In this study,a single dielectric barrier discharge(DBD)coaxial reactor was used to degrade 4,4'-sulfonylbis(TBBPS)in water using greenhouse gas(CO_(2))and argon as the carrier gases.The investigation focused on C...In this study,a single dielectric barrier discharge(DBD)coaxial reactor was used to degrade 4,4'-sulfonylbis(TBBPS)in water using greenhouse gas(CO_(2))and argon as the carrier gases.The investigation focused on CO_(2)conversion,reactive species formation,gas-liquid mass transfer mechanism,and degradation mechanism of TBBPS during the discharge plasma process.With the decrease of CO_(2)/Ar ratio in the process of plasma discharge,the emission spectrum intensity of Ar,CO_(2)and excited reactive species was enhanced.This increase promoted collision and dissociation of CO_(2),resulting in a series of chemical reactions that improved the production of reactive species such as·OH,^(1)O_(2),H_(2)O_(2)and O_(3).These reactive species initiated a sequence of reactions with TBBPS.Results indicated that at a gas flow rate of 240 mL/min with a CO_(2)/Ar ratio of 1:5,both the highest CO_(2)conversion rate(17.76%)and TBBPS degradation rate(94.24%)were achieved.The degradation mechanism was elucidated by determining types and contents of reactive species present in treatment liquid along with analysis of intermediate products using liquid chromatography-mass spectrometry techniques.This research provides novel insights into carbon dioxide utilization and water pollution control through dielectric barrier discharge plasma technology.展开更多
BACKGROUND Pigmented villonodular synovitis(PVNS)is a benign proliferative disorder that affects the synovial joints,bursae,and tendon sheaths.To date,few studies have reported on the treatment of postoperative pain a...BACKGROUND Pigmented villonodular synovitis(PVNS)is a benign proliferative disorder that affects the synovial joints,bursae,and tendon sheaths.To date,few studies have reported on the treatment of postoperative pain and edema in patients with PVNS.Herein,we present the case of a woman who developed pain and edema in the left lower limb 1 wk after synovectomy and arthroscopic partial meniscectomy and was unable to walk due to limited flexion and extension of the left knee.CASE SUMMARY A 32-year-old woman underwent synovectomy and arthroscopic partial meniscectomy successively and was treated with a combination of manual lymphatic drainage(MLD)and kinesio taping(KT)in our hospital to alleviate postoperative pain and edema.The following parameters were assessed at 2 wk post-treatment and 1 wk post-discharge follow up:suprapatellar circumference,infrapatellar circumference,visual analog scale score,knee range of motion,pittsburgh sleep quality index score,hamilton anxiety rating scale(HAMA)score,and hamilton depression rating scale(HAMD)score.After treatment,the postoperative pain and edema in the patient’s left knee were effectively relieved,resulting in improved sleep quality and remarkably attenuated HAMA and HAMD scores.CONCLUSION Combined MLD and KT may be an effective approach for relieving postoperative pain and edema in patients with PVNS.展开更多
BACKGROUND According to clinical data,a significant percentage of patients experience pain after surgery,highlighting the importance of alleviating postoperative pain.The current approach involves intravenous self-con...BACKGROUND According to clinical data,a significant percentage of patients experience pain after surgery,highlighting the importance of alleviating postoperative pain.The current approach involves intravenous self-control analgesia,often utilizing opioid analgesics such as morphine,sufentanil,and fentanyl.Surgery for colo-rectal cancer typically involves general anesthesia.Therefore,optimizing anes-thetic management and postoperative analgesic programs can effectively reduce perioperative stress and enhance postoperative recovery.The study aims to analyze the impact of different anesthesia modalities with multimodal analgesia on patients'postoperative pain.AIM To explore the effects of different anesthesia methods coupled with multi-mode analgesia on postoperative pain in patients with colorectal cancer.METHODS Following the inclusion criteria and exclusion criteria,a total of 126 patients with colorectal cancer admitted to our hospital from January 2020 to December 2022 were included,of which 63 received general anesthesia coupled with multi-mode labor pain and were set as the control group,and 63 received general anesthesia associated with epidural anesthesia coupled with multi-mode labor pain and were set as the research group.After data collection,the effects of postoperative analgesia,sedation,and recovery were compared.RESULTS Compared to the control group,the research group had shorter recovery times for