This paper sorted out the relevant literature on the basic theory of Mongolian medicine,explored the research methods and ideas of the basic theory of Mongolian medicine,and elaborated the idea of combining systems bi...This paper sorted out the relevant literature on the basic theory of Mongolian medicine,explored the research methods and ideas of the basic theory of Mongolian medicine,and elaborated the idea of combining systems biology to study part of the basic theory of Mongolian medicine.Through searching classic works and research papers in academic journals,this paper sorted out and summarized the research progress of the basic theory of Mongolian medicine and the existing problems in the current research,analyzed its characteristics,combined with systems biology methods to systematically explain some content in the basic theory,reveal its scientific connotation,and provide a basis for further research.展开更多
Objective: To investigate the risk factors of macrosomia and to predict the risk of macrosomia so as to reduce the incidence of macrosomia. Methods: A total of 2063 pregnant women who met the inclusion criteria were s...Objective: To investigate the risk factors of macrosomia and to predict the risk of macrosomia so as to reduce the incidence of macrosomia. Methods: A total of 2063 pregnant women who met the inclusion criteria were selected as the subjects from February 2016 to April 2017 in Jiading District Maternal and Child Health Hospital of Shanghai and Pudong New Area Maternal and Child Health Hospital. According to the birth weight of the neonates, the neonates were divided into the macrosomia group (neonatal weight > 4000 g, n=125) and the normal infant group (2500 g < neonatal weight < 4000 g, n=1938).The general data of age, number of pregnant women, BMI before pregnancy, gestational diabetes mellitus, glucose tolerance, weight gain during pregnancy, birth weight and gestational week were compared between the two groups. Multivariate logistic regression was used to analyze the risk factors of macrosomia. Results: ①There were significant differences in BMI, glucose tolerance, fasting blood sugar, weight gain in the second trimester, weight gain in the third trimester, birth weight and gestational week between the two groups (P<0.05). ②Single factor analysis showed that pre-pregnancy BMI, gestational week at first diagnosis, fasting blood glucose tolerance, weight gain in the second trimester, weight gain in the third trimester, gestational week and birth weight were the influencing factors of macrosomia (P<0.05). ③Multi-factor analysis showed that gestational weeks, gestational diabetes, fasting glucose tolerance and weight growth in the second trimester were the main factors affecting the production of macrosomia, among which gestational diabetes was the protective factor, while gestational weeks, fasting glucose tolerance and weight growth in the second trimester were the risk factors. Conclusion: The high risk factors for macrosomia are gestational weeks, glucose tolerance, fasting blood sugar and weight gain in the second trimester of pregnancy.We should strengthen regular obstetric examination, health care during pregnancy, reasonable diet and proper exercise, and strictly control the weight gain during the second trimester of pregnancy. At the same time, we should monitor blood sugar in time so as to reduce the incidence of macrosomia.展开更多
Objective:To investigate the correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia.Methods:A total of 183 healthy second-trimester pregnant women w...Objective:To investigate the correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia.Methods:A total of 183 healthy second-trimester pregnant women who received antenatal care in this hospital between December 2015 and December 2017 were selected as the normal control group, and 62 second-trimester pregnant women with preeclampsia who received antenatal care in this hospital during the same period were selected as the preeclampsia group. The difference of sFlt-1/PLGF ratio in the urine was compared between the two groups of pregnant women, and the expression levels of invasion-related genes and apoptosis-related genes in the placental tissues were detected. The Pearson test was adopted to further evaluate the correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia.Results: Urine sFlt-1/PLGF ratio of preeclampsia group was significantly higher than that in normal control group;Rho, ROCK, Notch-1, MMP9 and LAMA4 mRNA expression in placental tissues of preeclampsia group were lower than those of normal control group whereas CDKN1C mRNA expression was higher than that of normal control group;Bcl-2 and Survivin mRNA expression in placental tissues of preeclampsia group were lower than those of normal control group whereas Bax, Caspase-3 and Caspase-8 mRNA expression were higher than those of normal control group. Correlation analysis showed that the urine sFlt-1/PLGF ratio of pregnant women with preeclampsia was directly correlated with the expression of placental trophoblast invasion-related genes and apoptosis-related genes in pregnant women with preeclampsia.Conclusion: The sFlt-1/PLGF ratio abnormally increases in the urine of pregnant women with preeclampsia, which can further aggravate the abnormal invasion and apoptosis of placental trophoblast cells.展开更多
Artemisinin and its derivatives,commonly known as antimalarial drugs,have gradually come to be regarded as potential antitumor agents,although their cytotoxic efficacy and mechanisms of action remain to be settled.Her...Artemisinin and its derivatives,commonly known as antimalarial drugs,have gradually come to be regarded as potential antitumor agents,although their cytotoxic efficacy and mechanisms of action remain to be settled.Herein,we report that an artemisinin analog,ART1,can potently induce ferroptosis in a subset of cancer cell lines.Structure–activity relationship(SAR)analysis reveals that both the endoperoxide moiety and the artemisinin skeleton are required for the antitumor activity of ART1.Aided with ART1-based small-molecule tools,chemical proteomic analysis identified the HSD17B4 protein as a direct target of ART1.HSD17B4 resides in peroxisomes and is an essential enzyme in the catabolism of very-long-chain fatty acids.Our results demonstrate that ART1 initiates ferroptosis through selective oxidation of the fatty acids in peroxisomes by hijacking the HSD17B4 protein without disturbing its enzymatic function,providing a promising mechanism to develop therapeutics for cancer treatment.展开更多
文摘This paper sorted out the relevant literature on the basic theory of Mongolian medicine,explored the research methods and ideas of the basic theory of Mongolian medicine,and elaborated the idea of combining systems biology to study part of the basic theory of Mongolian medicine.Through searching classic works and research papers in academic journals,this paper sorted out and summarized the research progress of the basic theory of Mongolian medicine and the existing problems in the current research,analyzed its characteristics,combined with systems biology methods to systematically explain some content in the basic theory,reveal its scientific connotation,and provide a basis for further research.
