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Ultra-Robust and High-Performance Rotational Triboelectric Nanogenerator by Bearing Charge Pumping 被引量:1
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作者 Xianpeng Fu Yuhan Qin +6 位作者 Zhi Zhang Guoxu Liu jie cao Beibei Fan Zhaozheng Wang Zheng Wang Chi Zhang 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2024年第2期343-349,共7页
As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in pra... As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in practical applications.Here,an ultra-robust and high-performance rotational triboelectric nanogenerator(R-TENG)by bearing charge pumping is proposed.The R-TENG composes of a pumping TENG(P-TENG),an output TENG(O-TENG),a voltage-multiplying circuit(VMC),and a buffer capacitor.The P-TENG is designed with freestanding mode based on a rolling ball bearing,which can also act as the rotating mechanical energy harvester.The output low charge from the P-TENG is accumulated and pumped to the non-contact O-TENG,which can simultaneously realize ultralow mechanical wear and high output performance.The matched instantaneous power of R-TENG is increased by 32 times under 300 r/min.Furthermore,the transferring charge of R-TENG can remain 95%during 15 days(6.4×10^(6)cycles)continuous operation.This work presents a realizable method to further enhance the durability of TENG,which would facilitate the practical applications of high-performance TENG in harvesting distributed ambient micro mechanical energy. 展开更多
关键词 bearing charge pumping triboelectric nanogenerators ultralow mechanical wear ultra-robust voltage-multiplying circuit
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Secoemestrin C Ameliorates Psoriasis-like Skin Inflammation in Mice by Suppressing the TNF-α/NF-κB Signaling Pathway
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作者 Zhi-bin ZHU Meng-jie LIU +2 位作者 Jing WANG Zhou SHU jie cao 《Current Medical Science》 SCIE CAS 2024年第1期232-240,共9页
Objective Secoemestrin C(SC),an epitetrathiodioxopiperazine isolated from Aspergillus nidulans,has been previously reported to have immunomodulatory and hepatoprotective effects against acute autoimmune hepatitis.Howe... Objective Secoemestrin C(SC),an epitetrathiodioxopiperazine isolated from Aspergillus nidulans,has been previously reported to have immunomodulatory and hepatoprotective effects against acute autoimmune hepatitis.However,the effect of SC on regulating the inflammation and its underlying mechanisms in the pathogenesis of psoriasis remain unclear.This study aimed to evaluate the effects of SC on inflammatory dermatosis both in vitro and in vivo.Methods In vitro,HaCaT cells were induced with tumor necrosis factor-alpha(TNF-α,10 ng/mL)to establish an inflammatory injury model,and the expression of nuclear transcription factor-κB(NF-κB)pathway components was measured using qRT-PCR and Western blotting.An in vivo mouse model of imiquimod(IMQ)-induced psoriasis-like skin inflammation was used to evaluate the effectiveness of SC in alleviating psoriasis.Results SC significantly blocked the activation of NF-κB signaling in TNF-α-stimulated HaCaT cells.In addition,systemic and local administration of SC improved psoriatic dermatitis in the IMQ-induced mouse model.SC reduced skin scale and significantly inhibited the secretion of inflammatory factors in skin lesions.Conclusion The protective effect of SC against psoriatic-associated inflammation reveals its potential therapeutic value for treating psoriasis. 展开更多
关键词 secoemestrin C(SC) PSORIASIS tumor necrosis factor-alpha(TNF-α) nuclear transcription factor-kB(NF-kB) inflammation
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Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study
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作者 Shi-Yu ZHOU Fang-Chao LIU +12 位作者 Shu-Feng CHEN Jian-Xin LI jie cao Ke-Yong HUANG Zheng-Hao TANG Feng-Chao LIANG Dong-Sheng HU Lian-Cheng ZHAO Ying LI Jian-Feng HUANG Xiang-Feng LU Bin LU Dong-Feng GU 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2024年第7期751-759,共9页
BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH) in reducing cardiovascular risk.However,its role in subclinical atherosclerosis(SA) progression remains unclear.We aim to ... BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH) in reducing cardiovascular risk.However,its role in subclinical atherosclerosis(SA) progression remains unclear.We aim to examine the association of CVH,estimated by the American Heart Association's new Life's Essential 8(LE8),with the progression of SA.METHODS This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for5.7 years.The LE8 score(range,0–100) consisted of blood pressure,lipids,glucose,body mass index,smoking status,diet health,physical activity and sleep health was evaluated in 1998 and 2008–2009.Progression of SA was determined by carotid plaque and coronary artery calcification(CAC) in 2008–2009 and 2013–2014.Log-binomial regression model was used to estimate the association of LE8 score with SA progression.RESULTS Each 10 points increment in LE8 score was associated with 15.2%(RR:0.848,95% CI:0.797–0.902),17.7%(RR:0.823,95% CI:0.766–0.884) and 12.0%(RR:0.880,95% CI:0.845–0.916) lower risks of carotid plaque,CAC and overall SA progression,respectively.Compared with participants with non-ideal CVH at both visits,the participants with ideal CVH at both visits had39.1%(RR:0.609,95% CI:0.494–0.752),41.0%(RR:0.590,95% CI:0.456–0.764) and 29.7%(RR:0.703,95% CI:0.598–0.825) lower risks of carotid plaque,CAC and overall SA progression,respectively.CONCLUSIONS Higher LE8 scores were associated with lower risks of SA progression.Besides,long-term maintenance of optimal CVH was more beneficial to prevent SA progression. 展开更多
关键词 ATHEROSCLEROSIS PROSPECTIVE CARDIOVASCULAR
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Reform and Development of English Teaching in Colleges and Universities with the Integration of ChatGPT Technology
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作者 jie cao Jing cao Yuan Tao 《Journal of Contemporary Educational Research》 2024年第6期71-76,共6页
As an artificial intelligence-powered language generation model based on natural language processing,ChatGPT,like other artificial intelligence technologies,possesses super real-time dialogue capabilities and is consi... As an artificial intelligence-powered language generation model based on natural language processing,ChatGPT,like other artificial intelligence technologies,possesses super real-time dialogue capabilities and is considered an innovative and intelligent auxiliary teaching tool in the field of language learning.This article first analyzes the current state of development of artificial intelligence technologies such as ChatGPT.Secondly,it examines the challenges encountered in the reform and development of English teaching in colleges and universities in China.Lastly,it summarizes the applications and recommendations for using ChatGPT technology in college-level English teaching. 展开更多
关键词 ChatGPT Artificial intelligence technologies College English Reform and development
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冷拔小口径16MnNiV无缝钢管的显微组织与力学性能演变规律
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作者 李涵 李昭东 +3 位作者 曹杰 张可 曹燕光 雍岐龙 《材料工程》 EI CAS CSCD 北大核心 2023年第9期117-127,共11页
16MnNiV钢由16Mn,16MnV钢发展而来,棒坯经热穿孔轧制成为管坯后,再进行冷轧、冷拔和热处理,用于制备高强度小口径的高压油管。通过光学显微镜(OM)、扫描电子显微镜(SEM)、电子背散射衍射技术(EBSD)、透射电子显微镜(TEM)以及物理化学相... 16MnNiV钢由16Mn,16MnV钢发展而来,棒坯经热穿孔轧制成为管坯后,再进行冷轧、冷拔和热处理,用于制备高强度小口径的高压油管。通过光学显微镜(OM)、扫描电子显微镜(SEM)、电子背散射衍射技术(EBSD)、透射电子显微镜(TEM)以及物理化学相分析法研究了在拉拔制管过程中小口径16MnNiV无缝钢管显微组织与力学性能的演变,揭示了其微观组织以及第二相析出的变化规律,并计算了其强化增量,相关结果可以为高强度高压油管的材料研制和性能提升提供参考。结果表明,实验钢在拉拔制管过程中的主要组织为铁素体与珠光体,随着冷拔工艺的进行,实验钢的有效晶粒尺寸呈现减小趋势。从析出情况来看,一次拉拔后退火会增加其析出总量,二次拉拔后退火不改变其析出总量。通过EDS分析得知,析出的第二相粒子为VC。经过冷拔过程以及不同的热处理工艺,实验钢的抗拉强度和屈服强度均逐渐增加,伸长率逐渐降低。强化机理计算可知,由于冷拔过程变形量较大,实验钢屈服强度的提高主要来自于细晶强化的贡献。ϕ6.35 mm×3 mm圆管经过热处理后的抗拉强度达到960 MPa以上,屈服强度达到864 MPa,伸长率达到15.5%,相比于其他16Mn系高压油管产品,力学性能得到较大提升,同时获得了良好的强塑性匹配。 展开更多
关键词 无缝钢管 冷拔 铁素体 VC析出 强化增量 力学性能
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Interdecadal Variations of the March Atmospheric Heat Source over the Southeast Asian Low-Latitude Highlands
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作者 Dayong WEN jie cao 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第9期1584-1596,共13页
