Scedosporium boydii is considered an opportunist fungal pathogen in immunocompromised patients.It also causes serious and fatal central nervous system infections.In this study,a man with brain abscesses infected with ...Scedosporium boydii is considered an opportunist fungal pathogen in immunocompromised patients.It also causes serious and fatal central nervous system infections.In this study,a man with brain abscesses infected with S.boydii was diagnosed using multiple methods,including microscopy,culture combined with Matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MOLDI-TOF MS),internal transcribed spacer sequencing and Metagenomic next-generation sequencing(mNGS).This successful diagnosis highlights the importance of using a variety of techniques to identify and treat infections caused by this dangerous fungus.展开更多
Dear Editor,Clinical and anatomic investigations strongly suggest that a low orbital cerebrospinal fluid pressure (CSFP), parallel to an elevated intraocular pressure (IOP), may have a role in the pathogenesis of opti...Dear Editor,Clinical and anatomic investigations strongly suggest that a low orbital cerebrospinal fluid pressure (CSFP), parallel to an elevated intraocular pressure (IOP), may have a role in the pathogenesis of optic neuropathy (Ren et al., 2011, Wang et al., 2012). Optic neuropathy including glaucoma demonstrated structural alterations in the optic nerve head (ONH)and retinal nerve fiber layer (RNFL), as well as functional abnormalities such as visual field (VF) that eventually cause severe visual impairment and blindness.展开更多
文摘Scedosporium boydii is considered an opportunist fungal pathogen in immunocompromised patients.It also causes serious and fatal central nervous system infections.In this study,a man with brain abscesses infected with S.boydii was diagnosed using multiple methods,including microscopy,culture combined with Matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MOLDI-TOF MS),internal transcribed spacer sequencing and Metagenomic next-generation sequencing(mNGS).This successful diagnosis highlights the importance of using a variety of techniques to identify and treat infections caused by this dangerous fungus.
基金supported by the National Natural Science Foundation of China (81271005 and 81300767)the Beijing Natural Science Foundation (7122038 and 7162037)。
文摘Dear Editor,Clinical and anatomic investigations strongly suggest that a low orbital cerebrospinal fluid pressure (CSFP), parallel to an elevated intraocular pressure (IOP), may have a role in the pathogenesis of optic neuropathy (Ren et al., 2011, Wang et al., 2012). Optic neuropathy including glaucoma demonstrated structural alterations in the optic nerve head (ONH)and retinal nerve fiber layer (RNFL), as well as functional abnormalities such as visual field (VF) that eventually cause severe visual impairment and blindness.
