Car-following strategy of intelligent connected vehicle using extended disturbance observer adjusted by reinforcement learning

Disturbance observer-based control method has achieved good results in the carfollowing scenario of intelligent and connected vehicle(ICV).However,the gain of conventional extended disturbance observer(EDO)-based control method is usually set manually rather than adjusted adaptively according to real time traffic conditions,thus declining the car-following performance.To solve this problem,a car-following strategy of ICV using EDO adjusted by reinforcement learning is proposed.Different from the conventional method,the gain of proposed strategy can be adjusted by reinforcement learning to improve its estimation accuracy.Since the“equivalent disturbance”can be compensated by EDO to a great extent,the disturbance rejection ability of the carfollowing method will be improved significantly.Both Lyapunov approach and numerical simulations are carried out to verify the effectiveness of the proposed method.

Demyelinating neuropathy in patients with hepatitis B virus: A case report

BACKGROUND Hepatitis B rarely leads to demyelinating neuropathy,despite peripheral neuropathy being the first symptom of hepatitis B infection.CASE SUMMARY A 64-year-old man presented with sensorimotor symptoms in multiple peripheral nerves.Serological testing showed that these symptoms were due to hepatitis B.After undergoing treatment involving intravenous immunoglobulin and an antiviral agent,there was a notable improvement in his symptoms.CONCLUSION Although hepatitis B virus(HBV)infection is known to affect hepatocytes,it is crucial to recognize the range of additional manifestations linked to this infection.The connection between long-term HBV infection and demyelinating neuropathy has seldom been documented;hence,prompt diagnostic and treatment are essential.The patient's positive reaction to immunoglobulin seems to be associated with production of the antigen-antibody immune complex.

流空间视域下城市内部物流联系及其网络结构——以深圳市为例

以深圳市为例,基于“流空间”视域研究城市内部物流网络,将货车GPS数据作为物流“流动数据”,结合社区发现模型,识别城市内部重要物流节点及其空间联系特征,并采用社会网络分析法刻画城市内部物流网络结构。结果表明:深圳市内部物流联系整体偏弱,呈现“西密东疏”的空间联系特征,具有显著极化发展态势,形成物流活动西进西出而物流设施居中分布的错位布局;物流联系“异质相吸”特征明显,不同类型节点的物流活动更趋向于朝特定区域流动;城市内部物流网络依赖于“机场-工业区-港口-物流园”廊道的联系纽带作用,形成以廊道为轴心线向周边扩散的物流廊道网络模式。由此,从重塑物流空间、调整规划编制、培育新增长级等方面提出促进城市内部物流协调高质量发展的建议,支撑打造城市物流发展的“深圳样本”,并助力其融入粤港澳大湾区的世界级物流枢纽建设。

面向德才兼备拔尖创新人才培养的分析化学(2)教学思考与实践

在科学和技术日益精进的年代,探索如何培养德才兼备的拔尖创新人才是分析化学(2)教学实践的一项重要任务。基于对现有分析化学(2)经典教学内容中中国元素显示度不明显、理论知识与实践结合不够紧密、教学内容缺乏时代性和前沿性的思考等问题,我们不断完善教学内容和教学方法,在教学内容中融入思政案例、社会热点案例、科学前沿进展,推进分析化学(2)科学育人和思政育人双重育人功能的有机融合,对培养德才兼备拔尖创新人才进行了教学探究和实践。

Large-Scale Vehicle Platooning:Advances and Challenges in Scheduling and Planning Techniques

