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创伤后肘关节僵硬的病理机制及治疗进展
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作者 赵佳音 张晓萌 +2 位作者 张艳 李立 王瑞灯 《中华肩肘外科电子杂志》 2023年第2期181-185,共5页
肘关节僵硬是肘关节外伤后的常见问题,可导致上肢功能受损。软组织挛缩和异位骨形成是运动受限的两个主要原因。最近的研究已经阐明了导致这些疾病的许多途径,但确切的机制仍然未知。功能障碍的严重程度取决于初始创伤的性质和所使用的... 肘关节僵硬是肘关节外伤后的常见问题,可导致上肢功能受损。软组织挛缩和异位骨形成是运动受限的两个主要原因。最近的研究已经阐明了导致这些疾病的许多途径,但确切的机制仍然未知。功能障碍的严重程度取决于初始创伤的性质和所使用的治疗方法。根据病情的严重程度和潜在的违规结构,有几种不同的选择。手术治疗可能会显著改善运动,但很少能完全恢复,并发症并不少见。本文旨在阐述创伤后肘关节僵硬的病理机制及治疗进展。 展开更多
关键词 肘关节僵硬 异位骨化 手术治疗
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Micro-patterned hydroxyapatite/silk fibroin coatings on Mg-Zn-Y-Nd-Zr alloys for better corrosion resistance and cell behavior guidance 被引量:1
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作者 Lei CHANG Xiangrui LI +9 位作者 Xuhui TANG He ZHANG Ding HE Yujun WANG jiayin zhao Jingan LI Jun WANG Shijie ZHU Liguo WANG Shaokang GUAN 《Frontiers of Materials Science》 SCIE CSCD 2020年第4期413-425,共13页
In this study,a micro-patterned hydroxyapatite/silk fibroin(HA-SF)coating was firstly fabricated on the surface of Mg-Zn-Y-Nd-Zr alloy by template-assisted electrospraying technique coupling with spin coating techniqu... In this study,a micro-patterned hydroxyapatite/silk fibroin(HA-SF)coating was firstly fabricated on the surface of Mg-Zn-Y-Nd-Zr alloy by template-assisted electrospraying technique coupling with spin coating technique.Two types of micro-patterns were achieved with high contour accuracy,namely HA SF(line-pattern)and HA-SF(dot-pattern).The microstructure,composition,surface wettability and corrosion behaviors of the coatings were investigated by SEM,EDS,FTIR,XRD,water contact angle and potentiodynamic polarization test.The results revealed the hydrophilic nature of coatings and two orders of magnitude reduction of corrosion density(icorr)as compared with that of the substrate.All the micro-patterned surfaces promoted the attachment of MC3T3-E1 cells with visible filopodia after 1 d incubation.In addition,coatings with line pattern exhibited the superior guidance to cell migration as compared to dot pattern,and the preference of cell attachment in the convex zone was observed.In summary,the obtained micro-patterned HA-SF coatings possessed the remarkably improvement of anticorrosion ability and good efficacy in guidance of cell attachment and alignment,which can serve as a promising strategy for cellular response modulation at the interface of magnesium-based implants and bone. 展开更多
关键词 magnesium alloy silk fibroin HYDROXYAPATITE micro-patterned surface electrospraying technique
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