During embryonic development,organs undergo distinct and programmed morphological changes as they develop into their functional forms.While genetics and biochemical signals are well recognized regulators of morphogene...During embryonic development,organs undergo distinct and programmed morphological changes as they develop into their functional forms.While genetics and biochemical signals are well recognized regulators of morphogenesis,mechanical forces and the physical properties of tissues are now emerging as integral parts of this process as well.These physical factors drive coordinated cell movements and reorganizations,shape and size changes,proliferation and differentiation,as well as gene expression changes,and ultimately sculpt any developing structure by guiding correct cellular architectures and compositions.In this review we focus on several craniofacial structures,including the tooth,the mandible,the palate,and the cranium.We discuss the spatiotemporal regulation of different mechanical cues at both the cellular and tissue scales during craniofacial development and examine how tissue mechanics control various aspects of cell biology and signaling to shape a developing craniofacial organ.展开更多
基金supported by NSFC 81900965 from National Natural Science Foundation of ChinaJ.H.is supported by R00DE025874 from the National Institutes of Health/National Institute of Dental and Craniofacial Research(NIH/NIDCR).
文摘During embryonic development,organs undergo distinct and programmed morphological changes as they develop into their functional forms.While genetics and biochemical signals are well recognized regulators of morphogenesis,mechanical forces and the physical properties of tissues are now emerging as integral parts of this process as well.These physical factors drive coordinated cell movements and reorganizations,shape and size changes,proliferation and differentiation,as well as gene expression changes,and ultimately sculpt any developing structure by guiding correct cellular architectures and compositions.In this review we focus on several craniofacial structures,including the tooth,the mandible,the palate,and the cranium.We discuss the spatiotemporal regulation of different mechanical cues at both the cellular and tissue scales during craniofacial development and examine how tissue mechanics control various aspects of cell biology and signaling to shape a developing craniofacial organ.