orientation,extubation,eye-opening,and spontaneous respiration(P<0.05).The research group also showed lower Visual analog scale scores at 24 h and 48 h,higher Ramany scores at 6 h and 12 h,and improved cognitive function at 24 h,48 h,and 72 h(P<0.05).Additionally,interleukin-6 and interleukin-10 levels were significantly reduced at various time points in the research group compared to the control group(P<0.05).Levels of CD3+,CD4+,and CD4+/CD8+were also lower in the research group at multiple time points(P<0.05).CONCLUSION For patients with colorectal cancer,general anesthesia coupled with epidural anesthesia and multi-mode analgesia can achieve better postoperative analgesia and sedation effects,promote postoperative rehabilitation of patients,improve inflammatory stress and immune status,and have higher safety.展开更多
Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure,while the role of genetics and incident cardiovascular disease(CVD)remains unclear.Aims To examine t...Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure,while the role of genetics and incident cardiovascular disease(CVD)remains unclear.Aims To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample,and to explore the role of genetics and CVD onset.Methods A prospective study among 354 654 participants free of CVD and dementia(2006-2010,mean age 56.4 years)was conducted within the UK Biobank,with brain magnetic resonance imaging(MRl)measurement availablefor 15104participants since 2014.CVD risk burden was evaluated by the Framingham General Cardiovascular Risk Score(FGCRS).Dementia diagnosis was ascertained from inpatient and death register data.Results Overamedian 12.0-yearfollow-up,3998 all-cause dementia cases were identified.Higher FGCRS was associated with increasedall-cause dementia risk after adjusting for demographic,major lifestyle,clinical factors and the polygenic risk score(PRS)of Alzheimer's disease.Comparing the high versus low tertile of FGCRS,the odds ratios(ORs)and 95%confidence intervals(Cls)were 1.26(1.12 to 1.41)for all-cause dementia,1.67(1.33 to 2.09)for Alzheimer's disease and 1.53(1.07 to 2.16)for vascular dementia(all p_(treng)<0.05).Incident stroke and coronary heart disease accounted for 14%(95%Cl:9% to 21%)of the association between FGCRS and all-cause dementia.Interactions were not detected for FGCRS and PRS on the risk of any dementia subtype.We observed an 83%(95%Cl:47%to 128%)higher all-cause dementia risk comparing the high-high versus low-low FGCRS-PRS category.For brain volumes,higher FGCRS was associated with greater log-transformed white matter hyperintensities,smaller cortical volume and smaller grey matter volume.Conclusions Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes.The association of cardiovascular risk burden with all-cause dementia is largely independent of CVD onset and genetic predisposition to dementia.展开更多
Objective:To analyze the clinical efficacy,progression-free survival,and safety of anlotinib in the treatment of advanced lung cancer.Methods:A retrospective analysis was conducted using data from 60 patients with adv...Objective:To analyze the clinical efficacy,progression-free survival,and safety of anlotinib in the treatment of advanced lung cancer.Methods:A retrospective analysis was conducted using data from 60 patients with advanced lung cancer treated with anlotinib from May 2019 to May 2021.This analysis aimed to comprehensively evaluate the clinical efficacy,progression-free survival,and adverse reactions of anlotinib.Results:The median progression-free survival(PFS)for the 60 patients was 5.79 months,with an overall response rate(ORR)of 21%and a disease control rate(DCR)of 90%.In the first-line group,the median PFS was 6.20 months,ORR was 76.92%,and DCR was 84.61%.The second-line group showed a median PFS of 6.30 months,ORR of 28.57%,and DCR of 90.48%.In the third-line group,the median PFS was 5.34 months,ORR was 19.23%,and DCR was 92.30%.The single-agent group exhibited a median PFS of 5.09 months,ORR of 23.33%,and DCR of 76.67%.In the combination group,the median PFS was 6.53 months,ORR was 46.67%,and DCR was 100%.The combination group demonstrated a significantly higher medication effect than the single-drug group,and adverse drug reactions were mostly grade 1-2.Conclusion:Anlotinib exhibits a better disease control rate and survival benefit in the treatment of advanced lung cancer.The combination effect is superior to monotherapy,with relatively controllable adverse effects.展开更多