Based on the fifth-generation reanalysis dataset from the European Centre for Medium-Range Weather Forecasts for 1979–2019,we investigated the effects of the circumglobal teleconnection(CGT)on the interdecadal variat... Based on the fifth-generation reanalysis dataset from the European Centre for Medium-Range Weather Forecasts for 1979–2019,we investigated the effects of the circumglobal teleconnection(CGT)on the interdecadal variation of the March atmospheric heat source(AHS)over the Southeast Asian low-latitude highlands(SEALLH).The dominant mode of the March AHS over the SEALLH features a monopole structure with an 8–11-year period.Decadal variations in the AHS make an important contribution to the 11-year low-pass filtered component of the AHS index,whichexplains 54.3%of the total variance.The CGT shows a clear interdecadal variation,which explains 59.3%of the total variance.The March AHS over the SEALLH is significantly related to the CGT on interdecadal timescales.When the CGT is optimally excited by a significant cyclonic vorticity source near northern Africa(i.e.,in its positive phase),the SEALLH is dominated by anomalous southerly winds and ascending motions on the east of the anomalous cyclone.The enhanced advection and upward transfer result in a high-enthalpy air mass that converges into and condenses over the SEALLH,leading to a largerthan-average March AHS over this region.The key physical processes revealed by this diagnostic analysis are supported by numerical experiments. 展开更多
关键词 interdecadal variation atmospheric heat source circumglobal teleconnection low-latitude highlands Rossby wave source
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Lifestyle improvement and the reduced risk of cardiovascular disease:the China-PAR project
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作者 Ying-Ying JIANG Fang-Chao LIU +16 位作者 Chong SHEN Jian-Xin LI Ke-Yong HUANG Xue-Li YANG Ji-Chun CHEN Xiao-Qing LIU jie cao Shu-Feng CHEN Ling YU Ying-Xin ZHAO Xian-Ping WU Lian-Cheng ZHAO Ying LI Dong-Sheng HU Jian-Feng HUANG Xiang-Feng LU Dong-Feng GU 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2023年第11期779-787,共9页
BACKGROUND The benefits of healthy lifestyles are well recognized. However, the extent to which improving unhealthy lifestyles reduces cardiovascular disease(CVD) risk needs to be discussed. We evaluated the impact of... BACKGROUND The benefits of healthy lifestyles are well recognized. However, the extent to which improving unhealthy lifestyles reduces cardiovascular disease(CVD) risk needs to be discussed. We evaluated the impact of lifestyle improvement on CVD incidence using data from the China-PAR project(Prediction for Atherosclerotic Cardiovascular Disease Risk in China).METHODS A total of 12,588 participants free of CVD were followed up for three visits after the baseline examination. Changes in four lifestyle factors(LFs)(smoking, diet, physical activity, and alcohol consumption) were assessed through questionnaires from the baseline to the first follow-up visit. Cox proportional hazard models were used to estimate hazard ratios(HRs) and corresponding 95% confidence intervals(CIs). The risk advancement periods(RAPs: the age difference between exposed and unexposed participants reaching the same incident CVD risk) and population-attributable risk percentage(PAR%) were also calculated.RESULTS A total of 909 incident CVD cases occurred over a median follow-up of 11.14 years. Compared with maintaining 0-1healthy LFs, maintaining 3–4 healthy LFs was associated with a 40% risk reduction of incident CVD(HR = 0.60, 95% CI: 0.45–0.79)and delayed CVD risk by 6.31 years(RAP:-6.31 [-9.92,-2.70] years). The PAR% of maintaining 3–4 unhealthy LFs was 22.0%compared to maintaining 0-1 unhealthy LFs. Besides, compared with maintaining two healthy LFs, improving healthy LFs from 2to 3–4 was associated with a 23% lower risk of CVD(HR = 0.77, 95% CI: 0.60–0.98).CONCLUSIONS Long-term sustenance of healthy lifestyles or improving unhealthy lifestyles can reduce and delay CVD risk. 展开更多
关键词 HAZARD maintaining ALCOHOL
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A New Method for Image Tamper Detection Based on an Improved U-Net
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作者 jie Zhang Jianxun Zhang +2 位作者 Bowen Li jie cao Yifan Guo 《Intelligent Automation & Soft Computing》 SCIE 2023年第9期2883-2895,共13页
