“一点两线三面”创新实验平台的构建与实践

传统化学实验室功能单一、分布零散、共享性差,导致实验用房和实验设备利用效率低,这种建设模式不利于多学科知识的交叉融合,一定程度上影响学生综合素质的发展。本研究秉承“建优质平台,抓实践育人,树创新理念,育创新人才”的指导思想,在化学实验室资源整合共享、利用率提升、开放式管理以及创新应用型人才培养质量提升等方面积极进行教学改革,经过多年探索,搭建起“以提升学生创新实践能力为着力点”“教学科研两条主线”“教学科研三层面”的创新实验(训)平台,取得了一定成效,将为同类高校的创新实验(训)平台建设提供参考。

活血化瘀治疗冠脉微循环障碍的研究进展

冠状动脉微循环障碍广泛存在于多种心血管疾病中,与左室重构、心血管事件密切相关。本病病机演变以血瘀为核心,活血化瘀法可改善患者冠状动脉血流储备及微循环阻力指数,对于冠状动脉微循环障碍具有良好的治疗效果。机制方面,活血化瘀诸法可调节冠状动脉微血管功能障碍的诸多关键病理生理环节:如,活血化瘀可有效抑制炎症、氧化应激及血栓形成;活血化痰可保护血管内皮;益气活血能改善能量代谢;补肾活血促进血管新生、建立冠脉侧支循环。应用现代科学深入挖掘活血化瘀诸法治疗本病的机制,或为解决本病治疗提供新的思路。

Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage

The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow.Mitochondria are directly affected by direct factors such as ischemia,hypoxia,excitotoxicity,and toxicity of free hemoglobin and its degradation products,which trigger mitochondrial dysfunction.Dysfunctional mitochondria release large amounts of reactive oxygen species,inflammatory mediators,and apoptotic proteins that activate apoptotic pathways,further damaging cells.In response to this array of damage,cells have adopted multiple mitochondrial quality control mechanisms through evolution,including mitochondrial protein quality control,mitochondrial dynamics,mitophagy,mitochondrial biogenesis,and intercellular mitochondrial transfer,to maintain mitochondrial homeostasis under pathological conditions.Specific interventions targeting mitochondrial quality control mechanisms have emerged as promising therapeutic strategies for subarachnoid hemorrhage.This review provides an overview of recent research advances in mitochondrial pathophysiological processes after subarachnoid hemorrhage,particularly mitochondrial quality control mechanisms.It also presents potential therapeutic strategies to target mitochondrial quality control in subarachnoid hemorrhage.

