Relationship between granulomatous lobular mastitis and methylene tetrahydrofolate reductase gene polymorphism

BACKGROUND Variations in the methylene tetrahydrofolate reductase(MTHFR)gene have been reported as risk factors for numerous conditions,including cardiovascular disease,thrombophilia,stroke,hypertension and pregnancy-related complications.Moreover,it was reported there is an association between breast cancer and mutations in MTHFR-C677T.However,whether there is an association between MTHFR gene polymorphism and granulomatous lobular mastitis or not has been rarely investigated.AIM To analyze the association between MTHFR gene polymorphism and granulomatous lobular mastitis.METHODS Fifty-one patients with granulomatous lobular mastitis admitted to The First Hospital of Kunming were selected as study samples.Their hospitalization time ranged from February 2018 to February 2019.The 51 patients were included in the experimental group,and another 51 women who underwent physical examination at The First Hospital of Kunming in the same period were included in the control group.Deoxyribonucleic acid and MTFR genetic polymorphism testing were performed in each group.The association between MTHFR gene polymorphism and granulomatous lobular mastitis was observed.RESULTS There were significant differences in genotype frequency and allele frequency of C/C and C/T between the experimental group and the control group(all P<0.05).However,there was no significant difference in frequency of T/T genotype between the two groups(P>0.05).In addition,there was no significant difference in genotype frequency and allele frequency of A/A,A/C and C/C between the two groups(P>0.05).CONCLUSION MTHFR gene C677T locus polymorphism is closely related to granulomatous lobular mastitis.

Modeling of the mechano-electrochemical effect at corrosion defect with varied inclinations on oil/gas pipelines

A 3-dimensional finite element model was built to determine the effect of inclination angle of a corro sion defect on local mechano-electrochemical(M-E)effect in a simulated soil solution.Because of the high effect of the defect inclination angle on the M-E effect,when the inclination angle is 0°(i.e.,the primary axis of the defect parallel to the longitudinal direction of the pipe),the greate st stress concentration level at the defect can be observed,which is associated with the lowest corrosion potential,the greatest anodic current density and the most serious accelerated localized corrosion.When the inclination angle is 90°,the stress concentration level reduces and the corrosion potential becomes less negative,accompanying with the decreased anodic/cathodic current densities.Besides,when the ratio(r_(ca))of the primary axial length of the defect to its secondary axial length is 1,the defect inclination does not affect the stress and the electrochemical corrosion rate at the defect.With the increase of r_(ca),the effect of the defect inclination angle is more apparent.