Gastrointestinal stromal tumors (GISTs) are rare in infants. GIST was presumed to originate from the interstitial cells of Cajal (ICC), which has been proven by their immu-nophenotype (CD117 positive). About 95% of GI...Gastrointestinal stromal tumors (GISTs) are rare in infants. GIST was presumed to originate from the interstitial cells of Cajal (ICC), which has been proven by their immu-nophenotype (CD117 positive). About 95% of GISTs express CD117 and 80% of GISTs also express CD34. They locate mostly in the stomach or the small intestine and usu-ally cause obstruction (1)The UK National Registry of Childhood Tumors reported the incidence of GISTs at 0.02 per million per year in children below the age of 14 years (2)Here we will discuss a very rare case of infantile GIST with negative CD117 expression and make a review of lit-eratures about its clinical, histopathological, and prognos-tic findings.展开更多
文摘Gastrointestinal stromal tumors (GISTs) are rare in infants. GIST was presumed to originate from the interstitial cells of Cajal (ICC), which has been proven by their immu-nophenotype (CD117 positive). About 95% of GISTs express CD117 and 80% of GISTs also express CD34. They locate mostly in the stomach or the small intestine and usu-ally cause obstruction (1)The UK National Registry of Childhood Tumors reported the incidence of GISTs at 0.02 per million per year in children below the age of 14 years (2)Here we will discuss a very rare case of infantile GIST with negative CD117 expression and make a review of lit-eratures about its clinical, histopathological, and prognos-tic findings.
