Seeking for endometrial carcinoma-related genes and their bioinformatics analysis

Objective:Screening and excavating genes and biological information related to endometrial carcinoma(EC),to provide novel means for clinical diagnosis and treatment.Methods:The gene chip data of EC was obtained from the Gene Expression Omnibus(GEO)database,we integrated gene discrepantly expressive gene analysis,enrichment of genic function and pathway analysis,protein-protein interaction(PPI)network and literature mining to predict genes and pathways of EC.Results:Functional enrichment analysis identified 976differential expression genes were participated in cell cycle regulation,proliferation,biosynthesis,protein phosphorylation and fission biological process,etc.We found eight significantly up-regulated pathways in the microarray datasets,including the MAPK signaling pathway and mTOR pathway,and six down-regulated pathways,including the P53signaling pathway and cell cycle.Gene protein related interaction network analysis was further performed,and we found twelve distinct genes,including the PCNA and CCND1,these genes were located in key position of EC related network,which may be related to the pathogenesis and progression of EC.Furthermore,there was a high correlation between PCNA and CCND1with EC by consulting the related literature and data,however,the functional mechanism was uncleared.Conclusion:The pathogenesis and progression of EC may involve in several different pathways and genes,the genes PCNA,CCND1and MAPK signaling pathway may be valuable.

IPBES评估报告对全球生物多样性保护的影响——以美国传粉者保护政策为例

作为生物多样性领域首个政府间、多学科、跨领域的综合性科学政策平台,联合国生物多样性和生态系统服务政府间科学–政策平台(The Intergovernmental Science–Policy Platform on Biodiversity and Ecosystem Services,IPBES)将会对全球生物多样性保护及其他领域产生重要影响。本文通过分析美国传粉者保护政策的制定和实施过程,获得了生物多样性相关保护政策的制定为科学评估–政府关注–出台限制性政策措施的过程和模式。基于IPBES 2016年发布《传粉者、传粉与粮食生产评估报告》(The Assessment Report on Pollinators,Pollination and Food Production)的事实,推测IPBES交付品可能促进对新烟碱类农药产业和蜂产品尤其是野生蜂产品交易限制性政策的产生。并进一步分析了IPBES交付品可能在全球以及我国生物多样性保护及其相关领域带来的影响,比如可能通过促进生物多样性领域的科学评估,进一步主流化生物多样性保护问题,促使生物多样性保护成为重要的政治议题。本文旨在为我国建立生物多样性保护的适应性政策提供科学支持。