从“Z世代”到“Z时代”:中华优秀传统文化出版的创新路径

“Z世代”逐步成长为当今社会发展的中坚力量,日益成为出版文化的最主要的消费群体。出版业面向的“Z世代”,是具有超强媒介依赖、超级注意力的“超常读者”。出版业也在“Z世代”的影响下出现新转向,形成了可视化、社群式、情感化的新型出版文化场域,塑造了“文化Z时代”。出版作为中华优秀传统文化现代化创新的基础载体,在“Z时代”应当在内容路径上打造服务型、社交型出版;在技术路径上打造以虚强实的出版文化元宇宙;在传播路径上促进传统文化的再转化和新表达;在产业路径上加强产业融合、走向“出版+”的深度开发,从而有力推动中华优秀传统文化创造性转化和创新性发展。

Mesenchymal stem/stromal cells-derived exosomes for osteoporosis treatment

Osteoporosis is a systemic bone disease,which leads to decreased bone mass and an increased risk of fragility fractures.Currently,there are many anti-resorption drugs and osteosynthesis drugs,which are effective in the treatment of osteoporosis,but their usage is limited due to their contraindications and side effects.In regenerative medicine,the unique repair ability of mesenchymal stem cells(MSCs)has been favored by researchers.The exosomes secreted by MSCs have signal transduction and molecular delivery mechanisms,which may have therapeutic effects.In this review,we describe the regulatory effects of MSCs-derived exosomes on osteoclasts,osteoblasts,and bone immunity.We aim to summarize the preclinical studies of exosome therapy in osteoporosis.Furth-ermore,we speculate that exosome therapy can be a future direction to improve bone health.

Increased artemisinin production by promoting glandular secretory trichome formation and reconstructing the artemisinin biosynthetic pathway in Artemisia annua

Dear Editor,Artemisinin,which has potent antimalarial properties,is a sesquiterpene endoperoxide originally isolated from the traditional Chinese medicinal plant Artemisia annua.However,the artemisinin content in wild-type(WT)A.annua is low(1-10 mg/g dry weight),leading to its erratic supply and price fluctuations[1].

微颗粒实时在线监测仪在固液体系测量中的应用

使用自研的微颗粒实时在线监测仪对微颗粒在液相中的悬浮和沉降过程进行了在线定量测量研究。首先,通过与商用离线仪器Multisizer 4e的对比验证了自研的微颗粒监测仪实时、在线测量的可靠性。然后,选用了标准物质乳胶微球、Al2O3和ZrO2三种密度不同的百微米量级的微颗粒,对磁力搅拌器中稳定转速下的悬浮特性以及搅拌停止后颗粒的重力沉降过程进行实时在线观测,得到了这两种情形下测量点的颗粒浓度和粒度分布信息。实验结果表明,即使搅拌速度超过临界悬浮转速,搅拌容器中的Al2O3颗粒仍存在不同程度的非均匀分布状态,呈现出一定的浓度和粒度分布。在重力沉降的瞬变过程中,固体颗粒的粒径和密度在固液两相分离的过程中有着显著的作用。

Degradation of gate-recessed MOS-HEMTs and conventional HEMTs under DC electrical stress

The performance degradation of gate-recessed metal–oxide–semiconductor high electron mobility transistor(MOSHEMT)is compared with that of conventional high electron mobility transistor(HEMT)under direct current(DC)stress,and the degradation mechanism is studied.Under the channel hot electron injection stress,the degradation of gate-recessed MOS-HEMT is more serious than that of conventional HEMT devices due to the combined effect of traps in the barrier layer,and that under the gate dielectric of the device.The threshold voltage of conventional HEMT shows a reduction under the gate electron injection stress,which is caused by the barrier layer traps trapping the injected electrons and releasing them into the channel.However,because of defects under gate dielectrics which can trap the electrons injected from gate and deplete part of the channel,the threshold voltage of gate-recessed MOS-HEMT first increases and then decreases as the conventional HEMT.The saturation phenomenon of threshold voltage degradation under high field stress verifies the existence of threshold voltage reduction effect caused by gate electron injection.

