Nervous system injuries remain a great challenge due to limited natural tissue regeneration capabilities.Neural tissue engineering has been regarded as a promising approach for repairing nerve defects,which utilizes e...Nervous system injuries remain a great challenge due to limited natural tissue regeneration capabilities.Neural tissue engineering has been regarded as a promising approach for repairing nerve defects,which utilizes external biomaterial scaffolds to allow cells to migrate to the injury site and repair the tissue.Particularly,scaffolds with anisotropic structures biomimicking the native extracellular matrix(ECM)can effectively guide neural orientation and reconnection.Here,the advancements of scaffolds with anisotropic structures in the field of neural tissue engineering are presented.The fabrication strategies of scaffolds with anisotropic structures and their effects in vitro and in vivo are highlighted.We also discuss the challenges and provide a perspective of this field.展开更多
基金supported by the National Key R&D Program of China(Nos.2021YFA1101300 and 2020YFA0112503)Strate-gic Priority Research Program of the Chinese Academy of Sci-ence(No.XDA16010303)+6 种基金National Natural Science Foundation of China(Nos.82030029,81970882,and 92149304)Natural Science Foundation from Jiangsu Province(No.BE2019711)Science and Technology Department of Sichuan Province(No.2021YFS0371)Open Research Fund of State Key Laboratory of Genetic Engi-neering,Fudan University(No.SKLGE-2109)Guangdong Basic and Applied Basic Research Foundation(Nos.2021B1515120054 and 2019A1515111155)Shenzhen Fundamental Research Pro-gram(Nos.JCYJ20190814093401920,JCYJ20210324125608022,JCYJ20190813152616459,and JCYJ20190808120405672)Post-graduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX21_0080).
文摘Nervous system injuries remain a great challenge due to limited natural tissue regeneration capabilities.Neural tissue engineering has been regarded as a promising approach for repairing nerve defects,which utilizes external biomaterial scaffolds to allow cells to migrate to the injury site and repair the tissue.Particularly,scaffolds with anisotropic structures biomimicking the native extracellular matrix(ECM)can effectively guide neural orientation and reconnection.Here,the advancements of scaffolds with anisotropic structures in the field of neural tissue engineering are presented.The fabrication strategies of scaffolds with anisotropic structures and their effects in vitro and in vivo are highlighted.We also discuss the challenges and provide a perspective of this field.
