With the development of IoT and 5G technologies,more and more online resources are presented in trendy multimodal data forms over the Internet.Hence,effectively processing multimodal information is significant to the ...With the development of IoT and 5G technologies,more and more online resources are presented in trendy multimodal data forms over the Internet.Hence,effectively processing multimodal information is significant to the development of various online applications,including e-learning and digital health,to just name a few.However,most AI-driven systems or models can only handle limited forms of information.In this study,we investigate the correlation between natural language processing(NLP)and pattern recognition,trying to apply the mainstream approaches and models used in the computer vision(CV)to the task of NLP.Based on two different Twitter datasets,we propose a convolutional neural network based model to interpret the content of short text with different goals and application backgrounds.The experiments have demonstrated that our proposed model shows fairly competitive performance compared to the mainstream recurrent neural network based NLP models such as bidirectional long short-term memory(Bi-LSTM)and bidirectional gate recurrent unit(Bi-GRU).Moreover,the experimental results also demonstrate that the proposed model can precisely locate the key information in the given text.展开更多
Theranostic nanodrugs combining magnetic resonance imaging(MRI)and cancer therapy have attracted extensive interest in cancer diagnosis and treatment.Herein,a manganese(Mn)-doped mesoporous polydopamine(Mn-MPDA)nanodr...Theranostic nanodrugs combining magnetic resonance imaging(MRI)and cancer therapy have attracted extensive interest in cancer diagnosis and treatment.Herein,a manganese(Mn)-doped mesoporous polydopamine(Mn-MPDA)nanodrug incorporating the nitric oxide(NO)prodrug BNN6 and immune agonist R848 was developed.The nanodrug responded to the H^(+)and glutathione being enriched in tumor microenvironment to release R848 and Mn^(2+).The abundant Mn^(2+)produced through a Fenton-like reaction enabled a highly sensitive T1-T2 dual-mode MRI for monitoring the tumor accumulation process of the nanodrug,based on which an MRI-guided laser irradiation was achieved to trigger the NO gas therapy.Meanwhile,R848 induced the re-polarization of tumor-promoting M2-like macrophage to a tumoricidal M1 phenotype.Consequently,a potent synergistic antitumor effect was realized in mice bearing subcutaneous 4T1 breast cancer,which manifested the great promise of this multifunctional nanoplatform in cancer treatment.展开更多
基金This work was supported by the Australian Research Council Discovery Project(No.DP180101051)Natural Science Foundation of China(No.61877051).
文摘With the development of IoT and 5G technologies,more and more online resources are presented in trendy multimodal data forms over the Internet.Hence,effectively processing multimodal information is significant to the development of various online applications,including e-learning and digital health,to just name a few.However,most AI-driven systems or models can only handle limited forms of information.In this study,we investigate the correlation between natural language processing(NLP)and pattern recognition,trying to apply the mainstream approaches and models used in the computer vision(CV)to the task of NLP.Based on two different Twitter datasets,we propose a convolutional neural network based model to interpret the content of short text with different goals and application backgrounds.The experiments have demonstrated that our proposed model shows fairly competitive performance compared to the mainstream recurrent neural network based NLP models such as bidirectional long short-term memory(Bi-LSTM)and bidirectional gate recurrent unit(Bi-GRU).Moreover,the experimental results also demonstrate that the proposed model can precisely locate the key information in the given text.
基金supported by the National Natural Science Foundation of China(Nos.51933011 and 31971296)the Key Areas Research and Development Program of Guangzhou(No.202007020006)+3 种基金Guangdong Basic and Applied Basic Research Foundation(No.2020A1515010523)Guangzhou Science and Technology Bureau(No.202102010181)Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument(Sun Yat-sen University,No.2020B1212060077)approved by the Institutional Animal Care and Use Committee at Sun Yat-sen University(SYSU-IACUC-2021-000225).
文摘Theranostic nanodrugs combining magnetic resonance imaging(MRI)and cancer therapy have attracted extensive interest in cancer diagnosis and treatment.Herein,a manganese(Mn)-doped mesoporous polydopamine(Mn-MPDA)nanodrug incorporating the nitric oxide(NO)prodrug BNN6 and immune agonist R848 was developed.The nanodrug responded to the H^(+)and glutathione being enriched in tumor microenvironment to release R848 and Mn^(2+).The abundant Mn^(2+)produced through a Fenton-like reaction enabled a highly sensitive T1-T2 dual-mode MRI for monitoring the tumor accumulation process of the nanodrug,based on which an MRI-guided laser irradiation was achieved to trigger the NO gas therapy.Meanwhile,R848 induced the re-polarization of tumor-promoting M2-like macrophage to a tumoricidal M1 phenotype.Consequently,a potent synergistic antitumor effect was realized in mice bearing subcutaneous 4T1 breast cancer,which manifested the great promise of this multifunctional nanoplatform in cancer treatment.