It has been demonstrated thatβ-elemene could protect against carbon tetrachloride(CCl_(4))-induced liver fibrosis in our laboratory work,and the aim of this paper is to reveal the protective mechanisms ofβ-elemene.T...It has been demonstrated thatβ-elemene could protect against carbon tetrachloride(CCl_(4))-induced liver fibrosis in our laboratory work,and the aim of this paper is to reveal the protective mechanisms ofβ-elemene.The hepatic fibrosis experimental model was induced by the hypodermical injection of CCl_(4) in Wistar male rats.β-elemene was intraperitoneally administered into rats for 8 weeks(0.1 mL/100 g bodyweight per day),and plasma endotoxin content was assayed by biochemistry.The serum TNF-αlevel was detected using radioactive immunity.CD14 expression in rat livers was measured by immunohistochemistry and Western blot.The results showed thatβ-elemene can downregulate the levels of plasma endotoxins,serum TNF-α,and hepatic CD14 expression in rats with liver fibrosis.β-elemene plays an important role in downregulating the lipopolysaccharide signal transduction pathway,a significant pathway in hepatic fibrosis development.展开更多
Aqueous zinc-ion batteries(AZIBs)have garnered extensive attention as promising energy storage systems because of the advantages of low cost and high safety.However,severe parasitic reactions at the Zn anode surface p...Aqueous zinc-ion batteries(AZIBs)have garnered extensive attention as promising energy storage systems because of the advantages of low cost and high safety.However,severe parasitic reactions at the Zn anode surface pose a huge challenge for the practical application of AZIBs,especially the intricate hydrogen evolution reaction(HER)and Zn dendrite growth.Herein,zwitterionic taurine with isoelectric point property is introduced as an electrolyte additive to construct a passivation layer by adapting its net charge to the microenvironment variation for stabilizing the Zn anode.The experimental and theoretical results reveal that taurine can not only in-situ form a hydrophobic and zincophilic layer on the Zn anode surface via the chelation with Zn^(2+)in the alkaline interfacial microenvironment,but also buffer the pH change dynamically,thus effectively suppressing the HER and Zn dendrite growth.As a consequence,the taurine-containing electrolyte enables a stable cycling of Zn anodes in symmetric Zn∥Zn cells for more than 1800 h under a deep plating/stripping condition(5 mA cm^(-2)and 5 mAh cm^(-2)).More encouragingly,the full cells coupled with the NH_(4)V_(4)O_(10)cathode can also exhibit an excellent capacity retention of 89.8%after 1200 cycles.This efficient strategy with an environmental adaptive additive offers valuable insights for mitigating the side reactions to achieve practical AZIBs and beyond.展开更多
文摘It has been demonstrated thatβ-elemene could protect against carbon tetrachloride(CCl_(4))-induced liver fibrosis in our laboratory work,and the aim of this paper is to reveal the protective mechanisms ofβ-elemene.The hepatic fibrosis experimental model was induced by the hypodermical injection of CCl_(4) in Wistar male rats.β-elemene was intraperitoneally administered into rats for 8 weeks(0.1 mL/100 g bodyweight per day),and plasma endotoxin content was assayed by biochemistry.The serum TNF-αlevel was detected using radioactive immunity.CD14 expression in rat livers was measured by immunohistochemistry and Western blot.The results showed thatβ-elemene can downregulate the levels of plasma endotoxins,serum TNF-α,and hepatic CD14 expression in rats with liver fibrosis.β-elemene plays an important role in downregulating the lipopolysaccharide signal transduction pathway,a significant pathway in hepatic fibrosis development.
基金supported by the National Natural Science Foundation of China(12275189)Collaborative Innovation Center of Suzhou Nano Science&Technology+1 种基金the 111 ProjectJoint International Research Laboratory of Carbon-Based Functional Materials and Devices。
文摘Aqueous zinc-ion batteries(AZIBs)have garnered extensive attention as promising energy storage systems because of the advantages of low cost and high safety.However,severe parasitic reactions at the Zn anode surface pose a huge challenge for the practical application of AZIBs,especially the intricate hydrogen evolution reaction(HER)and Zn dendrite growth.Herein,zwitterionic taurine with isoelectric point property is introduced as an electrolyte additive to construct a passivation layer by adapting its net charge to the microenvironment variation for stabilizing the Zn anode.The experimental and theoretical results reveal that taurine can not only in-situ form a hydrophobic and zincophilic layer on the Zn anode surface via the chelation with Zn^(2+)in the alkaline interfacial microenvironment,but also buffer the pH change dynamically,thus effectively suppressing the HER and Zn dendrite growth.As a consequence,the taurine-containing electrolyte enables a stable cycling of Zn anodes in symmetric Zn∥Zn cells for more than 1800 h under a deep plating/stripping condition(5 mA cm^(-2)and 5 mAh cm^(-2)).More encouragingly,the full cells coupled with the NH_(4)V_(4)O_(10)cathode can also exhibit an excellent capacity retention of 89.8%after 1200 cycles.This efficient strategy with an environmental adaptive additive offers valuable insights for mitigating the side reactions to achieve practical AZIBs and beyond.
