A new dimeric psoralen-type furanocoumarin, notopterol-（18-O-20＇）-notopol （1）, was isolated from Notopterygium incisum for the first time and its structure was elucidated by spectroscopic methods.
A new isopimarane-type diterpene （liwariverol, 1） and eight known compounds were isolated and characterized from the EtOAc extract of the whole plant of Potamogeton crispus. The structure of 1 was elucidated to be 1...A new isopimarane-type diterpene （liwariverol, 1） and eight known compounds were isolated and characterized from the EtOAc extract of the whole plant of Potamogeton crispus. The structure of 1 was elucidated to be 17-hydroxy-8c^H-isopimara-9（11）,15- diene by means of spectroscopic methods. Among the isolates, crenulatoside A （2）, an acyclic sesquiterpene glycoside, was found to have anti-oxidative activity with enhancement of the expression of the NAD（P）H：quinone oxidoreductase 1 （NQO1） in human neuroblastoma SH-SY5Y cells at 100 μmol/L after a 24-h incubation.展开更多
基金in part,by NSFC grants(No.90713040,30640068),MOST(No.2003CB716601),NCET grant(No.NCET-06-0422)STCSM grants(No.06DZ19002,06PJ14033,07DZ22006).The authors are grateful to Dr.Jiang-Nan Peng and Prof.Mark T.Hamann(Department of Pharmacognosy,The University of Mississippi),Prof.Jian-Ming Yue(Shanghai Institute of Materia Medica),and Prof.Zheng Zhao(Shanghai Key Laboratory of Brain Functional Genomics)for their assistance of the measurement of MS spectral data.The authors wish to thank Prof.Jian-Wei Chen(Nanjing University of Traditional Chinese Medicine)for the plant identification.
文摘A new dimeric psoralen-type furanocoumarin, notopterol-（18-O-20＇）-notopol （1）, was isolated from Notopterygium incisum for the first time and its structure was elucidated by spectroscopic methods.
基金supported by an NSFC grant(No90713040)STCSM grants(Nos06DZ19002,07DZ22006, and 11DZ1921203)
文摘A new isopimarane-type diterpene （liwariverol, 1） and eight known compounds were isolated and characterized from the EtOAc extract of the whole plant of Potamogeton crispus. The structure of 1 was elucidated to be 17-hydroxy-8c^H-isopimara-9（11）,15- diene by means of spectroscopic methods. Among the isolates, crenulatoside A （2）, an acyclic sesquiterpene glycoside, was found to have anti-oxidative activity with enhancement of the expression of the NAD（P）H：quinone oxidoreductase 1 （NQO1） in human neuroblastoma SH-SY5Y cells at 100 μmol/L after a 24-h incubation.