Objective Lipopolysaccharide-induced tumor necrosis factor-αfactor(LITAF)protein is a newly discovered inflammatory protein.This study aims to study the role of LITAF in the formation of atherosclerosis.Methods A tot...Objective Lipopolysaccharide-induced tumor necrosis factor-αfactor(LITAF)protein is a newly discovered inflammatory protein.This study aims to study the role of LITAF in the formation of atherosclerosis.Methods A total of 10 C57BL/6J mice and 10 C57BL/6J mice with knockout of LITAF gene(C57BL/6J–LITAF–)were divided into two groups:the control group and the LITAF^(−/−)group.The animals were accommodated for 16 weeks and then euthanized with their hearts and aortas isolated thereafter.Next,the roots of the mouse aorta were cryosectioned and stained with Oil Red O staining and immunohistochemical staining(CD68,α-SMA,and Masson),respectively.The area of Oil Red O staining and the proportion of positive expression after immunohistochemical staining were then compared between the control and LITAF^(−/−)groups.At the same time,the blood of mice was collected for the extraction of proteins and RNA.The proteins and RNA were used to detect the expression of major molecules of the NF-κB inflammatory pathway in mice in the control group and the LITAF^(−/−)group by Western blotting and RT-PCR.Results Oil Red O staining of the aortic root sections of the mice in each group revealed that the area of atherosclerotic plaques in the LITAF^(−/−)group was substantially lower than that in the control group(P<0.05).Moreover,immunohistochemical staining determined that the expression level ofα-SMA and CD68 in the LITAF^(−/−)group was significantly lower than that in the control group,whereas the results were reversed following Masson staining(P<0.05).The expression levels of P65 and caspase 3 were significantly lower in the LITAF^(−/−)group than in the control group(P<0.05),whereas the expression level of IκB was higher in the LITAF^(−/−)group.Conclusion LITAF might participate in the formation of atherosclerotic plaque through the NF-κB pathway and play a promoting role in the formation of atherosclerosis.展开更多
Negative differential conductance(NDC)serves as a crucial characteristic that reveals various underlying physics and transport process in hybrid superconducting devices.We report the observation of gate-tunable NDC ou...Negative differential conductance(NDC)serves as a crucial characteristic that reveals various underlying physics and transport process in hybrid superconducting devices.We report the observation of gate-tunable NDC outside the superconducting energy gap on two types of hybrid semiconductor–superconductor devices,i.e.,normal metal–superconducting nanowire–normal metal and normal metal–superconducting nanowire–superconductor devices.Specifically,we study the dependence of the NDCs on back-gate voltage and magnetic field.When the back-gate voltage decreases,these NDCs weaken and evolve into positive differential conductance dips;and meanwhile they move away from the superconducting gap towards high bias voltage,and disappear eventually.In addition,with the increase of magnetic field,the NDCs/dips follow the evolution of the superconducting gap,and disappear when the gap closes.We interpret these observations and reach a good agreement by combining the Blonder–Tinkham–Klapwijk(BTK)model and the critical supercurrent effect in the nanowire,which we call the BTK-supercurrent model.Our results provide an in-depth understanding of the tunneling transport in hybrid semiconductor–superconductor devices.展开更多
[Objectives]The paper was to study the effect of magnetic field technology on physicochemical properties of fresh-cut apple during storage.[Methods]Using fresh-cut apples as materials,magnetic field assisted refrigera...[Objectives]The paper was to study the effect of magnetic field technology on physicochemical properties of fresh-cut apple during storage.[Methods]Using fresh-cut apples as materials,magnetic field assisted refrigeration and conventional refrigeration control groups were set up,and the preservation effects of magnetic field assisted refrigeration on fresh-cut apples were tested by measuring the changes of microorganisms and physicochemical indicators.In this experiment,the conditions of magnetic field assisted refrigeration group was set as follows:temperature 4℃,magnetic field intensity 5 mT,static magnetic field,and storage for 6 d.[Results]At 6 d post storage,the weight loss rate,total number of colonies and total number of fungi of fresh-cut apples increased;the L value and hardness showed a downward trend;the soluble solid content first increased and then decreased;and the total acid decreased first and then increased.The above indicators in magnetic field assisted refrigeration group changed more gently than that in conventional refrigeration group.Compared with conventional assisted refrigeration,the weight loss rate of fresh-cut apples treated by magnetic field combined with 4℃refrigeration was reduced by 68.00%;the hardness was increased by 12.23%;the total number of colonies and total number of fungi were reduced by 64.15%and 37.50%;and the L value did not change much.High content of soluble solids and total acid was maintained.[Conclusions]Magnetic field assisted refrigeration delays quality deterioration of fresh-cut apples during storage,prolongs shelf life,and further improves their edible quality and commodity value.展开更多