基金Key Medical Speciality (Obstetrics) of Jiading District, Shanghai (JDYXZDZK-8)
文摘Objective: To investigate the risk factors of macrosomia and to predict the risk of macrosomia so as to reduce the incidence of macrosomia. Methods: A total of 2063 pregnant women who met the inclusion criteria were selected as the subjects from February 2016 to April 2017 in Jiading District Maternal and Child Health Hospital of Shanghai and Pudong New Area Maternal and Child Health Hospital. According to the birth weight of the neonates, the neonates were divided into the macrosomia group (neonatal weight > 4000 g, n=125) and the normal infant group (2500 g < neonatal weight < 4000 g, n=1938).The general data of age, number of pregnant women, BMI before pregnancy, gestational diabetes mellitus, glucose tolerance, weight gain during pregnancy, birth weight and gestational week were compared between the two groups. Multivariate logistic regression was used to analyze the risk factors of macrosomia. Results: ①There were significant differences in BMI, glucose tolerance, fasting blood sugar, weight gain in the second trimester, weight gain in the third trimester, birth weight and gestational week between the two groups (P<0.05). ②Single factor analysis showed that pre-pregnancy BMI, gestational week at first diagnosis, fasting blood glucose tolerance, weight gain in the second trimester, weight gain in the third trimester, gestational week and birth weight were the influencing factors of macrosomia (P<0.05). ③Multi-factor analysis showed that gestational weeks, gestational diabetes, fasting glucose tolerance and weight growth in the second trimester were the main factors affecting the production of macrosomia, among which gestational diabetes was the protective factor, while gestational weeks, fasting glucose tolerance and weight growth in the second trimester were the risk factors. Conclusion: The high risk factors for macrosomia are gestational weeks, glucose tolerance, fasting blood sugar and weight gain in the second trimester of pregnancy.We should strengthen regular obstetric examination, health care during pregnancy, reasonable diet and proper exercise, and strictly control the weight gain during the second trimester of pregnancy. At the same time, we should monitor blood sugar in time so as to reduce the incidence of macrosomia.
文摘Objective:To investigate the correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia.Methods:A total of 183 healthy second-trimester pregnant women who received antenatal care in this hospital between December 2015 and December 2017 were selected as the normal control group, and 62 second-trimester pregnant women with preeclampsia who received antenatal care in this hospital during the same period were selected as the preeclampsia group. The difference of sFlt-1/PLGF ratio in the urine was compared between the two groups of pregnant women, and the expression levels of invasion-related genes and apoptosis-related genes in the placental tissues were detected. The Pearson test was adopted to further evaluate the correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia.Results: Urine sFlt-1/PLGF ratio of preeclampsia group was significantly higher than that in normal control group;Rho, ROCK, Notch-1, MMP9 and LAMA4 mRNA expression in placental tissues of preeclampsia group were lower than those of normal control group whereas CDKN1C mRNA expression was higher than that of normal control group;Bcl-2 and Survivin mRNA expression in placental tissues of preeclampsia group were lower than those of normal control group whereas Bax, Caspase-3 and Caspase-8 mRNA expression were higher than those of normal control group. Correlation analysis showed that the urine sFlt-1/PLGF ratio of pregnant women with preeclampsia was directly correlated with the expression of placental trophoblast invasion-related genes and apoptosis-related genes in pregnant women with preeclampsia.Conclusion: The sFlt-1/PLGF ratio abnormally increases in the urine of pregnant women with preeclampsia, which can further aggravate the abnormal invasion and apoptosis of placental trophoblast cells.
基金supported by the National Natural Science Foundation of China(no.21532002 to Z.-J.Y.and J.Z.,no.21761142001 to Z.-J.Y.).
文摘Artemisinin and its derivatives,commonly known as antimalarial drugs,have gradually come to be regarded as potential antitumor agents,although their cytotoxic efficacy and mechanisms of action remain to be settled.Herein,we report that an artemisinin analog,ART1,can potently induce ferroptosis in a subset of cancer cell lines.Structure–activity relationship(SAR)analysis reveals that both the endoperoxide moiety and the artemisinin skeleton are required for the antitumor activity of ART1.Aided with ART1-based small-molecule tools,chemical proteomic analysis identified the HSD17B4 protein as a direct target of ART1.HSD17B4 resides in peroxisomes and is an essential enzyme in the catabolism of very-long-chain fatty acids.Our results demonstrate that ART1 initiates ferroptosis through selective oxidation of the fatty acids in peroxisomes by hijacking the HSD17B4 protein without disturbing its enzymatic function,providing a promising mechanism to develop therapeutics for cancer treatment.
基金the Ministry of Science and Technology of China (No.2013CB836900)the National Natural Science foundation of China (Nos.31301169,21532002 and 21761142001).