Through vehicle-to-vehicle(V2V)communication,autonomizing a vehicle platoon can significantly reduce the distance between vehicles,thereby reducing air resistance and improving road traffic efficiency.The gradual maturation of platoon control technology is enabling vehicle platoons to achieve basic driving functions,thereby permitting large-scale vehicle platoon scheduling and planning,which is essential for industrialized platoon applications and generates significant economic benefits.Scheduling and planning are required in many aspects of vehicle platoon operation;here,we outline the advantages and challenges of a number of the most important applications,including platoon formation scheduling,lane-change planning,passing traffic light scheduling,and vehicle resource allocation.This paper’s primary objective is to integrate current independent platoon scheduling and planning techniques into an integrated architecture to meet the demands of large-scale platoon applications.To this end,we first summarize the general techniques of vehicle platoon scheduling and planning,then list the primary scenarios for scheduling and planning technique application,and finally discuss current challenges and future development trends in platoon scheduling and planning.We hope that this paper can encourage related platoon researchers to conduct more systematic research and integrate multiple platoon scheduling and planning technologies and applications.

Point cloud upsampling generative adversarial network based on residual multi-scale off-set attention

Background Owing to the limitations of the working principle of three-dimensional(3D) scanning equipment, the point clouds obtained by 3D scanning are usually sparse and unevenly distributed. Method In this paper, we propose a new generative adversarial network(GAN) that extends PU-GAN for upsampling of point clouds. Its core architecture aims to replace the traditional self-attention(SA) module with an implicit Laplacian offset attention(OA) module and to aggregate the adjacency features using a multiscale offset attention(MSOA)module, which adaptively adjusts the receptive field to learn various structural features. Finally, residual links are added to create our residual multiscale offset attention(RMSOA) module, which utilizes multiscale structural relationships to generate finer details. Result The results of several experiments show that our method outperforms existing methods and is highly robust.

Green Hydrothermal Synthesis and Applications of Sorbus pohuashanensis/Aronia melanocarpa Extracts Functionalized-Au/Ag/AuAg Nanoparticles

Nanoparticles(NPs)have already been widely used in catalysis,antibacterial and coating fields.Compared with the traditional toxic and harmful reducing reagents,green synthesis of NPs by using plant extracts is not only environmental-friendly and cost-effective but also conducive to the multi-level and efficient utilization of wild plant resources.In this study,the aqueous extracts from Sorbus pohuashanensis(SP)and Aronia melanocarpa(AM)fruits were used as the reducing and protective reagents for synthesizing Au/AgNPs,with the characteristics of originality operation and high repeatability.The SP/AM fruit extracts functionalized Au/AgNPs were characterized by UV-vis spectroscopy(UV-vis),transmission electron microscopy(TEM),energy dispersive spectroscopy(EDS),scanning electron microscope(SEM),X-ray diffraction(XRD)and Fourier transform infrared spectroscopy(FTIR).UV-vis spectrums showed the NPs peaks verified by the presence between 400–550 nm;TEM and SEM demonstrated NPs displayed approximately spherical structures;EDS confirmed the existence of Au/Ag elements;XRD measurements confirmed that the obtained NPs showed highly crystalline structures;FTIR demonstrated the fruits extracts were adsorbed on the surface of NPs.Primary experiments indicated that SP/AM fruit extracts functionalized-NPs could be used as the reagents for removing the organic dyes efficiently;Zone of inhibition tests(ZOI)explained that NPs have slow-release antibacterial activity.

Galectin-14 promotes hepatocellular carcinoma tumor growth via enhancing heparan sulfate proteoglycan modification

Hepatocellular carcinoma(HCC)is a highly heterogeneous malignancy and lacks effective treatment.Bulk-sequencing of different gene transcripts by comparing HCC tissues and adjacent normal tissues provides some clues for investigating the mechanisms or identifying potential targets for tumor progression.However,genes that are exclusively expressed in a subpopulation of HCC may not be enriched or detected through such a screening.In the current study,we performed a single cell-clone-based screening and identified galectin-14 as an essential molecule in the regulation of tumor growth.The aberrant expression of galectin-14 was significantly associated with a poor overall survival of liver cancer patients with database analysis.Knocking down galectin-14 inhibited the proliferation of tumor growth,whereas overexpressing galectin-14 promoted tumor growth in vivo.Non-targeted metabolomics analysis indicated that knocking down galectin-14 decreased glycometabolism;specifically that glycoside synthesis was significantly changed.Further study found that galectin-14 promoted the expression of cell surface heparan sulfate proteoglycans(HSPGs)that functioned as co-receptors,thereby increasing the responsiveness of HCC cells to growth factors,such as epidermal growth factor and transforming growth factor-alpha.In conclusion,the current study identifies a novel HCC-specific molecule galectin-14,which increases the expression of cell surface HSPGs and the uptake of growth factors to promote HCC cell proliferation.