Osteoarthritis （OA） is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the d...Osteoarthritis （OA） is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently, there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway（s） controlling these pathological processes.展开更多
Osteoarthritis(OA)is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body.The molecular mechanisms of OA are currently unknown.OA is a heterogeneous di...Osteoarthritis(OA)is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body.The molecular mechanisms of OA are currently unknown.OA is a heterogeneous disease that affects the entire joint,and multiple tissues are altered during OA development.To better understand the pathological mechanisms of OA,new approaches,methods,and techniques need to be used to understand OA pathogenesis.In this review,we first focus on the epigenetic regulation of OA,with a particular focus on DNA methylation,histone modification,and microRNA regulation,followed by a summary of several key mediators in OA-associated pain.We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain,such as CRISPR,scRNA sequencing,and lineage tracing.Next,we discuss the timely updates concerning cell death regulation in OA pathology,including pyroptosis,ferroptosis,and autophagy,as well as their individual roles in OA and potential molecular targets in treating OA.Finally,our review highlights new directions on the role of the synovial lymphatic system in OA.An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA.展开更多
基金supported jointly by National Natural Science Foundation of China(No.51877208)Anhui Provincial Key R&D Programmers(No.202004a07020047)。
文摘In this study,a single dielectric barrier discharge(DBD)coaxial reactor was used to degrade 4,4'-sulfonylbis(TBBPS)in water using greenhouse gas(CO_(2))and argon as the carrier gases.The investigation focused on CO_(2)conversion,reactive species formation,gas-liquid mass transfer mechanism,and degradation mechanism of TBBPS during the discharge plasma process.With the decrease of CO_(2)/Ar ratio in the process of plasma discharge,the emission spectrum intensity of Ar,CO_(2)and excited reactive species was enhanced.This increase promoted collision and dissociation of CO_(2),resulting in a series of chemical reactions that improved the production of reactive species such as·OH,^(1)O_(2),H_(2)O_(2)and O_(3).These reactive species initiated a sequence of reactions with TBBPS.Results indicated that at a gas flow rate of 240 mL/min with a CO_(2)/Ar ratio of 1:5,both the highest CO_(2)conversion rate(17.76%)and TBBPS degradation rate(94.24%)were achieved.The degradation mechanism was elucidated by determining types and contents of reactive species present in treatment liquid along with analysis of intermediate products using liquid chromatography-mass spectrometry techniques.This research provides novel insights into carbon dioxide utilization and water pollution control through dielectric barrier discharge plasma technology.
基金Shanghai Municipal Health Commission,No.20214Y0078and The Key Discipline Construction Project,No.SHXHZDXK202321.
文摘BACKGROUND Pigmented villonodular synovitis(PVNS)is a benign proliferative disorder that affects the synovial joints,bursae,and tendon sheaths.To date,few studies have reported on the treatment of postoperative pain and edema in patients with PVNS.Herein,we present the case of a woman who developed pain and edema in the left lower limb 1 wk after synovectomy and arthroscopic partial meniscectomy and was unable to walk due to limited flexion and extension of the left knee.CASE SUMMARY A 32-year-old woman underwent synovectomy and arthroscopic partial meniscectomy successively and was treated with a combination of manual lymphatic drainage(MLD)and kinesio taping(KT)in our hospital to alleviate postoperative pain and edema.The following parameters were assessed at 2 wk post-treatment and 1 wk post-discharge follow up:suprapatellar circumference,infrapatellar circumference,visual analog scale score,knee range of motion,pittsburgh sleep quality index score,hamilton anxiety rating scale(HAMA)score,and hamilton depression rating scale(HAMD)score.After treatment,the postoperative pain and edema in the patient’s left knee were effectively relieved,resulting in improved sleep quality and remarkably attenuated HAMA and HAMD scores.CONCLUSION Combined MLD and KT may be an effective approach for relieving postoperative pain and edema in patients with PVNS.
