To date,the overall response rate of PD-1 blockade remains unsatisfactory,partially due to limited understanding of tumor immune microenvironment(TIME).B-cell lymphoma 9(BCL9),a key transcription co-activator of the W...To date,the overall response rate of PD-1 blockade remains unsatisfactory,partially due to limited understanding of tumor immune microenvironment(TIME).B-cell lymphoma 9(BCL9),a key transcription co-activator of the Wnt pathway,is highly expressed in cancers.By genetic depletion and pharmacological inhibition of BCL9 in tumors,we found that BCL9 suppression reduced tumor growth.展开更多
Dear Editor,Prostate cancer(PC)is one of the most common noncutaneous cancers among men worldwide with a relatively higher incidence and mortality rate.1 Conventional screening for prostate cancer relies on prostate-s...Dear Editor,Prostate cancer(PC)is one of the most common noncutaneous cancers among men worldwide with a relatively higher incidence and mortality rate.1 Conventional screening for prostate cancer relies on prostate-specific antigen(PSA),a valuable biomarker but has some deficiencies.Radical prostatectomy,androgen ablation,and radiotherapy are still commonly used treatments for localized prostate cancer.展开更多
基金This study was partially supported by grants from National Natural Science Foundation of China(81872895 and 82073881 to D.Z.,81872915,82073904,and 82011530150 to M.-W.W.)Shanghai Municipal Education Commission(Shanghai Top-Level University Capacity Building Program DGF817029-04 to M.-W.W.)+1 种基金Shanghai Science and Technology Commission(18ZR1403900,20430713600,and 18JC1413800 to D.Z.)Fudan-SIMM Joint Research Fund(FU-SIMM20181010 to D.Z.and D.Y.).
文摘To date,the overall response rate of PD-1 blockade remains unsatisfactory,partially due to limited understanding of tumor immune microenvironment(TIME).B-cell lymphoma 9(BCL9),a key transcription co-activator of the Wnt pathway,is highly expressed in cancers.By genetic depletion and pharmacological inhibition of BCL9 in tumors,we found that BCL9 suppression reduced tumor growth.
基金This work was partially supported by grants from the National Natural Science Foundation of China 81872915(M.W.W.),81673470(C.H.Z.),81773792(D.H.Y.),and 81973373(D.H.Y.)the National Science&Technology Major Project"Key New Drug Creation and Manufacturing Program"of China(2018ZX09735-001 to M.W.W.and 2018ZX09711002-002-005 to D.H.Y.)+6 种基金the National Key R&D Program of China(2017YFC0114303 to B.D.and 2018YFA0507000 to M.W.W.)Strategic Priority Research Program of the Chinese Academy of Sciences XDA12020347(M.W.W.)2016 CAS Key Laboratory of Receptor Research External Collaboration Project(B.D.)the Natural Science Foundation of Shanghai Municipality 16ZR1406500(D.B.)the Guide Project of Science and Technology Commission of Shanghai Municipality 17411963100(B.D.)the Shanghai Cancer Research Charity Center Fund(B.D.)Novo Nordisk-CAS Research Fund NNCAS-2017-1-CC(D.H.Y.).
文摘Dear Editor,Prostate cancer(PC)is one of the most common noncutaneous cancers among men worldwide with a relatively higher incidence and mortality rate.1 Conventional screening for prostate cancer relies on prostate-specific antigen(PSA),a valuable biomarker but has some deficiencies.Radical prostatectomy,androgen ablation,and radiotherapy are still commonly used treatments for localized prostate cancer.
