The global ionosphere maps(GIM)provided by the International GNSS Service(IGS)are extensively utilized for ionospheric morphology monitoring,scientific research,and practical application.Assessing the credibility of G...The global ionosphere maps(GIM)provided by the International GNSS Service(IGS)are extensively utilized for ionospheric morphology monitoring,scientific research,and practical application.Assessing the credibility of GIM products in data-sparse regions is of paramount importance.In this study,measurements from the Crustal Movement Observation Network of China(CMONOC)are leveraged to evaluate the suitability of IGS-GIM products over China region in 2013-2014.The indices of mean error(ME),root mean square error(RMSE),and normalized RMSE(NRMSE)are then utilized to quantify the accuracy of IGS-GIM products.Results revealed distinct local time and latitudinal dependencies in IGS-GIM errors,with substantially high errors at nighttime(NRMSE:39%)and above 40°latitude(NRMSE:49%).Seasonal differences also emerged,with larger equinoctial deviations(NRMSE:33.5%)compared with summer(20%).A preliminary analysis implied that the irregular assimilation of sparse IGS observations,compounded by China’s distinct geomagnetic topology,may manifest as error variations.These results suggest that modeling based solely on IGS-GIM observations engenders inadequate representations across China and that a thorough examination would proffer the necessary foundation for advancing regional total electron content(TEC)constructions.展开更多
目的探讨远程缺血预处理(RIPC)预防急性冠状动脉综合征(ACS)患者择期经皮冠状动脉介入(PCI)术中无复流的临床价值。方法选取2019年5月至2021年5月温州市中医院收治的行择期PCI术的ACS患者160例,按照随机数字表法分为对照组和观察组各80...目的探讨远程缺血预处理(RIPC)预防急性冠状动脉综合征(ACS)患者择期经皮冠状动脉介入(PCI)术中无复流的临床价值。方法选取2019年5月至2021年5月温州市中医院收治的行择期PCI术的ACS患者160例,按照随机数字表法分为对照组和观察组各80例,分别给予现代医学常规治疗和现代医学常规治疗联合RIPC治疗。比较两组患者PCI术前及术后心肌梗死溶栓试验(TIMI)血流分级、TIMI心肌灌注分级(TMPG)、校正TIMI血流桢数(CTFC)及术中无复流、再灌注心律失常发生率,分析两组患者PCI术前及术后血清血管性血友病因子(vWF)、可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sVCAM-1)、髓过氧化物酶(MPO)、超氧化物歧化酶(SOD)、左心室射血分数(LVEF)、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)变化及PCI术后出血事件和主要不良心血管事件(MACE)发生情况。结果观察组PCI术后TIMI血流分级和TMPG分级均优于对照组(χ^(2)=12.104、13.976,P<0.05)。观察组PCI术中无复流、再灌注心律失常发生率明显低于对照组(χ^(2)=5.331、6.632,P<0.05),PCI术后CTFC明显低于对照组(t=15.494,P<0.01)。两组PCI术后24 h血清vWF、sICAM-1、sVCAM-1、MPO较PCI术前明显升高(P<0.05),但对照组升高较观察组更为显著(t=3.231、4.330、2.566、4.333,P<0.05);两组PCI术后24 h血清SOD较PCI术前明显降低(P<0.05),但对照组降低较观察组更为显著(t=4.880,P<0.05)。两组PCI术后30 d LVEF较PCI术前明显升高(P<0.05),且观察组升高较对照组更为显著(t=2.587,P<0.05);两组PCI术后30 d LVEDV、LVESV较PCI术前明显降低(P<0.05),且观察组降低较对照组更为显著(t=7.294、4.049,P<0.05)。两组患者随访期间出血事件和MACE发生率无统计学差异(P>0.05)。结论ACS患者行择期PCI术前接受RIPC治疗可降低术中无复流发生率,改善心肌微血流灌注和心功能,减轻PCI术后氧化应激反应和血管内皮损伤,且并未增加短期出血事件和MACE发生率。展开更多
Monolithic carbon electrodes with robust mechanical integrity and porous architecture are highly desired for capacitive deionization but remain challenging.Owing to the excellent mechanical strength and electroconduct...Monolithic carbon electrodes with robust mechanical integrity and porous architecture are highly desired for capacitive deionization but remain challenging.Owing to the excellent mechanical strength and electroconductivity,commercial carbon fibers cloth demonstrates great potential as high-performance electrodes for ions storage.Despite this,its direct application on capacitive deionization is rarely reported in terms of limited pore structure and natural hydrophobicity.Herein,a powerful metal-organic framework-engaged structural regulation strategy is developed to boost the desalination properties of carbon fibers.The obtained porous carbon fibers features hierarchical porous structure and hydrophilic surface providing abundant ions-accessible sites,and continuous graphitized carbon core ensuring rapid electrons transport.The catalytic-etching mechanism involving oxidation of Co and subsequent carbonthermal reduction is proposed and highly relies on annealing temperature and holding time.When directly evaluated as a current collector-free capacitive deionization electrode,the porous carbon fibers demonstrates much superior desalination capability than pristine carbon fibers,and remarkable cyclic stability up to 20 h with negligible degeneration.Particularly,the PCF-1000 showcases the highest areal salt adsorption capacity of 0.037 mg cm^(−2) among carbon microfibers.Moreover,monolithic porous carbon fibers-carbon nanotubes with increased active sites and good structural integrity by in-situ growth of carbon nanotubes are further fabricated to enhance the desalination performance(0.051 mg cm^(−2)).This work demonstrates the great potential of carbon fibers in constructing high-efficient and robust monolithic electrode for capacitive deionization.展开更多