Postoperative complications of concomitant fat embolism syndrome, pulmonary embolism and tympanic membrane perforation after tibiofibular fracture: A case report

BACKGROUND Fat embolism syndrome(FES)is a rare disease characterized by pulmonary distress,neurologic symptoms,and petechial rash and seriously threatens human life and health.It is still neglected clinically because of the lack of verifiable diagnostic criteria and atypical clinical symptoms.No studies on FES with pulmonary embolism(PE)and tympanic membrane perforation have been reported to date.Here,we report a rare case of concomitant FES,PE and tympanic membrane perforation after surgery in a patient with a tibiofibular fracture.CASE SUMMARY A 39-year-old man presented with right lower extremity pain due to a car accident while driving a motorbike on the road.X-ray and computed tomography scans revealed a fracture of the right mid-shaft tibia and proximal fibula categorized as a type A2 fracture according to the AO classification.A successful minimally invasive operation was performed 3 d after the injury.Postoperatively,the patient developed sudden symptoms of respiratory distress and hearing loss.Early diagnosis was made,and supportive treatments were used at the early stage of FES.Seven days after surgery,he presented a clear recovery from respiratory symptoms.The outcome of fracture healing was excellent,and his hearing of the left ear was mildly impaired at the last follow-up of 4 mo.CONCLUSION Concomitant FES,PE and tympanic membrane perforation are very rare but represent potentially fatal complications of trauma or orthopedic surgery and present with predominantly pulmonary symptoms.Early diagnosis and treatment can reduce the mortality of FES,and prevention is better than a cure.

Fluorine-plasma treated AlGaN/GaN high electronic mobility transistors under off-state overdrive stress

Influences of off-state overdrive stress on the fluorine-plasma treated AlGaN/GaN high-electronic mobility transistors(HEMTs)are experimentally investigated.It is observed that the reverse leakage current between the gate and source decreases after the off-state stress,whereas the current between the gate and drain increases.By analyzing those changes of the reverse currents based on the Frenkel–Poole model,we realize that the ionization of fluorine ions occurs during the off-state stress.Furthermore,threshold voltage degradation is also observed after the off-state stress,but the degradations of AlGaN/GaN HEMTs treated with different F-plasma RF powers are different.By comparing the differences between those devices,we find that the F-ions incorporated in the GaN buffer layer play an important role in averting degradation.Lastly,suggestions to obtain a more stable fluorine-plasma treated AlGaN/GaN HEMT are put forwarded.

关于北京—张家口地区整体建设冬季运动目的地游客印象感知的研究

2022年北京-张家口冬奥会为我国世界级冬季运动目的地的形成提供了巨大的历史机遇。国内游客对北京-张家口冬奥会的感知,对北京、张家口市整体建设世界级冬季运动目的地的支持程度,成为该冬季运动目的地能否成功建成的重要影响因素。本研究主要运用问卷调查的方法对国内游客对于该目的地的认知与认同度进行了大样本调查,从而总结出一些对建设京张冬季运动目的地有益的参考和启示。

Solvothermal-assisted assembly of MoS2 nanocages on graphene sheets to enhance the electrochemical performance of lithium-ion battery

An ordered hollow M0S2 nanocages/RGO nanocomposite is constructed by a simple solvothermal-assisted assembly method combined with freeze-drying and annealing.In this novel nanostructure,hollow M0S2 nanocages are homogeneously distributed on graphene sheets with a tight bond of C-O-Mo.The nanosized and hollow MoS2 nanocages can effectively accommodate the huge volume change during charge/discharge process and increase the number of electrochemical reaction active sites,accelerating the kinetics of lithiation/delithiation.The tight C-O-Mo bond between graphene and MoS2 further reinforces the structural stability,thus improve the electrical conductivity and substantially enhance the lithium storage performance of M0S2 anode material.As a result,this novel nanocomposite shows a long-cycle stability of 717.4 mAh·g^-1 after 800 cycles at a high current density of 3 A·g^-1,exhibiting great potential as an anode nanocomposite for advanced lithium-ion batteries.

中国科幻研究的知识演进与趋势探析(2000—2020年)——基于CSSCI来源期刊与北大核心期刊的CiteSpace可视化分析

基于国内科幻研究的兴起,文章采用CiteSpace软件绘制科学知识图谱展开可视化分析,以2000—2020年间发表于“CSSCI来源期刊”与“北大核心期刊”的1264篇科幻研究学术论文为研究对象,梳理20年来中国科幻研究的现状与热点议题,归纳中国科幻研究的知识演进,并探析未来科幻研究的趋势。研究发现,2000—2020年科幻研究日益兴盛,在作家作品、影视产业、文化理论、技术与社会等领域均有覆盖。科幻文学理论研究、科幻与科普的关系、科幻作品传播、科幻产业研究、草根科幻群体等方面是科幻研究的发展趋势,中国科幻研究具有巨大的发展空间。