文摘BACKGROUND According to clinical data,a significant percentage of patients experience pain after surgery,highlighting the importance of alleviating postoperative pain.The current approach involves intravenous self-control analgesia,often utilizing opioid analgesics such as morphine,sufentanil,and fentanyl.Surgery for colo-rectal cancer typically involves general anesthesia.Therefore,optimizing anes-thetic management and postoperative analgesic programs can effectively reduce perioperative stress and enhance postoperative recovery.The study aims to analyze the impact of different anesthesia modalities with multimodal analgesia on patients'postoperative pain.AIM To explore the effects of different anesthesia methods coupled with multi-mode analgesia on postoperative pain in patients with colorectal cancer.METHODS Following the inclusion criteria and exclusion criteria,a total of 126 patients with colorectal cancer admitted to our hospital from January 2020 to December 2022 were included,of which 63 received general anesthesia coupled with multi-mode labor pain and were set as the control group,and 63 received general anesthesia associated with epidural anesthesia coupled with multi-mode labor pain and were set as the research group.After data collection,the effects of postoperative analgesia,sedation,and recovery were compared.RESULTS Compared to the control group,the research group had shorter recovery times for orientation,extubation,eye-opening,and spontaneous respiration(P<0.05).The research group also showed lower Visual analog scale scores at 24 h and 48 h,higher Ramany scores at 6 h and 12 h,and improved cognitive function at 24 h,48 h,and 72 h(P<0.05).Additionally,interleukin-6 and interleukin-10 levels were significantly reduced at various time points in the research group compared to the control group(P<0.05).Levels of CD3+,CD4+,and CD4+/CD8+were also lower in the research group at multiple time points(P<0.05).CONCLUSION For patients with colorectal cancer,general anesthesia coupled with epidural anesthesia and multi-mode analgesia can achieve better postoperative analgesia and sedation effects,promote postoperative rehabilitation of patients,improve inflammatory stress and immune status,and have higher safety.
基金grants from the National Key R&D Program of China(2023YFF1104301)(by Geng Zong)National Natural Science Foundation of China(82373576)(by Geng Zong)+2 种基金National Science Fund for Excellent Young Scholars(81922060)(by Geng Zong)Strategic Priority CAS Project(XDB38010300)(by Geng Zong)the Zhejiang University Education Foundation Global Partnership Fund(by Changzheng Yuan).
文摘Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure,while the role of genetics and incident cardiovascular disease(CVD)remains unclear.Aims To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample,and to explore the role of genetics and CVD onset.Methods A prospective study among 354 654 participants free of CVD and dementia(2006-2010,mean age 56.4 years)was conducted within the UK Biobank,with brain magnetic resonance imaging(MRl)measurement availablefor 15104participants since 2014.CVD risk burden was evaluated by the Framingham General Cardiovascular Risk Score(FGCRS).Dementia diagnosis was ascertained from inpatient and death register data.Results Overamedian 12.0-yearfollow-up,3998 all-cause dementia cases were identified.Higher FGCRS was associated with increasedall-cause dementia risk after adjusting for demographic,major lifestyle,clinical factors and the polygenic risk score(PRS)of Alzheimer's disease.Comparing the high versus low tertile of FGCRS,the odds ratios(ORs)and 95%confidence intervals(Cls)were 1.26(1.12 to 1.41)for all-cause dementia,1.67(1.33 to 2.09)for Alzheimer's disease and 1.53(1.07 to 2.16)for vascular dementia(all p_(treng)<0.05).Incident stroke and coronary heart disease accounted for 14%(95%Cl:9% to 21%)of the association between FGCRS and all-cause dementia.Interactions were not detected for FGCRS and PRS on the risk of any dementia subtype.We observed an 83%(95%Cl:47%to 128%)higher all-cause dementia risk comparing the high-high versus low-low FGCRS-PRS category.For brain volumes,higher FGCRS was associated with greater log-transformed white matter hyperintensities,smaller cortical volume and smaller grey matter volume.Conclusions Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes.The association of cardiovascular risk burden with all-cause dementia is largely independent of CVD onset and genetic predisposition to dementia.