调控Ru的电子态以促进乙烯在酸中高选择性电氧化合成乙二醇

乙二醇(EG)是一种重要的化工产品,由于在化学品制造行业的广泛应用而备受关注.然而,目前工业上制备乙二醇主要采用乙烯作为原料,经过环氧化和水解两步反应,这一过程不仅需要高温高压,还需使用成本高的氧化剂(如H_(2)O_(2)),这违背了绿色化学的原则.因此,电催化阳极氧化作为一种新兴的合成策略,正逐渐受到研究者的青睐.该技术仅通过电子转移并利用水作为氧源,就能够高效合成高附加值含氧化学品.特别是,阳极氧化反应可与阴极还原反应(例如氢析出反应)相耦合,实现能量的高效利用.尽管电催化阳极氧化具有诸多优势,但目前在乙烯电氧化合成乙二醇过程中,其选择性仍然较低,这导致后续的纯化过程变得复杂且成本高昂.因此,开发高选择性的电氧化合成乙二醇技术,成为了一项迫切且极具挑战性的任务.本文提出了一种Ir和Ru合金化策略,以提高乙烯电氧化制备乙二醇的选择性和耐久性.研究结果表明,当Ir和Ru的原子比达到适当的比例(即Ir_(0.54)Ru_(0.46))时,所制备的IrRu合金表现出近100%的乙二醇选择性,远远优于Ru NPs对照组样品(43.8%).此外,在1.475 V的电压下,Ir_(0.54)Ru_(0.46)催化生成乙二醇产率达到了60.62 mmolgRu^(-1) h^(-1),是Ru NPs上最高产率(21.75 mmolgRu^(-1) h^(-1))的2.8倍.在耐久性测试中,Ir_(0.54)Ru_(0.46)能够稳定催化生成乙二醇超过12 h,其生成速率为6μmol L^(-1) h^(-1).相比之下,对照组样品Ru NPs在电解反应3 h后已失去活性.能量损失谱分析显示,Ir_(0.54)Ru_(0.46)在电解2 h后形成了稳定的表面富Ir核壳结构IrRu@Ir,这是催化剂稳定性提升的关键.先进光谱研究进一步揭示,Ir的引入导致了电子由Ru位点向Ir流动,使Ru位点带正电荷,从而减弱了OH的吸附.OH脱附实验结果表明,随着Ir/Ru原子比的增加,OH更容易从Ru位点脱附,这促进了OH与乙烯的偶联反应.自由基淬灭和氘代同位素标记实验结果表明,在IrRu催化剂上,乙烯到乙二醇的转化并非级联反应,而是直接的表面催化反应,其中OH的转移是决速步骤.X射线光电子能谱分析显示,随着合金中Ir比例的增加,合金d带中心下移,这有利于关键中间体(*OH等)的转移.原位红外光谱表明,乙烯分子在Ru位点上通过Pauling型吸附构型被活化.值得注意的是,仅检测到*CH_(2)CH_(2)OH中间体,而未检测到其他氧基团(如羰基),这表明在反应过程中没有发生过氧化现象.密度泛函理论计算进一步证实,与Ir合金化不仅加速了OH的转移,还优化了反应途径,使乙二醇的选择性达到100%.综上,本文设计了不同Ir/Ru原子比的IrRu合金催化剂,通过有效调控活性位点Ru的电子结构,优化了OH的结合能,使乙烯可以100%选择性高效转化为乙二醇,这为开发高选择性电催化剂用于乙二醇电合成提供了新思路.

Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury

Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability worldwide.Although PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely unknown.Identifying potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced PTH.In this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term recovery.Results indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury stage.Metabolic kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of PTH.Additionally,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying PTH.Moreover,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for PTH.Future studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment.

铜-焦脱镁叶绿酸a甲酯的合成及抗肿瘤活性研究实验教学设计

本实验设计合成了铜-焦脱镁叶绿酸a甲酯(Cu-MPPa),用于活性氧(ROS)介导的癌症治疗和消耗谷胱甘肽,并通过类Fenton反应循环产氧维持细胞内高浓度氧。实验过程中考察了Cu-MPPa的活性氧产生能力、氧气产生能力和谷胱甘肽消耗能力等性能。所合成中间体的结构用质谱进行了表征。这个实验综合了有机化学合成、仪器分析化学和生物化学实验,要求由三名学生组成实验小组,大约需要24学时,旨在培养学生综合创新能力、解决复杂问题能力和培养团队合作精神。

Substitutions of stem-loop subdomains in internal ribosome entry site of Senecavirus A:Impacts on rescue of sequence-modifying viruses

Senecavirus A(SVA)has a positive-sense,single-stranded RNA genome.Its 5´untranslated region harbors an internal ribosome entry site(IRES),comprising 10 larger or smaller stem-loop structures(including a pseudoknot)that have been demonstrated to be well conserved.However,it is still unclear whether each stem-loop subdomain,such as a single stem or loop,is also highly conserved.To clarify this issue in the present study,a set of 29 SVA cDNA clones were constructed by site-directed mutagenesis(SDM)on the IRES.The SDM-modified scenarios included:(1)stem-formed complementary sequences exchanging with each other;(2)loop transversion;(3)loop transition;and(4)point mutations.All cDNA clones were separately transfected into cells for rescuing viable viruses,whereas only four SVAs of interest could be recovered,and were genetically stable during 20 passages.One progeny grew significantly slower than the other three did.The dual-luciferase reporter assay showed that none of the SDM-modified IRESes significantly inhibited the IRES activity.Our previous study indicated that a single motif from any of the ten stem structures,if completely mutated,would cause the failure of virus recovery.Interestingly,our present study revealed three stem structures,whose individual complementary sequences could exchange with each other to rescue sequence-modifying SVAs.Moreover,one apical loop was demonstrated to have the ability to tolerate its own full-length transition,also having no impact on the recovery of sequence-modifying SVA.The present study suggested that not every stem-loop structure was strictly conserved in its conformation,while the full-length IRES itself was well conserved.This provides a new research direction on interaction between the IRES and many factors.