With the improvement of image editing technology,the threshold of image tampering technology decreases,which leads to a decrease in the authenticity of image content.This has also driven research on image forgery dete... With the improvement of image editing technology,the threshold of image tampering technology decreases,which leads to a decrease in the authenticity of image content.This has also driven research on image forgery detection techniques.In this paper,a U-Net with multiple sensory field feature extraction(MSCU-Net)for image forgery detection is proposed.The proposed MSCU-Net is an end-to-end image essential attribute segmentation network that can perform image forgery detection without any pre-processing or post-processing.MSCU-Net replaces the single-scale convolution module in the original network with an improved multiple perceptual field convolution module so that the decoder can synthesize the features of different perceptual fields use residual propagation and residual feedback to recall the input feature information and consolidate the input feature information to make the difference in image attributes between the untampered and tampered regions more obvious,and introduce the channel coordinate confusion attention mechanism(CCCA)in skip-connection to further improve the segmentation accuracy of the network.In this paper,extensive experiments are conducted on various mainstream datasets,and the results verify the effectiveness of the proposed method,which outperforms the state-of-the-art image forgery detection methods. 展开更多
关键词 Forgery detection multiple receptive fields cyclic residuals U-Net channel coordinate confusion attention
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Data Layout and Scheduling Tasks in a Meteorological Cloud Environmen
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作者 Kunfu Wang Yongsheng Hao jie cao 《Intelligent Automation & Soft Computing》 SCIE 2023年第7期905-920,共16页
With the proliferation of the internet,big data continues to grow exponentially,and video has become the largest source.Video big data intro-duces many technological challenges,including compression,storage,trans-miss... With the proliferation of the internet,big data continues to grow exponentially,and video has become the largest source.Video big data intro-duces many technological challenges,including compression,storage,trans-mission,analysis,and recognition.The increase in the number of multimedia resources has brought an urgent need to develop intelligent methods to organize and process them.The integration between Semantic link Networks and multimedia resources provides a new prospect for organizing them with their semantics.The tags and surrounding texts of multimedia resources are used to measure their semantic association.Two evaluation methods including clustering and retrieval are performed to measure the semantic relatedness between images accurately and robustly.A Fuzzy Rule-Based Model for Semantic Content Extraction is designed which performs classification with fuzzy rules.The features extracted are trained with the neural network where each network contains several layers among them each layer of neurons is dedicated to measuring the weight towards different semantic events.Each neuron measures its weight according to different features like shape,size,direction,speed,and other features.The object is identified by subtracting the background features and trained to detect based on the features like size,shape,and direction.The weight measurement is performed according to the fuzzy rules and based on the weight measures.These frameworks enhance the video analytics feature and help in video surveillance systems with better accuracy and precision. 展开更多
关键词 Video analytics video semantic substance model fuzzy rule image processing
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Data Layout and Scheduling Tasks in a Meteorological Cloud Environment
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作者 Kunfu Wang Yongsheng Hao jie cao 《Intelligent Automation & Soft Computing》 SCIE 2023年第7期1033-1052,共20页
