All-inorganic perovskite solar cells with efficiency>20%

The power conversion efficiency(PCE)of organic-inorganic hybrid metal halide perovskite solar cells(PSCs)has rocketed from around 3%to more than 25%in a decade,showing a miracle in the development history of photovoltaics^([1]).However,the hybrid perovskites still suffer from the issue of thermodynamic instability due to the volatile organic cations in perovskites.All-inorganic metal halide perovskites.

Multidimensional Optimization of Saccharomyces cerevisiae for Carotenoid Overproduction

Microbial synthesis of carotenoids is a highly desirable alternative to plant extraction and chemical synthesis.In this study,we investigated multidimensional strategies to improve the carotenoid synthesis in the industrial workhorse of Saccharomyces cerevisiae.First,we rewired the yeast central metabolism by optimizing non-oxidative glycolysis pathway for an improved acetyl-CoA supply.Second,we restricted the consumption of farnesyl pyrophosphate(FPP)by the down-regulation of squalene synthase using the PEST degron.Third,we further explored the human lipid binding/transfer protein saposin B(hSapB)-mediated metabolic sink for an enhanced storage of lipophilic carotenoids.Last,the copper-induced GAL expression system was engineered to function in the yeast-peptone-dextrose medium for an increased biomass accumulation.By combining the abovementioned strategies,the final engineered yeast produced 166.79±10.43 mg/Ⅰβ-carotene in shake flasks,which was nearly 5-fold improvement of the parental carotenoid-producing strain.Together,we envision that multidimensional strategies reported here might be applicable to other hosts for the future industrial development of carotenoid synthesis from renewable feedstocks.

Microbial Upcycling of Depolymerized Lignin into Value-Added Chemicals

Lignin is one of the most widespread organic compounds found on earth,boasting a wealth of aromatic molecules.The use of lignin feedstock for biochemical productions is of great importance for achieving"carbon neutrality."In recent years,a strategy for lignin valorization known as the"bio-funnel"has been proposed as a means to generate a variety of commercially valuable chemicals from lignin-derived compounds.The implementation of biocatalysis and metabolic engineering techniques has substantially advanced the biotransformation of depolymerized lignin into chemicals and materials within the supply chain.In this review,we present an overview of the latest advancements in microbial upcycling of depolymerized lignin into value-added chemicals.Besides,the review provides insights into the problems facing current biological lignin valorization while proposing further research directions to improve these technologies for the extensive accomplishment of the lignin upcycling.