Decoherence of fiber laser sources is of great importance in imaging applications,and most current studies use ordinary multi-mode fibers(MMFs).Here,a newly designed single-trench fiber(STF)is investigated to reduce t...Decoherence of fiber laser sources is of great importance in imaging applications,and most current studies use ordinary multi-mode fibers(MMFs).Here,a newly designed single-trench fiber(STF)is investigated to reduce the spatial coherence of fiber light source and compared with MMFs.By bending two fibers with different turns,speckle contrast of a 0.8-m-long STF can be reduced from 0.13 to 0.08,while a 0.8-m-long MMF shows an inverse result.Through speckle contrast and decoupling-mode analysis,the reason of this inverse trend is revealed.Firstly,the STF supports more modes than the MMF due to its larger core diameter.Secondly,mode leak from the first core of the STF can couple to the second core when bending the STF.Thus,power distribution among high and low-order modes become more even,reducing the spatial coherence considerably.However,in the MMF,high-order modes become leaky modes and decrease slightly when bending the fiber.This work provides a new method to modulate coherence of light source and a new angle to study decoherence principle using special fibers.展开更多
Albumin nanoparticles(ANPs)offer unique advantages for antitumor drug delivery system,including non-immunogenicity and inherent tumor-targeting capacity.At present,only a few products,such as ABRAXANE®and FYARRO™...Albumin nanoparticles(ANPs)offer unique advantages for antitumor drug delivery system,including non-immunogenicity and inherent tumor-targeting capacity.At present,only a few products,such as ABRAXANE®and FYARRO™,have been approved for clinical applications.The poor affinity of doxorubicin(DOX)for albumin,coupled with its numerous severe adverse reactions,poses challenges in the fabrication of desirable albumin nanoparticles loaded with DOX.In this study,we developed prodrugs by conjugating fatty acids of varying lengths with DOX.Our aim was to investigate the balance between efficacy and safety through the selection of appropriate modules.We synthesized five pH-sensitive doxorubicin-fatty acid prodrugs.Compared to free DOX,all DOX prodrug ANPs exhibited a uniform size distribution with desirable sizes of 150 nm.Additionally,DOX prodrugs with hydrazone bonds remained intact in blood circulation while releasing DOX within tumor cells.Significantly,the characteristics of prodrug ANPs were considerably influenced by the length of fatty acids,impacting their in vivo pharmacokinetics,antitumor effectiveness and tumor accumulation.This research offers a detailed understanding of the length of fatty acid influence on DOX-fatty acid prodrug-based ANPs,and it builds a good platform for creating ANPs which prioritize high drug loading,high efficiency,and minimal side effects.展开更多
To the Editor:Globally,acute kidney injury(AKI)is a common life-threatening condition.AKI is more prevalent in elderly patients,with increasing mortality rates.Compared with younger patients,older patients with AKI ha...To the Editor:Globally,acute kidney injury(AKI)is a common life-threatening condition.AKI is more prevalent in elderly patients,with increasing mortality rates.Compared with younger patients,older patients with AKI have a higher risk of persistent injury and poorer prognoses.[1]Older individuals often have comorbidities,increasing their susceptibility to AKI.Kidney Disease:Improving Global Outcomes(KDIGO)criteria define and stage AKI based on the higher stage of AKI defined by either serum creatinine(SCr)level or urine output(UO).[2]However,the record of UO is difficult to access in clinic,the data on the value of UO combined with SCr for AKI diagnosis or prognosis in elderly patients are lacking.Therefore,the objectives of this study were to investigate whether UO would influence the classification of AKI and improve the accuracy of prediction of the clinical prognosis in elderly patients.展开更多
Mushrooms can be found in forests worldwide and have long been exploited as resources in developed economies because of their important agro-industrial,medicinal and commercial uses.For less developed countries,such a...Mushrooms can be found in forests worldwide and have long been exploited as resources in developed economies because of their important agro-industrial,medicinal and commercial uses.For less developed countries,such as those within the Greater Mekong Subregion,wild harvesting and mushroom cultivation provides a much-needed alternative source of income for rural households.However,this has led to over-harvesting and ultimately environmental degradation in certain areas,thus management guidelines allowing for a more sustained approach to the use of wild mushrooms is required.This article addresses a selection of the most popular and highly sought after edible mushrooms from Greater Mekong Subregion:Astraeus hygrometricus,Boletus edulis,Morchella conica,Ophiocordyceps sinensis,Phlebopus portentosus,Pleurotus giganteus,Termitomyces eurhizus,Thelephora ganbajun,Tricholoma matsuake,and Tuber indicum in terms of value,ecology and conservation.The greatest threat to these and many other mushroom species is that of habitat loss and over-harvesting of wild stocks,thus,by creating awareness of these issues we wish to enable a more sustainable use of these natural products.Thus our paper provides baseline data for these fungi so that future monitoring can establish the effects of continued harvesting on mushroom populations and the related host species.展开更多
Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic options.Activation of fibroblasts is a prominent feature of pulmonary fibrosis.Here we report that lncRNA DACH1(...Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic options.Activation of fibroblasts is a prominent feature of pulmonary fibrosis.Here we report that lncRNA DACH1(dachshund homolog 1)is downregulated in the lungs of IPF patients and in an experimental mouse model of lung fibrosis.LncDACH1 knockout mice develop spontaneous pulmonary fibrosis,whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation,collagen deposition and differentiation of mouse lung fibroblasts.Similarly,forced expression of LncDACH1 not only prevented bleomycin(BLM)-induced lung fibrosis,but also reversed established lung fibrosis in a BLM model.Mechanistically,LncDACH1 binding to the serine/arginine-rich splicing factor 1(SRSF1)protein decreases its activity and inhibits the accumulation of Ctnnb1.Enhanced expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung fibroblasts.Furthermore,loss of LncDACH1 promoted proliferation,differentiation,and extracellular matrix(ECM)deposition in mouse lung fibroblasts,whereas such effects were abolished by silencing of Ctnnb1.In addition,a conserved fragment of LncDACH1 alleviated hyperproliferation,ECM deposition and differentiation of MRC-5 cells driven by TGF-β1.Collectively,LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation,suggesting that LncDACH1 might be a potential therapeutic target for pulmonary fibrosis.展开更多
Contrary to the conventional detection method like radiography,the near infrared light source has been demonstrated to be suitable for dental imaging due to different reflectivity among enamel,dentin,and caries lesion...Contrary to the conventional detection method like radiography,the near infrared light source has been demonstrated to be suitable for dental imaging due to different reflectivity among enamel,dentin,and caries lesion.In this paper,three light sources with different bandwidths based on a transillumination method are compared.The contrast among enamel,dentin,and caries lesion is calculated in different situations.The experimental results show that the random fiber laser has the best comprehensive quality in dental imaging due to its high spectral density,low coherence,and deep penetration.This work provides a guidance for light source selection in dental imaging.展开更多
The Hoechst and DOX tunnel images of the DOX-C_(22) ANPs group at 4 h in Fig.4(a)were mistakenly used with the neighboring images of DOX-C_(26) ANPs group.The images were corrected as follows to be correspondence with...The Hoechst and DOX tunnel images of the DOX-C_(22) ANPs group at 4 h in Fig.4(a)were mistakenly used with the neighboring images of DOX-C_(26) ANPs group.The images were corrected as follows to be correspondence with the accurate merged image.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11974071 and 61635005)in part by Sichuan Science and Technology Program,China(Grant No.2018HH0148)。
文摘Decoherence of fiber laser sources is of great importance in imaging applications,and most current studies use ordinary multi-mode fibers(MMFs).Here,a newly designed single-trench fiber(STF)is investigated to reduce the spatial coherence of fiber light source and compared with MMFs.By bending two fibers with different turns,speckle contrast of a 0.8-m-long STF can be reduced from 0.13 to 0.08,while a 0.8-m-long MMF shows an inverse result.Through speckle contrast and decoupling-mode analysis,the reason of this inverse trend is revealed.Firstly,the STF supports more modes than the MMF due to its larger core diameter.Secondly,mode leak from the first core of the STF can couple to the second core when bending the STF.Thus,power distribution among high and low-order modes become more even,reducing the spatial coherence considerably.However,in the MMF,high-order modes become leaky modes and decrease slightly when bending the fiber.This work provides a new method to modulate coherence of light source and a new angle to study decoherence principle using special fibers.
基金the National Key R&D Program of China(No.2022YFE0111600)National Natural Science Foundation of China(Nos.82272151 and 82204318)。
文摘Albumin nanoparticles(ANPs)offer unique advantages for antitumor drug delivery system,including non-immunogenicity and inherent tumor-targeting capacity.At present,only a few products,such as ABRAXANE®and FYARRO™,have been approved for clinical applications.The poor affinity of doxorubicin(DOX)for albumin,coupled with its numerous severe adverse reactions,poses challenges in the fabrication of desirable albumin nanoparticles loaded with DOX.In this study,we developed prodrugs by conjugating fatty acids of varying lengths with DOX.Our aim was to investigate the balance between efficacy and safety through the selection of appropriate modules.We synthesized five pH-sensitive doxorubicin-fatty acid prodrugs.Compared to free DOX,all DOX prodrug ANPs exhibited a uniform size distribution with desirable sizes of 150 nm.Additionally,DOX prodrugs with hydrazone bonds remained intact in blood circulation while releasing DOX within tumor cells.Significantly,the characteristics of prodrug ANPs were considerably influenced by the length of fatty acids,impacting their in vivo pharmacokinetics,antitumor effectiveness and tumor accumulation.This research offers a detailed understanding of the length of fatty acid influence on DOX-fatty acid prodrug-based ANPs,and it builds a good platform for creating ANPs which prioritize high drug loading,high efficiency,and minimal side effects.