Bone marrow mesenchymal stem cell-induced autophagy ameliorates TNBS-induced experimental colitis by downregulating the NLRP3 inflammasome

This study aimed to elucidate the potential mechanisms through which bone marrow-derived mesenchymal stem cells(BM-MSCs)may be effective in alleviating experimental colitis induced by treatment with 2,4,6-trinitrobenzene-sulfonate acid(TNBS),specifically through autophagy modulation.Methods:BM-MSCs were collected from BALB/c mice for subsequent experiments.The study employed cell counting kits(CCK-8)to investigate the impact of the MSC-conditioned medium(M medium)on the proliferation of RAW264.7 macrophages.The GFP-mRFP-LC3 adenovirus was transfected into RAW264.7 to detect autophagic flux.The gene expression of cytokines was assessed through quantitative reverse transcription polymerase chain reaction(qRT-PCR).Western blot analysis was employed to determine the presence of a binding interaction between NOD-like receptor protein 3(NLRP3)and autophagy.Furthermore,a colitis mouse model was established by TNBS induction.Clinical disease activity score was assessed regularly,and histological and morphometric analyses were performed on colonic tissues.Inflammatory serum cytokines were identified using an enzyme-linked immunosorbent assay.Results:BM-MSCs significantly promoted the proliferation of RAW264.7.In vitro lipopolysaccharide(LPS)-stimulated RAW264.7 cells,treated with BM-MSCs,triggered autophagy and inhibited cytokine mRNA expression.Additionally,in LPS-induced RAW264.7,BM-MSCs enhanced the Beclin1 protein expression and the microtubule-associated protein 1 light chain 3(LC3)-II to LC3-I ratio while suppressing the protein levels of NLRP3 and apoptosis-associated speck-like protein(ASC).Nevertheless,3-methyladenine(3-MA),an inhibitor of autophagy,prevented the impact of BM-MSCs by reducing the levels of NLRP3 and ASC proteins,suggesting that autophagy triggered the inhibition of the NLRP3 inflammasome.In comparison to the mice in the TNBS group,the mice in the TNBS+MSC group displayed a more acute form of colitis,and the IL1βand IL18 cytokines in their serum were lowered as well.In the meantime,3-MA raised IL1βand IL18 cytokine levels and worsened TNBS-induced experimental colitis.Conclusions:BM-MSCs can suppress inflammation in TNBS-induced experimental mice by inhibiting the NLRP3 inflammasome,thereby enhancing autophagy.

我国学前儿童数学监测指标体系的构建

对儿童学习和发展结果的评估与监控是教育质量监测的重要内容。学前儿童数学监测指标体系本质上是对3～6岁儿童在与数学学习有关的知识、能力、态度、学习品质等方面的发展的较为系统的期望。在厘清21世纪创新社会对人才数学素养要求的基础上,参考国内外研究文献和国内相关政策文件,本研究构建了学前儿童数学监测指标体系草案,然后采用德尔菲专家访谈方法,结合幼儿园教师在实践中的实际使用情况与反馈,对该指标体系进行了内容效度检验,并根据检验结果对指标体系进行了多次修改,最终确定的监测指标体系包含数学知识技能、过程性能力、态度和学习品质三个方面共20条指标,今后应进一步开发和完善与这一数学监测指标体系相匹配的注重儿童数学问题解决过程的诊断性测评工具和适合教师使用的观察评定表,以更好地发挥监测为改进教学、促进儿童发展服务的功能。

