BACKGROUND Clinical outcomes are poor if patients with acute heart failure(AHF)are discharged with residual congestion in the presence of renal dysfunction.However,there is no single indication to reflect the combined...BACKGROUND Clinical outcomes are poor if patients with acute heart failure(AHF)are discharged with residual congestion in the presence of renal dysfunction.However,there is no single indication to reflect the combined effects of the two related pathophysiological processes.We,therefore,proposed an indicator,congestion and renal index(CRI),and examined the associations between the CRI and one-year outcomes and the incremental prognostic value of CRI compared with the established scoring systems in a multicenter prospective cohort of AHF.METHODS We enrolled AHF patients and calculated the ratio of thoracic fluid content index divided by estimated glomerular filtration rate before discharge,as CRI.Then we examined the associations between CRI and one-year outcomes.RESULTS A total of 944 patients were included in the analysis(mean age 63.3±13.8 years,39.3%women).Compared with patients with CRI≤0.59 mL/min per kΩ,those with CRI>0.59 mL/min per kΩhad higher risks of cardiovascular death or HF hospitalization(HR=1.56[1.13-2.15])and all-cause death or all-cause hospitalization(HR=1.33[1.01-1.74]).CRI had an incremental prognostic value compared with the established scoring system.CONCLUSIONS In patients with AHF,CRI is independently associated with the risk of death or hospitalization within one year,and improves the risk stratification of the established risk models.展开更多
t To investigate the effect of Nb on the dehydro- genation properties of Mg-Nb composite films, Mg/Nb eight- layer film and Mg- 10 at% Nb alloy film with the similar Mg- to-Nb atomic ratio were prepared by magnetron s...t To investigate the effect of Nb on the dehydro- genation properties of Mg-Nb composite films, Mg/Nb eight- layer film and Mg- 10 at% Nb alloy film with the similar Mg- to-Nb atomic ratio were prepared by magnetron sputtering. Results show that both Mg/Nb eight-layer film and Mg- 10 at% Nb alloy film exhibit excellent de/hydrogenation properties. Mg- 10 at% Nb alloy film starts to release hydrogen at 108 ℃, and its desorption peak temperature is lower to 146 ℃, which is much better than that of pure MgH2 under the same condi- tion. Scanning electron microscopy （SEM） results demon- strate that the dispersive Nb nanoparticles in Mg/Nb eight- layer film may serve as nucleation sites for Mg ←→ MgH2 reactions, which can provide channels for H diffusion. For Mg- 10 at% Nb alloy film, the uniform distributions of Nb can accelerate the hydrogen diffusion and effectively improve the dehydrogenation kinetics for MgH2. This study provides an enlightening way for designing and preparing Mg-based composite films with excellent dehydrogenation properties.展开更多
基金This work was supported by the National Key Technology R&D Program(2015BAI12B02)from the Ministry of Science and Technology of China.
文摘BACKGROUND Clinical outcomes are poor if patients with acute heart failure(AHF)are discharged with residual congestion in the presence of renal dysfunction.However,there is no single indication to reflect the combined effects of the two related pathophysiological processes.We,therefore,proposed an indicator,congestion and renal index(CRI),and examined the associations between the CRI and one-year outcomes and the incremental prognostic value of CRI compared with the established scoring systems in a multicenter prospective cohort of AHF.METHODS We enrolled AHF patients and calculated the ratio of thoracic fluid content index divided by estimated glomerular filtration rate before discharge,as CRI.Then we examined the associations between CRI and one-year outcomes.RESULTS A total of 944 patients were included in the analysis(mean age 63.3±13.8 years,39.3%women).Compared with patients with CRI≤0.59 mL/min per kΩ,those with CRI>0.59 mL/min per kΩhad higher risks of cardiovascular death or HF hospitalization(HR=1.56[1.13-2.15])and all-cause death or all-cause hospitalization(HR=1.33[1.01-1.74]).CRI had an incremental prognostic value compared with the established scoring system.CONCLUSIONS In patients with AHF,CRI is independently associated with the risk of death or hospitalization within one year,and improves the risk stratification of the established risk models.
基金supported by the National Natural Science Foundation of China(Nos.51621001,51571091,and 51471070)Guangdong Natural Science Foundation(Nos.2016A030312011 and 2014A030313222)
文摘t To investigate the effect of Nb on the dehydro- genation properties of Mg-Nb composite films, Mg/Nb eight- layer film and Mg- 10 at% Nb alloy film with the similar Mg- to-Nb atomic ratio were prepared by magnetron sputtering. Results show that both Mg/Nb eight-layer film and Mg- 10 at% Nb alloy film exhibit excellent de/hydrogenation properties. Mg- 10 at% Nb alloy film starts to release hydrogen at 108 ℃, and its desorption peak temperature is lower to 146 ℃, which is much better than that of pure MgH2 under the same condi- tion. Scanning electron microscopy （SEM） results demon- strate that the dispersive Nb nanoparticles in Mg/Nb eight- layer film may serve as nucleation sites for Mg ←→ MgH2 reactions, which can provide channels for H diffusion. For Mg- 10 at% Nb alloy film, the uniform distributions of Nb can accelerate the hydrogen diffusion and effectively improve the dehydrogenation kinetics for MgH2. This study provides an enlightening way for designing and preparing Mg-based composite films with excellent dehydrogenation properties.