Meteorological model tasks require considerable meteorological basis data to support their execution.However,if the task and the mete-orological datasets are located on different clouds,that enhances the cost,executio... Meteorological model tasks require considerable meteorological basis data to support their execution.However,if the task and the mete-orological datasets are located on different clouds,that enhances the cost,execution time,and energy consumption of execution meteorological tasks.Therefore,the data layout and task scheduling may work together in the meteorological cloud to avoid being in various locations.To the best of our knowledge,this is the first paper that tries to schedule meteorological tasks with the help of the meteorological data set layout.First,we use the FP-Growth-M(frequent-pattern growth for meteorological model datasets)method to mine the relationship between meteorological models and datasets.Second,based on the relation,we propose a heuristics algorithm for laying out the meteorological datasets and scheduling tasks.Finally,we use simulation results to compare our proposed method with other methods.The simulation results show that our method reduces the number of involved clouds,the sizes of files from outer clouds,and the time of transmitting files. 展开更多
关键词 Meteorologicalmodels datalayout bigdata DATAMINING
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Forced Inspiratory Flow Volume Curve in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome
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作者 Donghui Wei Le Wang +4 位作者 Zhi Yu Haimei Zhao Ning Zhou Jing Zhang jie cao 《International Journal of Clinical Medicine》 CAS 2023年第5期260-273,共14页
Objective: Obstructive sleep apnea-hypopnea syndrome (OSA) is a disease of obstructive apnea or hypopnea caused by a repeated partial or complete collapse of the upper airway during sleep. The inspiratory part of the ... Objective: Obstructive sleep apnea-hypopnea syndrome (OSA) is a disease of obstructive apnea or hypopnea caused by a repeated partial or complete collapse of the upper airway during sleep. The inspiratory part of the flow-volume curve (F-V curve) can be used as an auxiliary means to evaluate upper airway obstruction in adults. This study is to evaluate the ability of the F-V curve to predict the OSA and explore inspiratory indicators related to airway obstruction during sleep. Methods: There were 332 patients included in this cross-sectional study, who were accompanied by snoring, daytime sleepiness and other symptoms, with suspicion of OSA. According to the nocturnal polysomnography, the subjects were distributed into mild to moderate OSA group, severe OSA group and non-OSA group. A pulmonary function test was used to collect the subjects’ spirometry and F-V curves. Results: There was no significant difference in a variety of indices derived from the F-V curve between OSA and normal subjects, including 25% inspiratory flow rate, middle inspiratory flow rate, 75% inspiratory flow rate, peak flow rate, and forced inspiratory flow rate in the first second. The pulmonary function parameters were significantly correlated with the weight, age and sex of the subjects. Conclusion: These findings suggest that the inspiratory curve of pulmonary function cannot evaluate the upper airway abnormalities in patients with obstructive apnea-hypopnea syndrome. 展开更多
关键词 Apnea-Hypopnea Index Obstructive Sleep Apnea Pulmonary Function Test Inspiratory Flow Volume Curve
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算法时代数据新闻的法律问题研究
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作者 曹杰 《新媒体与社会》 2023年第3期289-300,398,共13页
随着人工智能、大数据、物联网、区块链等新技术新工具的迭代升级,算法时代或数字时代给新闻行业带来前所未有的深刻变革和影响。在此背景下,数据新闻所处的媒介生态和技术条件发生嬗变,其本身的新闻模型、采编流程、主体、内容和技术... 随着人工智能、大数据、物联网、区块链等新技术新工具的迭代升级,算法时代或数字时代给新闻行业带来前所未有的深刻变革和影响。在此背景下,数据新闻所处的媒介生态和技术条件发生嬗变,其本身的新闻模型、采编流程、主体、内容和技术等均呈现新的特点。这些变化必然导致数据新闻在原有法律规制体系适用中产生一定的冲突或缺位,必须在与算法技术同频共生和相关法律关系调整之中,探寻破解法律适用与新闻采编流程再造以及法社会关系冲突的可行机制或路径。 展开更多
关键词 算法时代 数据新闻 法律冲突 法律适用
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经皮椎弓根钉棒微创内固定系统结合伤椎植骨治疗胸腰椎骨折的临床效果 被引量:21
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作者 曹杰 申才良 +2 位作者 于海洋 梁成民 焦伟 《中国现代医学杂志》 CAS 2018年第22期74-79,共6页
目的探讨经皮椎弓根钉棒微创内固定系统结合经椎弓根伤椎椎体内植骨治疗胸腰椎骨折的临床疗效。方法 2015年2月-2016年1月安徽医科大学第一附属医院骨科无需减压的胸腰椎骨折患者40例,随机分为两组,观察组20例在"C"型臂透视... 目的探讨经皮椎弓根钉棒微创内固定系统结合经椎弓根伤椎椎体内植骨治疗胸腰椎骨折的临床疗效。方法 2015年2月-2016年1月安徽医科大学第一附属医院骨科无需减压的胸腰椎骨折患者40例,随机分为两组,观察组20例在"C"型臂透视引导下应用微创内固定系统结合伤椎椎体内植骨治疗;对照组20例切开复位椎弓根内固定取髂骨植骨治疗,比较两组患者的临床参数和影像学指标。结果两组患者均顺利完成手术,获得随访13~24个月,观察组和对照组术后伤椎Cobb's角低于术前(P<0.05);观察组和对照组术后椎体前缘高度高于术前(P<0.05)。观察组术中出血量优于对照组(P<0.05);观察组的手术时间优于开放组(P<0.05);观察组术后引流量优于对照组(P<0.05);观察组的术后胸腰段Cobb's角(过屈位/过伸位)优于对照组(P<0.05),且观察组术后伤椎均未出现"蛋壳"效应。结论经皮椎弓根钉棒微创系统结合伤椎植骨治疗胸腰椎骨折手术创伤小、出血少、安全可靠、矫正效果满意、术后恢复快、保留胸腰段活动度,并有效防止伤椎出现"蛋壳"效应,能够即刻增加伤椎椎体的骨容量及前柱的抗压稳定性,值得临床推广。 展开更多