Time-resolved ultra-small-angle X-ray scattering beamline(BL10U1)at SSRF

The construction of a new beamline,BL10U1,was completed at the Shanghai synchrotron radiation facility in 2020.This multipurpose beamline was designed to provide X-ray scattering techniques such as ultra-small-angle X-ray scattering(USAXS),small-angle X-ray scattering(SAXS),wide-angle X-ray scattering,and microfocus SAXS(μSAXS)for a broad user community.To realize fast time-resolved USAXS experiments,the beamline adopted an in-vacuum undulator with a total length of 1.6 m as the photon source.An in-house cryogenic-cooled double multilayer monochromator was installed to deliver a photon flux of approximately 10^(13) photons/s at a photon energy of 10 keV.The three-year successful operation of this beamline demonstrated that the monochromator operated smoothly,as expected.BL10U1 has three end stations in succession:USAXS end station,μSAXS end station,and end station for industrial applications.The minimum scattering vector q~0.0042 nm^(-1) at 10 keV can be achieved at the USAXS end station equipped with a 28 m-long and 1.8 m-diameter vacuum flight tube.At theμSAXS end station,a beam spot of less than 10×8μm was achieved for micro-SAXS experiments.In contrast,in situ experimental instruments up to 5 m high and 8 m wide can be mounted at the industrial application end station,which offers industrial scientists the opportunity to use their large industrial equipment.BL10U1 opens up a new capability to investigate phenomena such as non-equilibrium and dynamic processes of materials with a wide length scale from angstroms to micrometers with millisecond time resolution.In this paper,we also report beamline design considerations and commissioning results.

Observation of HⅠaround three Satellite Galaxies of M31 with FAST:AndromedaⅡ,NGC 205,and NGC 185

With the exceptional sensitivity of the Five-hundred-meter Aperture Spherical radio Telescope,we conducted observations of the neutral hydrogen(HⅠ)in the circumgalactic medium of Andromeda’s(M31)satellite galaxies,specifically AndromedaⅡ,NGC 205,and NGC 185.Initially,three drift scans were executed for these satellites,with a detection limit of 4×10^(18)cm^(-2)(approximately 1.88×10^(3)M_Θof HⅠmass),followed by a more in-depth scan of a specific region.We discovered a C-shaped HⅠarc structure sharing a position and line-of-sight velocity similar to a stellar ring structure around AndromedaⅡ,hinting at a potential connection with AndromedaⅡ.In the context of NGC 205,we identified two mass concentrations in the northeast direction,which could be indicative of tidal streams resulting from the interaction between this galaxy and M31.These new lumps discovered could be very helpful in solving the missing interstellar medium problem for NGC 205.Observations regarding NGC 185are consistent with previous studies,and we did not detect any additional HⅠmaterial around this galaxy.These observational results enhance our understanding of the evolution of these satellite galaxies and provide insight into their historical interactions with the galaxy M31.

Exploring device physics of perovskite solar cell via machine learning with limited samples

Perovskite solar cells(PsCs)have developed tremendously over the past decade.However,the key factors influencing the power conversion efficiency(PCE)of PSCs remain incompletely understood,due to the complexity and coupling of these structural and compositional parameters.In this research,we demon-strate an effective approach to optimize PSCs performance via machine learning(ML).To address chal-lenges posed by limited samples,we propose a feature mask(FM)method,which augments training samples through feature transformation rather than synthetic data.Using this approach,squeeze-and-excitation residual network(SEResNet)model achieves an accuracy with a root-mean-square-error(RMSE)of 0.833%and a Pearson's correlation coefficient(r)of 0.980.Furthermore,we employ the permu-tation importance(PI)algorithm to investigate key features for PCE.Subsequently,we predict PCE through high-throughput screenings,in which we study the relationship between PCE and chemical com-positions.After that,we conduct experiments to validate the consistency between predicted results by ML and experimental results.In this work,ML demonstrates the capability to predict device performance,extract key parameters from complex systems,and accelerate the transition from laboratory findings to commercialapplications.