基金Key R&D Program of Yan’an Municipal Bureau of Science and Technology(Project No.2021YF-21)。
文摘Objective:To analyze the clinical efficacy,progression-free survival,and safety of anlotinib in the treatment of advanced lung cancer.Methods:A retrospective analysis was conducted using data from 60 patients with advanced lung cancer treated with anlotinib from May 2019 to May 2021.This analysis aimed to comprehensively evaluate the clinical efficacy,progression-free survival,and adverse reactions of anlotinib.Results:The median progression-free survival(PFS)for the 60 patients was 5.79 months,with an overall response rate(ORR)of 21%and a disease control rate(DCR)of 90%.In the first-line group,the median PFS was 6.20 months,ORR was 76.92%,and DCR was 84.61%.The second-line group showed a median PFS of 6.30 months,ORR of 28.57%,and DCR of 90.48%.In the third-line group,the median PFS was 5.34 months,ORR was 19.23%,and DCR was 92.30%.The single-agent group exhibited a median PFS of 5.09 months,ORR of 23.33%,and DCR of 76.67%.In the combination group,the median PFS was 6.53 months,ORR was 46.67%,and DCR was 100%.The combination group demonstrated a significantly higher medication effect than the single-drug group,and adverse drug reactions were mostly grade 1-2.Conclusion:Anlotinib exhibits a better disease control rate and survival benefit in the treatment of advanced lung cancer.The combination effect is superior to monotherapy,with relatively controllable adverse effects.
基金the National Natural Science Foundation of China(No.8207022248).
文摘Objective Lipopolysaccharide-induced tumor necrosis factor-αfactor(LITAF)protein is a newly discovered inflammatory protein.This study aims to study the role of LITAF in the formation of atherosclerosis.Methods A total of 10 C57BL/6J mice and 10 C57BL/6J mice with knockout of LITAF gene(C57BL/6J–LITAF–)were divided into two groups:the control group and the LITAF^(−/−)group.The animals were accommodated for 16 weeks and then euthanized with their hearts and aortas isolated thereafter.Next,the roots of the mouse aorta were cryosectioned and stained with Oil Red O staining and immunohistochemical staining(CD68,α-SMA,and Masson),respectively.The area of Oil Red O staining and the proportion of positive expression after immunohistochemical staining were then compared between the control and LITAF^(−/−)groups.At the same time,the blood of mice was collected for the extraction of proteins and RNA.The proteins and RNA were used to detect the expression of major molecules of the NF-κB inflammatory pathway in mice in the control group and the LITAF^(−/−)group by Western blotting and RT-PCR.Results Oil Red O staining of the aortic root sections of the mice in each group revealed that the area of atherosclerotic plaques in the LITAF^(−/−)group was substantially lower than that in the control group(P<0.05).Moreover,immunohistochemical staining determined that the expression level ofα-SMA and CD68 in the LITAF^(−/−)group was significantly lower than that in the control group,whereas the results were reversed following Masson staining(P<0.05).The expression levels of P65 and caspase 3 were significantly lower in the LITAF^(−/−)group than in the control group(P<0.05),whereas the expression level of IκB was higher in the LITAF^(−/−)group.Conclusion LITAF might participate in the formation of atherosclerotic plaque through the NF-κB pathway and play a promoting role in the formation of atherosclerosis.
基金the National Key Research and Development Program of China(Grant Nos.2022YFA1403400 and 2017YFA0304700)the National Natural Science Foundation of China(Grant Nos.12074417,92065203,92065106,61974138,11774405,11527806,and 12104489)+3 种基金the Strategic Priority Research Program B of Chinese Academy of Sciences(Grant Nos.XDB28000000 and XDB33000000)the Synergetic Extreme Condition User Facility sponsored by the National Development and Reform Commissionthe Innovation Program for Quantum Science and Technology(2021ZD0302600)the support from Youth Innovation Promotion Association,Chinese Academy of Sciences(Grant Nos.2017156 and Y2021043).
