Relationship between vitamin D binding protein gene polymorphism and allergic rhinitis in Hainan population

Objective: To explore the correlation between the genetic polymorphism of vitamin D binding protein gene (GC) and allergic rhinitis in Hainan population. Methods: 94 cases of patients with allergic rhinitis (AR) who visit a hospital between March 2017 and December 2017 and 113 cases of healthy controls specimen (HCs) were chosen for the research. We analyzed the 222016 and rs7041 polymorphism in the vitamin D-binding protein gene (GC) by snapshot method. Four kinds of hereditary models including co-dominant, dominant, recessive and super dominant were used to identify the significant SNPs by the online analysis software SNPStats. The statistical analysis was done by SPSS25.0. Results: As rs7041 polymorphisms loci is mentioned, the frequency of TT, GT and GG genotypes of in CR group and HC group is 40.4% VS 42.5%, 44.7% VS 42.5%, 14.9% VS 15%, respectively. Statistical analysis showed that there was no significant difference between the two groups. Three genotype were detected for rs222016 loci which is AG, GG and AA. The frequency of AG, GG and AA in CR group and HCs group is 44.8% VS 40.7%, 12.8% VS 25.7% and 40.4% VS 33.6%, with a P value of 0.062, which is close to significance. The frequency of allele G for rs222016 in the HC group was significantly higher than that in the CR group. Conclusion: There was no significant correlation between the polymorphism of rs7041 and the incidence of allergic rhinitis in Hainan population, and GG genotype and allele G of rs222016 loci was likely to be a protective factor from allergic rhinitis in Hainan.