The goal of delivering high-quality service has spurred research of 6G satellite communication networks.The limited resource-allocation problem has been addressed by next-generation satellite communication networks,es...The goal of delivering high-quality service has spurred research of 6G satellite communication networks.The limited resource-allocation problem has been addressed by next-generation satellite communication networks,especially multilayer networks with multiple low-Earth-orbit(LEO)and nonlow-Earth-orbit(NLEO)satellites.In this study,the resource-allocation problem of a multilayer satellite network consisting of one NLEO and multiple LEO satellites is solved.The NLEO satellite is the authorized user of spectrum resources and the LEO satellites are unauthorized users.The resource allocation and dynamic pricing problems are combined,and a dynamic gamebased resource pricing and allocation model is proposed to maximize the market advantage of LEO satellites and reduce interference between LEO and NLEO satellites.In the proposed model,the resource price is formulated as the dynamic state of the LEO satellites,using the resource allocation strategy as the control variable.Based on the proposed dynamic game model,an openloop Nash equilibrium is analyzed,and an algorithm is proposed for the resource pricing and allocation problem.Numerical simulations validate the model and algorithm.展开更多
The emergence and re-emergence of antibiotic-resistant bacteria,especially superbugs,are leading to complicated infections that are increasingly difficult to treat.Therefore,novel alternative antimicrobial therapies a...The emergence and re-emergence of antibiotic-resistant bacteria,especially superbugs,are leading to complicated infections that are increasingly difficult to treat.Therefore,novel alternative antimicrobial therapies are urgently needed to reduce the morbidity and mortality caused by antibiotic resistance.The development of biomimetic-based therapy is expected to provide innovative means for addressing this challenging task.As a kind of novel biomaterial,cytomembrane-based vesicles(MVs)continue to receive considerable attention in antimicrobial therapy owing to their inherent biocompatibility,design flexi-bility,and remarkable ability to interact with biological molecules or the surrounding environment.These remarkable cell-like properties and their inherent interaction with pathogens,toxins,and the immune system underlie MVs-based functional protein therapy and targeted delivery to develop advanced therapeutic strategies against bacterial infection.This review provides a fundamental under-standing of the characteristics and physiological functions of cytomembrane-based vesicles,focusing on their potential to combat bacterial infections,including detoxification,immune modulation,antibiotics delivery,and physical therapy.In addition,the future possibilities and remaining challenges for clinically implementing MVs in the field of antibacterial treatment are discussed.展开更多
基金This work is supported by the National Natural Science Foundation of China(Grant No.61971032)Fundamental Research Funds for the Central Universities(Grant No.FRF-TP-18-008A3).
文摘The goal of delivering high-quality service has spurred research of 6G satellite communication networks.The limited resource-allocation problem has been addressed by next-generation satellite communication networks,especially multilayer networks with multiple low-Earth-orbit(LEO)and nonlow-Earth-orbit(NLEO)satellites.In this study,the resource-allocation problem of a multilayer satellite network consisting of one NLEO and multiple LEO satellites is solved.The NLEO satellite is the authorized user of spectrum resources and the LEO satellites are unauthorized users.The resource allocation and dynamic pricing problems are combined,and a dynamic gamebased resource pricing and allocation model is proposed to maximize the market advantage of LEO satellites and reduce interference between LEO and NLEO satellites.In the proposed model,the resource price is formulated as the dynamic state of the LEO satellites,using the resource allocation strategy as the control variable.Based on the proposed dynamic game model,an openloop Nash equilibrium is analyzed,and an algorithm is proposed for the resource pricing and allocation problem.Numerical simulations validate the model and algorithm.
基金supported by the Major State Basic Research Development Program of China(2017YFA0205201)the National Natural Science Foundation of China(81925019 and U1705281)+1 种基金the Science Foundation of Fujian Province(2020Y4003)and Postdoctoral Science Foundation of China(2021T140399and 2021M691888).
文摘The emergence and re-emergence of antibiotic-resistant bacteria,especially superbugs,are leading to complicated infections that are increasingly difficult to treat.Therefore,novel alternative antimicrobial therapies are urgently needed to reduce the morbidity and mortality caused by antibiotic resistance.The development of biomimetic-based therapy is expected to provide innovative means for addressing this challenging task.As a kind of novel biomaterial,cytomembrane-based vesicles(MVs)continue to receive considerable attention in antimicrobial therapy owing to their inherent biocompatibility,design flexi-bility,and remarkable ability to interact with biological molecules or the surrounding environment.These remarkable cell-like properties and their inherent interaction with pathogens,toxins,and the immune system underlie MVs-based functional protein therapy and targeted delivery to develop advanced therapeutic strategies against bacterial infection.This review provides a fundamental under-standing of the characteristics and physiological functions of cytomembrane-based vesicles,focusing on their potential to combat bacterial infections,including detoxification,immune modulation,antibiotics delivery,and physical therapy.In addition,the future possibilities and remaining challenges for clinically implementing MVs in the field of antibacterial treatment are discussed.