关键词 胸腰椎骨折 经皮椎弓根螺钉 微创 伤椎植骨
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主动健康教育对江油市农村≥65岁老年人口结核病防治知识知晓率的效果分析 被引量:3
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作者 曹婕 陈刚 +5 位作者 刘平 李俊 高勇 雷洪林 敬锐 王富友 《结核病与肺部健康杂志》 2018年第4期279-283,共5页
目的评价开展多形式主动健康教育对农村地区老年人结核病防治核心知识知晓情况的效果。方法本次研究在2013—2014年结合四川省江油市基本公共卫生服务年度体检项目工作开展2次基线调查时进行。采用整群随机抽样方法抽取江油市的3个农村... 目的评价开展多形式主动健康教育对农村地区老年人结核病防治核心知识知晓情况的效果。方法本次研究在2013—2014年结合四川省江油市基本公共卫生服务年度体检项目工作开展2次基线调查时进行。采用整群随机抽样方法抽取江油市的3个农村乡镇(重华镇、厚坝镇、二郎庙镇)为调查点,于2013年7月至2014年7月开展结核病全乡镇多种方式的公众健康宣传教育,采用横断面调查的方法,在面对面入户基线调查前、干预实施1年后,使用统一设计的历年结核病基线调查采用的结核病防治核心知识知晓率问卷对调查点≥65岁常住老年人进行面对面询问调查,以了解干预前后的核心知识知晓情况。结果结核病核心知识总知晓率干预后(54.66%,15727/28775)较干预前(10.31%,3053/29640)提高了44.35%(χ2=13168.16,P<0.001);全部知晓率干预后(14.56%,838/5755)较干预前(1.55%,92/5928)提高了13.01%(χ2=674.53,P<0.001)。男性结核病核心知识总知晓率干预前[12.14%,1766/(2909×5)]、干预后[56.95%,7987/(2805×5)]均高于女性[分别为8.53%,1287/(3019×5);52.47%,7740/(2950×5)](χ2=104.81,P<0.05;χ2=58.06,P<0.05);干预前后男性提高了44.81%(χ2=6375.64,P<0.001),女性提高了43.94%(χ2=6829.73,P<0.001)。结论通过主动开展健康教育能够提高农村地区≥65岁老年人对结核病核心知识的知晓率,促进和改善农村地区老年结核病主动发现的防治工作,是农村地区老年结核病患者提高结核病防治知识的一种不可缺少的重要手段。 展开更多
关键词 结核 农村人口 老年人 健康教育 问卷调查 结果评价(卫生保健) 小地区分析
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Early constraint-induced movement therapy affects behavior and neuronal plasticity in ischemia-injured rat brains 被引量:12
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作者 Xi-Hua Liu Hong-Yan Bi +2 位作者 jie cao Shuo Ren Shou-Wei Yue 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第5期775-782,共8页
Constraint-induced movement therapy is an effective rehabilitative training technique used to improve the restoration of impaired upper extremity movement after stroke. However, whether constraint-induced movement the... Constraint-induced movement therapy is an effective rehabilitative training technique used to improve the restoration of impaired upper extremity movement after stroke. However, whether constraint-induced movement therapy is more effective than conventional rehabilitation in acute or sub-acute stroke remains controversial. The aim of the present study was to identify the optimal time to start constraint-induced movement therapy after ischemic stroke and to explore the mechanisms by which constraint-induced movement therapy leads to post-stroke recovery. Sixty-four adult male Sprague-Dawley rats were randomly divided into four groups: sham-surgery group, cerebral ischemia/reperfusion group, early constraint-induced movement therapy group, and late constraint-induced movement therapy group. Rat models of left middle cerebral artery occlusion were established according to the Zea Longa line embolism method. Constraint-induced movement therapy was conducted starting on day 1 or day 14 in the early constraint-induced movement therapy and late constraint-induced movement therapy groups, respectively. To explore the effect of each intervention time on neuromotor function, behavioral function was assessed using a balance beam walking test before surgery and at 8 and 21 days after surgery. The expression levels of brain-derived neurotrophic factor, nerve growth factor and Nogo receptor were evaluated using real time-polymerase chain reaction and western blot assay to assess the effect of each intervention time. The results showed that the behavioral score was significantly lower in the early constraint-induced movement therapy group than in the cerebral ischemia/reperfusion and late constraint-induced movement therapy groups at 8 days. At 21 days, the scores had significantly decreased in the early constraint-induced movement therapy and late constraint-induced movement therapy groups. At 8 days, only mild pyknosis appeared in neurons of the ischemic penumbra in the early constraint-induced movement therapy group, which was distinctly better than in the cerebral ischemia/reperfusion group. At 21 days, only a few vacuolated cells were observed and no obvious inflammatory cells were visible in late constraint-induced movement therapy group, which was much better than at 8 days. The mRNA and protein expression levels of brain-derived neurotrophic factor and nerve growth factor were