An efficient synthetic route has developed to the antitumor compound salvicine via 9 steps from ferruginol. The key reaction is the rearrangement or the angular methyl group ol. compound 7 to 4.5-seco-5. 10.-friedo-ab...An efficient synthetic route has developed to the antitumor compound salvicine via 9 steps from ferruginol. The key reaction is the rearrangement or the angular methyl group ol. compound 7 to 4.5-seco-5. 10.-friedo-abieta diterpene 8.展开更多
Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine analogues, fifteen of them were first reported. Some compounds were demonstrated potent cytotoxic...Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine analogues, fifteen of them were first reported. Some compounds were demonstrated potent cytotoxicity against tumor cells with the 50% inhibition concentration in the micromolar range. Furthermore some compounds showed potent topoisomerase II inhibitory effects. The preliminary structure-activity relationship of saprorthoquinone analogues was discussed according to their cytotoxicity against three tumor cells.展开更多
基金This work was supported by a grant for "1035" Major Project of New Drugs from the Ministry of Science and Technology of China (N
文摘An efficient synthetic route has developed to the antitumor compound salvicine via 9 steps from ferruginol. The key reaction is the rearrangement or the angular methyl group ol. compound 7 to 4.5-seco-5. 10.-friedo-abieta diterpene 8.
文摘Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine analogues, fifteen of them were first reported. Some compounds were demonstrated potent cytotoxicity against tumor cells with the 50% inhibition concentration in the micromolar range. Furthermore some compounds showed potent topoisomerase II inhibitory effects. The preliminary structure-activity relationship of saprorthoquinone analogues was discussed according to their cytotoxicity against three tumor cells.