BACKGROUND A case of neuromyelitis optica spectrum disorder(NMOSD)with positive cerebrospinal fluid(CSF)anti-aquaporin-4 antibody(AQP4-IgG)and anti-glial fibrillary acidic protein IgG(GFAP-IgG)at the time of relapse w...BACKGROUND A case of neuromyelitis optica spectrum disorder(NMOSD)with positive cerebrospinal fluid(CSF)anti-aquaporin-4 antibody(AQP4-IgG)and anti-glial fibrillary acidic protein IgG(GFAP-IgG)at the time of relapse was reported.The exact roles of GFAP-IgG in NMOSD are not fully understood and are the subject of ongoing research.This study revealed the possible connection between GFAPIgG and the occurrence or development of diseases.CASE SUMMARY A 19-year-old woman was admitted to the hospital due to a constellation of symptoms,including dizziness,nausea,and vomiting that commenced 1 year prior,reoccurred 2 mo ago,and were accompanied by visual blurring that also began 2 mo ago.Additionally,she presented with slurred speech and ptosis,both of which emerged 1 mo ago.Notably,her symptoms deteriorated 10 d prior to admission,leading to the onset of arm and leg weakness.During hospitalization,magnetic resonance imaging showed high T2-fluid attenuated inversion recovery signals,and slightly high and equal diffusion-weighted imaging signals.The serum antibody of AQP4-IgG tested positive at a dilution of 1:100.CSF antibody testing showed positive results for GFAP-IgG at a dilution of 1:10 and AQP4-IgG at a dilution of 1:32.Based on these findings,the patient was diagnosed with NMOSD.She received intravenous methylprednisolone at a daily dose of 500 mg for 5 d,followed by a tapering-off period.Afterward,the rate of reduction was gradually slowed down and the timely use of immunosuppressants was implemented.CONCLUSION The CFS was slightly GFAP-IgG-positive during the relapse period,which can aid in the diagnosis and treatment of the disease.展开更多
基金the National Key R&D Program of China(Grant No.2022YFF0503702)the National Natural Science Foundation of China(Grant Nos.42074186,41831071,42004136,and 42274195)+1 种基金the Natural Science Foundation of Jiangsu Province(Grant No.BK20211036)the Specialized Research Fund for State Key Laboratories,and the University of Science and Technology of China Research Funds of the Double First-Class Initiative(Grant No.YD2080002013).
文摘The global ionosphere maps(GIM)provided by the International GNSS Service(IGS)are extensively utilized for ionospheric morphology monitoring,scientific research,and practical application.Assessing the credibility of GIM products in data-sparse regions is of paramount importance.In this study,measurements from the Crustal Movement Observation Network of China(CMONOC)are leveraged to evaluate the suitability of IGS-GIM products over China region in 2013-2014.The indices of mean error(ME),root mean square error(RMSE),and normalized RMSE(NRMSE)are then utilized to quantify the accuracy of IGS-GIM products.Results revealed distinct local time and latitudinal dependencies in IGS-GIM errors,with substantially high errors at nighttime(NRMSE:39%)and above 40°latitude(NRMSE:49%).Seasonal differences also emerged,with larger equinoctial deviations(NRMSE:33.5%)compared with summer(20%).A preliminary analysis implied that the irregular assimilation of sparse IGS observations,compounded by China’s distinct geomagnetic topology,may manifest as error variations.These results suggest that modeling based solely on IGS-GIM observations engenders inadequate representations across China and that a thorough examination would proffer the necessary foundation for advancing regional total electron content(TEC)constructions.