Large‑scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits

Background Carcass traits are crucial indicators of meat production efficiency.However,the molecular regulatory mechanisms associated with these traits remain unclear.Results In this study,we conducted comprehensive transcriptomic and genomic analyses on 399 Tiannong partridge chickens to identify key genes and variants associated with carcass traits and to elucidate the underlying regulatory mechanisms.Based on association analyses with the elastic net(EN)model,we identified 12 candidate genes(AMY1A,AP3B2,CEBPG,EEF2,EIF4EBP1,FGFR1,FOXD3,GOLM1,LOC107052698,PABPC1,SERPINB6 and TBC1D16)for 4 carcass-related traits,namely live weight,dressed weight,eviscerated weight,and breast muscle weight.SERPINB6 was identified as the only overlapping gene by 3 analyses,EN model analysis,weighted gene co-expression network analysis and differential expression analysis.Cell-level experiments confirmed that SERPINB6 promotes the proliferation of chicken DF1 cells and primary myoblasts.Further expression genome-wide association study and association analysis indicated that rs317934171 is the critical site that enhances SERPINB6 expression.Furthermore,a dual-luciferase reporter assay proved that gga-miR-1615 targets the 3′UTR of SERPINB6.Conclusions Collectively,our findings reveal that SERPINB6 serves as a novel gene for chicken carcass traits by promoting fibroblast and myoblast proliferation.Additionally,the downstream variant rs317934171 regulates SERPINB6 expression.These results identify a new target gene and molecular marker for the molecular mechanisms of chicken carcass traits.

Rebuilding the theory of isotope fractionation for evaporation of silicate melts under vacuum condition

Isotope eff ects are pivotal in understanding silicate melt evaporation and planetary accretion processes.Based on the Hertz-Knudsen equation,the current theory often fails to predict observed isotope fractionations of laboratory experiments due to its oversimplified assumptions.Here,we point out that the Hertz-Knudsen-equation-based theory is incomplete for silicate melt evaporation cases and can only be used for situations where the vaporized species is identical to the one in the melt.We propose a new model designed for silicate melt evaporation under vacuum.Our model considers multiple steps including mass transfer,chemical reaction,and nucleation.Our derivations reveal a kinetic isotopic fractionation factor(KIFF orα)αour model=[m(^(1)species)/m(^(2)species)]^(0.5),where m(species)is the mass of the reactant of reaction/nucleation-limiting step or species of diffusion-limiting step and superscript 1 and 2 represent light and heavy isotopes,respectively.This model can eff ectively reproduce most reported KIFFs of laboratory experiments for various elements,i.e.,Mg,Si,K,Rb,Fe,Ca,and Ti.And,the KIFF-mixing model referring that an overall rate of evaporation can be determined by two steps jointly can account for the eff ects of low P_(H2)pressure,composition,and temperature.In addition,we find that chemical reactions,diffusion,and nucleation can control the overall rate of evaporation of silicate melts by using the fitting slope in ln(−ln f)versus ln(t).Notably,our model allows for the theoretical calculations of parameters like activation energy(E_(a)),providing a novel approach to studying compositional and environmental eff ects on evaporation processes,and shedding light on the formation and evolution of the proto-solar and Earth-Moon systems.

Genetic Variations and Nonalcoholic Fatty Liver Disease:Field Synopsis,Systematic Meta-Analysis,and Epidemiological Evidence

Objective To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease(NAFLD).Methods Literature from Web of Science,PubMed,and Embase between January 1980 and September 2022 was systematically searched.Meta-analyses of the genetic variants were conducted using at least five data sources.The epidemiologic credibility of the significant associations was graded using the Venice criteria.Results Based on literature screening,399 eligible studies were included,comprising 381 candidate gene association,16 genome-wide association,and 2 whole-exome sequencing studies.We identified 465 genetic variants in 173 genes in candidate gene association studies,and 25 genetic variants in 17 genes were included in the meta-analysis.The meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD,with cumulative epidemiological evidence of an association graded as strong for two variants in two genes(HFE,TNF),moderate for four variants in three genes(TM6SF2,GCKR,and ADIPOQ),and weak for five variants in five genes(MBOAT7,PEMT,PNPLA3,LEPR,and MTHFR).Conclusion This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD,which may help understand the genetic architecture of NAFLD risk.