5～6岁儿童数学问题解决的认知诊断评估工具

基于认知诊断评估理论和技术,本研究采用文献分析、专家研讨和口语报告法构建5～6岁儿童"数与运算"领域数学问题解决的认知模型,对627名5～6岁儿童进行认知诊断评估,运用认知诊断模型—数据拟合对认知模型和诊断测验进行质量检验。结果显示,认知属性对题目难度的解释量为0.879,效应量为0.834,平均HCI为0.749;认知诊断测验题目的平均区分度为0.707(标准差为0.299);除两题的题目拟合度S-X^2指标的显著性水平<0.01,其他题目的拟合度都较好;测验的信度为0.95;平均掌握概率与测验总分呈单调递增曲线。以上结果说明,本研究构建的儿童数学问题解决认知模型良好,编制的认知诊断测验具有较理想的测量信度与效度,可以作为评估儿童数学问题解决的有效工具,并可以提供精细丰富的诊断信息,从而为相关教育教学及干预研究提供科学依据。

“儿童的视角”:历史生成与方法论探寻

从思想史的角度进行考察,"视角"本是指西方文艺复兴时期的一种绘画技法,后由尼采提出"视角主义",认为每个生命都有其认识与体验世界的方式,意义世界是多重视角的存在。"儿童的视角"指的是儿童对自身生活世界丰富而多元化的体验、感知和理解,能够为人类社会贡献生命力、真理以及爱的纽带。理解和珍视"儿童的视角"应该成为成人社会的自觉实践和教育活动的基础。儿童视角研究带有一种行动者意味,需要采用跨学科研究方法。目前兴盛于北欧的现象图析学在儿童视角研究方面做出了有益的探索,值得我们借鉴。

IgG4-Related Pancreatitis: A Case Report and Review of Literature

Background: Immunoglobulin G4-related pancreatitis (IgG4-RAIP) is a relatively rare chronic inflammatory disease of the pancreas. The cause of this disease is still unclear. Due to the lack of specific clinical symptoms and imaging findings, it is often misdiagnosed as pancreatic cancer. Clinicians are paying more and more attention to it. Case report: We are reporting an IgG4-RAIP case, in which the patient had been misdiagnosed as pancreatic cancer and prepared for surgical treatment but finally was diagnosed as IgG4-RAIP after pancreatic biopsy and serum immune test. And the patient was recovered after the treatment of glucocorticoids. Discussion: In order to make more patients get correct diagnosis and reasonable treatment, when we encounter undiagnosed cases of pancreatitis or pancreatic cancer in clinical work, it is very important to conduct pancreatic biopsy and serum immune blood test before operation for these patients. Conclusion: Pancreatic biopsy and serum immune blood test can effectively reduce the occurrence of misdiagnosis of IgG4-RAIP.

甘肃民族歌剧的发展历程及其作品特征——从教学歌剧《文成公主》谈起

教学歌剧《文成公主》是新时期中国民族歌剧舞台艺术发展的阶段性成果,更是中国原创民族歌剧发展道路上的一部里程碑之作,其成功源于甘肃歌剧长期以来坚守的延安精神和中华民族共同体创作理念。甘肃歌剧有着丰富多彩的民族主题创作题材、特色浓郁的民族色彩音乐语言、独树一帜的民族风格表现形式和旗帜鲜明的强烈民族品格,其立足于西部敦煌、丝路、多民族特色的创演实践的丰厚积累,为形成风格独特的甘肃民族歌剧打下了坚实的基础。