基金Special Scientific Research Project of Military Health Care(No.21BJZ17)
文摘To the Editor:Globally,acute kidney injury(AKI)is a common life-threatening condition.AKI is more prevalent in elderly patients,with increasing mortality rates.Compared with younger patients,older patients with AKI have a higher risk of persistent injury and poorer prognoses.[1]Older individuals often have comorbidities,increasing their susceptibility to AKI.Kidney Disease:Improving Global Outcomes(KDIGO)criteria define and stage AKI based on the higher stage of AKI defined by either serum creatinine(SCr)level or urine output(UO).[2]However,the record of UO is difficult to access in clinic,the data on the value of UO combined with SCr for AKI diagnosis or prognosis in elderly patients are lacking.Therefore,the objectives of this study were to investigate whether UO would influence the classification of AKI and improve the accuracy of prediction of the clinical prognosis in elderly patients.
基金the National Natural Science Foundation of China(81901790 and 21803006)the Natural Science Foundation of Beijing(7204274)+1 种基金the Fundamental Research Funds for the Central Universitiesthe Interdisciplinary Medicine Seed Fund of Peking University(BMU2017MX015)。
基金funding this project.Also,value added products from basidiomycetes:Putting Thailand’s biodiversity to use(BRN049/2553)the French-Thai cooperation PHC SIAM 2011(project 25587RA)+2 种基金the National Research Council of Thailand(NRCT)the project-Taxonomy,Phylogeny and cultivation of Lentinus species in northern Thailand(NRCT/55201020007)Fund(TRF)project number BRG5580009 and Mae Fah Luang University,the project-Taxonomy,Phylogeny and cultivation of Lentinus species in northern Thailand(MFU/54101020048)are thanked for providing support to this study.
文摘Mushrooms can be found in forests worldwide and have long been exploited as resources in developed economies because of their important agro-industrial,medicinal and commercial uses.For less developed countries,such as those within the Greater Mekong Subregion,wild harvesting and mushroom cultivation provides a much-needed alternative source of income for rural households.However,this has led to over-harvesting and ultimately environmental degradation in certain areas,thus management guidelines allowing for a more sustained approach to the use of wild mushrooms is required.This article addresses a selection of the most popular and highly sought after edible mushrooms from Greater Mekong Subregion:Astraeus hygrometricus,Boletus edulis,Morchella conica,Ophiocordyceps sinensis,Phlebopus portentosus,Pleurotus giganteus,Termitomyces eurhizus,Thelephora ganbajun,Tricholoma matsuake,and Tuber indicum in terms of value,ecology and conservation.The greatest threat to these and many other mushroom species is that of habitat loss and over-harvesting of wild stocks,thus,by creating awareness of these issues we wish to enable a more sustainable use of these natural products.Thus our paper provides baseline data for these fungi so that future monitoring can establish the effects of continued harvesting on mushroom populations and the related host species.
基金supported by the National Natural Science Foundation of China (32171127 and 91949109)the HMU Marshal Initiative Funding (HMUMIF-21023, China)+3 种基金the Major Scientific Fund Project of Heilongjiang Province (ZD2019H001, China)the CAMS Innovation Fund for Medical Sciences (CIFMS, 2019-I2M5-078, China)the Guangdong Province Basic and Applied Basic Research Fund (2021A1515111049, China)Postgraduate Research and Practice Innovation Program of HMU (YJSCX202015HYD, China)
文摘Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic options.Activation of fibroblasts is a prominent feature of pulmonary fibrosis.Here we report that lncRNA DACH1(dachshund homolog 1)is downregulated in the lungs of IPF patients and in an experimental mouse model of lung fibrosis.LncDACH1 knockout mice develop spontaneous pulmonary fibrosis,whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation,collagen deposition and differentiation of mouse lung fibroblasts.Similarly,forced expression of LncDACH1 not only prevented bleomycin(BLM)-induced lung fibrosis,but also reversed established lung fibrosis in a BLM model.Mechanistically,LncDACH1 binding to the serine/arginine-rich splicing factor 1(SRSF1)protein decreases its activity and inhibits the accumulation of Ctnnb1.Enhanced expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung fibroblasts.Furthermore,loss of LncDACH1 promoted proliferation,differentiation,and extracellular matrix(ECM)deposition in mouse lung fibroblasts,whereas such effects were abolished by silencing of Ctnnb1.In addition,a conserved fragment of LncDACH1 alleviated hyperproliferation,ECM deposition and differentiation of MRC-5 cells driven by TGF-β1.Collectively,LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation,suggesting that LncDACH1 might be a potential therapeutic target for pulmonary fibrosis.
基金supported in part by the National Natural Science Foundation of China(Grant Nos.11974071 and 61635005)in part by Sichuan Science and Technology Program(Grant No.2018HH0148)。
文摘Contrary to the conventional detection method like radiography,the near infrared light source has been demonstrated to be suitable for dental imaging due to different reflectivity among enamel,dentin,and caries lesion.In this paper,three light sources with different bandwidths based on a transillumination method are compared.The contrast among enamel,dentin,and caries lesion is calculated in different situations.The experimental results show that the random fiber laser has the best comprehensive quality in dental imaging due to its high spectral density,low coherence,and deep penetration.This work provides a guidance for light source selection in dental imaging.
文摘The Hoechst and DOX tunnel images of the DOX-C_(22) ANPs group at 4 h in Fig.4(a)were mistakenly used with the neighboring images of DOX-C_(26) ANPs group.The images were corrected as follows to be correspondence with the accurate merged image.