HiFAST:An HI Data Calibration and Imaging Pipeline for FAST.Ⅱ.Flux Density Calibration

Accurate flux density calibration is essential for precise analysis and interpretation of observations across different observation modes and instruments.In this research,we first introduce the flux calibration model that incorporated in Hi FAST pipeline,and designed for processing HⅠ21 cm spectra.Furthermore,we investigate different calibration techniques and assess the dependence of the gain parameter on the time and environmental factors.A comparison is carried out in various observation modes(e.g.,tracking and scanning modes)to determine the flux density gain(G),revealing insignificant discrepancies in G among different methods.Long-term monitoring data shows a linear correlation between G and atmospheric temperature.After subtracting the G-Temperature dependence,the dispersion of G is reduced to<3%over a one-year timescale.The stability of the receiver response of Five-hundred-meter Aperture Spherical radio Telescope(FAST)is considered sufficient to facilitate HⅠobservations that can accommodate a moderate error in flux calibration(e.g.,>~5%)when utilizing a constant G for calibration purposes.Our study will serve as a useful addition to the results provided by Jiang et al.Detailed measurement of G for the 19 beams of FAST,covering the frequency range 1000-1500 MHz,can be found on the Hi FAST homepage:https://hifast.readthedocs.io/fluxgain.

Engineered AAV13 variants with enhanced transduction and confined spread

Precise targeting of specific regions within the central nervous system(CNS)is crucial for both scientific research and gene therapy in the context of brain diseases.Adeno-associated virus 13(AAV13)is known for its restricted diffusion range within the CNS,making it an ideal choice for precise labeling and administration within small brain regions.However,AAV13 mediates relatively low expression of target genes.Here,we introduced specifically engineered modifications to the AAV13 capsid protein to enhance its transduction efficiency.We first constructed AAV13-YF by mutating tyrosine to phenylalanine on the surface of the AAV13 capsid.We then inserted the 7m8 peptide,known to enhance cell transduction,into positions 587/588 and 585/586 of the AAV13 capsid,resulting in two distinct variants named AAV13-587-7m8 and AAV13-585-7m8,respectively.We found that AAV13-YF exhibited superior in vitro infectivity in HEK293T cells compared to AAV13,while AAV13-587-7m8 and AAV13-585-7m8 showed enhanced CNS infection capabilities in C57BL/6 mice,with AAV13-587-7m8 infection retaining a limited spread range.These modified AAV13 variants hold promising potential for applications in gene therapy and neuroscience research.

Unraveling links between aging,circadian rhythm and cancer:Insights from evidence-based analysis

Aging and circadian rhythms have been connected for decades,but their molecular interaction has remained unknown,especially for cancers.In this situation,we summarized the current research actuality and problems in this field using the bibliometric analysis.Publications in the PubMed and Web of Science databases were retrieved.Overall,there is a rising trend in the publication volume regarding aging and circadian rhythms in the field of cancer.Researchers from USA,Germany,Italy,China and England have greater studies than others.Top three publication institutions are University of California System,UDICE-French Research Universities and University of Texas System.Current research hotspots include oxidative stress,breast cancer,melatonin,cell cycle,calorie restriction,prostate cancer and NF-κB.In conclusion,results generated by bibliometric analysis indicate that many approaches involve in the complex interactions between aging and circadian rhythm in cancer.These established and emerging research directions guide our exploration of the regulatory mechanisms of aging and circadian rhythms in cancer and provide a reference for developing new research avenues.

qSTA2-2,a novel QTL that contributes to seed starch synthesis in Zea mays L.