氧化石墨烯量子点修饰氧掺杂多孔g-C3N4在光催化降解和抗菌中的应用（英文）

偶氮类合成色素具有遗传毒性、致癌性和致泻性,而食源性致病菌易引发细菌性感染和食物中毒事件,食品加工过程中产生的色素废水和致病菌废水若未经妥善处理就排入水体,会对水体及环境造成污染,废水中的偶氮类色素和致病菌还会通过食物链对人体健康产生威胁.因此,寻求更为高效、绿色、安全的处理技术和净化材料有效去除食品废水中高污染性和毒害性的偶氮类色素和致病菌显得尤为迫切.g-C3N4是一种具有可见光响应的有机半导体光催化材料,广泛应用于降解污染物、杀灭致病菌、催化有机反应等领域.然而,g-C3N4本身存在着比表面积小、光吸收性能差、光氧化能力低以及光生载流子迁移效率低等缺点,限制了其光催化性能.针对上述问题,我们对g-C3N4的空间和电子结构进行了设计,将形貌调控、元素掺杂和助催化剂修饰三种改性方法相结合,以获得兼具大比表面积、优异光吸收性能、强氧化能力以及快速光生载流子迁移能力的高活性g-C3N4基光催化体系.本文通过水热法制备了氧掺杂多孔氮化碳(PCNO),通过酸剥离法制备了氧化石墨烯量子点(ox-GQDs),最后通过自组装法将助催化剂ox-GQDs修饰到PCNO上,制备了ox-GQDs/PCNO复合光催化剂.零维的ox-GQDs可以通过氢键、π-π作用和化学键作用,与二维的PCNO实现紧密接触,均匀地分散在PCNO的表面和内部孔道上.由于ox-GQDs独特的上转换特性、电子捕获能力和过氧化物酶活性,ox-GQDs/PCNO复合光催化剂具有比PCNO更佳的光吸收性能、更高的电荷转移效率以及更强的光氧化能力.因此,ox-GQDs/PCNO复合材料在降解偶氮类色素和杀灭致病菌方面均表现出更为优异的可见光催化性能,活性最佳的复合材料ox-GQDs-0.2%/PCNO降解偶氮类色素苋菜红的速率常数约是PCNO的3.1倍,并且该材料能在可见光照射4 h内杀灭99.6%的大肠杆菌,远超过PCNO 31.9%的抗菌活性.另外,光生空穴、超氧自由基和羟基自由基被证实是ox-GQDs/PCNO体系在光催化反应中产生的活性物种,可以彻底矿化偶氮类色素并有效杀灭致病菌.本研究可以拓展g-C3N4基光催化剂在环境净化领域的应用前景,并为阐明ox-GQDs在复合光催化体系中的作用提供新的见解.

新时代教师以何种方式影响学生

进入中国特色社会主义建设新时代,教师承担着立德树人的重任,肩负着传播知识、传播思想、传播真理,塑造灵魂、塑造生命、塑造新人的使命。教师以何种方式影响学生以实现这种重任和使命就是当下教育研究中的重要命题。一靠思想、道德、素养,通过“四标准”影响学生;二靠初心、使命、担当,通过“引路人”影响学生;三靠定力、自信、智慧,通过“四统一”影响学生;四靠理想、信念、追求,通过“下功夫”影响学生。从而培养德智体美劳全面发展的社会主义建设者和接班人。

便携式软袋在急诊急救护理中的应用探讨

目的:探讨便携式软袋在急诊急救护理中的应用效果。方法:采用自行设计量表调查100例急诊便携式软袋使用患者或家属满意度以及30例急诊护士的满意度。结果:便携式软袋使用后,病人满意度从78.7%提高至97.4%;急诊护士的满意度从76.7%提高至93.3%。结论:便携式软袋的应用即可保证病人就医安全,提高急诊优质护理服务满意度,又可使急诊护士感受到操作简易,能真正体现优质护理的意义即病人满意、护士满意,促进了护患和谐。

