Bone and cartilage tissues are essential for movement and structure,yet diseases like osteoarthritis affect millions.Traditional therapies have limitations,necessitating innovative approaches.Organoid technology,lever...Bone and cartilage tissues are essential for movement and structure,yet diseases like osteoarthritis affect millions.Traditional therapies have limitations,necessitating innovative approaches.Organoid technology,leveraging stem cells’regenerative potential,offers a novel platform for disease modelling and therapy.This review focuses on advancements in bone/cartilage organoid technology,highlighting the role of stem cells,biomaterials,and external factors in organoid development.We discuss the implications of these organoids for regenerative medicine,disease research,and personalised treatment strategies,presenting organoids as a promising avenue for enhancing cartilage repair and bone regeneration.Bone/cartilage organoids will play a greater role in the treatment of bone/cartilage diseases in the future,and promote the progress of biological tissue engineering.展开更多
基金supported by National Natural Science Foundation of China(No.82272568)Sanming Project of Medicine in Shenzhen(No.SZSM202211019)+2 种基金Guangdong Basic and Applied Basic Research Foundation(Nos.2023A1515220019&2022A1515220056)“Merro”Young Physician Innovation and Development Project(No.GSKQNJJ-2023-004)Peking University Shenzhen Hospital Scientific Research Fund(No.KYQD2023297).
文摘Bone and cartilage tissues are essential for movement and structure,yet diseases like osteoarthritis affect millions.Traditional therapies have limitations,necessitating innovative approaches.Organoid technology,leveraging stem cells’regenerative potential,offers a novel platform for disease modelling and therapy.This review focuses on advancements in bone/cartilage organoid technology,highlighting the role of stem cells,biomaterials,and external factors in organoid development.We discuss the implications of these organoids for regenerative medicine,disease research,and personalised treatment strategies,presenting organoids as a promising avenue for enhancing cartilage repair and bone regeneration.Bone/cartilage organoids will play a greater role in the treatment of bone/cartilage diseases in the future,and promote the progress of biological tissue engineering.
