patients.Considering the routine presence of oral contaminations and aesthetic restoration of facial structures,the current clinical treatments are however limited,incapable to reconstruct the structural integrity and regeneration,spurring the need for cost-effective mandibular tissue engineering.Hydrogel systems possess great merit for mandibular reconstruction with precise involvement of cells and bioactive factors.In this review,current clinical treatments and distinct mode(s)of mandible formation and pathological resorption are summarized,followed by a review of hydrogel-related mandibular tissue engineering,and an update on the advanced fabrication of hydrogels with improved mechanical property,antibacterial ability,injectable form,and 3D bioprinted hydrogel constructs.The exploration of advanced hydrogel systems will lay down a solid foundation for a bright future with more biocompatible,effective,and personalized treatment in mandibular reconstruction.

Manganese catalyzed urea and polyurea synthesis using methanol as C1 source

The manganese-catalyzed dehydrogenative coupling between methanol and amines for the synthesis of ureas and polyureas is described. Importantly, catalytic efficiency can be improved by the newly synthesized MACHO ligands. Furthermore, this highly atom-economical protocol demonstrates a broad substrate scope with good functional group tolerance, producing H_(2)as the sole byproduct. Mechanistic studies disclose that formamide is formed through manganese-catalyzed formylation of amine with methanol.Subsequent dehydrogenation affords a transient isocyanate, which is attacked by another equivalent of amine to provide the final product.

Tuning Charge Transport of Oligopeptide Junctions via Interfacial Amino Acids

Comprehensive Summary,The charge transport through peptides can imitate the corresponding processes in more complicated proteins,enabling us to develop high-performance bioelectronic devices and to understand the mechanisms of biomolecular recognition and information transfer.While charge transport modulation through individual peptides has been achieved via various covalent strategies,the intermolecular modulation is still very challenging,which may capture the charge transport between proteins.To tackle this challenge,we used well-defined self-assembled monolayers(SAMs)of oligopeptides as a model to imitate the interface of proteins and explored an interfacial amino acid strategy for charge transport modulation.We showed that non-covalently interfaced charged amino acids(e.g.,arginine)effectively attenuated the charge transport of glutamic acid terminated polyglycine peptide SAMs.By analyzing the relationship of the charge transport with the molecular frontier orbital relative to the Fermi energy level of the electrode,the molecule-electrodes coupling(Γ),and the trends in skewness and kurtosis with voltage and the dielectric constant(εr),we showed that the attenuation was from the decreasedΓand the reduced polarizability.We present an efficient strategy to modulate the charge transport of oligopeptide-SAM junctions by intermolecular interactions,which will advance our understanding of charge transport in biological systems and facilitate developing future electronics.

Iron oxide nanoparticles with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy

Metal-based nanomaterials usually have broad-spectrum antibacterial properties,low biological toxicity and no drug resistance due to their intrinsic enzyme-like catalytic properties and external field(magnetic,thermal,acoustic,optical and electrical)responsiveness.Herein,iron oxide(Fe_(3)O_(4))nanoparticles(IONPs)synthesized by us have good biosafety,excellent photothermal conversion ability and peroxidase-like catalytic activity,which can be used to construct a photothermal-enzymes combined antibacterial treatment platform.IONPs with peroxide-like catalytic activity can induce H_(2)O_(2)to catalyze the production of·OH in a slightly acidic environment,thus achieving certain bactericidal effects and increasing the sensitivity of bacteria to heat.When stimulated by near-infrared light,the photothermal effect could destroy bacterial cell membranes,resulting in cleavage and inactivation of bacterial protein,DNA or RNA.Meanwhile,it can also improve the catalytic activity of peroxidase-like and promote IONPs to catalyze the production of more·OH for killing bacteria.After IONPs synergistic treatment,the antibacterial rate of Escherichia coli and Staphylococcus aureus reached nearly 100%.It also has an obvious killing effect on bacteria in infected wounds of mice and can effectively promote the healing of S.aureusinfected wounds,which has great application potential in clinical anti-infection treatment.

The quality attribute of watershed ecosystem is more important than the landscape attribute in controlling erosion of red soil in southern China

Landscape and quality attributes are major ecosystem characteristics closely associated with soil conservation service(SCS).However,the intrinsic mechanisms by which these two attributes influence SCS are still unclear.Therefore,this study quantitatively analyzed the landscape pattern,ecological quality,and SCS in the Lianshui River watershed(a typical soil and water loss area of red soil in southern China)and its sub-watersheds in 2019.The boosted regression tree model was used to explore the influence of 15 factors(i.e.,landscape and quality attributes)on SCS at the sub-watershed scale.According to the results,compared with the landscape attribute,the quality attribute of the watershed ecosystem could better explain the spatial heterogeneity of SCS across 66 sub-watersheds.The overall degree of influence of five quality factors on SCS reached 57.81%,with the highest being the normalized differential build-up and bare soil index(NDBSI),at 25.11%.Among 10 landscape factors,aggregation had the greatest influence on SCS,at 28.64%.The relationships between key influencing factors and SCS were nonmonotonic and non-linear,with threshold effects.For example,NDBSI values of 0.18e0.41 had a positive influence on SCS,while NDBSI values of 0.41e0.65 had a negative influence on SCS.The findings broaden our understanding of the response of SCS to changes in landscape and quality attributes at the sub-watershed scale,and could offer comprehensive support for soil erosion management in the watershed ecosystem.