水杨醛亚胺共价修饰碳纳米管负载镍催化剂的合成及催化乙烯齐聚性能

以1,4-丁二胺为起始剂,4-羟基水杨醛和四水合乙酸镍为原料,经亲核加成和配位反应合成具有配位能力的水杨醛亚胺配体和含有活性羟基的水杨醛亚胺镍催化剂。通过缩合反应将水杨醛亚胺镍催化剂共价接枝到碳纳米管上,合成有机配体共价修饰碳纳米管催化剂。傅里叶变换红外光谱、核磁共振氢谱、X射线衍射等表征结果证实了合成的水杨醛亚胺配体及催化剂结构与理论结构相符。经助催化剂MAO活化后,2种催化剂均表现出良好的催化乙烯齐聚性能。条件优化实验确定了2种催化剂的较佳聚合条件,Ni用量5μmol、Al/Ni为500、反应压力0.7 MPa、反应时间30 min,均相催化剂和负载催化剂最佳反应温度分别为25℃和35℃。此条件下,均相催化剂催化乙烯齐聚活性为1.99×10^(5) g/(mol·Ni·h),齐聚产物C8和C10+选择性分别为30.38%和29.65%。负载催化剂催化乙烯齐聚活性为5.25×10^(5) g/(mol·Ni·h),齐聚产物C8和C10+选择性分别为38.14%和15.28%。与均相催化剂相比,负载催化剂具有更好的催化活性和重复利用性。

Electroacupuncture improves learning and memory functions in a rat cerebral ischemia/reperfusion injury model through PI3K/Akt signaling pathway activation

Electroacupuncture has been widely used to treat cognitive impairment after cerebral ischemia,but the underlying mechanism has not yet been fully elucidated.Studies have shown that autophagy plays an important role in the formation and development of cognitive impairment,and the phosphoinositide 3-kinase(PI3K)/Akt signaling pathway plays an important role in autophagy regulation.To investigate the role played by the PI3K/Akt signaling pathway in the electroacupuncture treatment of cerebral ischemia/reperfusion rat models,we first established a rat model of cerebral ischemia/reperfusion through the occlusion of the middle cerebral artery using the suture method.Starting at 2 hours after modeling,electroacupuncture was delivered at the Shenting(GV24)and Baihui(GV20)acupoints,with a dilatational wave(1-20 Hz frequency,2 mA intensity,6 V peak voltage),for 30 minutes/day over 8 consecutive days.Our results showed that electroacupuncture reduced the infarct volume in a rat model of cerebral ischemia/reperfusion injury,increased the mRNA expression levels of the PI3K/Akt signaling pathwayrelated factors Beclin-1,mammalian target of rapamycin(mTOR),and PI3K,increased the protein expression levels of phosphorylated Akt,Beclin-1,PI3K,and mTOR in the ischemic cerebral cortex,and simultaneously reduced p53 mRNA and protein expression levels.In the Morris water maze test,the latency to find the hidden platform was significantly shortened among rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture stimulation.In the spatial probe test,the number of times that a rat crossed the target quadrant was increased in rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture stimulation.Electroacupuncture stimulation applied to the Shenting(GV24)and Baihui(GV20)acupoints activated the PI3K/Akt signaling pathway and improved rat learning and memory impairment.This study was approved by the Animal Ethics Committee of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,China(approval No.8150150901)on March 10,2016.

Bending of Timoshenko beam with effect of crack gap based on equivalent spring model

Considering the effect of crack gap, the bending deformation of the Timoshenko beam with switching cracks is studied. To represent a crack with gap as a nonlinear unidirectional rotational spring, the equivalent flexural rigidity of the cracked beam is derived with the generalized Dirac delta function. A closed-form general solution is obtained for bending of a Timoshenko beam with an arbitrary number of switching cracks. Three examples of bending of the Timoshenko beam are presented. The influence of the beam＇s slenderness ratio, the crack＇s depth, and the external load on the crack state and bending performances of the cracked beam is analyzed. It is revealed that a cusp exists on the deflection curve, and a jump on the rotation angle curve occurs at a crack location. The relation between the beam＇s deflection and load is bilinear, each part corresponding to an open or closed state of crack, respectively. When the crack is open, flexibility of the cracked beam decreases with the increase of the beam＇s slenderness ratio and the decrease of the crack depth. The results are useful in identifying non-destructive cracks on a beam.