The seed storage materials accumulate during seed development,and are essential for seed germination and seedling establishment.Here we employed two bi-parental populations of an F2:3 population developed from a cross of improved 220(I220,small seeds with low starch)and PH4CV(large seeds with high starch),as well as recombinant-inbred lines(RILs)of X178(high starch)and its improved introgression line I178(low starch),to identify the genes that control seed storage materials.We identified a total of 12 QTLs for starch,protein and oil,which explained 3.44-10.79%of the phenotypic variances.Among them,qSTA2-1 identified in F2:3 and qSTA2-2 identified in the RILs partially overlapped at an interval of 7.314-9.554 Mb,and they explained 3.44-10.21%of the starch content variation,so they were selected for further study.Fine mapping of qSTA2-2 with the backcrossed populations of ^(I220)/PH4CV in each generation narrowed it down to a 199.7 kb interval that contains 14 open reading frames(ORFs).Transcriptomic analysis of developing seeds from the near-isogenic lines(NILs)of ^(I220)/PH4CV(BC_(5)F_(2))showed that only 11 ORFs were expressed in 20 days after pollination(DAP)seeds.Five of them were upregulated and six of them were downregulated in NIL^(I220),and the differentially expressed genes(DEGs)between NIL^(I220) and NIL^(PH4CV) were enriched in starch metabolism,hormone signal transduction and glycosaminoglycan degradation.Of the eleven NIL^(I220) differential expressed ORFs,ORF4(Zm00001d002260)and ORF5(Zm00001d002261)carry 75%protein sequence similarity,both encodes an glycolate oxidase,were the possible candidates of qSTA2-2.Further analysis and validation indicated that mutation of the qSTA2-2 locus resulted in the dysfunction of ABA accumulation,the embryo/endosperm ratio and the starch and hormone levels.

Preliminary geological interpretation of long-wavelength magnetic anomalies over China and surrounding regions

Long-wavelength(>500 km)magnetic anomalies originating in the lithosphere were first found in satellite magnetic surveys.Compared to the striking magnetic anomalies around the world,the long-wavelength magnetic anomalies in China and surrounding regions are relatively weak.Specialized research on each of these anomalies has been quite inadequate;their geological origins remain unclear,in particular their connection to tectonic activity in the Chinese and surrounding regions.We focus on six magnetic high anomalies over the(1)Tarim Basin,(2)Sichuan Basin(3)Great Xing’an Range,(4)Barmer Basin,(5)Central Myanmar Basin,and(6)Sunda and Banda Arcs,and a striking magnetic low anomaly along the southern part of the Himalayan-Tibetan Plateau.We have analyzed their geological origins by reviewing related research and by detailed comparison with geological results.The tectonic backgrounds for these anomalies belong to two cases:either ancient basin basement,or subduction-collision zone.However,the geological origins of large-scale regional magnetic anomalies are always subject to dispute,mainly because of limited surface exposure of sources,later tectonic destruction,and superposition of multi-phase events.

Reliability of DC-link capacitor in pulsed power supply for accelerator magnet

Capacitors are widely used in pulsed magnet power supplies to reduce ripple voltage,store energy,and decrease power variation.In this study,DC-link capacitors in pulsed power supplies were investigated.By deriving an analytical method for the capacitor current on the H-bridge topology side,the root-mean-square value of the capacitor current was calculated,which helps in selecting the DC-link capacitors.The proposed method solves this problem quickly and with high accuracy.The current reconstruction of the DC-link capacitor is proposed to avoid structural damage in the capacitor’s current measurement,and the capacitor’s hotspot temperature and temperature rise are calculated using the FFT transform.The test results showed that the error between the calculated and measured temperature increases was within 1.5℃.Finally,the lifetime of DC-link capacitors was predicted based on Monte Carlo analysis.The proposed method can evaluate the reliability of DC-link capacitors in a non-isolated switching pulsed power supply for accelerators and is also applicable to film capacitors.

Potentials of ribosomopathy gene as pharmaceutical targets for cancer treatment

Ribosomopathies encompass a spectrum of disorders arising from impaired ribosome biogenesis and reduced functionality.Mutation or dysexpression of the genes that disturb any finely regulated steps of ribosome biogenesis can result in different types of ribosomopathies in clinic,collectively known as ribosomopathy genes.Emerging data suggest that ribosomopathy patients exhibit a significantly heightened susceptibility to cancer.Abnormal ribosome biogenesis and dysregulation of some ribosomopathy genes have also been found to be intimately associated with cancer development.The correlation between ribosome biogenesis or ribosomopathy and the development of malignancies has been well established.This work aims to review the recent advances in the research of ribosomopathy genes among human cancers and meanwhile,to excavate the potential role of these genes,which have not or rarely been reported in cancer,in the disease development across cancers.We plan to establish a theoretical framework between the ribosomopathy gene and cancer development,to further facilitate the potential of these genes as diagnostic biomarker as well as pharmaceutical targets for cancer treatment.