文摘目的探讨远程缺血预处理(RIPC)预防急性冠状动脉综合征(ACS)患者择期经皮冠状动脉介入(PCI)术中无复流的临床价值。方法选取2019年5月至2021年5月温州市中医院收治的行择期PCI术的ACS患者160例,按照随机数字表法分为对照组和观察组各80例,分别给予现代医学常规治疗和现代医学常规治疗联合RIPC治疗。比较两组患者PCI术前及术后心肌梗死溶栓试验(TIMI)血流分级、TIMI心肌灌注分级(TMPG)、校正TIMI血流桢数(CTFC)及术中无复流、再灌注心律失常发生率,分析两组患者PCI术前及术后血清血管性血友病因子(vWF)、可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sVCAM-1)、髓过氧化物酶(MPO)、超氧化物歧化酶(SOD)、左心室射血分数(LVEF)、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)变化及PCI术后出血事件和主要不良心血管事件(MACE)发生情况。结果观察组PCI术后TIMI血流分级和TMPG分级均优于对照组(χ^(2)=12.104、13.976,P<0.05)。观察组PCI术中无复流、再灌注心律失常发生率明显低于对照组(χ^(2)=5.331、6.632,P<0.05),PCI术后CTFC明显低于对照组(t=15.494,P<0.01)。两组PCI术后24 h血清vWF、sICAM-1、sVCAM-1、MPO较PCI术前明显升高(P<0.05),但对照组升高较观察组更为显著(t=3.231、4.330、2.566、4.333,P<0.05);两组PCI术后24 h血清SOD较PCI术前明显降低(P<0.05),但对照组降低较观察组更为显著(t=4.880,P<0.05)。两组PCI术后30 d LVEF较PCI术前明显升高(P<0.05),且观察组升高较对照组更为显著(t=2.587,P<0.05);两组PCI术后30 d LVEDV、LVESV较PCI术前明显降低(P<0.05),且观察组降低较对照组更为显著(t=7.294、4.049,P<0.05)。两组患者随访期间出血事件和MACE发生率无统计学差异(P>0.05)。结论ACS患者行择期PCI术前接受RIPC治疗可降低术中无复流发生率,改善心肌微血流灌注和心功能,减轻PCI术后氧化应激反应和血管内皮损伤,且并未增加短期出血事件和MACE发生率。
基金We gratefully acknowledge financial supports from the Natural Science Founda-tion of Shandong Province (No.ZR2020QE066)Taishan Scholar Project (No.ts201511080)+1 种基金the fellowship of China Postdoctoral Science Foundation (No.2020M672081)Opening Project of State Key Laboratory of Advanced Tech-nology for Float Glass (No.2020KF08).
文摘Monolithic carbon electrodes with robust mechanical integrity and porous architecture are highly desired for capacitive deionization but remain challenging.Owing to the excellent mechanical strength and electroconductivity,commercial carbon fibers cloth demonstrates great potential as high-performance electrodes for ions storage.Despite this,its direct application on capacitive deionization is rarely reported in terms of limited pore structure and natural hydrophobicity.Herein,a powerful metal-organic framework-engaged structural regulation strategy is developed to boost the desalination properties of carbon fibers.The obtained porous carbon fibers features hierarchical porous structure and hydrophilic surface providing abundant ions-accessible sites,and continuous graphitized carbon core ensuring rapid electrons transport.The catalytic-etching mechanism involving oxidation of Co and subsequent carbonthermal reduction is proposed and highly relies on annealing temperature and holding time.When directly evaluated as a current collector-free capacitive deionization electrode,the porous carbon fibers demonstrates much superior desalination capability than pristine carbon fibers,and remarkable cyclic stability up to 20 h with negligible degeneration.Particularly,the PCF-1000 showcases the highest areal salt adsorption capacity of 0.037 mg cm^(−2) among carbon microfibers.Moreover,monolithic porous carbon fibers-carbon nanotubes with increased active sites and good structural integrity by in-situ growth of carbon nanotubes are further fabricated to enhance the desalination performance(0.051 mg cm^(−2)).This work demonstrates the great potential of carbon fibers in constructing high-efficient and robust monolithic electrode for capacitive deionization.
基金Hospital Level Project of Jiaxing First Hospital,No.2022-YB-034.
文摘BACKGROUND A case of neuromyelitis optica spectrum disorder(NMOSD)with positive cerebrospinal fluid(CSF)anti-aquaporin-4 antibody(AQP4-IgG)and anti-glial fibrillary acidic protein IgG(GFAP-IgG)at the time of relapse was reported.The exact roles of GFAP-IgG in NMOSD are not fully understood and are the subject of ongoing research.This study revealed the possible connection between GFAPIgG and the occurrence or development of diseases.CASE SUMMARY A 19-year-old woman was admitted to the hospital due to a constellation of symptoms,including dizziness,nausea,and vomiting that commenced 1 year prior,reoccurred 2 mo ago,and were accompanied by visual blurring that also began 2 mo ago.Additionally,she presented with slurred speech and ptosis,both of which emerged 1 mo ago.Notably,her symptoms deteriorated 10 d prior to admission,leading to the onset of arm and leg weakness.During hospitalization,magnetic resonance imaging showed high T2-fluid attenuated inversion recovery signals,and slightly high and equal diffusion-weighted imaging signals.The serum antibody of AQP4-IgG tested positive at a dilution of 1:100.CSF antibody testing showed positive results for GFAP-IgG at a dilution of 1:10 and AQP4-IgG at a dilution of 1:32.Based on these findings,the patient was diagnosed with NMOSD.She received intravenous methylprednisolone at a daily dose of 500 mg for 5 d,followed by a tapering-off period.Afterward,the rate of reduction was gradually slowed down and the timely use of immunosuppressants was implemented.CONCLUSION The CFS was slightly GFAP-IgG-positive during the relapse period,which can aid in the diagnosis and treatment of the disease.