significantly higher, but expression levels of Nogo receptor were significantly lower in the early constraint-induced movement therapy group compared with the cerebral ischemia/reperfusion and late constraint-induced movement therapy groups at 8 days. The changes in expression levels at 21 days were larger but similar in both the early constraint-induced movement therapy and late constraint-induced movement therapy groups. Besides, the protein nerve growth factor level was higher in the late constraint-induced movement therapy group than in the early constraint-induced movement therapy group at 21 days. These results suggest that both early(1 day) and late(14 days) constraint-induced movement therapy induces molecular plasticity and facilitates functional recovery after ischemic stroke, as illustrated by the histology. The mechanism may be associated with downregulation of Nogo receptor expression and upregulation of brain-derived neurotrophic factor and nerve growth factor expression. 展开更多
关键词 NERVE REGENERATION ischemic stroke rehabilitation constraint-induced movement therapy NERVE growth factors functional recovery neuronal plasticity real time-polymerase chain reaction western BLOT assay rats neural REGENERATION
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Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients 被引量:22
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作者 Yu-Yuan Li Quan-Xing Ge +5 位作者 jie cao Yong-Jian Zhou Yan-Lei Du Bo Shen Yu-Jui Yvonne Wan Yu-Qiang Nie 《World Journal of Gastroenterology》 SCIE CAS 2016年第11期3227-3233,共7页
AIM: To investigate Fusobacterium nucleatum (F. nucleatum) abundance in colorectal cancer (CRC) tissues and its association with CRC invasiveness in Chinese patients.METHODS: The resected cancer and adjacent normal ti... AIM: To investigate Fusobacterium nucleatum (F. nucleatum) abundance in colorectal cancer (CRC) tissues and its association with CRC invasiveness in Chinese patients.METHODS: The resected cancer and adjacent normal tissues (10 cm beyond cancer margins) from 101 consecutive patients with CRC were collected. Fluorescent quantitative polymerase chain reaction (FQ-PCR) was applied to detect F. nucleatum in CRC and normal tissues. The difference of F. nucleatum abundance between cancer and normal tissues and the relationship of F. nucleatum abundance with clinical variables were evaluated. Fluorescence in situ hybridization (FISH) analysis was performed on 22 CRC tissues with the highest F. nucleatum abundance by FQ-PCR testing to confirm FQ-PCR results.RESULTS: The median abundance of F. nucleatum in CRC tissues [0.242 (0.178-0.276)] was significantly higher than that in normal controls [0.050 (0.023-0.067)] (P &#x0003c; 0.001). F. nucleatum was over-represented in 88/101 (87.1%) CRC samples. The abundance of F. nucleatum determined by 2<sup>-&#x00394;CT</sup> was significantly greater in tumor samples [0.242 (0.178, 0.276)] than in normal controls [0.050 (0.023, 0.067)] (P &#x0003c; 0.001). The frequency of patients with lymph node metastases was higher in the over-abundance group [52/88 (59.1%)] than in the under-abundance group [0/13 (0%)] (P &#x0003c; 0.005). No significant association of F. nucleatum with other clinico-pathological variables was observed (P &#x0003e; 0.05). FISH analysis also found more F. nucleatum in CRC than in normal tissues (median number 6, 25<sup>th</sup> 3, 75<sup>th</sup> 10 vs 2, 25<sup>th</sup> 1, 75<sup>th</sup> 5) (P &#x0003c; 0.01).CONCLUSION: F. nucleatum was enriched in CRC tissues and associated with CRC development and metastasis. 展开更多
关键词 Colorectal cancer Fusobacterium nucleatum METASTASES Fluorescent quantitative polymerase chain reaction Fluorescence in situ hybridization
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Risk factors and surgical outcomes for spontaneous rupture of BCLC stages A and B hepatocellular carcinoma: A case-control study 被引量:19
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作者 Jing Li Liang Huang +5 位作者 Cai-Feng Liu jie cao Jian-Jun Yan Feng Xu Meng-Chao Wu Yi-Qun Yan 《World Journal of Gastroenterology》 SCIE CAS 2014年第27期9121-9127,共7页
AIM: To investigate the risk factors and surgical outcomes for spontaneous rupture of Barcelona Clinic Liver Cancer (BCLC) stages A and B hepatocellular carcinoma (HCC).