文摘Negative differential conductance(NDC)serves as a crucial characteristic that reveals various underlying physics and transport process in hybrid superconducting devices.We report the observation of gate-tunable NDC outside the superconducting energy gap on two types of hybrid semiconductor–superconductor devices,i.e.,normal metal–superconducting nanowire–normal metal and normal metal–superconducting nanowire–superconductor devices.Specifically,we study the dependence of the NDCs on back-gate voltage and magnetic field.When the back-gate voltage decreases,these NDCs weaken and evolve into positive differential conductance dips;and meanwhile they move away from the superconducting gap towards high bias voltage,and disappear eventually.In addition,with the increase of magnetic field,the NDCs/dips follow the evolution of the superconducting gap,and disappear when the gap closes.We interpret these observations and reach a good agreement by combining the Blonder–Tinkham–Klapwijk(BTK)model and the critical supercurrent effect in the nanowire,which we call the BTK-supercurrent model.Our results provide an in-depth understanding of the tunneling transport in hybrid semiconductor–superconductor devices.
基金Supported by Rural Revitalization Science and Technology Innovation Boost Action Plan of Shandong Province“Apple Step Processing and High Value Utilization Technology Research and Product Creation”(2022TZXD007-04).
文摘[Objectives]The paper was to study the effect of magnetic field technology on physicochemical properties of fresh-cut apple during storage.[Methods]Using fresh-cut apples as materials,magnetic field assisted refrigeration and conventional refrigeration control groups were set up,and the preservation effects of magnetic field assisted refrigeration on fresh-cut apples were tested by measuring the changes of microorganisms and physicochemical indicators.In this experiment,the conditions of magnetic field assisted refrigeration group was set as follows:temperature 4℃,magnetic field intensity 5 mT,static magnetic field,and storage for 6 d.[Results]At 6 d post storage,the weight loss rate,total number of colonies and total number of fungi of fresh-cut apples increased;the L value and hardness showed a downward trend;the soluble solid content first increased and then decreased;and the total acid decreased first and then increased.The above indicators in magnetic field assisted refrigeration group changed more gently than that in conventional refrigeration group.Compared with conventional assisted refrigeration,the weight loss rate of fresh-cut apples treated by magnetic field combined with 4℃refrigeration was reduced by 68.00%;the hardness was increased by 12.23%;the total number of colonies and total number of fungi were reduced by 64.15%and 37.50%;and the L value did not change much.High content of soluble solids and total acid was maintained.[Conclusions]Magnetic field assisted refrigeration delays quality deterioration of fresh-cut apples during storage,prolongs shelf life,and further improves their edible quality and commodity value.
基金supported by NIH grants AR055915 and AR054465 to DC
文摘Osteoarthritis （OA） is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently, there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway（s） controlling these pathological processes.
基金supported by the National Natural Science Foundation of China(NSFC)grants(82030067,82161160342,and 82172397)to D.C.and L.T.a grant from the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2020353)to L.T.+1 种基金supported by the National Key Research and Development Program of China(2021YFB3800800 to L.T.and D.C)supported by the research grant NIH AG0599775.
文摘Osteoarthritis(OA)is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body.The molecular mechanisms of OA are currently unknown.OA is a heterogeneous disease that affects the entire joint,and multiple tissues are altered during OA development.To better understand the pathological mechanisms of OA,new approaches,methods,and techniques need to be used to understand OA pathogenesis.In this review,we first focus on the epigenetic regulation of OA,with a particular focus on DNA methylation,histone modification,and microRNA regulation,followed by a summary of several key mediators in OA-associated pain.We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain,such as CRISPR,scRNA sequencing,and lineage tracing.Next,we discuss the timely updates concerning cell death regulation in OA pathology,including pyroptosis,ferroptosis,and autophagy,as well as their individual roles in OA and potential molecular targets in treating OA.Finally,our review highlights new directions on the role of the synovial lymphatic system in OA.An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA.
