1.Introduction Chemotherapy is the traditional treatment for clinical cancer patient[1,2].However,the therapeutic effect is often severely limited by the multidrug resistance(MDR)[3,4],which was commonly mediated by i...1.Introduction Chemotherapy is the traditional treatment for clinical cancer patient[1,2].However,the therapeutic effect is often severely limited by the multidrug resistance(MDR)[3,4],which was commonly mediated by inactivating drugs,increasing efflux,stimulating DNA repair mechanisms,and/or activating detoxification pathways[5-7].Recent studies are committing to develop reasonable strategies for intervention of the molecular pathways mediating MDR,of which P-glycoprotein(P-gp)has been widely investigated[8].So far,several kinds of P-gp inhibitors,including verapamil[9],vitamin E[10],cyclosporin A[11],and small interfering RNA(siRNA)[12].展开更多
he immune system can robustly respond to pathogens, while it is capableor malntaining Itolerance to self and innocu- ous antigens, so that the body is not jeopar- dized by autoimmune reactivity. Under certain circumst...he immune system can robustly respond to pathogens, while it is capableor malntaining Itolerance to self and innocu- ous antigens, so that the body is not jeopar- dized by autoimmune reactivity. Under certain circumstances, nonetheless, control of homeostasis of the immune system is sus- pended, and the body subsequently fails to recognize its own constituent parts as self, which contributes to homeostatic peripheral expansion and autoimmune diseases. Although autoimmunity is extensively studied, the ori- gins of this increasing public health challenge remain not well understood.展开更多
基金We acknowledge the financial support from the National Natural Science Foundation of China(No.U20A20260,51973213)Natural Science Foundation of Hebei Province(C20202006)。
文摘1.Introduction Chemotherapy is the traditional treatment for clinical cancer patient[1,2].However,the therapeutic effect is often severely limited by the multidrug resistance(MDR)[3,4],which was commonly mediated by inactivating drugs,increasing efflux,stimulating DNA repair mechanisms,and/or activating detoxification pathways[5-7].Recent studies are committing to develop reasonable strategies for intervention of the molecular pathways mediating MDR,of which P-glycoprotein(P-gp)has been widely investigated[8].So far,several kinds of P-gp inhibitors,including verapamil[9],vitamin E[10],cyclosporin A[11],and small interfering RNA(siRNA)[12].
文摘he immune system can robustly respond to pathogens, while it is capableor malntaining Itolerance to self and innocu- ous antigens, so that the body is not jeopar- dized by autoimmune reactivity. Under certain circumstances, nonetheless, control of homeostasis of the immune system is sus- pended, and the body subsequently fails to recognize its own constituent parts as self, which contributes to homeostatic peripheral expansion and autoimmune diseases. Although autoimmunity is extensively studied, the ori- gins of this increasing public health challenge remain not well understood.