关键词 Hepatocellular carcinoma RUPTURE Risk factor Tumor location Surgical outcome
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p28^GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity 被引量:14
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作者 Rong-Yang Dai Yao Chen +8 位作者 Jing Fu Li-Wei Dong Yi-Bin Ren Guang-Zhen Yang You-Wen Qian jie cao Shan-Hua Tang Sheng-Li Yang Hong-Yang Wang 《Cell Research》 SCIE CAS CSCD 2009年第11期1243-1257,共15页
It has been shown that oncoprotein p28GANK, which is consistently overexpressed in human hepatocellular carcinoma (HCC), plays a critical role in tumorigenesis of HCC. However, the underlying mechanism remains uncle... It has been shown that oncoprotein p28GANK, which is consistently overexpressed in human hepatocellular carcinoma (HCC), plays a critical role in tumorigenesis of HCC. However, the underlying mechanism remains unclear. Here, we demonstrated that p28GANK inhibits apoptosis in HCC cells induced by the endoplasmic reticulum (ER) stress. During ER stress, p28GANK enhances the unfolded protein response, promotes ER recovery from translational repression, and thereby facilitates cell's ability to cope with the stress conditions. Furthermore, p28GANK upregulates glucose-regulated protein 78 (GRP78), a key ER chaperone protein, which subsequently enhances the ER folding capacity and promotes recovery from ER stress. We also demonstrated that p28GANK increases p38 mitogen-activated protein kinase and Akt phosphorylation, and inhibits nuclear factor kappa B (NF-κB) activation under ER stress, which in turn contributes to GRP78 upregulation. Taken together, our results indicate that p28GANK inhibits ER stress-induced apoptosis in HCC cells, at least in part, by enhancing the adaptive response and GRP78 expression. We propose that p28GANK has potential implications for HCC progression under the ER stress conditions. 展开更多
关键词 p28GANK ER stress UPR GRP78 APOPTOSIS
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Beneficial effects of moderate to vigorous physical activity on cardiovascular disease among Chinese adults 被引量:20
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作者 Qiong LIU Fang-Chao LIU +16 位作者 Ke-Yong HUANG Jian-Xin LI Xue-Li YANG Xin-Yan WANG Ji-Chun CHEN Xiao-Qing LIU jie cao Chong SHEN Ling YU Fang-Hong LU Xian-Ping WU Lian-Cheng ZHAO Ying LI Dong-Sheng HU Xiang-Feng LU Jian-Feng HUANG Dong-Feng GU 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2020年第2期85-95,共11页
Background In China,lack of evidence remains a significant challenge for the national initiative to promote physical activity(PA).We aimed to quantify the beneficial effects of meeting or maintaining the recommended P... Background In China,lack of evidence remains a significant challenge for the national initiative to promote physical activity(PA).We aimed to quantify the beneficial effects of meeting or maintaining the recommended PA level[150 minutes per week(min/wk)of moderate PA or 75 min/wk of vigorous PA or an equivalent combination]on incident cardiovascular disease(CVD)among Chinese population.Methods We included 100,560 participants without history of CVD from three cohorts in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project.Cox proportional hazards models were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for CVD events and its subtypes,including stroke,coronary heart disease,heart failure,and CVD death.Results During a median follow-up of 7.3 years(range:6–15 years),777,163 person-years and 4693 incident CVD events were observed.Compared with participants who were inactive at baseline,the multivariable adjusted HR(95%CI)of developing CVD was 0.74(0.69–0.79)for those who met recommended moderate to vigorous physical activity(MVPA)level at baseline.Furthermore,the risk of CVD incidence was reduced with increment of MVPA(Ptrend<0.001),and the HR(95%CI)of highly-active versus inactive category was 0.62(0.56–0.68).Compared with individuals who were inactive both at the baseline and follow-up,those keeping active over the period of follow-up had a substantial lower risk of incident CVD with the HR(95%CI)of 0.57(0.43–0.77).Conclusions The findings demonstrated that meeting and maintaining the recommended MVPA level could reduce the cardiovascular risk.Wider adoption of the PA recommendations would have considerable health impacts to the Chinese population. 展开更多
关键词 Cardiovascular disease China Cohort study Physical activity
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Similarity criteria and coal-like material in coal and gas outburst physical simulation 被引量:19
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作者 Bo Zhao Guangcai Wen +5 位作者 Haitao Sun Dongling Sun Huiming Yang jie cao Linchao Dai Bo Wang 《International Journal of Coal Science & Technology》 EI 2018年第2期167-178,共12页
Coal and gas outburst is one of the main gas hazards in coal mines. However, due to the risks of the coal and gas outburst, the field test is difficult to complete. Therefore, an effective approach to studying the mec... Coal and gas outburst is one of the main gas hazards in coal mines. However, due to the risks of the coal and gas outburst, the field test is difficult to complete. Therefore, an effective approach to studying the mechanism and development of outburst is to conduct the similar physical simulation. However, the similarity criteria and similar materials in outburst are the key factors which restrict the development of physical simulation. To solve those problems, this paper has established similarity criteria base on mechanics model, solid-fluid coupling model and energy model, and presented high similar materials. Combining with three groups of similar number, and considering similar mechanical parameters and deformation and failure regularity, the similarity criteria of outburst is determined on the basis of the energy model. According to those criteria, we put forward a similar material consists of pulverized coal, cement, sand, activated carbon, and water. The similar material has high compressive strength and the accordant characteristics with the raw coal, include density, porosity, adsorption, desorption. The new research is promising for preventing and controlling gas hazards in the future. 展开更多
关键词 Coal and gas outburst Physical simulation Similarity criteria Similar material
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